Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, gamma | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein kinase c epsilon type | 0.0306 | 0.6255 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7221 | 0.711 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7221 | 0.711 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.2349 | 0.2043 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.1298 | 0.2075 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.9186 | 0.9153 |
Brugia malayi | protein kinase C II. | 0.0306 | 0.6255 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0283 | 0.54 | 0.8634 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0143 | 0.0384 | 0.0613 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0283 | 0.54 | 0.8634 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0143 | 0.0384 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7221 | 0.711 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0228 | 0.3435 | 0.5492 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0283 | 0.54 | 0.8634 |
Onchocerca volvulus | 0.0333 | 0.7221 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0306 | 0.6255 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0244 | 0.4017 | 0.6423 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0306 | 0.6255 | 0.6105 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0143 | 0.0384 | 0.0613 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0152 | 0.0716 | 0.0345 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0283 | 0.54 | 0.8634 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0306 | 0.6255 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0228 | 0.3435 | 0.5492 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.1298 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 29.7 nM | Displacement of [3H]PDBu from PKCnu C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 29.7 nM | Displacement of [3H]PDBu from PKCnu C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 51.1 nM | Displacement of [3H]PDBu from PKCtheta C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 51.1 nM | Displacement of [3H]PDBu from PKCtheta C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 52.1 nM | Displacement of [3H]PDBu from PKCdelta C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 52.1 nM | Displacement of [3H]PDBu from PKCdelta C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 80.1 nM | Displacement of [3H]PDBu from PKCepsilon C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 80.1 nM | Displacement of [3H]PDBu from PKCepsilon C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 112 nM | Displacement of [3H]PDBu from PKCalpha C1A domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 112 nM | Displacement of [3H]PDBu from PKCalpha C1A domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 127 nM | Displacement of [3H]PDBu from PKCbeta C1A domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 127 nM | Displacement of [3H]PDBu from PKCbeta C1A domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 234 nM | Displacement of [3H]PDBu from PKCgamma C1A domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 234 nM | Displacement of [3H]PDBu from PKCgamma C1A domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 721 nM | Displacement of [3H]PDBu from PKCalpha C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 721 nM | Displacement of [3H]PDBu from PKCalpha C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 1100 nM | Displacement of [3H]PDBu from PKCgamma C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 1100 nM | Displacement of [3H]PDBu from PKCgamma C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 9380 nM | Displacement of [3H]PDBu from PKCbeta C1B domain (unknown origin) | ChEMBL. | 17977729 |
Ki (binding) | = 9380 nM | Displacement of [3H]PDBu from PKCbeta C1B domain (unknown origin) | ChEMBL. | 17977729 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.