Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroligin | 0.0034 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | carboxylesterase | 0.02 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | carboxylesterase | 0.0034 | 0.0208 | 0.0208 |
Onchocerca volvulus | 0.0034 | 0.0208 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Echinococcus multilocularis | acetylcholinesterase | 0.02 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0208 | 0.0208 |
Echinococcus granulosus | acetylcholinesterase | 0.02 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0034 | 0.0208 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0208 | 0.0208 |
Echinococcus multilocularis | acetylcholinesterase | 0.02 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0034 | 0.0208 | 0.0208 |
Echinococcus granulosus | acetylcholinesterase | 0.02 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.02 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.02 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0.0208 | 1 | |
Onchocerca volvulus | 0.0034 | 0.0208 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0034 | 0.0208 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0034 | 0.0208 | 0.0208 |
Echinococcus multilocularis | neuroligin | 0.0034 | 0.0208 | 0.0208 |
Echinococcus multilocularis | carboxylesterase 5A | 0.02 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0034 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0034 | 0.0208 | 0.0208 |
Echinococcus granulosus | carboxylesterase 5A | 0.02 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0208 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0208 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0208 | 0.0208 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0034 | 0.0208 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0208 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0034 | 0.0208 | 0.0208 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0034 | 0.0208 | 0.0208 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.02 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0034 | 0.0208 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0034 | 0.0208 | 0.0208 |
Brugia malayi | Carboxylesterase family protein | 0.0034 | 0.0208 | 0.0208 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0034 | 0.0208 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0034 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0208 | 0.0208 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0034 | 0.0208 | 0.0208 |
Schistosoma mansoni | acetylcholinesterase | 0.0034 | 0.0208 | 0.0208 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0034 | 0.0208 | 0.0208 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.5 nM | Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase | ChEMBL. | 18318463 |
IC50 (functional) | = 4.5 nM | Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase | ChEMBL. | 18318463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.