Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.117722 | 1 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.117722 | 1 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.117722 | 1 | 1 |
Leishmania major | AMP deaminase, putative | 0.117722 | 1 | 1 |
Schistosoma mansoni | AMP deaminase | 0.117722 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0419704 | 0 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.117722 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0757515 | 0.445946 | 0.445946 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.117722 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0419704 | 0 | 0.5 |
Echinococcus granulosus | AMP deaminase 2 | 0.117722 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0419704 | 0 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0419704 | 0 | 0.5 |
Toxoplasma gondii | AMP deaminase | 0.117722 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0419704 | 0 | 0.5 |
Echinococcus multilocularis | AMP deaminase 2 | 0.117722 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0419704 | 0 | 0.5 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.117722 | 1 | 1 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.117722 | 1 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.117722 | 1 | 1 |
Plasmodium falciparum | AMP deaminase, putative | 0.117722 | 1 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.117722 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.117722 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.09 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC50 (functional) | = 1.09 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC90 (functional) | = 1.65 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
IC90 (functional) | = 1.65 uM | Antitrypanosomal activity against Trypanosoma brucei 427 at pH 7.4 | ChEMBL. | 18281929 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei | ChEMBL23 | 18281929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.