Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0183 | 1 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0105 | 0.4957 | 0.5256 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0175 | 0.9431 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0077 | 0.3155 | 0.3957 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1101 | 0.1265 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.0364 | 0.0386 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1101 | 0.1168 |
Echinococcus multilocularis | muscleblind protein | 0.0163 | 0.8706 | 0.9231 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0163 | 0.8706 | 0.9231 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0105 | 0.4957 | 0.5256 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.8706 | 1 |
Brugia malayi | PHD-finger family protein | 0.0034 | 0.0364 | 0.0386 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.3155 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1101 | 0.1168 |
Echinococcus granulosus | peregrin | 0.0034 | 0.0364 | 0.0386 |
Echinococcus multilocularis | peregrin | 0.0034 | 0.0364 | 0.0386 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0183 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0183 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0364 | 0.0457 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.1213 | 0.1286 |
Giardia lamblia | PHD finger protein 15 | 0.0034 | 0.0364 | 0.5 |
Brugia malayi | hypothetical protein | 0.0134 | 0.6816 | 0.7227 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1101 | 0.1381 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.1213 | 0.1286 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1101 | 0.1168 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0077 | 0.3155 | 0.3345 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.8706 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.3155 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0034 | 0.0364 | 0.0418 |
Brugia malayi | Muscleblind-like protein | 0.0163 | 0.8706 | 0.9231 |
Brugia malayi | jmjC domain containing protein | 0.0105 | 0.4957 | 0.5256 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.2671 | 0.3068 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.6816 | 0.7829 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.3155 | 0.5 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0034 | 0.0364 | 0.0386 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1101 | 0.1381 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0034 | 0.0364 | 0.0457 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0105 | 0.4957 | 0.6218 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0105 | 0.4957 | 0.5694 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1101 | 0.1381 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0034 | 0.0364 | 0.0386 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0034 | 0.0364 | 0.0364 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1101 | 0.1168 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0175 | 0.9431 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0077 | 0.3155 | 0.3345 |
Brugia malayi | jmjC domain containing protein | 0.0175 | 0.9431 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0183 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0183 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0183 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0183 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.0364 | 0.0364 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.3155 | 0.3957 |
Onchocerca volvulus | Huntingtin homolog | 0.0134 | 0.6816 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0105 | 0.4957 | 0.6218 |
Brugia malayi | hypothetical protein | 0.0077 | 0.3155 | 0.3345 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0183 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.3155 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0134 | 0.6816 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1101 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3015 | 0.3464 |
Schistosoma mansoni | jumonji domain containing protein | 0.0152 | 0.7972 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.6816 | 0.7829 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0364 | 0.0418 |
Plasmodium falciparum | phd finger protein, putative | 0.0034 | 0.0364 | 0.0364 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0163 | 0.8706 | 0.9231 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.8 ug ml-1 | Antifungal activity against Trichophyton asteroides was determined in vitro | ChEMBL. | 3302258 |
MIC (functional) | = 6.3 ug ml-1 | Antifungal activity against Candida albicans was determined in vitro | ChEMBL. | 3302258 |
MIC (functional) | = 6.3 ug ml-1 | Antifungal activity against Candida albicans was determined in vitro | ChEMBL. | 3302258 |
MIC (functional) | = 50 ug ml-1 | Antifungal activity against Aspergillus fumigatus was determined in vitro | ChEMBL. | 3302258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.