Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.0631 | 0.0527 | 0.0503 |
Echinococcus granulosus | Mastin | 0.0385 | 0.0035 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0026 | 0.0026 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2198 | 0.3663 | 0.7348 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0609 | 0.0484 | 0.0459 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2198 | 0.3663 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0609 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.151 | 0.2286 | 0.2286 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2198 | 0.3663 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0385 | 0.0035 | 0.0009 |
Onchocerca volvulus | 0.1562 | 0.2389 | 0.2369 | |
Toxoplasma gondii | hypothetical protein | 0.0911 | 0.1088 | 0.2158 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.038 | 0.0026 | 0.0017 |
Echinococcus granulosus | dihydrofolate reductase | 0.0637 | 0.0539 | 0.0515 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0911 | 0.1088 | 0.1088 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0569 | 0.0404 | 0.479 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0427 | 0.0119 | 0.0094 |
Brugia malayi | Dihydrofolate reductase | 0.0637 | 0.0539 | 0.0539 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2198 | 0.3663 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0637 | 0.0539 | 0.0515 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0743 | 0.0752 | 0.1148 |
Echinococcus granulosus | serotonin transporter | 0.5367 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.5367 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.5367 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5367 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.2158 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0814 | 0.0893 | 0.0869 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0911 | 0.1088 | 0.1065 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.038 | 0.0026 | 0.0017 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.5367 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0911 | 0.1088 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 0.0631 | 0.0631 |
Brugia malayi | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.2158 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0624 | 0.0513 | 0.6428 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2198 | 0.3663 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0911 | 0.1088 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1562 | 0.2389 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1562 | 0.2389 | 0.2369 |
Brugia malayi | WGR domain containing protein | 0.151 | 0.2286 | 0.2286 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.2856 | 0.4978 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.1306 | 0.1878 | 0.1857 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0026 | 0.0026 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0814 | 0.0893 | 0.0869 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0911 | 0.1088 | 0.1065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0431 | 0.0128 | 0.066 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0911 | 0.1088 | 0.1065 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.151 | 0.2286 | 0.5271 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0624 | 0.0513 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.5367 | 1 | 1 |
Onchocerca volvulus | 0.0911 | 0.1088 | 0.1065 | |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0911 | 0.1088 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.151 | 0.2286 | 0.2266 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.2749 | 0.4763 | 0.475 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0624 | 0.0513 | 0.6428 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0609 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.5367 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.038 | 0.0026 | 0.0026 |
Brugia malayi | WGR domain containing protein | 0.2749 | 0.4763 | 0.4763 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0609 | 0.0484 | 0.0459 |
Brugia malayi | thymidylate synthase | 0.1562 | 0.2389 | 0.2389 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0911 | 0.1088 | 0.1065 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0026 | 0.0026 |
Onchocerca volvulus | 0.5367 | 1 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.1562 | 0.2389 | 0.2389 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0911 | 0.1088 | 0.1065 |
Loa Loa (eye worm) | serotonin transporter b | 0.5367 | 1 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.2749 | 0.4763 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.2158 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.2749 | 0.4763 | 0.475 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0911 | 0.1088 | 0.1065 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.151 | 0.2286 | 0.2266 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0026 | 0.0026 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0427 | 0.0119 | 0.0094 |
Onchocerca volvulus | 0.0911 | 0.1088 | 0.1065 | |
Loa Loa (eye worm) | norepinephrine transporter | 0.5367 | 1 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0911 | 0.1088 | 0.1065 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0431 | 0.0128 | 0.066 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0911 | 0.1088 | 0.1065 |
Brugia malayi | Fibulin-1 precursor | 0.038 | 0.0026 | 0.0026 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0661 | 0.0587 | 0.0587 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.038 | 0.0026 | 0.0026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0743 | 0.0752 | 1 |
Brugia malayi | hypothetical protein | 0.0743 | 0.0752 | 0.0752 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0637 | 0.0539 | 0.0539 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0624 | 0.0513 | 0.6428 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0665 | 0.0596 | 0.0572 |
Onchocerca volvulus | 0.0683 | 0.0631 | 0.0607 | |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0026 | 0.0026 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.151 | 0.2286 | 0.5271 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.1088 |
Onchocerca volvulus | 0.0525 | 0.0315 | 0.029 | |
Echinococcus multilocularis | serotonin transporter | 0.5367 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0624 | 0.0513 | 0.6428 |
Echinococcus multilocularis | thymidylate synthase | 0.1562 | 0.2389 | 0.2369 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0624 | 0.0513 | 0.6428 |
Echinococcus multilocularis | enteropeptidase | 0.0385 | 0.0035 | 0.0009 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0854 | 0.0973 | 0.095 |
Echinococcus multilocularis | Mastin | 0.0385 | 0.0035 | 0.0009 |
Brugia malayi | dihydrofolate reductase family protein | 0.0637 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.1088 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.038 | 0.0026 | 0.0026 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0911 | 0.1088 | 0.1065 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.1088 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0683 | 0.0631 | 0.0607 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0624 | 0.0513 | 0.6428 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.2092 | 0.345 | 0.345 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0911 | 0.1088 | 0.1065 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.151 | 0.2286 | 0.2266 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Echinococcus granulosus | enteropeptidase | 0.0385 | 0.0035 | 0.0009 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0911 | 0.1088 | 0.1065 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0385 | 0.0035 | 0.0009 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0624 | 0.0513 | 0.0513 |
Echinococcus granulosus | WGR domain containing protein | 0.0854 | 0.0973 | 0.095 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0427 | 0.0119 | 0.0094 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.2749 | 0.4763 | 0.475 |
Mycobacterium ulcerans | thymidylate synthase | 0.1562 | 0.2389 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.038 | 0.0026 | 0.0026 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1562 | 0.2389 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0385 | 0.0035 | 0.0009 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0911 | 0.1088 | 0.1065 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2198 | 0.3663 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.038 | 0.0026 | 0.0026 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0569 | 0.0404 | 0.479 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0637 | 0.0539 | 0.0515 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0911 | 0.1088 | 0.1088 |
Onchocerca volvulus | 0.0911 | 0.1088 | 0.1065 | |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 0.0323 | 0.0323 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0661 | 0.0587 | 0.0587 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0683 | 0.0631 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.5367 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.1562 | 0.2389 | 0.2369 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0911 | 0.1088 | 0.1065 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0409 | 0.0084 | 0.0058 |
Toxoplasma gondii | hypothetical protein | 0.0911 | 0.1088 | 0.2158 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0665 | 0.0596 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.1083 | 0.1432 | 0.1432 |
Brugia malayi | Trypsin family protein | 0.0683 | 0.0631 | 0.0631 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 M | Inhibitory activity against Glucosylceramidase in mouse liver at a concentration of 10e-4 M; NA is inactive | ChEMBL. | 10386923 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.