Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.061 | 0.4428 | 0.4426 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0217 | 0.1444 | 0.4194 |
Echinococcus granulosus | defective proboscis extension response | 0.0034 | 0.0053 | 0.0049 |
Brugia malayi | Hemopexin family protein | 0.0479 | 0.3437 | 0.5168 |
Echinococcus multilocularis | carbonic anhydrase | 0.0217 | 0.1444 | 0.1441 |
Brugia malayi | hexokinase type II | 0.0049 | 0.0169 | 0.0248 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0362 | 0.2548 | 0.3833 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0331 | 0.2308 | 0.3184 |
Echinococcus multilocularis | protein dispatched 1 | 0.0066 | 0.0294 | 0.029 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1343 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0217 | 0.1444 | 0.4194 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.033 | 0.0497 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.111 | 0.3223 |
Echinococcus multilocularis | Protein lozenge | 0.0057 | 0.0226 | 0.0222 |
Schistosoma mansoni | nephrin | 0.0034 | 0.0053 | 0.0143 |
Echinococcus granulosus | hexokinase | 0.0155 | 0.0972 | 0.0969 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0136 | 0.083 | 0.0826 |
Loa Loa (eye worm) | hexokinase type II | 0.0155 | 0.0972 | 0.1463 |
Echinococcus multilocularis | hexokinase type 2 | 0.0155 | 0.0972 | 0.0969 |
Brugia malayi | hexokinase | 0.0155 | 0.0972 | 0.1458 |
Loa Loa (eye worm) | hexokinase | 0.0097 | 0.0533 | 0.0802 |
Echinococcus granulosus | hexokinase type 2 | 0.0155 | 0.0972 | 0.0969 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0034 | 0.0053 | 0.0143 |
Echinococcus granulosus | hexokinase | 0.0155 | 0.0972 | 0.0969 |
Echinococcus multilocularis | Immunoglobulin | 0.0034 | 0.0053 | 0.0049 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0034 | 0.0053 | 0.0074 |
Brugia malayi | Matrixin family protein | 0.0362 | 0.2548 | 0.3829 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0331 | 0.2308 | 0.3468 |
Echinococcus multilocularis | Immunoglobulin | 0.0034 | 0.0053 | 0.0049 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0707 | 0.5166 | 1 |
Onchocerca volvulus | 0.0097 | 0.0533 | 0.0833 | |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0034 | 0.0053 | 0.0049 |
Echinococcus granulosus | expressed conserved protein | 0.0071 | 0.033 | 0.0327 |
Schistosoma mansoni | patched 1 | 0.0058 | 0.0232 | 0.0664 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0598 | 0.0899 |
Loa Loa (eye worm) | hexokinase | 0.0155 | 0.0972 | 0.1463 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0441 | 0.3148 | 0.4733 |
Echinococcus multilocularis | neuroglian | 0.0034 | 0.0053 | 0.0049 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0154 | 0.0964 | 0.2798 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0058 | 0.0232 | 0.0228 |
Loa Loa (eye worm) | runx1 | 0.0057 | 0.0226 | 0.034 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0331 | 0.2308 | 0.3472 |
Echinococcus granulosus | carbonic anhydrase II | 0.0331 | 0.2308 | 0.2305 |
Treponema pallidum | hexokinase (hxk) | 0.0155 | 0.0972 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.0972 | 0.1524 | |
Brugia malayi | hypothetical protein | 0.0453 | 0.3235 | 0.4863 |
Brugia malayi | Hexokinase family protein | 0.0155 | 0.0972 | 0.1458 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0079 | 0.0392 | 0.0389 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0331 | 0.2308 | 0.3184 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.3004 | 0.452 |
Echinococcus granulosus | carbonic anhydrase | 0.0217 | 0.1444 | 0.1441 |
Echinococcus granulosus | carbonic anhydrase | 0.0217 | 0.1444 | 0.1441 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0058 | 0.0232 | 0.0228 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0069 | 0.0319 | 0.0919 |
Loa Loa (eye worm) | hexokinase | 0.0155 | 0.0972 | 0.1463 |
Brugia malayi | Hexokinase family protein | 0.0097 | 0.0533 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.0232 | 0.5 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0707 | 0.5166 | 1 |
Schistosoma mansoni | lozenge | 0.0057 | 0.0226 | 0.0647 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0422 | 0.3004 | 0.8739 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0058 | 0.0232 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.3148 | 0.4736 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0331 | 0.2308 | 0.671 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0477 | 0.3423 | 0.342 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0169 | 0.0254 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0073 | 0.0347 | 0.0516 |
Echinococcus granulosus | twitchin | 0.0034 | 0.0053 | 0.0049 |
Echinococcus granulosus | hexokinase | 0.0155 | 0.0972 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.1444 | 0.2172 |
Echinococcus multilocularis | geminin | 0.0173 | 0.111 | 0.1107 |
Schistosoma mansoni | hexokinase | 0.0155 | 0.0972 | 0.2821 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0073 | 0.0347 | 0.0999 |
Leishmania major | carbonic anhydrase-like protein | 0.0331 | 0.2308 | 0.3184 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.1444 | 0.2172 |
Loa Loa (eye worm) | matrixin family protein | 0.0901 | 0.6647 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0155 | 0.0971 | 0.0968 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0004 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0217 | 0.1444 | 0.2168 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0232 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 0.3235 | 0.4866 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0217 | 0.1444 | 0.2168 |
Brugia malayi | Matrixin family protein | 0.0362 | 0.2548 | 0.3829 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0155 | 0.0971 | 0.0968 |
Brugia malayi | Matrixin family protein | 0.0362 | 0.2548 | 0.3829 |
Onchocerca volvulus | 0.0155 | 0.0972 | 0.1524 | |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0136 | 0.083 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.1444 | 0.2172 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0038 | 0.0082 | 0.0118 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0058 | 0.0232 | 0.0228 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0477 | 0.3423 | 0.342 |
Echinococcus granulosus | neuropeptide s receptor | 0.0477 | 0.3423 | 0.342 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0392 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.2548 | 0.3833 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0079 | 0.0392 | 0.0585 |
Brugia malayi | CHE-14 protein | 0.0058 | 0.0232 | 0.0343 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0477 | 0.3423 | 0.342 |
Echinococcus granulosus | neuroglian | 0.0034 | 0.0053 | 0.0049 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0441 | 0.3148 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0217 | 0.1444 | 0.1441 |
Echinococcus granulosus | roundabout 2 | 0.0034 | 0.0053 | 0.0049 |
Echinococcus multilocularis | roundabout 2 | 0.0034 | 0.0053 | 0.0049 |
Echinococcus multilocularis | adam 17 protease | 0.0154 | 0.0964 | 0.0961 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.111 | 0.3223 |
Schistosoma mansoni | tyrosine kinase | 0.0152 | 0.0951 | 0.2759 |
Onchocerca volvulus | 0.0479 | 0.3437 | 0.5404 | |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0073 | 0.0347 | 0.0343 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0004 | 0.0006 |
Echinococcus multilocularis | protein patched | 0.0058 | 0.0232 | 0.0228 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0217 | 0.1444 | 0.4194 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0136 | 0.083 | 0.2406 |
Echinococcus multilocularis | hexokinase | 0.0155 | 0.0972 | 0.0969 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0707 | 0.5166 | 1 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0707 | 0.5166 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0803 | 0.5901 | 0.8878 |
Onchocerca volvulus | Matrilysin homolog | 0.0863 | 0.6357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Echinococcus granulosus | geminin | 0.0173 | 0.111 | 0.1107 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0053 | 0.0074 |
Echinococcus multilocularis | hexokinase | 0.0155 | 0.0972 | 0.0969 |
Loa Loa (eye worm) | hexokinase | 0.0048 | 0.0159 | 0.0239 |
Plasmodium falciparum | carbonic anhydrase | 0.0217 | 0.1444 | 0.1124 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0707 | 0.5166 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0217 | 0.1444 | 0.2168 |
Toxoplasma gondii | hypothetical protein | 0.0217 | 0.1444 | 0.1124 |
Onchocerca volvulus | 0.0155 | 0.0972 | 0.1524 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0217 | 0.1444 | 0.4194 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0004 | 0.0006 |
Echinococcus granulosus | adam 17 protease | 0.0169 | 0.1081 | 0.1078 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0331 | 0.2308 | 0.3184 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0217 | 0.1444 | 0.2168 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0034 | 0.0053 | 0.0049 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0217 | 0.1444 | 0.2168 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 0.2253 | 0.3389 |
Schistosoma mansoni | hypothetical protein | 0.0479 | 0.3437 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0097 | 0.0528 | 0.0525 |
Mycobacterium ulcerans | hydrolase | 0.0441 | 0.3148 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0362 | 0.2548 | 0.4004 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 0.3235 | 0.4866 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Schistosoma mansoni | vesicular amine transporter | 0.0034 | 0.0053 | 0.0143 |
Echinococcus granulosus | carbonic anhydrase | 0.0217 | 0.1444 | 0.1441 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0707 | 0.5166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0053 | 0.008 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0034 | 0.0053 | 0.0074 |
Echinococcus multilocularis | hexokinase | 0.0155 | 0.0972 | 0.0969 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0034 | 0.0053 | 0.0143 |
Brugia malayi | Hexokinase family protein | 0.0048 | 0.0159 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.2548 | 0.3833 |
Echinococcus multilocularis | expressed conserved protein | 0.0071 | 0.033 | 0.0327 |
Schistosoma mansoni | carbonic anhydrase | 0.0217 | 0.1444 | 0.4194 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0331 | 0.2308 | 0.671 |
Echinococcus granulosus | Immunoglobulin | 0.0034 | 0.0053 | 0.0049 |
Brugia malayi | Matrixin family protein | 0.0362 | 0.2548 | 0.3829 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0331 | 0.2308 | 0.2305 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0097 | 0.0528 | 0.0525 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0803 | 0.5901 | 0.9282 |
Schistosoma mansoni | cell adhesion molecule | 0.0034 | 0.0053 | 0.0143 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0331 | 0.2308 | 0.3468 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0331 | 0.2308 | 0.3472 |
Onchocerca volvulus | 0.0362 | 0.2548 | 0.4004 | |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0079 | 0.0392 | 0.0389 |
Onchocerca volvulus | Hexokinase homolog | 0.0097 | 0.0533 | 0.0833 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0707 | 0.5166 | 1 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0707 | 0.5166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0169 | 0.0254 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0707 | 0.5166 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0073 | 0.0347 | 0.0343 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0217 | 0.1444 | 0.2172 |
Echinococcus multilocularis | carbonic anhydrase | 0.0217 | 0.1444 | 0.1441 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0441 | 0.3148 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0155 | 0.0972 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0155 | 0.0972 | 1 |
Onchocerca volvulus | 0.0453 | 0.3235 | 0.5085 | |
Brugia malayi | Matrixin family protein | 0.0901 | 0.6647 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0038 | 0.0082 | 0.0124 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0707 | 0.5166 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 210 nM | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | ChEMBL. | 12039560 |
Ki (binding) | = 1250 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | ChEMBL. | 12039560 |
Ki (binding) | = 21400 nM | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | ChEMBL. | 12039560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.