Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0321 | 0.1801 | 0.1801 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0321 | 0.1801 | 0.1431 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1329 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0153 | 0.0432 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0321 | 0.1801 | 0.1505 |
Onchocerca volvulus | 0.0321 | 0.1801 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0321 | 0.1801 | 0.1431 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1329 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1329 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1329 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1329 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.091 | 0.6592 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1329 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1329 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1329 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.091 | 0.6592 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.091 | 0.6592 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.091 | 0.6592 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0321 | 0.1801 | 0.1505 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.091 | 0.6592 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0349 | 0.0349 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.091 | 0.6592 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1329 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.