Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0085 | 0.3609 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.3609 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0085 | 0.3609 | 0.5 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0105 | 0.6099 | 0.3897 |
Leishmania major | adenine aminohydrolase | 0.0085 | 0.3609 | 0.5 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0105 | 0.6099 | 0.6099 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0135 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0085 | 0.3609 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0085 | 0.3609 | 0.5 |
Brugia malayi | glycyl-tRNA synthetase | 0.0105 | 0.6099 | 0.3897 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0135 | 1 | 0.5 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0105 | 0.6099 | 0.6099 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0105 | 0.6099 | 0.3897 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0085 | 0.3609 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0085 | 0.3609 | 0.5 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3609 | 0.3609 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0105 | 0.6099 | 0.3897 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0085 | 0.3609 | 0.5 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0105 | 0.6099 | 0.3897 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0113 | 0.7218 | 0.7218 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0085 | 0.3609 | 0.5 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0135 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.3609 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Collateral index (functional) | = 6 | Collateral index in anesthetized dog at the dose of 0.01 mg/kg, i.v. after 60 minutes of administration | ChEMBL. | 12699747 |
Max collateral index (functional) | = 52 | Maximum collateral index in anesthetized dog at the dose of 0.01mg/kg, i.v. | ChEMBL. | 12699747 |
Max hypotension (functional) | NT 44 % | Maximum hypertension was measured in anesthetized dog as percent at the dose of 0.01 mg/kg, i.v. | ChEMBL. | 12699747 |
NG ratio (functional) | = 2 | Ratio of the CIAUC value to that of nitroglycerin (NTG ratio) | ChEMBL. | 12699747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.