Detailed information for compound 52908

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.528 | Formula: C26H26NO3PS
  • H donors: 0 H acceptors: 2 LogP: 5.72 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=O)(Cc1ccc(cc1)c1nc(c(s1)c1ccccc1)c1ccccc1)OCC
  • InChi: 1S/C26H26NO3PS/c1-3-29-31(28,30-4-2)19-20-15-17-23(18-16-20)26-27-24(21-11-7-5-8-12-21)25(32-26)22-13-9-6-10-14-22/h5-18H,3-4,19H2,1-2H3
  • InChiKey: FZVRTJBMGMFCQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus slit 2 protein 0.0049 0.0603 0.0903
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Echinococcus multilocularis protein jagged 2 0.0049 0.0603 0.0903
Brugia malayi Pre-SET motif family protein 0.0034 0.0348 0.0311
Echinococcus granulosus lamin dm0 0.0031 0.029 0.0427
Schistosoma mansoni pyruvate kinase 0.0038 0.0419 0.0344
Echinococcus multilocularis pyruvate kinase 0.002 0.0092 0.0126
Schistosoma mansoni hypothetical protein 0.0049 0.0603 0.0529
Echinococcus granulosus 6 phosphofructokinase 0.0125 0.1933 0.2928
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Echinococcus granulosus pyruvate kinase 0.002 0.0092 0.0126
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Toxoplasma gondii thioredoxin reductase 0.0054 0.0699 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0419 0.164
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.1933 0.187
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0339 0.4201
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.1917 0.8781
Trypanosoma cruzi aldo-keto reductase 0.0034 0.0346 0.1446
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0339 0.7648
Giardia lamblia Aldose reductase 0.0034 0.0346 0.511
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0339 0.0263
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0092 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0668 0.1002
Brugia malayi Animal haem peroxidase family protein 0.0242 0.3987 0.3963
Echinococcus granulosus pyruvate kinase 0.0038 0.0419 0.0623
Echinococcus granulosus neurogenic locus notch protein 0.0049 0.0603 0.0903
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0419 0.1839
Echinococcus multilocularis lamin dm0 0.0031 0.029 0.0427
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0339 0.4969
Onchocerca volvulus 0.0242 0.3987 0.876
Echinococcus multilocularis fat cadherin tumor suppressor 0.0049 0.0603 0.0903
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0346 0.0309
Schistosoma mansoni pyruvate kinase 0.0038 0.0419 0.0344
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0339 0.4201
Toxoplasma gondii EGF family domain-containing protein 0.0049 0.0603 0.8455
Brugia malayi Calcium binding EGF domain containing protein 0.0049 0.0603 0.0566
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Echinococcus multilocularis aldo keto reductase 0.0034 0.0346 0.0512
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0346 0.0309
Schistosoma mansoni notch 0.0049 0.0603 0.0529
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0339 0.0263
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0326 0.0482
Brugia malayi Muscle positioning protein 4 0.0049 0.0603 0.0566
Onchocerca volvulus Slit protein homolog 0.0049 0.0603 0.074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0668 0.1002
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0419 0.0304
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Onchocerca volvulus Peroxidase homolog 0.0242 0.3987 0.876
Echinococcus granulosus protein jagged 1 0.0049 0.0603 0.0903
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.1917 0.8837
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0339 0.0263
Giardia lamblia Pyruvate kinase 0.0038 0.0419 0.6497
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.2159 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Entamoeba histolytica aldose reductase, putative 0.0034 0.0346 0.0757
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0339 0.4201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0348 0.0273
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Schistosoma mansoni pol-related 0.0034 0.0346 0.027
Brugia malayi EGF-like domain containing protein 0.0049 0.0603 0.0566
Onchocerca volvulus 0.0242 0.3987 0.876
Echinococcus granulosus notch 0.0049 0.0603 0.0903
Trypanosoma brucei aldo-keto reductase, putative 0.0034 0.0346 0.1446
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.1933 0.187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0668 0.0595
Echinococcus multilocularis lamin 0.0031 0.029 0.0427
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.2159 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0034 0.0346 0.1446
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0339 0.0263
Echinococcus multilocularis pyruvate kinase 0.002 0.0092 0.0126
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0419 0.0419
Mycobacterium ulcerans glutaminase 0.0585 1 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Onchocerca volvulus Peroxidasin homolog 0.0242 0.3987 0.876
Schistosoma mansoni septate junction protein 0.0049 0.0603 0.0529
Onchocerca volvulus 0.0242 0.3987 0.876
Onchocerca volvulus 0.0049 0.0603 0.074
Echinococcus granulosus neurogenic locus notch protein 0.0049 0.0603 0.0903
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Echinococcus multilocularis neural cadherin 0.0049 0.0603 0.0903
Schistosoma mansoni 6-phosphofructokinase 0.0125 0.1933 0.187
Onchocerca volvulus 0.0034 0.0346 0.0132
Schistosoma mansoni hypothetical protein 0.0049 0.0603 0.0529
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0339 0.4201
Brugia malayi Thioredoxin reductase 0.0054 0.0699 0.0663
Schistosoma mansoni hypothetical protein 0.039 0.6578 0.6551
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Giardia lamblia High cysteine protein 0.0049 0.0603 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0346 0.027
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Schistosoma mansoni hypothetical protein 0.0049 0.0603 0.0529
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0346 0.0309
Brugia malayi EGF-like domain containing protein 0.0049 0.0603 0.0566
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0419 0.0419
Giardia lamblia Pyruvate kinase 0.002 0.0092 0.0282
Leishmania major trypanothione reductase 0.0054 0.0699 0.3347
Brugia malayi 6-phosphofructokinase 0.0125 0.1933 0.1902
Entamoeba histolytica phosphofructokinase, putative 0.0125 0.1933 1
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.3987 0.3987
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0419 0.1839
Brugia malayi intermediate filament protein 0.0031 0.029 0.0253
Echinococcus multilocularis musashi 0.0031 0.029 0.0427
Onchocerca volvulus 0.0272 0.451 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Mycobacterium ulcerans oxidoreductase 0.0034 0.0346 0.027
Echinococcus granulosus hypothetical protein 0.0034 0.0346 0.0512
Echinococcus granulosus neurogenic locus notch protein 4 0.0049 0.0603 0.0903
Echinococcus granulosus aldo keto reductase 0.0034 0.0346 0.0512
Loa Loa (eye worm) phosphofructokinase 0.0125 0.1933 0.1933
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.3932 0.3932
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.2159 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0049 0.0603 0.074
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0339 0.0263
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0699 0.2985
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0419 0.1839
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0419 0.0344
Schistosoma mansoni pyruvate kinase 0.002 0.0092 0.0015
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0699 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0348 0.0273
Mycobacterium tuberculosis Probable reductase 0.0124 0.1917 0.8837
Echinococcus granulosus intermediate filament protein 0.0031 0.029 0.0427
Echinococcus granulosus fibropellin Ia 0.0049 0.0603 0.0903
Echinococcus multilocularis aldo keto reductase 0.0034 0.0346 0.0512
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Echinococcus multilocularis aldehyde reductase 0.0024 0.0173 0.0248
Entamoeba histolytica phosphofructokinase, putative 0.0125 0.1933 1
Schistosoma mansoni cell polarity protein 0.0049 0.0603 0.0529
Schistosoma mansoni laminin gamma-3 chain 0.0049 0.0603 0.0529
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Trypanosoma brucei prostaglandin f synthase 0.0034 0.0346 0.1446
Giardia lamblia Aldose reductase 0.0034 0.0346 0.511
Loa Loa (eye worm) 6-phosphofructokinase 0.0125 0.1933 0.1933
Echinococcus multilocularis pyruvate kinase 0.0038 0.0419 0.0623
Loa Loa (eye worm) blistered cuticle protein 3 0.0242 0.3987 0.3987
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0031 0.029 0.029
Loa Loa (eye worm) intermediate filament protein 0.0031 0.029 0.029
Schistosoma mansoni slit 0.0049 0.0603 0.0529
Trypanosoma brucei trypanothione reductase 0.0054 0.0699 0.3347
Echinococcus granulosus pyruvate kinase 0.0038 0.0419 0.0623
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0125 0.1933 0.8866
Loa Loa (eye worm) glutaminase 0.0585 1 1
Onchocerca volvulus 0.0049 0.0603 0.074
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Brugia malayi Animal haem peroxidase family protein 0.0242 0.3987 0.3963
Loa Loa (eye worm) notch protein 0.0049 0.0603 0.0603
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0668 0.0595
Trypanosoma cruzi aldo/keto reductase, putative 0.0034 0.0346 0.1446
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0034 0.0346 0.1446
Onchocerca volvulus Chorion peroxidase homolog 0.0242 0.3987 0.876
Echinococcus multilocularis 6 phosphofructokinase 0.0125 0.1933 0.2928
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Onchocerca volvulus 0.0034 0.0346 0.0132
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0419 0.1239
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0346 0.027
Echinococcus granulosus pyruvate kinase 0.002 0.0092 0.0126
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0419 0.0382
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0034 0.0346 0.0309
Onchocerca volvulus 0.0034 0.0346 0.0132
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Entamoeba histolytica aldose reductase, putative 0.0034 0.0346 0.0757
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0419 0.0344
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0339 0.0263
Brugia malayi Cadherin domain containing protein 0.0049 0.0603 0.0566
Leishmania major aldo-keto reductase-like protein 0.0034 0.0346 0.1446
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0668 0.0668
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0348 0.0273
Schistosoma mansoni intermediate filament proteins 0.0031 0.029 0.0214
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0125 0.1933 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0078 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.1933 0.187
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Brugia malayi EGF-like domain containing protein 0.0049 0.0603 0.0566
Loa Loa (eye worm) oxidoreductase 0.0034 0.0346 0.0346
Schistosoma mansoni peroxidasin 0.0242 0.3987 0.394
Echinococcus granulosus pyruvate kinase 0.002 0.0092 0.0126
Onchocerca volvulus 0.0049 0.0603 0.074
Toxoplasma gondii aldose reductase, putative 0.0034 0.0346 0.4321
Leishmania major pyruvate kinase 0.0038 0.0419 0.1839
Onchocerca volvulus 0.0034 0.0346 0.0132
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Brugia malayi Calcium binding EGF domain containing protein 0.0049 0.0603 0.0566
Echinococcus multilocularis protein jagged 1 0.0049 0.0603 0.0903
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0348 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0668 0.0595
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0348 0.4358
Schistosoma mansoni hypothetical protein 0.0049 0.0603 0.0529
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Brugia malayi Peroxidasin 0.0242 0.3987 0.3963
Echinococcus multilocularis aldo keto reductase 0.0034 0.0346 0.0512
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0346 0.027
Echinococcus granulosus protein jagged 2 0.0049 0.0603 0.0903
Schistosoma mansoni hypothetical protein 0.0049 0.0603 0.0529
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Schistosoma mansoni glutaminase 0.0585 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0078 0.0039
Plasmodium vivax SET domain protein, putative 0.0034 0.0348 0.4358
Brugia malayi Animal haem peroxidase family protein 0.0242 0.3987 0.3963
Echinococcus granulosus protein jagged 2 0.0049 0.0603 0.0903
Echinococcus multilocularis fibropellin Ia 0.0049 0.0603 0.0903
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0668 0.1002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Echinococcus multilocularis pyruvate kinase 0.0038 0.0419 0.0623
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0419 0.0419
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0339 0.1406
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0699 0.1049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0668 0.1002
Loa Loa (eye worm) glutathione reductase 0.0054 0.0699 0.0699
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0049 0.0603 0.0529
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Loa Loa (eye worm) oxidoreductase 0.0034 0.0346 0.0346
Brugia malayi notch-like transmembrane receptor 0.0049 0.0603 0.0566
Loa Loa (eye worm) 6-phosphofructokinase 0.0125 0.1933 0.1933
Onchocerca volvulus 0.0049 0.0603 0.074
Echinococcus multilocularis peroxidasin 0.0242 0.3987 0.6055
Trichomonas vaginalis set domain proteins, putative 0.0272 0.451 0.4467
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0419 0.5493
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.3987 0.3987
Onchocerca volvulus Putative cubilin 0.0049 0.0603 0.074
Echinococcus multilocularis geminin 0.039 0.6578 1
Trichomonas vaginalis phosphofructokinase, putative 0.0125 0.1933 0.187
Leishmania major pyruvate kinase 0.0038 0.0419 0.1839
Echinococcus multilocularis neurogenic locus notch protein 4 0.0049 0.0603 0.0903
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Brugia malayi hypothetical protein 0.0242 0.3987 0.3963
Schistosoma mansoni notch 0.0049 0.0603 0.0529
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0034 0.0346 0.0872
Schistosoma mansoni hypothetical protein 0.0049 0.0603 0.0529
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0039 0.0039
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0339 0.4201
Brugia malayi Calcium binding EGF domain containing protein 0.0049 0.0603 0.0566
Brugia malayi Cadherin domain containing protein 0.0049 0.0603 0.0566
Echinococcus granulosus aldo keto reductase 0.0034 0.0346 0.0512
Brugia malayi EGF-like domain containing protein 0.0049 0.0603 0.0566
Brugia malayi EGF-like domain containing protein 0.0049 0.0603 0.0566
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0125 0.1933 0.8918
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0049 0.0603 0.0566
Onchocerca volvulus 0.0049 0.0603 0.074
Schistosoma mansoni lamin 0.0031 0.029 0.0214
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0034 0.0346 0.027
Brugia malayi glutaminase DH11.1 0.0585 1 1
Echinococcus multilocularis notch 0.0049 0.0603 0.0903
Schistosoma mansoni notch 0.0049 0.0603 0.0529
Plasmodium falciparum glutathione reductase 0.0054 0.0699 1
Loa Loa (eye worm) oxidoreductase 0.0034 0.0346 0.0346
Brugia malayi phosphofructokinase 0.0125 0.1933 0.1902
Schistosoma mansoni aldo-keto reductase 0.0034 0.0346 0.027
Entamoeba histolytica aldose reductase, putative 0.0034 0.0346 0.0757
Onchocerca volvulus Dual oxidase homolog 0.0242 0.3987 0.876
Echinococcus multilocularis neurogenic locus notch protein 0.0049 0.0603 0.0903
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Loa Loa (eye worm) hypothetical protein 0.0038 0.0419 0.0419
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0668 0.0632
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0419 0.0304
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Leishmania major prostaglandin f synthase, putative 0.0034 0.0346 0.1446
Echinococcus granulosus peroxidasin 0.0242 0.3987 0.6055
Echinococcus granulosus neural cadherin 0.0049 0.0603 0.0903
Echinococcus granulosus neurogenic locus protein delta 0.0049 0.0603 0.0903
Echinococcus granulosus protein jagged 1 0.0049 0.0603 0.0903
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0348 0.0273
Loa Loa (eye worm) hypothetical protein 0.0034 0.0348 0.0348
Mycobacterium ulcerans 6-phosphofructokinase 0.0125 0.1933 0.187
Brugia malayi 6-phosphofructokinase 0.0125 0.1933 0.1902
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.1917 0.8837
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Brugia malayi Animal haem peroxidase family protein 0.0242 0.3987 0.3963
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0346 0.027
Schistosoma mansoni lamin 0.0031 0.029 0.0214
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0339 0.0263
Loa Loa (eye worm) Notch2 0.0049 0.0603 0.0603
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0078 0.5
Schistosoma mansoni peroxidasin 0.0242 0.3987 0.394
Mycobacterium tuberculosis Probable oxidoreductase 0.0034 0.0346 0.129
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0699 0.1049
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0034 0.0346 0.0512
Onchocerca volvulus Peroxidase homolog 0.0242 0.3987 0.876
Loa Loa (eye worm) hypothetical protein 0.0027 0.0216 0.0216
Entamoeba histolytica phosphofructokinase, putative 0.0125 0.1933 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0346 0.0346
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.1917 0.8837
Plasmodium falciparum pyruvate kinase 0.0038 0.0419 0.5493
Trichomonas vaginalis glutaminase, putative 0.0585 1 1
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0419 0.0344
Echinococcus granulosus aldehyde reductase 0.0024 0.0173 0.0248
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0339 0.4201
Plasmodium falciparum thioredoxin reductase 0.0054 0.0699 1
Brugia malayi glutathione reductase 0.0054 0.0699 0.0663
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0339 0.4201
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0419 0.0304
Brugia malayi Blistered cuticle protein 3 0.0242 0.3987 0.3963
Echinococcus multilocularis aldo keto reductase 0.0034 0.0346 0.0512
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.029 0.0253
Echinococcus multilocularis neurogenic locus notch protein 0.0049 0.0603 0.0903
Loa Loa (eye worm) oxidoreductase 0.0034 0.0346 0.0346
Echinococcus multilocularis slit 2 protein 0.0049 0.0603 0.0903
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Plasmodium vivax glutathione reductase, putative 0.0054 0.0699 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.1917 0.8837
Echinococcus multilocularis pyruvate kinase 0.002 0.0092 0.0126
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0125 0.1933 1
Brugia malayi EGF-like domain containing protein 0.0049 0.0603 0.0566
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Schistosoma mansoni 6-phosphofructokinase 0.0125 0.1933 0.187
Schistosoma mansoni notch 0.0049 0.0603 0.0529
Schistosoma mansoni notch 0.0049 0.0603 0.0529
Plasmodium falciparum pyruvate kinase 2 0.002 0.0092 0.0238
Schistosoma mansoni aldo-keto reductase 0.0034 0.0346 0.027
Onchocerca volvulus 0.0034 0.0348 0.0137
Schistosoma mansoni hypothetical protein 0.0049 0.0603 0.0529
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0699 0.0699
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.3987 0.3987
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Echinococcus multilocularis neurogenic locus protein delta 0.0049 0.0603 0.0903
Echinococcus multilocularis pyruvate kinase 0.003 0.0278 0.0408
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0419 0.5493
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0216 0.0216
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0699 0.3347
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0034 0.0346 0.0512
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0078 0.0103
Brugia malayi EGF-like domain containing protein 0.0049 0.0603 0.0566
Chlamydia trachomatis pyruvate kinase 0.0038 0.0419 1
Brugia malayi Animal haem peroxidase family protein 0.0242 0.3987 0.3963
Echinococcus granulosus geminin 0.039 0.6578 1
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0092 0.0238
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0348 0.0515
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.2159 1
Onchocerca volvulus Peroxidasin homolog 0.0242 0.3987 0.876
Echinococcus multilocularis protein jagged 1 0.0049 0.0603 0.0903
Brugia malayi Delta serrate ligand family protein 0.0049 0.0603 0.0566
Echinococcus granulosus aldo keto reductase 0.0034 0.0346 0.0512
Loa Loa (eye worm) oxidoreductase 0.0034 0.0346 0.0346
Echinococcus multilocularis neurogenic locus protein delta 0.0049 0.0603 0.0903
Loa Loa (eye worm) hypothetical protein 0.0049 0.0603 0.0603
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.1917 0.8837
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0339 0.7648
Onchocerca volvulus 0.0034 0.0346 0.0132
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0049 0.0603 0.074
Leishmania major ATP-dependent phosphofructokinase 0.0125 0.1933 1
Schistosoma mansoni hypothetical protein 0.039 0.6578 0.6551
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0078 0.5
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0125 0.1933 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0419 0.0382
Loa Loa (eye worm) hypothetical protein 0.0242 0.3987 0.3987
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0348 0.0515
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0339 0.0714
Trichomonas vaginalis aldo/keto reductase, putative 0.0034 0.0346 0.027
Brugia malayi GCC2 and GCC3 family protein 0.0049 0.0603 0.0566
Onchocerca volvulus 0.0034 0.0346 0.0132
Trichomonas vaginalis aldo-keto reductase, putative 0.0034 0.0346 0.027
Echinococcus granulosus delta-like protein 1 0.0049 0.0603 0.0903
Loa Loa (eye worm) animal heme peroxidase 0.0242 0.3987 0.3987
Schistosoma mansoni notch 0.0049 0.0603 0.0529
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0419 0.1839
Brugia malayi Pre-SET motif family protein 0.0239 0.3932 0.3908
Echinococcus granulosus lamin 0.0031 0.029 0.0427

Activities

Activity type Activity value Assay description Source Reference
Max increase in coronary flow (functional) = 23 % Maximum increase in the coronary flow of isolated guinea pig heart when a dose of 10 ug/heart is administered ChEMBL. 2738888

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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