Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kallikrein 1 | Starlite/ChEMBL | References |
Sus scrofa | Elastase 2A | Starlite/ChEMBL | References |
Bos taurus | Alpha-chymotrypsin | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Bos taurus | Trypsin I | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | cathepsin G | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0158 | 0.7523 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.7523 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.4673 | 0.5 |
Onchocerca volvulus | 0.0158 | 0.7523 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.7523 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.232 | 0.3084 | |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.4673 | 0.6212 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.4673 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.4673 | 0.5 |
Onchocerca volvulus | 0.013 | 0.4673 | 0.6212 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0158 | 0.7523 | 1 |
Brugia malayi | Trypsin family protein | 0.0158 | 0.7523 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.4673 | 0.6212 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.4673 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.4673 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.4673 | 0.6212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
APTT (functional) | = 4 uM | Concentration of inhibitor required to produce a 2-fold prolongation in activated partial Thromboplastin time (APTT) in human plasma | ChEMBL. | 7739010 |
Ki (binding) | = 0.007 nM | Binding affinity against alpha thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.007 nM | Binding affinity against alpha thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.024 nM | Binding affinity against gamma thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.024 nM | Binding affinity against gamma thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.152 nM | Binding affinity against Chymotrypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.152 nM | Binding affinity against Chymotrypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.27 nM | Binding affinity against Trypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.27 nM | Binding affinity against Trypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.365 nM | Binding affinity of the compound towards porcine pancreatic elastase | ChEMBL. | 7739010 |
Ki (binding) | = 0.365 nM | Binding affinity of the compound towards porcine pancreatic elastase | ChEMBL. | 7739010 |
Ki (binding) | = 0.916 nM | Binding affinity against cathepsin G | ChEMBL. | 7739010 |
Ki (binding) | = 0.916 nM | Binding affinity against cathepsin G | ChEMBL. | 7739010 |
Ki (binding) | = 2.6 nM | Binding affinity against Coagulation factor X | ChEMBL. | 7739010 |
Ki (binding) | = 2.6 nM | Binding affinity against Coagulation factor X | ChEMBL. | 7739010 |
Ki (binding) | = 4.2 nM | Binding affinity against protein Ca | ChEMBL. | 7739010 |
Ki (binding) | = 5.5 nM | Binding affinity against plasmin | ChEMBL. | 7739010 |
Ki (binding) | = 5.5 nM | Binding affinity against plasmin | ChEMBL. | 7739010 |
Ki (binding) | = 7 nM | Binding affinity against thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 7 nM | Binding affinity against thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 9.5 nM | Binding affinity against kallikrein | ChEMBL. | 7739010 |
Ki (binding) | = 9.5 nM | Binding affinity against kallikrein | ChEMBL. | 7739010 |
Ki (binding) | = 15 nM | Binding affinity against Urokinase plasminogen activator | ChEMBL. | 7739010 |
Ki (binding) | = 15 nM | Binding affinity against Urokinase plasminogen activator | ChEMBL. | 7739010 |
TT (binding) | = 1.1 uM | Concentration of inhibitor required to produce a 2-fold prolongation in Thrombin time (TT) | ChEMBL. | 7739010 |
TT (binding) | = 1.1 uM | Concentration of inhibitor required to produce a 2-fold prolongation in Thrombin time (TT) | ChEMBL. | 7739010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.