Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0003 | 0.0003 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.0497 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0048 | 0.0003 | 1 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0003 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0003 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0048 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0048 | 0.0003 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0052 | 0.0497 | 0.0497 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0142 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0003 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.0497 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Onchocerca volvulus | 0.0048 | 0.0003 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0003 | 0.0003 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0003 | 0.0003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0052 | 0.0497 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0052 | 0.0497 | 0.0497 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0003 | 0.0003 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0052 | 0.0497 | 1 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Onchocerca volvulus | 0.0048 | 0.0003 | 1 | |
Treponema pallidum | ATP-dependent RNA helicase | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0142 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0142 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Entamoeba histolytica | cysteine protease, putative | 0.0048 | 0.0003 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0048 | 0.0003 | 0.0003 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0142 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0052 | 0.0497 | 0.0497 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0048 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Loa Loa (eye worm) | cysteine protease | 0.0048 | 0.0003 | 0.0003 |
Echinococcus granulosus | cathepsin l1 | 0.0048 | 0.0003 | 0.0003 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Echinococcus multilocularis | cathepsin b | 0.0142 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Echinococcus granulosus | cathepsin b | 0.0142 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0142 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0052 | 0.0497 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Onchocerca volvulus | Cathepsin F homolog | 0.0048 | 0.0003 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0048 | 0.0003 | 0.0003 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0048 | 0.0003 | 0.0003 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0003 | 0.0003 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0048 | 0.0003 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0003 | 0.0003 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0047 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0052 | 0.0497 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0048 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0048 | 0.0003 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0048 | 0.0003 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0003 | 0.0003 |
Onchocerca volvulus | Cathepsin L homolog | 0.0048 | 0.0003 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0003 | 0.0003 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Loa Loa (eye worm) | ctsf protein | 0.0048 | 0.0003 | 0.0003 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0048 | 0.0003 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Leishmania major | cysteine peptidase A (CPA) | 0.0048 | 0.0003 | 0.0052 |
Echinococcus multilocularis | cysteine protease | 0.0048 | 0.0003 | 0.0003 |
Echinococcus granulosus | cathepsin b | 0.0142 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0003 | 0.0003 |
Toxoplasma gondii | cathepsin B | 0.0052 | 0.0497 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0048 | 0.0003 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Plasmodium vivax | vivapain-2 | 0.0048 | 0.0003 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Toxoplasma gondii | cathepsin CPL | 0.0048 | 0.0003 | 0.0052 |
Onchocerca volvulus | 0.0048 | 0.0003 | 1 | |
Onchocerca volvulus | 0.0048 | 0.0003 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0048 | 0.0003 | 0.0003 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0048 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | fibroinase | 0.0048 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Leishmania major | cathepsin L-like protease | 0.0048 | 0.0003 | 0.0052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Brugia malayi | Cathepsin L-like precursor | 0.0048 | 0.0003 | 0.0003 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0048 | 0.0003 | 0.0052 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0142 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0048 | 0.0003 | 0.0052 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0048 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0048 | 0.0003 | 0.0003 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Collateral index (functional) | = 16 | Collateral index in anesthetized dog at the dose of 0.01 mg/kg, i.v. after 60 minutes of administration | ChEMBL. | 12699747 |
Max collateral index (functional) | = 23 | Maximum collateral index in anesthetized dog at the dose of 0.01mg/kg, i.v. | ChEMBL. | 12699747 |
Max hypotension (functional) | NT 8 % | Maximum hypertension was measured in anesthetized dog as percent at the dose of 0.01 mg/kg, i.v. | ChEMBL. | 12699747 |
NG ratio (functional) | = 1.9 | Ratio of the CIAUC value to that of nitroglycerin (NTG ratio) | ChEMBL. | 12699747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.