Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | cathepsin G | Starlite/ChEMBL | References |
Sus scrofa | Elastase 2A | Starlite/ChEMBL | References |
Homo sapiens | kallikrein 1 | Starlite/ChEMBL | References |
Bos taurus | Alpha-chymotrypsin | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Bos taurus | Trypsin I | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0158 | 0.7378 | 1 |
Brugia malayi | Trypsin family protein | 0.0158 | 0.7378 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.4361 | 0.591 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.4361 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.4361 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.4361 | 0.591 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0158 | 0.7378 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Onchocerca volvulus | 0.0158 | 0.7378 | 1 | |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.4361 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.7378 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.7378 | 1 |
Onchocerca volvulus | 0.0106 | 0.1869 | 0.2534 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.4361 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.4361 | 0.591 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.4361 | 0.5 |
Onchocerca volvulus | 0.013 | 0.4361 | 0.591 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
APTT (functional) | = 2.5 uM | Concentration of inhibitor required to produce a 2-fold prolongation in activated partial Thromboplastin time (APTT) in human plasma | ChEMBL. | 7739010 |
Ki (binding) | = 0.011 nM | Binding affinity against gamma thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.011 nM | Binding affinity against Chymotrypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.011 nM | Binding affinity against gamma thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.011 nM | Binding affinity against Chymotrypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.018 nM | Binding affinity against alpha thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.018 nM | Binding affinity against alpha thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 0.15 nM | Binding affinity against Trypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.15 nM | Binding affinity against Trypsin | ChEMBL. | 7739010 |
Ki (binding) | = 0.187 nM | Binding affinity against cathepsin G | ChEMBL. | 7739010 |
Ki (binding) | = 0.187 nM | Binding affinity against cathepsin G | ChEMBL. | 7739010 |
Ki (binding) | = 1.2 nM | Binding affinity against Coagulation factor X | ChEMBL. | 7739010 |
Ki (binding) | = 1.2 nM | Binding affinity against Coagulation factor X | ChEMBL. | 7739010 |
Ki (binding) | > 4.3 nM | Binding affinity against kallikrein | ChEMBL. | 7739010 |
Ki (binding) | > 4.3 nM | Binding affinity against Urokinase plasminogen activator | ChEMBL. | 7739010 |
Ki (binding) | > 4.3 nM | Binding affinity against protein Ca | ChEMBL. | 7739010 |
Ki (binding) | > 4.3 nM | Binding affinity against kallikrein | ChEMBL. | 7739010 |
Ki (binding) | > 4.3 nM | Binding affinity against Urokinase plasminogen activator | ChEMBL. | 7739010 |
Ki (binding) | = 4.5 nM | Binding affinity against plasmin | ChEMBL. | 7739010 |
Ki (binding) | = 4.5 nM | Binding affinity against plasmin | ChEMBL. | 7739010 |
Ki (binding) | = 7.25 nM | Binding affinity of the compound towards porcine pancreatic elastase | ChEMBL. | 7739010 |
Ki (binding) | = 7.25 nM | Binding affinity of the compound towards porcine pancreatic elastase | ChEMBL. | 7739010 |
Ki (binding) | = 18 nM | Binding affinity against thrombin | ChEMBL. | 7739010 |
Ki (binding) | = 18 nM | Binding affinity against thrombin | ChEMBL. | 7739010 |
TT (binding) | = 0.53 uM | Concentration of inhibitor required to produce a 2-fold prolongation in Thrombin time (TT) | ChEMBL. | 7739010 |
TT (binding) | = 0.53 uM | Concentration of inhibitor required to produce a 2-fold prolongation in Thrombin time (TT) | ChEMBL. | 7739010 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.