Detailed information for compound 53323

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.338 | Formula: C19H15F2N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.87 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1nc1n2CCC(=C1C(=O)Nc1c(F)cccc1F)O
  • InChi: 1S/C19H15F2N3O3/c1-27-14-7-3-6-12-17(14)22-18-15(13(25)8-9-24(12)18)19(26)23-16-10(20)4-2-5-11(16)21/h2-7,25H,8-9H2,1H3,(H,23,26)
  • InChiKey: OZKYCVOYECPCLK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus GABA-A receptor; anion channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 447 aa 25.7 %
Onchocerca volvulus Large subunit GTPase 1 homolog GABA-A receptor; anion channel   467 aa 496 aa 26.0 %
Schistosoma mansoni Cys-loop ligand gated ion channel subunit GABA-A receptor; anion channel   467 aa 479 aa 29.2 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 454 aa 29.5 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 494 aa 25.5 %
Onchocerca volvulus Gamma-aminobutyric acid receptor subunit beta homolog GABA-A receptor; anion channel   467 aa 433 aa 34.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 468 aa 28.6 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog GABA-A receptor; anion channel   467 aa 418 aa 19.6 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 441 aa 33.8 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 435 aa 29.7 %
Echinococcus granulosus glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit GABA-A receptor; anion channel   467 aa 379 aa 19.3 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 375 aa 21.9 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative GABA-A receptor; anion channel   467 aa 384 aa 19.5 %
Echinococcus multilocularis glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Brugia malayi Cation transporter family protein GABA-A receptor; anion channel   467 aa 453 aa 28.5 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 454 aa 30.4 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 434 aa 26.7 %
Onchocerca volvulus Eukaryotic initiation factor 4A-III homolog GABA-A receptor; anion channel   467 aa 453 aa 26.9 %
Echinococcus multilocularis glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 478 aa 28.7 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 446 aa 28.0 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 446 aa 29.1 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 461 aa 27.8 %
Echinococcus granulosus glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 439 aa 29.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.1546 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0044 0.0043
Echinococcus granulosus g protein coupled receptor 0.1546 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1546 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0086 0.0086
Echinococcus granulosus 7TM GPCR rhodopsin 0.1546 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.1546 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.027 0.027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0587 0.0567
Echinococcus granulosus tm gpcr rhodopsin 0.1546 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0086 0.3037
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0083 0.0589
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 0.0044 0.0044
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0044 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0282 0.0486
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0247 0.0247
Schistosoma mansoni nAChR subunit 0.0023 0.0044 0.0043
Echinococcus multilocularis chromobox protein 1 0.0068 0.0339 0.0339
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0083 0.1406
Onchocerca volvulus 0.0023 0.0044 0.0022
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0044 0.0043
Echinococcus granulosus mitogen activated protein kinase 0.005 0.022 0.022
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0038 0.0147 0.0253
Echinococcus granulosus neuropeptides capa receptor 0.1546 1 1
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0339 0.2417
Mycobacterium ulcerans hypothetical protein 0.0038 0.0147 0.0253
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0065
Onchocerca volvulus 0.1546 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis allatostatin A receptor 0.1546 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0079 0.0079
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0022 0.0021
Brugia malayi ORL1-like opioid receptor 0.1546 1 1
Echinococcus granulosus somatostatin receptor 0.1546 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0165 0.0143
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1546 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0587 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0522 0.0501
Onchocerca volvulus 0.0023 0.0044 0.0022
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0022 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1546 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0044 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0044 0.0043
Trypanosoma brucei protein kinase, putative 0.005 0.022 0.3745
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.027 0.027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0197 0.0196
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.027 0.0249
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.0511
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 0.0044 0.0043
Echinococcus multilocularis protein dispatched 1 0.0047 0.0203 0.0202
Onchocerca volvulus 0.0047 0.0203 0.0182
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.1546 1 1
Echinococcus multilocularis RUN 0.0019 0.0022 0.0021
Schistosoma mansoni neuropeptide receptor 0.1546 1 1
Trichomonas vaginalis set domain proteins, putative 0.023 0.1402 1
Brugia malayi follicle stimulating hormone receptor 0.1546 1 1
Brugia malayi GnHR receptor homolog 0.1546 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0001 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0022 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.1546 1 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0147 0.0253
Loa Loa (eye worm) melatonin receptor type 1A 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1546 1 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0044 0.0043
Brugia malayi Dopamine receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.0035
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0197 0.0176
Echinococcus granulosus 7tm_1 domain containing protein 0.1546 1 1
Schistosoma mansoni lipoxygenase 0.0019 0.0022 0.0021
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0022 0.0021
Schistosoma mansoni nAChR subunit 0.0023 0.0044 0.0043
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0044 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.1546 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0057 0.0956
Echinococcus multilocularis neuropeptide receptor 0.1546 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0044 0.0044
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0791 0.079
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Schistosoma mansoni opsin-like receptor 0.1546 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.027 0.027
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.022 0.7797
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1546 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0282 0.0282
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 0.0044 0.0043
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1546 1 1
Echinococcus granulosus g protein coupled receptor 0.1546 1 1
Schistosoma mansoni amine GPCR 0.1546 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Brugia malayi hypothetical protein 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 0.0044 0.0043
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Brugia malayi Doublecortin family protein 0.0019 0.0022 0.0022
Echinococcus granulosus serotonin receptor 0.1546 1 1
Schistosoma mansoni adenoreceptor 0.1546 1 1
Brugia malayi Thioredoxin reductase 0.0046 0.0197 0.0197
Brugia malayi hypothetical protein 0.1546 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1546 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0658 0.1136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1546 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0587 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0057 0.2855
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1546 1 1
Schistosoma mansoni nAChR subunit 0.0023 0.0044 0.0043
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0339 0.0318
Schistosoma mansoni hypothetical protein 0.1546 1 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0203 0.0202
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1546 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0282 0.0282
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0083 0.0589
Onchocerca volvulus 0.1546 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.1546 1 1
Brugia malayi hypothetical protein 0.1546 1 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0339 0.0339
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 0.0044 0.0044
Echinococcus granulosus tm gpcr rhodopsin 0.1546 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1546 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0282 1
Echinococcus multilocularis dro:myosuppressin receptor 0.1546 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1219 0.12
Brugia malayi sulfakinin receptor protein 0.1546 1 1
Brugia malayi chromobox protein homolog 3 0.0038 0.0145 0.0145
Brugia malayi larval opioid receptor 0.1546 1 1
Echinococcus granulosus g-protein coupled receptor 0.1546 1 1
Schistosoma mansoni nAChR subunit 0.0023 0.0044 0.0043
Brugia malayi Pre-SET motif family protein 0.0029 0.0086 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0057 0.2855
Schistosoma mansoni amine GPCR 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Leishmania major hypothetical protein, conserved 0.0025 0.0057 0.0956
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0902 0.5792 1
Echinococcus granulosus neuropeptide FF receptor 2 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0282 0.4803
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0522 0.8709
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 0.0044 0.0022
Echinococcus granulosus chromobox protein 1 0.0068 0.0339 0.0339
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0038 0.0147 0.1267
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.022 0.3745
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0083 0.4201
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Schistosoma mansoni loxhd1 0.0019 0.0022 0.0021
Plasmodium vivax SET domain protein, putative 0.0029 0.0086 0.4358
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0587 0.4187
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0197 0.0176
Brugia malayi MAP kinase sur-1 0.005 0.022 0.022
Brugia malayi hypothetical protein 0.1546 1 1
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0044 0.0022
Brugia malayi G protein-coupled receptor F59B2.13 0.1546 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0225 0.0204
Brugia malayi Melatonin receptor type 1A 0.1546 1 1
Brugia malayi neuropeptide F receptor 0.1546 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0083 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0072 0.0511
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0044 0.0022
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0587 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0083 0.4201
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 0.0044 0.0044
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1546 1 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0044 0.0043
Brugia malayi jmjC domain containing protein 0.0057 0.027 0.027
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.022 0.3745
Brugia malayi Cation transporter family protein 0.0023 0.0044 0.0044
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.027 0.027
Echinococcus granulosus tumor protein p63 0.0329 0.2044 0.2043
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0083 0.2928
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.022 0.022
Schistosoma mansoni nAChR subunit 0.0023 0.0044 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0083 0.2928
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0038 0.0147 0.0253
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0044 0.0043
Brugia malayi G protein-coupled receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis fmrfamide receptor 0.1546 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0582 0.1004
Brugia malayi G-protein coupled receptor 0.1546 1 1
Brugia malayi Dopamine receptor protein 1 0.1546 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0145 0.0123
Echinococcus granulosus tachykinin peptides receptor 99D 0.1546 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Brugia malayi hypothetical protein 0.023 0.1399 0.1399
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0164 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0001 0.5
Onchocerca volvulus 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0282 0.0486
Schistosoma mansoni patched 1 0.0041 0.0165 0.0164
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0587 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1546 1 1
Echinococcus multilocularis neuropeptide receptor 0.1546 1 1
Brugia malayi Serotonin receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0145 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0083 0.0589
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0083 0.3755
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0159 0.0158
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0791 0.079
Schistosoma mansoni histamine h1 receptor 0.1546 1 1
Schistosoma mansoni nAChR subunit 0.0023 0.0044 0.0043
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0021
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0587 0.0567
Echinococcus multilocularis orexin receptor type 2 0.1546 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0057 0.2855
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0044 0.0044
Brugia malayi Dopamine receptor protein 2 0.1546 1 1
Onchocerca volvulus 0.0023 0.0044 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.1546 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0532 0.0531
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.027 0.027
Brugia malayi phosphofructokinase 0.0106 0.0587 0.0587
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0022 0.1078
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0044 0.0044
Brugia malayi G-protein coupled receptor 0.1546 1 1
Schistosoma mansoni hypothetical protein 0.0047 0.0203 0.0202
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0001 0.0001
Brugia malayi hypothetical protein 0.1546 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1546 1 1
Echinococcus granulosus g protein coupled receptor 0.1546 1 1
Brugia malayi Heterochromatin protein 1 0.0068 0.0339 0.0339
Plasmodium falciparum thioredoxin reductase 0.0046 0.0197 1
Echinococcus multilocularis protein patched 0.0041 0.0165 0.0164
Brugia malayi AKH receptor 0.1546 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Schistosoma mansoni amine GPCR 0.1546 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.1546 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.022 0.022
Brugia malayi neuropeptide F receptor 0.1546 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0044 0.0044
Toxoplasma gondii thioredoxin reductase 0.0046 0.0197 0.697
Brugia malayi jmjC domain containing protein 0.0057 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Schistosoma mansoni rab6-interacting 0.0019 0.0022 0.0021
Brugia malayi hypothetical protein 0.1546 1 1
Brugia malayi hypothetical protein 0.0019 0.0022 0.0022
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.022 0.3745
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.022 0.3745
Echinococcus granulosus neuropeptide receptor A26 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0587 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0044 0.0043
Echinococcus granulosus biogenic amine 5HT receptor 0.1546 1 1
Onchocerca volvulus 0.0048 0.0211 0.0189
Brugia malayi CHE-14 protein 0.0041 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0203 0.0203
Echinococcus multilocularis g-protein coupled receptor 0.1546 1 1
Echinococcus granulosus chromobox protein 1 0.0068 0.0339 0.0339
Echinococcus multilocularis S formylglutathione hydrolase 0.0038 0.0147 0.0146
Echinococcus multilocularis neuropeptide Y receptor 0.1546 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0587 0.0587
Echinococcus granulosus neuropeptides capa receptor 0.1546 1 1
Echinococcus granulosus expressed conserved protein 0.009 0.0484 0.0484
Echinococcus granulosus fmrfamide receptor 0.1546 1 1
Schistosoma mansoni opsin-like receptor 0.1546 1 1
Schistosoma mansoni chromobox protein 0.0068 0.0339 0.0339
Schistosoma mansoni alpha-1 adrenergic receptor 0.1546 1 1
Echinococcus granulosus allatostatin A receptor 0.1546 1 1
Schistosoma mansoni hypothetical protein 0.1546 1 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0247 0.0247
Brugia malayi 6-phosphofructokinase 0.0106 0.0587 0.0587
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0165 0.0164
Schistosoma mansoni biogenic amine (5HT) receptor 0.1546 1 1
Echinococcus granulosus neuropeptide Y receptor 0.1546 1 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.0044 0.0044
Onchocerca volvulus 0.023 0.1402 0.1383
Onchocerca volvulus 0.0023 0.0044 0.0022
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1546 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1546 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1546 1 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0023 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis neuropeptide s receptor 0.1546 1 1
Brugia malayi RE15519p 0.1546 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1546 1 1
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0044 0.0022
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0038 0.0147 0.0253
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Loa Loa (eye worm) esterase D 0.0038 0.0147 0.0125
Echinococcus multilocularis expressed conserved protein 0.009 0.0484 0.0484
Echinococcus granulosus peptide allatostatin:somatostatin 0.1546 1 1
Schistosoma mansoni biogenic amine receptor 0.1546 1 1
Echinococcus multilocularis serotonin receptor 0.1546 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0057 0.0956
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0147 0.0253
Loa Loa (eye worm) LGC-31 protein 0.0023 0.0044 0.0022
Onchocerca volvulus 0.1546 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Brugia malayi putative neuropeptide receptor 0.1546 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.022 0.1568
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0044 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0282 0.0282
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0587 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0145 0.1028
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 0.0044 0.0022
Schistosoma mansoni lipoxygenase 0.0054 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.004 0.0155 0.0155
Brugia malayi hypothetical protein 0.0025 0.0057 0.0057
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1546 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0582 0.1004
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 0.0044 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.1546 1 1
Echinococcus granulosus S formylglutathione hydrolase 0.0038 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.1546 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0339 0.2417
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis fmrfamide receptor 0.1546 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.022 0.1568
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1399 0.1399
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1546 1 1
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0038 0.0147 0.0253
Echinococcus multilocularis g protein coupled receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0022 0.0021
Loa Loa (eye worm) G-protein coupled receptor 0.1546 1 1
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0038 0.0147 0.0253
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0083 0.0589
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0282 0.0282
Brugia malayi Pre-SET motif family protein 0.0202 0.1219 0.1219
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0902 0.5792 1
Onchocerca volvulus 0.003 0.0091 0.0069
Echinococcus granulosus dro:myosuppressin receptor 0.1546 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0057 0.199
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1546 1 1
Onchocerca volvulus 0.0023 0.0044 0.0022
Brugia malayi 6-phosphofructokinase 0.0106 0.0587 0.0587
Brugia malayi hypothetical protein 0.1546 1 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 0.0044 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.1546 1 1
Schistosoma mansoni biogenic amine receptor 0.1546 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0282 0.0486
Schistosoma mansoni biogenic amine receptor 0.1546 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1546 1 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.022 0.022
Onchocerca volvulus 0.1546 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0086 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0582 0.1004
Echinococcus granulosus neuropeptide Y receptor 0.1546 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Brugia malayi Serotonin receptor 0.1546 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0587 0.4187
Trypanosoma brucei trypanothione reductase 0.0046 0.0197 0.3347
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 0.0044 0.0043
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Onchocerca volvulus Neuropeptide F receptor homolog 0.1546 1 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 0.0044 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0044 0.0043
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0587 0.1013
Loa Loa (eye worm) neuropeptide F receptor 0.1546 1 1
Echinococcus granulosus hypothetical protein 0.1546 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Echinococcus multilocularis nAChR subunit 0.0023 0.0044 0.0043
Schistosoma mansoni nAChR subunit 0.0023 0.0044 0.0043
Echinococcus granulosus neuropeptide receptor 0.1546 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0211 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0587 0.4187
Schistosoma mansoni jumonji domain containing protein 0.0057 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0165 0.0164
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus granulosus orexin receptor type 2 0.1546 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.022 0.0199
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 0.0044 0.0043
Schistosoma mansoni hypothetical protein 0.004 0.0155 0.0155
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.022 0.3745
Onchocerca volvulus 0.1546 1 1
Echinococcus multilocularis g protein coupled receptor 0.1546 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1546 1 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0022 0.1078
Onchocerca volvulus 0.1546 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1546 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.022 0.3745
Schistosoma mansoni growth hormone secretagogue receptor 0.1546 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.022 0.022
Echinococcus multilocularis neuropeptide receptor A26 0.1546 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0165 0.1173
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0164 0.1163
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0587 0.078
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0587 0.0587
Loa Loa (eye worm) G-protein coupled receptor 0.1546 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.022 0.1568
Mycobacterium ulcerans hypothetical protein 0.0038 0.0147 0.0253
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0038 0.0147 0.0253
Plasmodium falciparum glutathione reductase 0.0046 0.0197 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.027 0.027
Echinococcus granulosus sex peptide receptor 0.1546 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0522 0.0522
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1546 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0044 0.0043
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 0.0044 0.0022
Brugia malayi Tachykinin-like peptides receptor 99D 0.1546 1 1
Brugia malayi hypothetical protein 0.1546 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0197 0.0196
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0587 0.1013
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.1546 1 1
Echinococcus granulosus RUN 0.0019 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis somatostatin receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0165 0.0143
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0083 0.0589
Onchocerca volvulus 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Brugia malayi Cation transporter family protein 0.0023 0.0044 0.0044
Loa Loa (eye worm) TYRA-2 protein 0.1546 1 1
Brugia malayi glutathione reductase 0.0046 0.0197 0.0197
Brugia malayi hypothetical protein 0.1546 1 1
Echinococcus granulosus neuropeptide receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0044 0.0043
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0582 0.1004
Loa Loa (eye worm) hypothetical protein 0.0308 0.1912 0.1895
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0083 0.4201
Echinococcus multilocularis tumor protein p63 0.0329 0.2044 0.2043
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.5049 0.5049
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0147 0.0253
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0044 0.0043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1546 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1546 1 1
Schistosoma mansoni hypothetical protein 0.1546 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.022 0.1568
Echinococcus granulosus neuropeptide s receptor 0.1546 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0083 0.4201
Schistosoma mansoni neuropeptide receptor 0.1546 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1546 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.022 0.3745
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0211 0.021
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0164 0.1163
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 0.0044 0.0043
Echinococcus granulosus G protein coupled receptor 139 0.1546 1 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 0.0044 0.0043
Schistosoma mansoni myosin xvIII 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Plasmodium vivax glutathione reductase, putative 0.0046 0.0197 1
Schistosoma mansoni opsin-like receptor 0.1546 1 1
Schistosoma mansoni rab6-interacting 0.0019 0.0022 0.0021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0197 0.0339
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0083 0.0589
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0582 0.077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Leishmania major trypanothione reductase 0.0046 0.0197 0.3347
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Schistosoma mansoni neuropeptide receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Schistosoma mansoni amine GPCR 0.1546 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1546 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0587 0.0567
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0083 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1546 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0522 0.0522
Schistosoma mansoni amine GPCR 0.1546 1 1
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0038 0.0147 0.0253
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0197 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0582 0.1004
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1546 1 1
Echinococcus multilocularis serotonin receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1546 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0658 0.0906
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0044 0.0044
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0083 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0658 0.1136
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0902 0.5792 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.1546 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0044 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0057 0.0956
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0658 0.1136
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0083 0.2928
Echinococcus granulosus rhodopsin orphan GPCR 0.1546 1 1
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1399 0.1399
Echinococcus granulosus nAChR subunit 0.0023 0.0044 0.0043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0044 0.0043
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 0.0044 0.0022
Onchocerca volvulus Putative nachr subunit 0.0023 0.0044 0.0022
Brugia malayi Esterase D 0.0038 0.0147 0.0147
Giardia lamblia Kinase, CMGC MAPK 0.005 0.022 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0044 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0587 0.4187
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1546 1 1
Schistosoma mansoni neuropeptide receptor 0.1546 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0155 0.0155
Onchocerca volvulus 0.1546 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0155 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1546 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1546 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0145 0.1028
Schistosoma mansoni neuropeptide F-like receptor 0.1546 1 1
Onchocerca volvulus 0.1546 1 1
Onchocerca volvulus 0.0023 0.0044 0.0022
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0165 0.0164
Loa Loa (eye worm) hypothetical protein 0.1546 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.1546 1 1
Brugia malayi hypothetical protein 0.1546 1 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0044 0.0043
Echinococcus multilocularis g protein coupled receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.023 0.1399 0.138
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1546 1 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 0.0044 0.0044
Mycobacterium tuberculosis Possible conserved membrane protein 0.0038 0.0147 0.0253
Schistosoma mansoni polycystin 1-related 0.0019 0.0022 0.0021
Schistosoma mansoni chromobox protein 0.0068 0.0339 0.0339
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0587 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 0.0044 0.0044
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0044 0.0043
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0587 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0282 0.0486
Loa Loa (eye worm) neuropeptide F receptor 0.1546 1 1
Onchocerca volvulus 0.004 0.0159 0.0137
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1546 1 1
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0587 0.0587
Brugia malayi hypothetical protein 0.0118 0.067 0.067
Brugia malayi Cation transporter family protein 0.0023 0.0044 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0197 0.3347
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1546 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0086 0.0086
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1546 1 1
Mycobacterium tuberculosis Probable conserved exported protein 0.0038 0.0147 0.0253
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1546 1 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.0582 0.1004
Echinococcus multilocularis sex peptide receptor 0.1546 1 1
Loa Loa (eye worm) hypothetical protein 0.1546 1 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) mg kg-1 In vivo inhibitory activity of the compound against metrazole-induced seizures in mice by intraperitoneal administration was determined; ND is no data ChEMBL. 10386933
ED50 (functional) mg kg-1 In vivo inhibitory activity of the compound against metrazole-induced seizures in mice by peroral administration was determined; ND is no data ChEMBL. 10386933
ED50 (functional) 0 mg kg-1 In vivo inhibitory activity of the compound against metrazole-induced seizures in mice by intraperitoneal administration was determined; ND is no data ChEMBL. 10386933
ED50 (functional) 0 mg kg-1 In vivo inhibitory activity of the compound against metrazole-induced seizures in mice by peroral administration was determined; ND is no data ChEMBL. 10386933
GS (binding) = 3.7 GABA shift which is the ratio of binding in the absence and presence of GABA (1 mM) was determined ChEMBL. 10386933
GS (binding) = 3.7 GABA shift which is the ratio of binding in the absence and presence of GABA (1 mM) was determined ChEMBL. 10386933
IC50 (binding) = 156 nM In vitro inhibitory against Gamma-aminobutyric-acid A receptor from rat cerebral cortex using [3H]-flunitrazepam as the radioligand ChEMBL. 10386933
IC50 (binding) = 156 nM In vitro inhibitory against Gamma-aminobutyric-acid A receptor from rat cerebral cortex using [3H]-flunitrazepam as the radioligand ChEMBL. 10386933
MED (functional) 0 mg kg-1 Inhibitory activity of the compound was determined by experimentally-induced conflict test in rats after intraperitoneal administration; ND is no data ChEMBL. 10386933
MED (functional) 0 mg kg-1 Inhibitory activity of the compound was determined by experimentally-induced conflict test in rats after oral administration; ND is no data ChEMBL. 10386933

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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