Detailed information for compound 53428

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.298 | Formula: C17H25BrN2
  • H donors: 0 H acceptors: 0 LogP: 3.69 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CC[N+]2(C1)CCN(CC2)C/C=C/c1ccccc1.[Br-]
  • InChi: 1S/C17H25N2.BrH/c1-2-7-17(8-3-1)9-6-10-18-11-15-19(16-12-18)13-4-5-14-19;/h1-3,6-9H,4-5,10-16H2;1H/q+1;/p-1/b9-6+;
  • InChiKey: RHKHAEITPOURAW-MLBSPLJJSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0153 0.0148
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0371 0.2514
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0371 0.0839
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0067 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0457 0.0452
Schistosoma mansoni hypothetical protein 0.0048 0.0567 0.0735
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0515 0.0668
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0153 0.0198
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0124 0.0775
Brugia malayi Bromodomain containing protein 0.0034 0.0352 0.0377
Brugia malayi PHD-finger family protein 0.0015 0.0069 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.6672 0.6671
Leishmania major hypothetical protein, conserved 0.0031 0.0318 0.2151
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.1463 1
Trypanosoma cruzi ISWI complex protein 0.0031 0.0318 0.2151
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0371 0.0367
Loa Loa (eye worm) hypothetical protein 0.0612 0.9197 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0792 0.0788
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.022 0.3901
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0373 0.0369
Brugia malayi AMP-binding enzyme family protein 0.0025 0.022 0.0234
Brugia malayi hypothetical protein 0.0181 0.2607 0.2831
Echinococcus multilocularis geminin 0.0515 0.7717 0.7716
Schistosoma mansoni transcription factor LCR-F1 0.0181 0.2607 0.3378
Schistosoma mansoni hypothetical protein 0.0031 0.0318 0.0412
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0792 0.0861
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0371 0.2514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0515 0.0511
Brugia malayi Muscleblind-like protein 0.0612 0.9197 1
Echinococcus multilocularis expressed protein 0.0036 0.0384 0.0379
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0371 0.2514
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0067 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0371 0.2514
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0792 0.1026
Toxoplasma gondii ABC1 family protein 0.0035 0.0371 0.2514
Echinococcus multilocularis peregrin 0.0034 0.0352 0.0347
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0371 0.2514
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0153 0.0148
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0373 0.0484
Mycobacterium leprae Probable lipase LipE 0.0035 0.0371 1
Brugia malayi PHD-finger family protein 0.0053 0.0647 0.0699
Schistosoma mansoni jumonji domain containing protein 0.0075 0.098 0.127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0744 0.0809
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0153 0.0148
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0384 0.0379
Schistosoma mansoni rotamase 0.0036 0.0384 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0384 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0181 0.2607 0.2603
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0153 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0153 0.0161
Brugia malayi jmjC domain containing protein 0.004 0.0457 0.0492
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.022 0.3901
Brugia malayi N-terminal motif family protein 0.0175 0.2509 0.2724
Loa Loa (eye worm) hypothetical protein 0.0036 0.0384 0.0417
Schistosoma mansoni bromodomain containing protein 0.0132 0.185 0.2397
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0153 0.0148
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0792 0.0856
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0005 0.0005
Onchocerca volvulus 0.0035 0.0371 0.0496
Loa Loa (eye worm) RNA binding protein 0.0062 0.0792 0.0861
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0965 0.0961
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0153 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Echinococcus granulosus jumonji domain containing protein 0.004 0.0449 0.0445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0153 0.0166
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0371 0.2514
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0457 0.0592
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0371 1
Brugia malayi Bromodomain containing protein 0.0156 0.2217 0.2407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0153 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0025 0.022 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0135
Mycobacterium tuberculosis Conserved protein 0.0035 0.0371 0.0839
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0153 0.0148
Schistosoma mansoni hypothetical protein 0.0181 0.2607 0.3378
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0371 0.0839
Echinococcus multilocularis tumor protein p63 0.0665 1 1
Schistosoma mansoni cpg binding protein 0.0037 0.0406 0.0526
Brugia malayi CXXC zinc finger family protein 0.0031 0.0318 0.0341
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0153 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0153 0.0161
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.0098
Brugia malayi nuclear hormone receptor 0.0021 0.0153 0.0161
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0075 0.0077
Onchocerca volvulus 0.0236 0.3454 0.7515
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0153 0.0198
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0371 0.0632
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0371 0.0481
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0135
Echinococcus multilocularis zinc finger protein 0.0042 0.048 0.0475
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0153 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Trichomonas vaginalis rotamase, putative 0.0035 0.0371 0.0014
Giardia lamblia PHD finger protein 15 0.0029 0.0277 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0153 0.0161
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0153 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0384 0.0497
Loa Loa (eye worm) hypothetical protein 0.0175 0.2509 0.2728
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0449 0.0445
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0384 0.0418
Trypanosoma brucei ISWI complex protein 0.0031 0.0318 0.2151
Brugia malayi Pax transcription factor protein 2 0.0236 0.3454 0.3752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0153 0.0166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0371 0.0481
Brugia malayi PHD-finger family protein 0.0029 0.0277 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0153 0.0166
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0573 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0153 0.0166
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0371 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0404
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0371 0.0839
Brugia malayi hypothetical protein 0.0308 0.4546 0.494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0515 0.0511
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0277 0.0301
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0153 0.0148
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0371 0.0399
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0371 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.1463 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1276 0.1271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0153 0.0166
Echinococcus multilocularis muscleblind protein 1 0.0612 0.9197 0.9197
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.3241 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0277 0.0273
Brugia malayi Bromodomain containing protein 0.0079 0.1039 0.1126
Schistosoma mansoni hypothetical protein 0.0515 0.7717 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0792 0.1026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0371 0.0839
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0153 0.0148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0587 0.0634
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0371 0.0839
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.022 0.3901
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.1326 0.1718
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0277 0.1871
Leishmania major hypothetical protein, conserved 0.0106 0.1463 1
Echinococcus granulosus cpg binding protein 0.0037 0.0406 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0153 0.0161
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0371 0.2514
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Entamoeba histolytica hypothetical protein 0.0181 0.2607 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0153 0.0161
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0181 0.2607 0.2603
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0384 0.0379
Echinococcus multilocularis GPCR, family 2 0.0015 0.0075 0.0071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0082
Brugia malayi hypothetical protein 0.0106 0.1463 0.1587
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0153 0.0198
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.0567 0.0563
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0239
Echinococcus granulosus muscleblind protein 0.0612 0.9197 0.9197
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0277 0.1833
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0587 0.0639
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0153 0.0161
Brugia malayi hypothetical protein 0.0069 0.0887 0.096
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.1463 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0153 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0515 0.0668
Loa Loa (eye worm) hypothetical protein 0.0049 0.0587 0.0639
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0515 0.056
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.0098
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0371 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0153 0.0148
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0318 0.0346
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0153 0.0148
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1605 0.1745
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0404
Mycobacterium ulcerans hypothetical protein 0.0025 0.022 0.3901
Loa Loa (eye worm) hypothetical protein 0.0145 0.2056 0.2235
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0153 0.0161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0515 0.0668
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0153 0.0148
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0153 0.0198
Leishmania major hypothetical protein, conserved 0.0035 0.0371 0.2514
Brugia malayi beta-lactamase family protein 0.0035 0.0371 0.0399
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0965 0.0961
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0075 0.0071
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0371 0.2479
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0792 0.1026
Brugia malayi beta-lactamase 0.0035 0.0371 0.0399
Schistosoma mansoni hypothetical protein 0.0033 0.035 0.0454
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.035 0.0376
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.2509 0.5363
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0005 0.0006
Brugia malayi ecdysteroid receptor 0.0021 0.0153 0.0161
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0153 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0153 0.0198
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0373 0.0484
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0135
Mycobacterium ulcerans lipase LipD 0.0035 0.0371 1
Onchocerca volvulus 0.0097 0.1326 0.267
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0239
Loa Loa (eye worm) hypothetical protein 0.0049 0.0591 0.0642
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0153 0.0148
Onchocerca volvulus 0.0031 0.0318 0.0376
Entamoeba histolytica hypothetical protein 0.0181 0.2607 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0075 0.0082
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0188 0.02
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0485 0.0528
Brugia malayi jmjC domain containing protein 0.0094 0.1276 0.1383
Schistosoma mansoni hypothetical protein 0.0042 0.0485 0.0629
Brugia malayi RNA binding protein 0.0062 0.0792 0.0856
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0153 0.0198
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0371 0.0404
Brugia malayi MH2 domain containing protein 0.0115 0.1605 0.174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0153 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0371 0.2514
Loa Loa (eye worm) hypothetical protein 0.0308 0.4546 0.4942
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0153 0.0198
Loa Loa (eye worm) hypothetical protein 0.0084 0.1116 0.1213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0153 0.0148
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0392 0.0427
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0404
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0277 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0404
Loa Loa (eye worm) hypothetical protein 0.0106 0.1463 0.1591
Echinococcus granulosus dnaJ subfamily B 0.0447 0.6672 0.6671
Schistosoma mansoni zinc finger protein 0.0031 0.0318 0.0412
Loa Loa (eye worm) pax transcription factor protein 2 0.0236 0.3454 0.3756
Loa Loa (eye worm) hypothetical protein 0.0612 0.9197 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.022 0.3901
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0153 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Onchocerca volvulus 0.0035 0.0371 0.0496
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0404
Loa Loa (eye worm) hypothetical protein 0.0079 0.1042 0.1132
Onchocerca volvulus Alhambra homolog 0.0029 0.0277 0.0283
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.022 0.148
Loa Loa (eye worm) hypothetical protein 0.0015 0.0069 0.0075
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.037 0.0365
Echinococcus multilocularis cpg binding protein 0.0037 0.0406 0.0401
Trypanosoma cruzi ISWI complex protein 0.0031 0.0318 0.2151
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0004 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0153 0.0161
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.0567 0.0563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0135
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0792 0.0861
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0153 0.0198
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0239
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0515 0.0555
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0135
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0384 0.0413
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.1738 0.1734
Brugia malayi AMP-binding enzyme family protein 0.0025 0.022 0.0234
Schistosoma mansoni cpg binding protein 0.0037 0.0406 0.0526
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.022 0.148
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.1463 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0457 0.0592
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0075 0.0071
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1605 0.1745
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0371 0.0839
Onchocerca volvulus 0.0035 0.0371 0.0496
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0075 0.0077
Onchocerca volvulus 0.0025 0.022 0.0153
Onchocerca volvulus 0.0308 0.4546 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0153 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0792 0.1026
Brugia malayi steroid hormone receptor 0.0021 0.0153 0.0161
Loa Loa (eye worm) hypothetical protein 0.0029 0.0277 0.0301
Loa Loa (eye worm) beta-lactamase 0.0035 0.0371 0.0404
Echinococcus granulosus peregrin 0.0034 0.0352 0.0347
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0856 0.111
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.1463 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1203 0.1308
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.022 0.3901
Echinococcus multilocularis muscleblind protein 0.0612 0.9197 0.9197
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0573 0.0742
Plasmodium falciparum phd finger protein, putative 0.0029 0.0277 0.1833
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0075 0.0071
Brugia malayi TAR-binding protein 0.0062 0.0792 0.0856
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.1738 0.1734
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0153 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0153 0.0161
Echinococcus granulosus zinc finger protein 0.0042 0.048 0.0475
Echinococcus granulosus expressed protein 0.0036 0.0384 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0153 0.0161
Entamoeba histolytica hypothetical protein 0.0181 0.2607 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0371 1
Schistosoma mansoni hypothetical protein 0.0447 0.6672 0.8646
Schistosoma mansoni cpg binding protein 0.0031 0.0318 0.0413
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.022 0.0358
Echinococcus granulosus GPCR family 2 0.0015 0.0075 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0153 0.0161
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0371 0.0839
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0166
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0124 0.005
Schistosoma mansoni hypothetical protein 0.0029 0.0277 0.0359
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0005 0.0006
Entamoeba histolytica hypothetical protein 0.0181 0.2607 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.022 0.148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0153 0.0161
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0124 0.0775
Mycobacterium tuberculosis Conserved protein 0.0035 0.0371 0.0839
Loa Loa (eye worm) hypothetical protein 0.0033 0.035 0.0381
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0153 0.0148
Mycobacterium ulcerans beta-lactamase 0.0035 0.0371 1
Schistosoma mansoni hypothetical protein 0.0015 0.0075 0.0098
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0373 0.0369
Mycobacterium tuberculosis Conserved protein 0.0035 0.0371 0.0839
Echinococcus granulosus geminin 0.0515 0.7717 0.7716
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0573 0.0568
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0101 0.0131
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0277 0.1871
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0153 0.0166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0153 0.0166
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.1463 1
Schistosoma mansoni hypothetical protein 0.0515 0.7717 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.022 0.3901
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0822 0.5603
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.1463 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0792 0.1026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0515 0.0511
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.022 0.0358
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0153 0.0161
Brugia malayi beta-lactamase family protein 0.0035 0.0371 0.0399
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1276 0.1271
Loa Loa (eye worm) hypothetical protein 0.0097 0.1326 0.1442
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0153 0.0198
Echinococcus granulosus tar DNA binding protein 0.0062 0.0792 0.0788
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0384 0.0497
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0153 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0457 0.0497
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0587 0.0634
Schistosoma mansoni coup transcription factor 0.0021 0.0153 0.0198
Schistosoma mansoni zinc finger protein 0.0042 0.048 0.0622
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0277 0.0359
Trichomonas vaginalis rotamase, putative 0.0036 0.0384 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0515 0.0511
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.022 0.3901
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0075 0.0071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0404

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Analgesic activity was evaluated in mice after s.c. administration of 20 mg/kg. ChEMBL. 12699749
Inhibition (functional) = 33 % Sedative activity was evaluated in mice after s.c. administration of 20 mg/kg. ChEMBL. 12699749

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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