Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | replicative DNA helicase | 0.1266 | 0.9305 | 1 |
Loa Loa (eye worm) | twinkle helicase | 0.0362 | 0.2143 | 1 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1266 | 0.9305 | 1 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.1266 | 0.9305 | 1 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.1266 | 0.9305 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.1174 | 0.8578 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.1354 | 1 | 1 |
Echinococcus granulosus | dual specificity protein phosphatase | 0.0321 | 0.1824 | 0.1712 |
Schistosoma mansoni | Replicative DNA helicase | 0.1266 | 0.9305 | 1 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.1266 | 0.9305 | 1 |
Schistosoma mansoni | dual specificity protein phosphatase | 0.0321 | 0.1824 | 0.1842 |
Giardia lamblia | Dual specificity phosphatase, catalytic | 0.0321 | 0.1824 | 0.5 |
Onchocerca volvulus | 0.0321 | 0.1824 | 1 | |
Brugia malayi | Dual specificity phosphatase, catalytic domain containing protein | 0.0321 | 0.1824 | 1 |
Loa Loa (eye worm) | dual specificity phosphatase | 0.0321 | 0.1824 | 0.8408 |
Leishmania major | pteridine reductase 1 | 0.0091 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1174 | 0.8578 | 0.9219 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.1266 | 0.9305 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1174 | 0.8578 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0091 | 0 | 0.5 |
Echinococcus multilocularis | dual specificity protein phosphatase | 0.0321 | 0.1824 | 0.1712 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1174 | 0.8578 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1174 | 0.8578 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0091 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0091 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1174 | 0.8578 | 0.9219 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Collateral index (functional) | = 8 | Collateral index in anesthetized dog at the dose of 0.01 mg/kg, i.v. after 60 minutes of administration | ChEMBL. | 12699747 |
Max collateral index (functional) | = 45 | Maximum collateral index in anesthetized dog at the dose of 0.01mg/kg, i.v. | ChEMBL. | 12699747 |
Max hypotension (functional) | NT 23 % | Maximum hypertension was measured in anesthetized dog as percent at the dose of 0.01 mg/kg, i.v. | ChEMBL. | 12699747 |
NG ratio (functional) | = 2.5 | Ratio of the CIAUC value to that of nitroglycerin (NTG ratio) | ChEMBL. | 12699747 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.