TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.428 | Formula: C20H25N3O7
H donors: 4 H acceptors: 6 LogP: -0.77 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)/C=C\C(=O)O.COc1ccc(cc1)C(=O)NC(=O)NC1CN2CCC1CC2
InChi: 1S/C16H21N3O3.C4H4O4/c1-22-13-4-2-12(3-5-13)15(20)18-16(21)17-14-10-19-8-6-11(14)7-9-19;5-3(6)1-2-4(7)8/h2-5,11,14H,6-10H2,1H3,(H2,17,18,20,21);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChiKey: ANIOXWZUEFRMJD-BTJKTKAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Serotonin 3 (5-HT3) receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	477 aa	26.6 %
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	Serotonin 3 (5-HT3) receptor	483 aa	387 aa	25.6 %
Echinococcus multilocularis	nAChR subunit	Serotonin 3 (5-HT3) receptor	483 aa	495 aa	24.2 %
Onchocerca volvulus	Putative zinc finger protein	Serotonin 3 (5-HT3) receptor	483 aa	489 aa	25.8 %
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	Serotonin 3 (5-HT3) receptor	483 aa	514 aa	23.2 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	489 aa	31.3 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	482 aa	23.9 %
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	484 aa	26.0 %
Onchocerca volvulus	39S ribosomal protein L13, mitochondrial homolog	Serotonin 3 (5-HT3) receptor	483 aa	490 aa	31.0 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type des-2 homolog	Serotonin 3 (5-HT3) receptor	483 aa	464 aa	24.8 %
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	26.9 %
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	Serotonin 3 (5-HT3) receptor	483 aa	503 aa	22.3 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	465 aa	27.3 %
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Serotonin 3 (5-HT3) receptor	483 aa	445 aa	25.6 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	452 aa	29.2 %
Drosophila melanogaster	nicotinic Acetylcholine Receptor alpha2	Serotonin 3 (5-HT3) receptor	483 aa	541 aa	25.5 %
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-3 precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	505 aa	21.2 %
Brugia malayi	Cation transporter family protein	Serotonin 3 (5-HT3) receptor	483 aa	507 aa	28.2 %
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	463 aa	26.8 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	461 aa	24.3 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Serotonin 3 (5-HT3) receptor	483 aa	478 aa	25.1 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	Serotonin 3 (5-HT3) receptor	483 aa	394 aa	19.3 %
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Serotonin 3 (5-HT3) receptor	483 aa	445 aa	25.4 %
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	24.7 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	473 aa	27.5 %
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	470 aa	27.7 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	Serotonin 3 (5-HT3) receptor	483 aa	388 aa	21.9 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	482 aa	25.1 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	26.7 %
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	470 aa	26.8 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	465 aa	27.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Brugia malayi	neuropeptide F receptor	0.1514	1	1
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0154	0.0252
Onchocerca volvulus		0.1514	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.1514	1	1
Brugia malayi	6-phosphofructokinase	0.0109	0.0618	0.0618
Schistosoma mansoni	amine GPCR	0.1514	1	1
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0214	0.0213
Brugia malayi	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	serotonin receptor	0.1514	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.006	0.2855
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0357	0.0335
Toxoplasma gondii	PAN domain-containing protein	0.0075	0.0393	0.051
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.0925	0.6071	1
Schistosoma mansoni	patched 1	0.0042	0.0174	0.0173
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0232	0.1568
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0023	0.0022
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0174	0.0173
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0091	0.0068
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0091	0.009
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0393	0.037
Toxoplasma gondii	hypothetical protein	0.0075	0.0393	0.051
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.1514	1	1
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0207	0.0185
Mycobacterium tuberculosis	Possible conserved membrane protein	0.0039	0.0154	0.0252
Brugia malayi	Doublecortin family protein	0.002	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0174	0.0151
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0618	0.4187
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0088	1
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.0612	0.1008
Echinococcus granulosus	rhodopsin orphan GPCR	0.1514	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.0693	0.114
Schistosoma mansoni	rab6-interacting	0.002	0.0023	0.0022
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0088	0.0589
Mycobacterium tuberculosis	Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular	0.0039	0.0154	0.0252
Brugia malayi	hypothetical protein	0.1514	1	1
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0618	0.0617
Schistosoma mansoni	amine GPCR	0.1514	1	1
Onchocerca volvulus		0.0075	0.0393	0.037
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.1514	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.1514	1	1
Brugia malayi	hypothetical protein	0.002	0.0023	0.0023
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.1514	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0232	0.3745
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0618	0.0617
Brugia malayi	hypothetical protein	0.1514	1	1
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0207	1
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0222	0.0221
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0163	0.0163
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0232	0.0231
Brugia malayi	Pre-SET motif family protein	0.0208	0.1283	0.1283
Brugia malayi	hypothetical protein	0.002	0.0023	0.0023
Onchocerca volvulus		0.0237	0.1475	0.1455
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0174	0.1173
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0232	0.3745
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.006	0.0956
Echinococcus granulosus	tachykinin peptides receptor 99D	0.1514	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.1514	1	1
Toxoplasma gondii	microneme protein MIC4	0.0075	0.0393	0.051
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0109	0.0618	1
Brugia malayi	Serotonin receptor	0.1514	1	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.026	0.026
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.1514	1	1
Echinococcus granulosus	chromobox protein 1	0.007	0.0357	0.0356
Schistosoma mansoni	chromobox protein	0.007	0.0357	0.0356
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.1514	1	1
Toxoplasma gondii	microneme protein MIC17B	0.0075	0.0393	0.051
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0001	0.5
Onchocerca volvulus		0.1514	1	1
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0088	0.0113
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0284	0.0284
Brugia malayi	ORL1-like opioid receptor	0.1514	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.1514	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1514	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.0549	0.0549
Brugia malayi	Dopamine receptor protein 2	0.1514	1	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0232	0.3745
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Brugia malayi	AKH receptor	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0088	0.0589
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0297	0.0488
Loa Loa (eye worm)	neuropeptide F receptor	0.1514	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0297	0.0488
Onchocerca volvulus		0.0075	0.0393	0.037
Brugia malayi	MAP kinase sur-1	0.0051	0.0232	0.0232
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1514	1	1
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0207	1
Schistosoma mansoni	loxhd1	0.002	0.0023	0.0022
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Echinococcus multilocularis	somatostatin receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.1514	1	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0088	0.4201
Schistosoma mansoni	histamine h1 receptor	0.1514	1	1
Schistosoma mansoni	neuropeptide receptor	0.1514	1	1
Schistosoma mansoni	lipoxygenase	0.002	0.0023	0.0022
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.1514	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0207	0.3347
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0393	0.037
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.1514	1	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.0549	0.0549
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Schistosoma mansoni	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.1514	1	1
Schistosoma mansoni	lipoxygenase	0.0055	0.026	0.026
Brugia malayi	phosphofructokinase	0.0109	0.0618	0.0618
Schistosoma mansoni	growth hormone secretagogue receptor	0.1514	1	1
Toxoplasma gondii	hypothetical protein	0.0075	0.0393	0.051
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1472	0.1453
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0088	0.0589
Echinococcus granulosus	orexin receptor type 2	0.1514	1	1
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0214	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0393	0.037
Echinococcus granulosus	allatostatin A receptor	0.1514	1	1
Brugia malayi	6-phosphofructokinase	0.0109	0.0618	0.0618
Brugia malayi	Dopamine receptor	0.1514	1	1
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0618	1
Schistosoma mansoni	hypothetical protein	0.002	0.0023	0.0022
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.0549	0.0549
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0088	0.0113
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0088	0.0589
Schistosoma mansoni	biogenic amine receptor	0.1514	1	1
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Brugia malayi	jmjC domain containing protein	0.0059	0.0284	0.0284
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Echinococcus multilocularis	expressed conserved protein	0.0093	0.051	0.0509
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0214	0.0214
Echinococcus granulosus	rhodopsin orphan GPCR	0.1514	1	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0023	0.1078
Toxoplasma gondii	PAN domain-containing protein	0.0075	0.0393	0.051
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.006	0.0956
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1514	1	1
Brugia malayi	hypothetical protein	0.1514	1	1
Leishmania major	trypanothione reductase	0.0047	0.0207	0.3347
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0152	0.1028
Echinococcus multilocularis	sex peptide receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Echinococcus granulosus	neuropeptide receptor	0.1514	1	1
Schistosoma mansoni	hypothetical protein	0.1514	1	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0232	0.3745
Entamoeba histolytica	endo-1,4-beta-xylanase, putative	0.0039	0.0154	0.1248
Onchocerca volvulus		0.0041	0.0167	0.0144
Echinococcus multilocularis	protein patched	0.0042	0.0174	0.0173
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0393	0.037
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0088	0.4201
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0076	0.0511
Onchocerca volvulus		0.0075	0.0393	0.037
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0154	0.0252
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0167	0.0166
Echinococcus granulosus	7tm_1 domain containing protein	0.1514	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.1514	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1514	1	1
Echinococcus granulosus	neuropeptide s receptor	0.1514	1	1
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Loa Loa (eye worm)	TYRA-2 protein	0.1514	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1514	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0163	0.0163
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0618	1
Schistosoma mansoni	polycystin 1-related	0.002	0.0023	0.0022
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0091	0.009
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.1283	0.1263
Echinococcus granulosus	g-protein coupled receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.1514	1	1
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0075	0.0393	0.051
Toxoplasma gondii	subtilisin SUB12	0.0075	0.0393	0.051
Echinococcus multilocularis	fmrfamide receptor	0.1514	1	1
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0039	0.0154	0.0252
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0393	0.037
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1514	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Mycobacterium ulcerans	secreted Mpt51/Mpb51 antigen protein FbpD	0.0039	0.0154	0.0252
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0297	0.0296
Schistosoma mansoni	amine GPCR	0.1514	1	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0088	0.1406
Mycobacterium ulcerans	secreted antigen 85-B FbpB	0.0039	0.0154	0.0252
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.1514	1	1
Echinococcus multilocularis	tumor protein p63	0.0338	0.215	0.215
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Brugia malayi	G-protein coupled receptor	0.1514	1	1
Brugia malayi	sulfakinin receptor protein	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0023	0.0022
Echinococcus granulosus	rhodopsin orphan GPCR	0.1514	1	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0393	0.037
Echinococcus multilocularis	S formylglutathione hydrolase	0.0039	0.0154	0.0153
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0088	0.3755
Echinococcus multilocularis	g protein coupled receptor	0.1514	1	1
Brugia malayi	Pre-SET motif family protein	0.003	0.0091	0.0091
Echinococcus granulosus	G protein coupled receptor 139	0.1514	1	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0297	0.4803
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0297	0.0488
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1514	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.1514	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0163	0.0163
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0393	0.037
Brugia malayi	hypothetical protein	0.1514	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0096	0.0073
Echinococcus granulosus	expressed conserved protein	0.0093	0.051	0.0509
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0618	0.4187
Loa Loa (eye worm)	G-protein coupled receptor	0.1514	1	1
Echinococcus multilocularis	neuropeptide receptor	0.1514	1	1
Mycobacterium ulcerans	secreted antigen 85-A FbpA	0.0039	0.0154	0.0252
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.1514	1	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0297	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0393	0.037
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0091	0.009
Echinococcus multilocularis	neuropeptides capa receptor	0.1514	1	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0001	0.0001
Echinococcus granulosus	serotonin receptor	0.1514	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0297	0.0296
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.1514	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.1514	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.0693	0.0911
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Brugia malayi	larval opioid receptor	0.1514	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.1514	1	1
Schistosoma mansoni	opsin-like receptor	0.1514	1	1
Schistosoma mansoni	myosin xvIII	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0618	0.0596
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0172	0.1163
Echinococcus multilocularis	allatostatin A receptor	0.1514	1	1
Toxoplasma gondii	microneme protein MIC17C	0.0075	0.0393	0.051
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0297	0.0488
Schistosoma mansoni	neuropeptide receptor	0.1514	1	1
Brugia malayi	G-protein coupled receptor	0.1514	1	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0023	0.0022
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0091	0.009
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.056	0.0559
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.0075	0.0393	0.037
Toxoplasma gondii	microneme protein, putative	0.0075	0.0393	0.051
Loa Loa (eye worm)	hypothetical protein	0.005	0.0222	0.0199
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus granulosus	S formylglutathione hydrolase	0.0039	0.0154	0.0153
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.006	0.2855
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0152	0.1028
Mycobacterium leprae	SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C)	0.0925	0.6071	1
Onchocerca volvulus		0.0075	0.0393	0.037
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.1514	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.1514	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.1514	1	1
Echinococcus granulosus	sex peptide receptor	0.1514	1	1
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.1472	0.1472
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.0075	0.0393	0.037
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Brugia malayi	neuropeptide F receptor	0.1514	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0232	0.1568
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0154	0.0252
Schistosoma mansoni	hypothetical protein	0.0041	0.0163	0.0163
Onchocerca volvulus		0.0031	0.0096	0.0073
Echinococcus granulosus	chromobox protein 1	0.007	0.0357	0.0356
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0075	0.0393	0.051
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0232	0.3745
Brugia malayi	Dopamine receptor protein 1	0.1514	1	1
Schistosoma mansoni	amine GPCR	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Plasmodium vivax	SET domain protein, putative	0.003	0.0091	0.4358
Schistosoma mansoni	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	fmrfamide receptor	0.1514	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Brugia malayi	putative neuropeptide receptor	0.1514	1	1
Schistosoma mansoni	adenoreceptor	0.1514	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1514	1	1
Echinococcus multilocularis	chromobox protein 1	0.007	0.0357	0.0356
Brugia malayi	CHE-14 protein	0.0042	0.0174	0.0174
Echinococcus multilocularis	g protein coupled receptor	0.1514	1	1
Echinococcus granulosus	dro:myosuppressin receptor	0.1514	1	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0812	0.5313	0.5312
Brugia malayi	chromobox protein homolog 3	0.0039	0.0152	0.0152
Echinococcus granulosus	tumor protein p63	0.0338	0.215	0.215
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.0925	0.6071	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0207	0.0185
Brugia malayi	hypothetical protein	0.1514	1	1
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0154	0.0252
Brugia malayi	hypothetical protein	0.1514	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.1514	1	1
Echinococcus granulosus	somatostatin receptor	0.1514	1	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.0612	0.1008
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.1514	1	1
Echinococcus granulosus	g protein coupled receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.0693	0.114
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0076	0.0511
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0284	0.0284
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0232	0.0209
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.0612	0.1008
Brugia malayi	RE15519p	0.1514	1	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.1514	1	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0174	0.0173
Leishmania major	ATP-dependent phosphofructokinase	0.0109	0.0618	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Schistosoma mansoni	opsin-like receptor	0.1514	1	1
Schistosoma mansoni	biogenic amine receptor	0.1514	1	1
Mycobacterium tuberculosis	Probable reductase	0.0108	0.0612	0.1008
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.1514	1	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0297	0.0296
Echinococcus granulosus	RUN	0.002	0.0023	0.0022
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.0612	0.1008
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0174	0.0151
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0297	0.0296
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Brugia malayi	glutathione reductase	0.0047	0.0207	0.0207
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0023	0.1078
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Schistosoma mansoni	neuropeptide receptor	0.1514	1	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0232	0.0231
Onchocerca volvulus		0.1514	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.1514	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.1514	1	1
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0232	0.0231
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0088	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.006	0.0077
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0088	0.4201
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0088	0.4201
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0357	0.2417
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0232	0.1568
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0618	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0232	0.0231
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.1514	1	1
Brugia malayi	hypothetical protein	0.0122	0.0705	0.0705
Mycobacterium tuberculosis	Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A)	0.0039	0.0154	0.0252
Schistosoma mansoni	rab6-interacting	0.002	0.0023	0.0022
Echinococcus multilocularis	orexin receptor type 2	0.1514	1	1
Plasmodium falciparum	glutathione reductase	0.0047	0.0207	1
Brugia malayi	hypothetical protein	0.0237	0.1472	0.1472
Schistosoma mansoni	alpha-1 adrenergic receptor	0.1514	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.1514	1	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0172	0.0149
Echinococcus granulosus	g protein coupled receptor	0.1514	1	1
Toxoplasma gondii	PAN domain-containing protein	0.1167	0.7682	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.0832	0.0831
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0618	0.0596
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.0832	0.0831
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0088	0.0589
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0207	0.034
Echinococcus granulosus	biogenic amine 5HT receptor	0.1514	1	1
Brugia malayi	Esterase D	0.0039	0.0154	0.0154
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0284	0.0262
Echinococcus granulosus	tm gpcr rhodopsin	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	serotonin receptor	0.1514	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0618	1
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0109	0.0618	0.0785
Onchocerca volvulus		0.0075	0.0393	0.037
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0232	0.3745
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.1514	1	1
Echinococcus granulosus	neuropeptide receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.0318	0.2012	0.1994
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0232	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1514	1	1
Leishmania major	hypothetical protein, conserved	0.0025	0.006	0.0956
Onchocerca volvulus		0.0075	0.0393	0.037
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0154	0.0252
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0091	0.009
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0618	0.4187
Echinococcus granulosus	hypothetical protein	0.1514	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0237	0.0215
Echinococcus granulosus	neuropeptide receptor A26	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.1514	1	1
Brugia malayi	hypothetical protein	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.1472	0.1472
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0357	0.2417
Echinococcus granulosus	g protein coupled receptor	0.1514	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.1514	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.1514	1	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0214	0.0213
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.1514	1	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0023	0.0022
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0232	0.0301
Schistosoma mansoni	neuropeptide receptor	0.1514	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.1514	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0393	0.037
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.1514	1	1
Trypanosoma brucei	trypanothione reductase	0.0047	0.0207	0.3347
Echinococcus multilocularis	6 phosphofructokinase	0.0109	0.0618	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0393	0.037
Brugia malayi	Melatonin receptor type 1A	0.1514	1	1
Mycobacterium tuberculosis	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind	0.0039	0.0154	0.0252
Toxoplasma gondii	PAN domain-containing protein	0.0075	0.0393	0.051
Brugia malayi	hypothetical protein	0.0025	0.006	0.006
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0232	0.1568
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.0612	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0152	0.013
Echinococcus multilocularis	dro:myosuppressin receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Schistosoma mansoni	hypothetical protein	0.1514	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0549	0.0528
Echinococcus multilocularis	neuropeptide FF receptor 2	0.1514	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0207	1
Onchocerca volvulus		0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.006	0.0037
Echinococcus multilocularis	chromobox protein 1	0.007	0.0357	0.0356
Brugia malayi	Serotonin receptor	0.1514	1	1
Echinococcus multilocularis	g protein coupled receptor	0.1514	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.1514	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.006	0.0956
Mycobacterium ulcerans	6-phosphofructokinase	0.0109	0.0618	0.1017
Onchocerca volvulus		0.1514	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1514	1	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0284	0.0284
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0088	0.0589
Echinococcus multilocularis	RUN	0.002	0.0023	0.0022
Brugia malayi	Thioredoxin reductase	0.0047	0.0207	0.0207
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0172	0.1163
Echinococcus multilocularis	neuropeptide Y receptor	0.1514	1	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.0612	0.1008
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.1514	1	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0091	0.0117
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.1514	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.1514	1	1
Onchocerca volvulus		0.0075	0.0393	0.037
Schistosoma mansoni	biogenic amine receptor	0.1514	1	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0393	0.037
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1514	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1514	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.1514	1	1
Loa Loa (eye worm)	esterase D	0.0039	0.0154	0.0131
Onchocerca volvulus		0.005	0.0222	0.0199
Echinococcus granulosus	neuropeptides capa receptor	0.1514	1	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0207	0.0207
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.1475	1
Toxoplasma gondii	PAN domain-containing protein	0.1167	0.7682	1
Onchocerca volvulus		0.0075	0.0393	0.037
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0152	0.013
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0109	0.0618	0.1017
Onchocerca volvulus	Neuropeptide F receptor homolog	0.1514	1	1
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0088	0.0113
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Brugia malayi	follicle stimulating hormone receptor	0.1514	1	1
Brugia malayi	GnHR receptor homolog	0.1514	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Echinococcus multilocularis	neuropeptide receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1514	1	1
Brugia malayi	PAN domain containing protein	0.0075	0.0393	0.0393
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1514	1	1
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0023	0.0022
Toxoplasma gondii	microneme protein MIC17A	0.0075	0.0393	0.051
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0232	0.0231
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1514	1	1
Toxoplasma gondii	PAN domain-containing protein	0.0075	0.0393	0.051
Loa Loa (eye worm)	PAN domain-containing protein	0.0075	0.0393	0.037
Echinococcus granulosus	fmrfamide receptor	0.1514	1	1
Brugia malayi	jmjC domain containing protein	0.0059	0.0284	0.0284
Echinococcus granulosus	rhodopsin orphan GPCR	0.1514	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1514	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.1514	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0618	0.4187
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0023	0.0022
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0091	0.009
Mycobacterium tuberculosis	Probable conserved exported protein	0.0039	0.0154	0.0252
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1514	1	1
Brugia malayi	Heterochromatin protein 1	0.007	0.0357	0.0357
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.0693	0.114
Schistosoma mansoni	amine GPCR	0.1514	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1514	1	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0174	0.0173
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Trypanosoma brucei	protein kinase, putative	0.0051	0.0232	0.3745
Echinococcus granulosus	neuropeptide Y receptor	0.1514	1	1
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.1514	1	1
Onchocerca volvulus		0.1514	1	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0284	0.0284
Echinococcus granulosus	tm gpcr rhodopsin	0.1514	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0088	0.0589
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.1514	1	1
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0618	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0284	0.0284
Brugia malayi	hypothetical protein	0.1514	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1514	1	1
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0207	0.0269
Onchocerca volvulus		0.0048	0.0214	0.0191
Schistosoma mansoni	chromobox protein	0.007	0.0357	0.0356
Onchocerca volvulus		0.0075	0.0393	0.037
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Schistosoma mansoni	opsin-like receptor	0.1514	1	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.0549	0.8709
Brugia malayi	G protein-coupled receptor	0.1514	1	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.006	0.2855
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0232	0.3745
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.026	0.026
Echinococcus granulosus	6 phosphofructokinase	0.0109	0.0618	0.0617
Loa Loa (eye worm)	phosphofructokinase	0.0109	0.0618	0.0596
Loa Loa (eye worm)	hypothetical protein	0.1514	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (functional)	> 6.5	In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.	ChEMBL.	1578478
pA2 (functional)	< 6.5	In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.	ChEMBL.	1578478

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 53520