Detailed information for compound 53539

Basic information

Technical information
  • TDR Targets ID: 53539
  • Name: 5-[3-[4-[[2-(1-benzofuran-2-yl)-5-methyl-1,3- oxazol-4-yl]methoxy]phenyl]propyl]-1,3-oxazol idine-2,4-dione
  • MW: 446.452 | Formula: C25H22N2O6
  • H donors: 1 H acceptors: 3 LogP: 4.65 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(O1)CCCc1ccc(cc1)OCc1nc(oc1C)c1cc2c(o1)cccc2
  • InChi: 1S/C25H22N2O6/c1-15-19(26-24(31-15)22-13-17-6-2-3-7-20(17)32-22)14-30-18-11-9-16(10-12-18)5-4-8-21-23(28)27-25(29)33-21/h2-3,6-7,9-13,21H,4-5,8,14H2,1H3,(H,27,28,29)
  • InChiKey: BMPQBDULQQBXAI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-[3-[4-[[2-(benzofuran-2-yl)-5-methyl-oxazol-4-yl]methoxy]phenyl]propyl]oxazolidine-2,4-dione
  • 5-[3-[4-[[2-(2-benzofuranyl)-5-methyl-4-oxazolyl]methoxy]phenyl]propyl]oxazolidine-2,4-dione
  • 5-[3-[4-[[2-(benzofuran-2-yl)-5-methyl-oxazol-4-yl]methoxy]phenyl]propyl]oxazolidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0328 0.1824 0.2377
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0824 0.5014 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0222 0.1143 0.1143
Schistosoma mansoni protein kinase 0.0463 0.2691 0.2691
Echinococcus granulosus Rac GTPase activating protein 1 0.0222 0.1143 0.1143
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0121 0.0498 0.083
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0162 0.0761 0.1365
Giardia lamblia Kinase, CMGC CK2 0.0463 0.2691 0.4856
Plasmodium falciparum casein kinase 2, alpha subunit 0.0463 0.2691 0.4856
Schistosoma mansoni tyrosine kinase 0.0483 0.2818 0.2818
Loa Loa (eye worm) AGC/PKN protein kinase 0.0328 0.1824 0.2377
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0824 0.5014 0.5014
Echinococcus multilocularis protein kinase c iota type 0.0732 0.4419 0.4419
Schistosoma mansoni tyrosine kinase 0.0483 0.2818 0.2818
Echinococcus multilocularis cyclin dependent kinase 1 0.0162 0.0761 0.0761
Echinococcus multilocularis cyclin dependent kinase 1 0.0162 0.0761 0.0761
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0038 0.0038
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0121 0.0498 0.0849
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0121 0.0498 0.0993
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.0761 0.0761
Trypanosoma cruzi cdc2-related kinase 3 0.0162 0.0761 0.1365
Schistosoma mansoni voltage-gated potassium channel 0.0187 0.0919 0.0919
Schistosoma mansoni serine/threonine protein kinase 0.0723 0.4359 0.4359
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.1017 0.625 0.625
Echinococcus granulosus NDR protein kinase 0.0328 0.1824 0.1824
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.1824 0.1824
Echinococcus granulosus mitogen activated protein kinase 0.0188 0.0927 0.0927
Echinococcus multilocularis casein kinase ii subunit beta 0.0121 0.0498 0.0498
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.2691 0.4856
Echinococcus multilocularis N chimaerin 0.0222 0.1143 0.1143
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.1824 0.1824
Schistosoma mansoni tyrosine kinase 0.0548 0.3239 0.3239
Giardia lamblia Kinase, CMGC GSK 0.0824 0.5014 1
Echinococcus granulosus casein kinase ii subunit beta 0.0121 0.0498 0.0498
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0121 0.0498 0.0849
Echinococcus granulosus protein kinase c eta type 0.0222 0.1143 0.1143
Giardia lamblia Kinase, CMGC MAPK 0.0188 0.0927 0.095
Echinococcus granulosus voltage gated potassium channel 0.005 0.0038 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0761 0.0583
Echinococcus granulosus twitchin 0.0073 0.0186 0.0186
Schistosoma mansoni voltage-gated potassium channel 0.0187 0.0919 0.0919
Echinococcus granulosus serine:threonine protein kinase N2 0.0328 0.1824 0.1824
Schistosoma mansoni serine/threonine protein kinase 0.1601 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0162 0.0761 0.1365
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0188 0.0927 0.1701
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0121 0.0498 0.0849
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0328 0.1824 0.1824
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0558 0.33 0.33
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0062 0.0118 0.0154
Schistosoma mansoni tyrosine kinase 0.0779 0.472 0.472
Entamoeba histolytica PH domain containing protein kinase, putative 0.0159 0.0744 0.1348
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0123 0.0509 0.0634
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0222 0.1143 0.1143
Echinococcus granulosus mitogen activated protein kinase 3 0.0188 0.0927 0.0927
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0463 0.2691 0.4856
Echinococcus granulosus raf serine:threonine protein kinase 0.0233 0.1213 0.1213
Schistosoma mansoni hypothetical protein 0.0222 0.1143 0.1143
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.0062
Toxoplasma gondii diacylglycerol kinase, putative 0.0222 0.1143 0.1428
Trypanosoma cruzi cdc2-related kinase 1 0.0162 0.0761 0.1365
Onchocerca volvulus 0.0256 0.1367 0.2726
Loa Loa (eye worm) Csnk2b protein 0.0121 0.0498 0.0649
Plasmodium vivax glycogen synthase kinase 3, putative 0.0824 0.5014 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0028 0.0035
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0188 0.0927 0.1701
Echinococcus multilocularis Rac GTPase activating protein 1 0.0222 0.1143 0.1143
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.0927 0.0927
Loa Loa (eye worm) TK/INSR protein kinase 0.0548 0.3239 0.4222
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.005 0.0038 0.0048
Echinococcus granulosus N chimaerin 0.0222 0.1143 0.1143
Schistosoma mansoni atypical protein kinase C 0.0745 0.4505 0.4505
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0243 0.1277 0.1665
Schistosoma mansoni nephrin 0.0061 0.0112 0.0112
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0222 0.1143 0.1143
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0824 0.5014 0.5014
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0121 0.0498 0.083
Loa Loa (eye worm) raf kinase 0.0222 0.1143 0.1489
Echinococcus granulosus insulin receptor 0.0548 0.3239 0.3239
Plasmodium falciparum protein kinase 5 0.0162 0.0761 0.0583
Schistosoma mansoni protein kinase 0.0161 0.0751 0.0751
Toxoplasma gondii CMGC kinase, CK2 family 0.0463 0.2691 0.4856
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0256 0.1367 0.1367
Giardia lamblia Kinase, CMGC GSK 0.0824 0.5014 1
Entamoeba histolytica protein kinase, putative 0.0328 0.1824 0.3535
Loa Loa (eye worm) hypothetical protein 0.005 0.0038 0.005
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Brugia malayi RhoGAP domain containing protein 0.0222 0.1143 0.1423
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0171 0.0818 0.0818
Leishmania major casein kinase II, putative 0.0463 0.2691 0.5283
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0243 0.1277 0.1277
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.1073 0.6609 0.8614
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Loa Loa (eye worm) RasGEF domain-containing protein 0.0222 0.1143 0.1489
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.2691 0.4856
Echinococcus multilocularis voltage gated potassium channel 0.005 0.0038 0.0038
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0824 0.5014 0.5014
Echinococcus granulosus protein kinase shaggy 0.0824 0.5014 0.5014
Brugia malayi diacylglycerol kinase 0.0222 0.1143 0.1423
Brugia malayi Casein kinase II, alpha chain 0.0463 0.2691 0.335
Loa Loa (eye worm) hypothetical protein 0.0141 0.0626 0.0816
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Echinococcus multilocularis insulin receptor 0.0548 0.3239 0.3239
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0188 0.0927 0.095
Brugia malayi cell division control protein 2 homolog 0.0162 0.0761 0.0948
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.016 0.0746 0.0548
Loa Loa (eye worm) hypothetical protein 0.0733 0.4429 0.5773
Entamoeba histolytica protein kinase, putative 0.0073 0.0186 0.0217
Loa Loa (eye worm) AGC/NDR protein kinase 0.0328 0.1824 0.2377
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0188 0.0927 0.1701
Giardia lamblia Kinase, CMGC CDK 0.0162 0.0761 0.0583
Echinococcus multilocularis epidermal growth factor receptor 0.0493 0.2889 0.2889
Entamoeba histolytica casein kinase, putative 0.0463 0.2691 0.5292
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.1277 0.1277
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0824 0.5014 0.6535
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.2691 0.4856
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0123 0.0509 0.0664
Schistosoma mansoni protein kinase 0.0161 0.0751 0.0751
Schistosoma mansoni rac gtpase activating protein 0.0222 0.1143 0.1143
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0162 0.0761 0.0992
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Echinococcus granulosus epidermal growth factor receptor 0.0493 0.2889 0.2889
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Onchocerca volvulus 0.0222 0.1143 0.2279
Schistosoma mansoni protein kinase C 0.0256 0.1367 0.1367
Brugia malayi protein kinase C II. 0.0723 0.4359 0.5428
Trypanosoma brucei cdc2-related kinase 3 0.0162 0.0761 0.1365
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Entamoeba histolytica cell division protein kinase 2, putative 0.0162 0.0761 0.1382
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0188 0.0927 0.1701
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.0118 0.0147
Loa Loa (eye worm) hypothetical protein 0.0955 0.5852 0.7627
Brugia malayi Protein kinase c protein 2 0.1294 0.8031 1
Trypanosoma brucei cdc2-related kinase 1 0.0162 0.0761 0.1365
Brugia malayi Protein kinase domain containing protein 0.0162 0.0761 0.0948
Brugia malayi Protein kinase domain containing protein 0.02 0.1003 0.1249
Schistosoma mansoni unc-13 (munc13) 0.0256 0.1367 0.1367
Echinococcus granulosus cyclin dependent kinase 1 0.0162 0.0761 0.0761
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0761 0.0583
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0121 0.0498 0.083
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0162 0.0761 0.0992
Brugia malayi C1-like domain containing protein 0.0243 0.1277 0.1591
Brugia malayi Csnk2b protein 0.0121 0.0498 0.062
Loa Loa (eye worm) hypothetical protein 0.0733 0.4429 0.5773
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0307 0.1689 0.2637
Plasmodium vivax unspecified product 0.0463 0.2691 0.4856
Echinococcus multilocularis epidermal growth factor receptor 0.0779 0.472 0.472
Brugia malayi Protein kinase domain containing protein 0.0328 0.1824 0.2271
Schistosoma mansoni cell adhesion molecule 0.0061 0.0109 0.0109
Echinococcus granulosus Diacylglycerol kinase theta 0.0222 0.1143 0.1143
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0171 0.0818 0.0818
Trypanosoma cruzi cdc2-related kinase 3 0.0162 0.0761 0.1365
Echinococcus granulosus roundabout 2 0.0074 0.0193 0.0193
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0558 0.33 0.33
Schistosoma mansoni protein kinase 0.0161 0.0751 0.0751
Brugia malayi RhoGAP domain containing protein 0.0222 0.1143 0.1423
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Echinococcus granulosus casein kinase ii subunit alpha 0.0463 0.2691 0.2691
Echinococcus granulosus serine:threonine protein kinase N2 0.0159 0.0744 0.0744
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0824 0.5014 1
Entamoeba histolytica protein kinase, putative 0.0824 0.5014 1
Echinococcus multilocularis mitogen activated protein kinase 0.0188 0.0927 0.0927
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.005 0.0038 0.0038
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0824 0.5014 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0171 0.0818 0.1066
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.2691 0.4856
Loa Loa (eye worm) hypothetical protein 0.1238 0.7673 1
Entamoeba histolytica protein kinase, putative 0.0328 0.1824 0.3535
Schistosoma mansoni tyrosine kinase 0.0493 0.2889 0.2889
Loa Loa (eye worm) hypothetical protein 0.0148 0.0673 0.0877
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0056 0.0081 0.0105
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0243 0.1277 0.1591
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.1213 0.1213
Brugia malayi Protein kinase domain containing protein 0.0548 0.3239 0.4033
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0171 0.0818 0.1018
Brugia malayi hypothetical protein 0.0048 0.0028 0.0035
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0328 0.1824 0.2377
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Loa Loa (eye worm) AGC/AKT protein kinase 0.0328 0.1824 0.2377
Echinococcus multilocularis raf serine:threonine protein kinase 0.0233 0.1213 0.1213
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Schistosoma mansoni serine/threonine kinase 0.0328 0.1824 0.1824
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0188 0.0927 0.1701
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0188 0.0927 0.1208
Echinococcus granulosus cyclin dependent kinase 0.0162 0.0761 0.0761
Echinococcus granulosus RNA directed DNA polymerase 0.1017 0.625 0.625
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0051 0.0048 0.0048
Entamoeba histolytica protein kinase domain containing protein 0.0824 0.5014 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0466 0.2713 0.2713
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Echinococcus granulosus myotubularin protein 13 0.0222 0.1143 0.1143
Echinococcus multilocularis Diacylglycerol kinase theta 0.0222 0.1143 0.1143
Echinococcus multilocularis serine threonine protein kinase 0.1379 0.8577 0.8577
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0222 0.1143 0.1143
Brugia malayi RhoGEF domain containing protein 0.0222 0.1143 0.1423
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Echinococcus multilocularis casein kinase ii subunit alpha 0.0463 0.2691 0.2691
Loa Loa (eye worm) hypothetical protein 0.0064 0.0132 0.0172
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0927 0.095
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0927 0.095
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0038 0.0038
Brugia malayi Fibronectin type III domain containing protein 0.0048 0.0028 0.0035
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0162 0.0761 0.1365
Onchocerca volvulus 0.0733 0.4429 0.8833
Schistosoma mansoni diacylglycerol kinase theta 0.0222 0.1143 0.1143
Trichomonas vaginalis CMGC family protein kinase 0.0162 0.0761 0.0583
Echinococcus multilocularis neuroglian 0.0052 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.0243 0.1277 0.1591
Echinococcus granulosus cyclin dependent kinase 5 0.0162 0.0761 0.0761
Trichomonas vaginalis CMGC family protein kinase 0.0824 0.5014 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0328 0.1824 0.1824
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.1277 0.1277
Echinococcus multilocularis cyclin dependent kinase 0.0162 0.0761 0.0761
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0121 0.0498 0.083
Brugia malayi Pleckstrin Homology Domain 0.0222 0.1143 0.1423
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0222 0.1143 0.1489
Brugia malayi p70 ribosomal S6 kinase beta 0.0328 0.1824 0.2271
Schistosoma mansoni serine/threonine protein kinase 0.1601 1 1
Entamoeba histolytica protein kinase, putative 0.0328 0.1824 0.3535
Brugia malayi Variant SH3 domain containing protein 0.0222 0.1143 0.1423
Brugia malayi protein kinase C3,putative 0.0425 0.2451 0.3051
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.2691 0.4856
Giardia lamblia Kinase, CMGC CDK 0.0162 0.0761 0.0583
Trichomonas vaginalis CMGC family protein kinase 0.0824 0.5014 1
Loa Loa (eye worm) hypothetical protein 0.1061 0.6532 0.8514
Brugia malayi Hr1 repeat family protein 0.0328 0.1824 0.2271
Schistosoma mansoni tyrosine kinase 0.0493 0.2889 0.2889
Echinococcus multilocularis roundabout 2 0.0074 0.0193 0.0193
Schistosoma mansoni tyrosine kinase 0.0548 0.3239 0.3239
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0256 0.1367 0.1367
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Echinococcus multilocularis mitogen activated protein kinase 3 0.0188 0.0927 0.0927
Echinococcus multilocularis myotubularin protein 13 0.0222 0.1143 0.1143
Echinococcus multilocularis RNA directed DNA polymerase 0.1017 0.625 0.625
Brugia malayi diacylglycerol kinase 0.0222 0.1143 0.1423
Plasmodium falciparum glycogen synthase kinase 3 0.0824 0.5014 1
Entamoeba histolytica protein kinase, putative 0.0328 0.1824 0.3535
Trypanosoma cruzi casein kinase II, putative 0.0463 0.2691 0.5283
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1601 1 1
Brugia malayi Ras association domain family 1 isoform A 0.0222 0.1143 0.1423
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0162 0.0761 0.0761
Brugia malayi intracellular kinase 0.0824 0.5014 0.6243
Echinococcus multilocularis protein kinase c eta type 0.0222 0.1143 0.1143
Trypanosoma brucei rac serine-threonine kinase, putative 0.0328 0.1824 0.3522
Loa Loa (eye worm) hypothetical protein 0.0189 0.0933 0.1216
Loa Loa (eye worm) hypothetical protein 0.0256 0.1367 0.1781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0188 0.0927 0.1701
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.1824 0.1824
Echinococcus multilocularis 0.0236 0.1236 0.1236
Trypanosoma brucei Casein kinase II 0.0463 0.2691 0.5283
Echinococcus granulosus protein kinase C gamma type 0.1379 0.8577 0.8577
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0927 0.095
Schistosoma mansoni vav2 0.0222 0.1143 0.1143
Schistosoma mansoni protein kinase C mu 0.0243 0.1277 0.1277
Schistosoma mansoni protein kinase C mu 0.0222 0.1143 0.1143
Loa Loa (eye worm) TK/EGFR protein kinase 0.0779 0.472 0.6152
Loa Loa (eye worm) hypothetical protein 0.0064 0.0132 0.0172
Toxoplasma gondii AGC kinase 0.0328 0.1824 0.2935
Schistosoma mansoni casein kinase II beta subunit 0.0121 0.0498 0.0498
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0243 0.1277 0.1277
Loa Loa (eye worm) hypothetical protein 0.1017 0.625 0.8146
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Echinococcus multilocularis protein kinase shaggy 0.0824 0.5014 0.5014
Brugia malayi Protein kinase domain containing protein 0.0328 0.1824 0.2271
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0493 0.2889 0.2889
Echinococcus granulosus neuroglian 0.0052 0.0051 0.0051
Echinococcus granulosus unc 13 munc13 0.0256 0.1367 0.1367
Echinococcus granulosus protein kinase c epsilon type 0.0723 0.4359 0.4359
Schistosoma mansoni tyrosine kinase 0.0483 0.2818 0.2818
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0161 0.0751 0.0751
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0222 0.1143 0.1489
Entamoeba histolytica diacylglycerol kinase, putative 0.0222 0.1143 0.2156
Schistosoma mansoni vesicular amine transporter 0.005 0.0039 0.0039
Echinococcus granulosus epidermal growth factor receptor 0.0779 0.472 0.472
Echinococcus granulosus protein kinase c iota type 0.0732 0.4419 0.4419
Brugia malayi Protein kinase domain containing protein 0.0328 0.1824 0.2271
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.2691 0.4856
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0328 0.1824 0.1824
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0824 0.5014 0.6535
Echinococcus multilocularis protein kinase c epsilon type 0.0723 0.4359 0.4359
Echinococcus granulosus potassium voltage gated channel subfamily H 0.005 0.0038 0.0038
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0121 0.0498 0.0993
Entamoeba histolytica hypothetical protein 0.0222 0.1143 0.2156
Schistosoma mansoni unc-13 (munc13) 0.0256 0.1367 0.1367
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.016 0.0746 0.0548
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0162 0.0761 0.0992
Echinococcus multilocularis cyclin dependent kinase 5 0.0162 0.0761 0.0761
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0161 0.0751 0.0751
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0927 0.095
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0188 0.0927 0.1701
Trichomonas vaginalis CMGC family protein kinase 0.0463 0.2691 0.4856
Trichomonas vaginalis AGC family protein kinase 0.0328 0.1824 0.2935
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0328 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0037
Echinococcus multilocularis serine:threonine protein kinase 38 0.0328 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0733 0.4429 0.5773
Loa Loa (eye worm) hypothetical protein 0.0222 0.1143 0.1489
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0162 0.0761 0.0583
Schistosoma mansoni diacylglycerol kinase theta 0.0222 0.1143 0.1143
Trypanosoma brucei protein kinase, putative 0.0188 0.0927 0.1701
Brugia malayi MAP kinase sur-1 0.0188 0.0927 0.1154
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0439 0.2537 0.3306
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0328 0.1824 0.1824
Entamoeba histolytica protein kinase domain containing protein 0.0824 0.5014 1
Entamoeba histolytica protein kinase domain containing protein 0.0463 0.2691 0.5292
Echinococcus multilocularis serine:threonine protein kinase N2 0.0328 0.1824 0.1824
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0222 0.1143 0.1489
Echinococcus multilocularis unc 13 (munc13) 0.0256 0.1367 0.1367
Entamoeba histolytica cell division protein kinase 2, putative 0.0162 0.0761 0.1382
Entamoeba histolytica diacylglycerol kinase, putative 0.0222 0.1143 0.2156
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0328 0.1824 0.2377
Onchocerca volvulus 0.0824 0.5014 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0328 0.1824 0.2377
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0463 0.2691 0.3507
Onchocerca volvulus 0.0222 0.1143 0.2279
Brugia malayi Furin-like cysteine rich region family protein 0.0779 0.472 0.5877
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0328 0.1824 0.1824
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0723 0.4359 0.5682
Plasmodium vivax protein kinase Crk2 0.0162 0.0761 0.0583
Trypanosoma brucei protein kinase, putative 0.0824 0.5014 1
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.0761 0.0761

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.823 Plasma lipid-lowering activity at a dosage of 0.001% in the diet in KKAy mice ChEMBL. 11906293
Activity (functional) = 12 Plasma lipid-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. ChEMBL. 11906293
Activity (functional) = 27 Plasma glucose-lowering activity at a dosage of 0.001% in the diet in KKAy mice ChEMBL. 11906293
Activity (functional) = 47 Plasma glucose-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. ChEMBL. 11906293
Activity (functional) = 71 Plasma lipid-lowering activity at a dosage of 0.01% in the diet in KKAy mice ChEMBL. 11906293
ND (functional) 0 Effective dose for 25% reduction in plasma glucose-lowering activity of KKAy mice;ND denotes no-data ChEMBL. 11906293
ND (functional) 0 Plasma glucose-lowering activity at a dosage of 0.01% in the diet in KKA(y) mice. ChEMBL. 11906293
ND (functional) 0 Effective dose for 25% reduction in plasma lipid-lowering activity of KKA(y) mice. ChEMBL. 11906293

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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