Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | ctsf protein | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0054 | 0.1752 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0055 | 0.1881 | 0.1881 |
Loa Loa (eye worm) | cathepsin B | 0.0054 | 0.1752 | 0.1752 |
Brugia malayi | Protein kinase domain containing protein | 0.0055 | 0.1881 | 0.1881 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.1323 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0146 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0054 | 0.1752 | 0.1752 |
Echinococcus granulosus | cathepsin b | 0.0146 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0042 | 0.0688 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1881 | 0.1881 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0146 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0055 | 0.1881 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Onchocerca volvulus | Cathepsin L homolog | 0.0049 | 0.1323 | 0.7035 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Onchocerca volvulus | 0.0055 | 0.1881 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0049 | 0.1323 | 0.7035 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Brugia malayi | Fibulin-1 precursor | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.1323 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0055 | 0.1881 | 0.1881 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0049 | 0.1323 | 0.1323 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Brugia malayi | Kringle domain containing protein | 0.0055 | 0.1881 | 0.1881 |
Loa Loa (eye worm) | cysteine protease | 0.0049 | 0.1323 | 0.1323 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.1323 | 0.1323 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0042 | 0.0688 | 0.0688 |
Toxoplasma gondii | cathepsin CPL | 0.0049 | 0.1323 | 0.5323 |
Toxoplasma gondii | kringle domain-containing protein | 0.0055 | 0.1881 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Onchocerca volvulus | Arrow homolog | 0.0042 | 0.0688 | 0.3659 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1881 | 0.1881 |
Giardia lamblia | Cathepsin B precursor | 0.0054 | 0.1752 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0055 | 0.1881 | 0.1281 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Echinococcus granulosus | Tolloid protein 1 | 0.0042 | 0.0688 | 0.0688 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0049 | 0.1323 | 0.1323 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.1323 | 0.1323 |
Schistosoma mansoni | egf-like domain protein | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0054 | 0.1752 | 0.7695 |
Toxoplasma gondii | cathepsin B | 0.0054 | 0.1752 | 0.8922 |
Echinococcus granulosus | cathepsin l1 | 0.0049 | 0.1323 | 0.1323 |
Giardia lamblia | Cathepsin B precursor | 0.0054 | 0.1752 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0146 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0146 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0054 | 0.1752 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0055 | 0.1881 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0042 | 0.0688 | 0.0688 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0146 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0049 | 0.1323 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0042 | 0.0688 | 0.0688 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Loa Loa (eye worm) | fibroinase | 0.0049 | 0.1323 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Echinococcus multilocularis | cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Echinococcus multilocularis | cysteine protease | 0.0049 | 0.1323 | 0.0682 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0042 | 0.0688 | 0.0688 |
Echinococcus multilocularis | cathepsin b | 0.0146 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0146 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0688 | 0.0688 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Giardia lamblia | Cathepsin B precursor | 0.0054 | 0.1752 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0049 | 0.1323 | 0.0682 |
Echinococcus granulosus | laminin | 0.0042 | 0.0688 | 0.0688 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0049 | 0.1323 | 0.1323 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.1881 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0042 | 0.0688 | 0.0688 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Onchocerca volvulus | 0.0049 | 0.1323 | 0.7035 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0054 | 0.1752 | 0.1752 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0049 | 0.1323 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0049 | 0.1323 | 0.0682 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Onchocerca volvulus | Cathepsin L homolog | 0.0049 | 0.1323 | 0.7035 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1323 | 0.1323 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0055 | 0.1881 | 0.1881 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0049 | 0.1323 | 0.7551 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logP (ADMET) | = 7.26 | Partition coefficient (logP) | ChEMBL. | 11334564 |
Ratio (functional) | = 2.19 | Tumor and skin uptake ratio of the compound | ChEMBL. | 11334564 |
Skin uptake (functional) | = 4.8 uM | Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Skin uptake (functional) | = 4.8 uM | Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Tumor uptake (functional) | = 10.5 uM | Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Tumor uptake (functional) | = 10.5 uM | Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. | ChEMBL. | 11334564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.