Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0034 | 0.0542 |
Echinococcus granulosus | neuroglian | 0.0037 | 0.0028 | 0.0342 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0225 | 0.0267 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.7886 | 1 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.003 | 0.0408 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0225 | 0.0267 | 1 |
Echinococcus multilocularis | neuroglian | 0.0037 | 0.0028 | 0.0342 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.003 | 0.002 | 0.0741 |
Schistosoma mansoni | tyrosine kinase | 0.0225 | 0.0267 | 1 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0225 | 0.0267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0034 | 0.0542 |
Echinococcus granulosus | roundabout 2 | 0.0041 | 0.0034 | 0.0561 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0025 | 0.0211 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0035 | 0.0025 | 0.0218 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0232 | 0.0276 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0039 | 0.003 | 0.0408 |
Schistosoma mansoni | vesicular amine transporter | 0.003 | 0.002 | 0.0741 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.7886 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1024 | 0.1282 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.7886 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.7886 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.7886 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1024 | 0.1282 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0041 | 0.0034 | 0.0561 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.7886 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1024 | 0.1282 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.003 | 0.002 | 0.0741 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1024 | 0.1282 | 0.5 |
Schistosoma mansoni | nephrin | 0.0037 | 0.0028 | 0.1058 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.7886 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.1024 | 0.1282 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0232 | 0.0276 | 1 |
Echinococcus granulosus | twitchin | 0.0037 | 0.0028 | 0.0342 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0225 | 0.0267 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0035 | 0.0025 | 0.0943 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | In vivo effects in mice against H3 receptor on N6-methylhistamine levels in brain (following oral dosing of compound) | ChEMBL. | 12672253 |
ED50 (functional) | > 10 mg kg-1 | In vivo effects in mice against H3 receptor on N6-methylhistamine levels in brain (following oral dosing of compound) | ChEMBL. | 12672253 |
Ki (binding) | = 167 nM | Displacement of [125I]-iodoproxyfan from human histamine H3 receptor expressing CHO cells | ChEMBL. | 12672253 |
Ki (binding) | = 167 nM | Displacement of [125I]-iodoproxyfan from human histamine H3 receptor expressing CHO cells | ChEMBL. | 12672253 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.