Detailed information for compound 536503

Basic information

Technical information
  • TDR Targets ID: 536503
  • Name: [(1R,4S)-4-(2-amino-1-hydroxy-6-oxo-purin-9-y l)cyclopent-2-en-1-yl]methyl-[hydroxy(phospho nooxy)phosphoryl]oxy-phosphinic acid
  • MW: 487.193 | Formula: C11H16N5O11P3
  • H donors: 6 H acceptors: 10 LogP: -4.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: On1c(N)nc2c(c1=O)ncn2[C@@H]1C=C[C@@H](C1)CP(=O)(OP(=O)(OP(=O)(O)O)O)O
  • InChi: 1S/C11H16N5O11P3/c12-11-14-9-8(10(17)16(11)18)13-5-15(9)7-2-1-6(3-7)4-28(19,20)26-30(24,25)27-29(21,22)23/h1-2,5-7,18H,3-4H2,(H2,12,14)(H,19,20)(H,24,25)(H2,21,22,23)/t6-,7+/m0/s1
  • InChiKey: AWUISRXNYYRNBL-NKWVEPMBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(1R,4S)-4-(2-amino-1-hydroxy-6-oxo-9-purinyl)-1-cyclopent-2-enyl]methyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid
  • [(1R,4S)-4-(2-azanyl-1-hydroxy-6-oxo-purin-9-yl)cyclopent-2-en-1-yl]methyl-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphinic acid
  • [(1R,4S)-4-(2-amino-1-hydroxy-6-keto-purin-9-yl)cyclopent-2-en-1-yl]methyl-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphinic acid
  • [(1R,4S)-4-(2-amino-1-hydroxy-6-oxopurin-9-yl)cyclopent-2-en-1-yl]methyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid
  • carbovir triphosphate
  • [(1R,4S)-4-(2-amino-1-hydroxy-6-oxopurin-9-yl)-1-cyclopent-2-enyl]methyl-(hydroxy-phosphonooxyphosphoryl)oxyphosphinic acid
  • [(1R,4S)-4-(2-amino-1-hydroxy-6-oxo-purin-9-yl)-1-cyclopent-2-enyl]methyl-(hydroxy-phosphonooxy-phosphoryl)oxy-phosphinic acid
  • [(1R,4S)-4-(2-amino-1-hydroxy-6-oxo-9-purinyl)-1-cyclopent-2-enyl]methyl-(hydroxy-phosphonooxyphosphoryl)oxyphosphinic acid
  • [(1R,4S)-4-(2-amino-1-hydroxy-6-keto-purin-9-yl)-1-cyclopent-2-enyl]methyl-(hydroxy-phosphonooxy-phosphoryl)oxy-phosphinic acid
  • Triphosphoric acid, P-((4-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2-cyclopenten-1-yl)methyl) ester, cis-(+-)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0219 0.2104 0.3113
Schistosoma mansoni myst-related protein 0.0024 0.0089 0.0131
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0671 0.6758 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1394 0.1589
Loa Loa (eye worm) hypothetical protein 0.0049 0.0342 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0062 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Onchocerca volvulus 0.0034 0.0188 0.018
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0638 0.0944
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0118 0.0189
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.0883 0.1006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0866 0.8772 1
Schistosoma mansoni hypothetical protein 0.0031 0.0164 0.0243
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0638 0.0681
Brugia malayi ImpB/MucB/SamB family protein 0.0326 0.3201 0.3649
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.1394 0.1387
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0151 0.1394 0.2001
Leishmania major DNA damage repair protein, putative 0.0068 0.0544 0.0579
Schistosoma mansoni hypothetical protein 0.0113 0.1002 0.1483
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0009 0.0037
Trypanosoma brucei unspecified product 0.0151 0.1402 0.1508
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0219 0.2104 0.2148
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0054 0.0397 0.0452
Schistosoma mansoni thyroid hormone receptor 0.002 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0128 0.1162 0.1324
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0043 0.0049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0219 0.2104 0.2148
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0009 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0883 0.1306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.2826
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.008 0.067 0.1142
Echinococcus multilocularis dna polymerase eta 0.0326 0.3201 0.4737
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0151 0.1394 0.1421
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0883 0.0875
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0084 0.0124
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0009 0.0018
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0883 0.0946
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0378
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0054 0.0397 0.0588
Leishmania major hypothetical protein, conserved 0.0052 0.0381 0.0403
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0397 0.2829
Trypanosoma brucei hypothetical protein, conserved 0.0151 0.1394 0.15
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0009 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0043 0.0064
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0118 0.0134
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.067 0.479
Schistosoma mansoni terminal deoxycytidyl transferase 0.0219 0.2104 0.3113
Schistosoma mansoni hypothetical protein 0.0079 0.0656 0.0971
Echinococcus granulosus histone acetyltransferase KAT2B 0.043 0.4272 0.6321
Echinococcus multilocularis protein dispatched 1 0.0048 0.0331 0.049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.2386 0.3531
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.008 0.067 0.0296
Trypanosoma brucei unspecified product 0.0219 0.2104 0.2268
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0883 0.0875
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0842 0.1245
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0055 0.0409 0.0605
Trypanosoma cruzi DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Schistosoma mansoni hypothetical protein 0.0034 0.0188 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0188 0.0215
Plasmodium falciparum DNA repair protein REV1, putative 0.0068 0.0544 0.504
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0043 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0188 0.0215
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.0883 0.1306
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1002 0.1483
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.1394 0.1387
Entamoeba histolytica deoxycytidyl transferase, putative 0.0219 0.2104 0.3619
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0316 0.0308
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Loa Loa (eye worm) FYVE zinc finger family protein 0.0054 0.0397 0.0453
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0247 0.2386 0.3531
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0043 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.0638 0.0944
Loa Loa (eye worm) DOMON domain-containing protein 0.0031 0.0164 0.0187
Trichomonas vaginalis DNA polymerase eta, putative 0.0219 0.2104 0.2097
Onchocerca volvulus 0.0151 0.1394 0.1387
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0118 0.1028
Trypanosoma brucei DNA polymerase kappa, putative 0.0151 0.1402 0.1508
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0671 0.6758 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0118 0.0175
Brugia malayi nuclear receptor NHR-88 0.002 0.0043 0.0049
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0578 0.5798 1
Mycobacterium ulcerans lipase LipD 0.0151 0.1394 0.2001
Echinococcus granulosus zinc finger protein 0.0022 0.0073 0.0108
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0912 0.9246 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0219 0.2104 0.3113
Entamoeba histolytica acetyltransferase, GNAT family 0.0119 0.107 0.1833
Schistosoma mansoni DNA polymerase eta 0.0326 0.3201 0.4737
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0671 0.6758 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0128 0.1162 0.1719
Giardia lamblia DNA damage repair protein 0.0068 0.0544 0.0924
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0128 0.1164 0.1251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0043 0.0049
Schistosoma mansoni patched 1 0.0042 0.0271 0.0401
Schistosoma mansoni SET domain protein 0.0021 0.0054 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0062 0.0053
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.013 0.1182 0.1174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0049
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0054 0.0397 0.042
Echinococcus granulosus histone acetyltransferase KAT2B 0.013 0.1182 0.1749
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0912 0.9246 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.001
Brugia malayi CHE-14 protein 0.0042 0.0271 0.0309
Brugia malayi ImpB/MucB/SamB family protein 0.0219 0.2104 0.2399
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0009 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0043 0.0064
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.0883 0.1006
Echinococcus multilocularis MAM 0.0034 0.0188 0.0279
Mycobacterium tuberculosis Probable lipase LipD 0.0151 0.1394 0.1421
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0247 0.2386 0.3531
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0638 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0118 0.0189
Leishmania major DNA polymerase eta, putative 0.0175 0.1641 0.1767
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0357 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Trypanosoma cruzi DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Trichomonas vaginalis esterase, putative 0.0151 0.1394 0.1387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.1162 0.1719
Brugia malayi Bromodomain containing protein 0.0022 0.0073 0.0083
Trypanosoma brucei ISWI complex protein 0.0021 0.0062 0.0057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.008 0.067 0.0991
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0316 0.0308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.0883 0.0875
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.0638 0.0681
Mycobacterium tuberculosis Conserved hypothetical protein 0.0481 0.4795 0.4907
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0081 0.0073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.1162 0.1719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0043 0.0049
Onchocerca volvulus 0.0151 0.1394 0.1387
Loa Loa (eye worm) hypothetical protein 0.0151 0.1394 0.1589
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0068 0.0544 0.1366
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.008 0.067 0.0716
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.0409 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0128 0.1162 0.1719
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0068 0.0544 0.1366
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0009 0.0018
Brugia malayi exodeoxyribonuclease III family protein 0.008 0.067 0.0763
Entamoeba histolytica phosphoinositide kinase, putative 0.0054 0.0397 0.067
Echinococcus granulosus expressed conserved protein 0.0091 0.0781 0.1156
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0043 0.0064
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0054 0.0397 0.042
Entamoeba histolytica hypothetical protein 0.0113 0.1002 0.1716
Loa Loa (eye worm) hypothetical protein 0.0151 0.1394 0.1589
Trichomonas vaginalis set domain proteins, putative 0.0985 1 1
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0378
Schistosoma mansoni DNA polymerase IV / kappa 0.0068 0.0544 0.0805
Mycobacterium tuberculosis Conserved protein 0.0151 0.1394 0.1421
Loa Loa (eye worm) CXXC zinc finger family protein 0.0203 0.1937 0.2208
Schistosoma mansoni hypothetical protein 0.0528 0.5284 0.7818
Schistosoma mansoni bromodomain containing protein 0.0022 0.0073 0.0108
Brugia malayi SEA domain containing protein 0.0031 0.0164 0.0187
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0054 0.0397 0.0995
Loa Loa (eye worm) hypothetical protein 0.0097 0.0842 0.0959
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.0009 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.0326 0.3201 0.3456
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.042
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.0419
Onchocerca volvulus 0.0031 0.0164 0.0155
Onchocerca volvulus 0.0031 0.0164 0.0155
Entamoeba histolytica hypothetical protein 0.0024 0.0089 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0381 0.3507
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0043 0.0049
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0271 0.0401
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0043 0.0064
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0009 0.0018
Entamoeba histolytica hypothetical protein 0.0113 0.1002 0.1716
Trypanosoma brucei DNA polymerase IV, putative 0.0219 0.2104 0.2268
Schistosoma mansoni zinc finger protein 0.0022 0.0073 0.0108
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0962 0.9762 1
Brugia malayi hypothetical protein 0.0113 0.1002 0.1143
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0578 0.5798 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0151 0.1394 0.1421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0043 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0544 0.0579
Loa Loa (eye worm) hypothetical protein 0.0034 0.0188 0.0215
Echinococcus multilocularis dna polymerase kappa 0.0219 0.2104 0.3113
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0054 0.0397 0.0588
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0271 0.0309
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0049
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Loa Loa (eye worm) histone methyltransferase 0.0067 0.0537 0.0612
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0378
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0099 0.0858 0.1269
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0271 0.0262
Entamoeba histolytica hypothetical protein 0.0113 0.1002 0.1716
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0118 0.0118
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0638 0.0944
Plasmodium vivax SET domain protein, putative 0.0128 0.1162 0.8328
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0118 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0544 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0009 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0219 0.2104 0.2268
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0381 0.2714
Onchocerca volvulus 0.0671 0.6758 0.6756
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0049
Loa Loa (eye worm) TK/ALK protein kinase 0.0034 0.0188 0.0215
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0043 0.0034
Loa Loa (eye worm) hypothetical protein 0.0151 0.1394 0.1589
Leishmania major DNA polymerase kappa, putative 0.0068 0.0544 0.0579
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0043 0.0064
Giardia lamblia DINP protein human, muc B family 0.0219 0.2104 0.3619
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0118 0.0175
Echinococcus granulosus dna polymerase eta 0.0326 0.3201 0.4737
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.013 0.1182 0.2974
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0009 0.001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.0883 0.1306
Mycobacterium tuberculosis Conserved protein 0.0151 0.1394 0.1421
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.0883 0.0946
Schistosoma mansoni cpg binding protein 0.0215 0.2057 0.3043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0638 0.063
Onchocerca volvulus 0.0031 0.0164 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.1453 0.1564
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.008 0.067 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0043 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.008 0.067 0.0662
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0009 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0381 0.0956
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0043 0.0049
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0842 0.1439
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0054 0.0397 0.0587
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0378
Echinococcus granulosus dna polymerase kappa 0.0219 0.2104 0.3113
Treponema pallidum exodeoxyribonuclease (exoA) 0.008 0.067 0.1142
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0054 0.0397 0.042
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0067 0.0537 0.0794
Loa Loa (eye worm) pip kinase 2 0.0671 0.6758 0.7704
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.013 0.1182 0.2974
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0271 0.0401
Schistosoma mansoni cript-related 0.0016 0.0009 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0432 0.4292 0.4637
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.1394 0.1387
Trichomonas vaginalis ap endonuclease, putative 0.008 0.067 0.0662
Trypanosoma brucei DNA polymerase IV, putative 0.0219 0.2104 0.2268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0043 0.0064
Echinococcus granulosus cpg binding protein 0.0215 0.2057 0.3043
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0184 0.021
Schistosoma mansoni synaptojanin 0.0016 0.0009 0.0013
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0054 0.0397 0.042
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0043 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0671 0.6758 1
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1002 0.1483
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0118 0.0293
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.1394 0.1387
Brugia malayi MH2 domain containing protein 0.0118 0.1055 0.1203
Mycobacterium tuberculosis Probable lipase LipE 0.0151 0.1394 0.1421
Brugia malayi beta-lactamase 0.0151 0.1394 0.1589
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0043 0.0034
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0883 0.0946
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0009 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.2386 0.3531
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0043 0.0049
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.008 0.067 0.0763
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0316 0.0308
Schistosoma mansoni myst-related protein 0.0024 0.0089 0.0131
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0043 0.0064
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0054 0.0397 0.0995
Mycobacterium ulcerans DNA polymerase IV 0.0219 0.2104 0.367
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0043 0.0034
Leishmania major DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.0544 0.0579
Loa Loa (eye worm) RecQ helicase 0.0023 0.0081 0.0093
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0054 0.0397 0.042
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0054 0.0397 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0043 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0151 0.1394 0.1421
Brugia malayi hypothetical protein 0.0052 0.0381 0.0434
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0043 0.0064
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0054 0.0397 0.3655
Brugia malayi acetyltransferase, GNAT family protein 0.0442 0.44 0.5015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0067 0.0537 0.0794
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0099 0.0858 0.1269
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0009 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0436 0.4334 0.6412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.1162 0.1719
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0009 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0022 0.0073 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0049
Giardia lamblia Hypothetical protein 0.0054 0.0397 0.067
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0009 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0128 0.1164 0.1251
Brugia malayi beta-lactamase family protein 0.0151 0.1394 0.1589
Echinococcus multilocularis expressed conserved protein 0.0091 0.0781 0.1156
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0342 0.039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0043 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0043 0.0049
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0316 0.0308
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1271 0.1881
Giardia lamblia Fructose-bisphosphate aldolase 0.0578 0.5798 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0083
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0043 0.0049
Trichomonas vaginalis helicase, putative 0.0046 0.0316 0.0308
Brugia malayi SET domain containing protein 0.0021 0.0054 0.0061
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0282 0.2751 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0009 0.0018
Brugia malayi PHD-finger family protein 0.0022 0.0073 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0049
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0054 0.0397 0.0587
Echinococcus multilocularis protein patched 0.0042 0.0271 0.0401
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0043 0.0049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.067 0.6227
Loa Loa (eye worm) hypothetical protein 0.0671 0.6758 0.7704
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0247 0.2386 0.3531
Onchocerca volvulus 0.0034 0.0188 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0638 0.063
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0054 0.0397 0.042
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0049
Toxoplasma gondii hypothetical protein 0.0147 0.1358 0.3418
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0054 0.0397 0.042
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0009 0.0018
Trypanosoma brucei DNA polymerase eta, putative 0.0326 0.3201 0.3456
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0381 0.0403
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Trypanosoma brucei DNA damage repair protein, putative 0.0068 0.0544 0.0579
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0084 0.0124
Leishmania major DNA polymerase eta, putative 0.0326 0.3201 0.3456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0316 0.0308
Echinococcus multilocularis geminin 0.0528 0.5284 0.7818
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0043 0.0064
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0009 0.0013
Leishmania major mitochondrial DNA polymerase beta 0.0912 0.9246 1
Plasmodium vivax SET domain containing protein 0.002 0.0046 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Loa Loa (eye worm) acetyltransferase 0.0442 0.44 0.5015
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0432 0.4292 0.4637
Mycobacterium tuberculosis Probable hydrolase 0.0151 0.1394 0.1421
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.008 0.067 0.0716
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0342 0.039
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0187
Toxoplasma gondii exonuclease III APE 0.008 0.067 0.1683
Trypanosoma cruzi ISWI complex protein 0.0021 0.0062 0.0057
Brugia malayi hypothetical protein 0.0034 0.019 0.0216
Brugia malayi Pip kinase protein 1 0.0054 0.0397 0.0452
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0052 0.0409
Schistosoma mansoni cpg binding protein 0.0215 0.2057 0.3043
Mycobacterium ulcerans hypothetical protein 0.0151 0.1394 0.2001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0043 0.0064
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0128 0.1162 0.2923
Echinococcus granulosus bloom syndrome protein 0.0023 0.0081 0.012
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0118 0.0175
Trichomonas vaginalis bromodomain-containing protein, putative 0.013 0.1182 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Toxoplasma gondii ABC1 family protein 0.0151 0.1394 0.3509
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0083
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.008 0.067 0.0716
Brugia malayi CCR4 0.0016 0.0009 0.001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0068 0.0544 0.062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0164 0.0187
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0175 0.1641 0.413
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0054 0.0397 0.0452
Trypanosoma brucei unspecified product 0.0151 0.1402 0.1508
Schistosoma mansoni ap endonuclease 0.008 0.067 0.0991
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1055 0.1203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Trypanosoma brucei polo-like protein kinase 0.0101 0.0883 0.0946
Schistosoma mansoni hypothetical protein 0.0033 0.0184 0.0272
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0271 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0883 0.0875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.1394 0.2063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1002 0.1483
Echinococcus multilocularis synaptojanin 1 0.0016 0.0009 0.0013
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.067
Echinococcus granulosus mixed lineage leukemia protein mll 0.0055 0.0409 0.0605
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0271 0.0401
Loa Loa (eye worm) beta-lactamase 0.0151 0.1394 0.1589
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0128 0.1164 0.1251
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0128 0.1164 0.1251
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0219 0.2104 0.2097
Onchocerca volvulus 0.0128 0.1162 0.1154
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0357 0.0349
Echinococcus multilocularis beta LACTamase domain containing family member 0.0151 0.1394 0.2063
Trichomonas vaginalis hypothetical protein 0.0025 0.0096 0.0088
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0118 0.0134
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0219 0.2104 0.3113
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0054 0.0397 0.0587
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.0638 0.0727
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0054 0.0397 0.042
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0442 0.44 0.651
Loa Loa (eye worm) hypothetical protein 0.0151 0.1394 0.1589
Mycobacterium ulcerans hypothetical protein 0.0481 0.4795 1
Schistosoma mansoni cpg binding protein 0.0203 0.1937 0.2866
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0842 0.1245
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.042
Echinococcus granulosus geminin 0.0528 0.5284 0.7818
Trypanosoma cruzi DNA damage repair protein, putative 0.0068 0.0544 0.0579
Loa Loa (eye worm) hypothetical protein 0.0151 0.1394 0.1589
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0009 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.1394 0.15
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.0638 0.0944
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0118 0.0175
Brugia malayi ecdysteroid receptor 0.002 0.0043 0.0049
Plasmodium vivax histone acetyltransferase GCN5, putative 0.013 0.1182 0.8473
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0544 0.0579
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.008 0.067 0.0716
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0118 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0544 0.0579
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0247 0.2386 0.272
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0043 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0043 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0096 0.0088
Brugia malayi Pre-SET motif family protein 0.0128 0.1162 0.1324
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0055 0.0409 0.0605
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0043 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0062 0.0053
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0118 0.0175
Onchocerca volvulus 0.0203 0.1937 0.193
Plasmodium falciparum zinc finger protein, putative 0.0024 0.0089 0.0754
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0151 0.1394 0.1589
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Entamoeba histolytica exodeoxyribonuclease III, putative 0.008 0.067 0.1142
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0342 0.039
Brugia malayi Protein kinase domain containing protein 0.0034 0.0188 0.0215
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0316 0.0308
Trichomonas vaginalis chaperonin, putative 0.0027 0.0118 0.0109
Schistosoma mansoni bromodomain containing protein 0.0022 0.0073 0.0108
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Plasmodium falciparum histone acetyltransferase GCN5 0.0119 0.107 1
Treponema pallidum fructose-bisphosphate aldolase 0.0578 0.5798 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0043 0.0064
Brugia malayi nuclear hormone receptor 0.002 0.0043 0.0049
Echinococcus granulosus synaptojanin 1 0.0016 0.0009 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0151 0.1402 0.1508
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.0638 0.0944
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0883 0.0875
Echinococcus granulosus MAM 0.0034 0.0188 0.0279
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.1162 0.1719
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0043 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.1394 0.15
Entamoeba histolytica hypothetical protein 0.0113 0.1002 0.1716
Onchocerca volvulus 0.0021 0.0054 0.0045
Trypanosoma brucei DNA damage repair protein, putative 0.0068 0.0544 0.0579
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0842 0.0959
Schistosoma mansoni hypothetical protein 0.0023 0.0084 0.0124
Schistosoma mansoni kinase 0.0051 0.0371 0.0549
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0009 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0883 0.0875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0247 0.2386 0.3531
Brugia malayi Pip kinase protein 2 0.0671 0.6758 0.7704
Schistosoma mansoni hypothetical protein 0.0034 0.0188 0.0279
Echinococcus granulosus beta LACTamase domain containing family member 0.0151 0.1394 0.2063
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0118 0.0822
Echinococcus multilocularis zinc finger protein 0.0022 0.0073 0.0108
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0009 0.0013
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0009 0.0013
Brugia malayi polk-prov protein 0.0068 0.0544 0.062
Brugia malayi CXXC zinc finger family protein 0.0203 0.1937 0.2208
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0009 0.001
Trypanosoma cruzi DNA damage repair protein, putative 0.0068 0.0544 0.0579
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0442 0.44 0.651
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0081 0.012
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0054 0.0397 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0858 0.0978
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0043 0.0064
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0054 0.0397 0.0995
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0316 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0883 0.0875
Schistosoma mansoni ap endonuclease 0.008 0.067 0.0991
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0638 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0151 0.1402 0.1508
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0054 0.0397 0.042
Onchocerca volvulus 0.002 0.0043 0.0034
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0054 0.0397 0.0388
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0081 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Brugia malayi Pre-SET motif family protein 0.0866 0.8772 1
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0054 0.0397 0.042
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.1394 0.1387
Mycobacterium tuberculosis Probable esterase LipL 0.0151 0.1394 0.1421
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.042
Leishmania major hypothetical protein, conserved 0.0151 0.1394 0.15
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.1162 0.1719
Brugia malayi F/Y-rich N-terminus family protein 0.0067 0.0529 0.0603
Brugia malayi hypothetical protein 0.0034 0.0188 0.0215
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.008 0.067 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0858 0.0978
Trypanosoma cruzi DNA polymerase kappa, putative 0.0219 0.2104 0.2268
Mycobacterium ulcerans DNA polymerase IV 0.0219 0.2104 0.367
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0883 0.0875
Toxoplasma gondii histone lysine methyltransferase SET1 0.0401 0.3971 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0381 0.0403
Echinococcus granulosus FTZ F1 alpha 0.0392 0.3879 0.574
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0638 0.0944
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0638 0.063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0184 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0247 0.2386 0.3531
Onchocerca volvulus 0.0031 0.0164 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0049
Schistosoma mansoni coup transcription factor 0.002 0.0043 0.0064
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0022 0.0073 0.0108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0151 0.1394 0.1589
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0054 0.0397 0.0388
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0219 0.2104 0.2399
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0009 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0381 0.0403
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0009 0.0013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.008 0.067 0.0991
Onchocerca volvulus 0.0031 0.0164 0.0155
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1271 0.1881
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0081 0.0093
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.0638 0.0944
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0054 0.0397 0.042
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0009 0.0018
Schistosoma mansoni hypothetical protein 0.0528 0.5284 0.7818
Giardia lamblia Histone acetyltransferase GCN5 0.0119 0.107 0.1833
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.1069 0.1582
Echinococcus multilocularis cpg binding protein 0.0215 0.2057 0.3043
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0043 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0578 0.5798 0.5795
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1055 0.1203
Brugia malayi Muscle positioning protein 4 0.0031 0.0164 0.0187
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.042
Giardia lamblia Kinase, PLK 0.0101 0.0883 0.151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0043 0.0049
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0031 0.0046
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0282 0.2751 0.5193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.1394 0.2063
Schistosoma mansoni nocturnin 0.0016 0.0009 0.0013
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0043 0.0049
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0077 0.0638 0.1087
Brugia malayi steroid hormone receptor 0.002 0.0043 0.0049
Loa Loa (eye worm) hypothetical protein 0.0077 0.0638 0.0727
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.001
Schistosoma mansoni synaptojanin 0.0016 0.0009 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.0544 0.0579
Loa Loa (eye worm) hypothetical protein 0.0052 0.0381 0.0434
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0282 0.2751 0.2812
Trypanosoma brucei chrX additional, unordered contigs 0.0068 0.0544 0.0579
Schistosoma mansoni nuclear hormone receptor 0.002 0.0043 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0316 0.0308
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0883 0.151
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0912 0.9246 1
Mycobacterium ulcerans beta-lactamase 0.0151 0.1394 0.2001
Loa Loa (eye worm) hypothetical protein 0.0117 0.1048 0.1195
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0432 0.4292 0.4637
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0043 0.0064
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0009 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0043 0.0049
Brugia malayi beta-lactamase family protein 0.0151 0.1394 0.1589
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0247 0.2386 0.272
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.0638 0.1087
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0054 0.0397 0.067
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0009 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0381 0.3507
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0316 0.0308
Loa Loa (eye worm) hypothetical protein 0.0099 0.0858 0.0978
Onchocerca volvulus 0.0151 0.1394 0.1387
Plasmodium vivax hypothetical protein, conserved 0.0151 0.1394 1
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0118 0.0134
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0219 0.2104 0.2268
Echinococcus multilocularis FTZ F1 alpha 0.0099 0.0858 0.1269
Plasmodium vivax DNA repair protein REV1, putative 0.0068 0.0544 0.3884
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0055 0.0409 0.0605
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0054 0.0397 0.0587
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0189 0.028
Trypanosoma cruzi DNA polymerase eta, putative 0.0175 0.1641 0.1767
Loa Loa (eye worm) hypothetical protein 0.0326 0.3201 0.3649
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0857 0.1268
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0009 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0099 0.0858 0.1269
Mycobacterium tuberculosis Conserved protein 0.0151 0.1394 0.1421
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0009 0.001
Loa Loa (eye worm) pip kinase 1 0.0054 0.0397 0.0452
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0009 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0151 0.1394 0.2001
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0638 0.0681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0043 0.0049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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