Detailed information for compound 536511

Basic information

Technical information
  • TDR Targets ID: 536511
  • Name: 3,4-dihydro-1H-isoquinolin-2-yl(pyrrolidin-2- yl)methanone
  • MW: 230.306 | Formula: C14H18N2O
  • H donors: 1 H acceptors: 1 LogP: 1.38 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCc2c(C1)cccc2)C1CCCN1
  • InChi: 1S/C14H18N2O/c17-14(13-6-3-8-15-13)16-9-7-11-4-1-2-5-12(11)10-16/h1-2,4-5,13,15H,3,6-10H2
  • InChiKey: XVQFBLXWWPWKBC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dihydro-1H-isoquinolin-2-yl(2-pyrrolidinyl)methanone
  • 3,4-dihydro-1H-isoquinolin-2-yl-pyrrolidin-2-ylmethanone
  • 3,4-dihydro-1H-isoquinolin-2-yl-pyrrolidin-2-yl-methanone
  • 3,4-dihydro-1H-isoquinolin-2-yl-(2-pyrrolidinyl)methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0583 0.2695 0.2695
Onchocerca volvulus 0.0094 0.0307 0.0307
Toxoplasma gondii microneme protein MIC17C 0.0232 0.0983 0.1793
Schistosoma mansoni hypothetical protein 0.0254 0.1088 0.1088
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0254 0.1088 0.1088
Echinococcus multilocularis enteropeptidase 0.0254 0.1088 0.2781
Schistosoma mansoni hypothetical protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0247 0.1053 0.1053
Schistosoma mansoni ap endonuclease 0.0062 0.0149 0.0149
Schistosoma mansoni glutamate receptor AMPA 0.0121 0.0438 0.0438
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0149 0.0316
Brugia malayi dihydrofolate reductase family protein 0.0297 0.1299 0.1299
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0041 0.0046 0.0046
Onchocerca volvulus 0.0232 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0254 0.1088 0.1088
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Echinococcus multilocularis protein jagged 2 0.0094 0.0307 0.0769
Onchocerca volvulus 0.0254 0.1088 0.1088
Echinococcus multilocularis slit 2 protein 0.0094 0.0307 0.0769
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0041 0.0046 0.0095
Schistosoma mansoni glutamate receptor kainate 0.0121 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Brugia malayi notch-like transmembrane receptor 0.0094 0.0307 0.0307
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0983 0.0983
Echinococcus multilocularis protein patched 0.0045 0.007 0.0157
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus multilocularis geminin 0.0533 0.2452 0.6298
Toxoplasma gondii exonuclease III APE 0.0062 0.0149 0.0025
Echinococcus granulosus nmda type glutamate receptor 0.0827 0.3889 1
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0983 0.1793
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0963 0.2461
Brugia malayi Muscle positioning protein 4 0.0094 0.0307 0.0307
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1026 0.4857 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.0149 0.0214
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Mycobacterium ulcerans thymidylate synthase 0.0728 0.3406 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0079 0.0234 0.0582
Loa Loa (eye worm) RGC/RGC protein kinase 0.0041 0.0046 0.0046
Echinococcus multilocularis glycoprotein Antigen 5 0.0254 0.1088 0.2781
Echinococcus multilocularis tissue type plasminogen activator 0.0583 0.2695 0.6924
Onchocerca volvulus 0.0232 0.0983 0.0983
Echinococcus granulosus transmembrane protease serine 3 0.0254 0.1088 0.2781
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0195 0.048
Onchocerca volvulus 0.0232 0.0983 0.0983
Schistosoma mansoni septate junction protein 0.0094 0.0307 0.0307
Echinococcus granulosus tyrosine kinase 0.0041 0.0046 0.0095
Onchocerca volvulus Huntingtin homolog 0.0118 0.0426 0.0426
Brugia malayi Dihydrofolate reductase 0.0297 0.1299 0.1299
Schistosoma mansoni notch 0.0094 0.0307 0.0307
Brugia malayi hypothetical protein 0.0254 0.1088 0.1088
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) RGC/RGC protein kinase 0.0041 0.0046 0.0046
Schistosoma mansoni glutaminase 0.0557 0.2569 0.2569
Echinococcus multilocularis protein jagged 1 0.0094 0.0307 0.0769
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.0149 0.0214
Schistosoma mansoni notch 0.0094 0.0307 0.0307
Brugia malayi hypothetical protein 0.0071 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Mycobacterium tuberculosis Hypothetical protein 0.0347 0.154 0.4272
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Schistosoma mansoni notch 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus granulosus neurogenic locus notch protein 4 0.0094 0.0307 0.0769
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0056 0.012 0.012
Onchocerca volvulus 0.0232 0.0983 0.0983
Echinococcus multilocularis expressed conserved protein 0.01 0.0334 0.0838
Brugia malayi Kringle domain containing protein 0.0583 0.2695 0.2695
Echinococcus granulosus thymidylate synthase 0.0728 0.3406 0.8757
Schistosoma mansoni eyes absent homolog 0.0096 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0254 0.1088 0.1088
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1026 0.4857 1
Loa Loa (eye worm) glutamate receptor 2 0.0121 0.0438 0.0438
Schistosoma mansoni hypothetical protein 0.0044 0.0062 0.0062
Plasmodium falciparum cysteine repeat modular protein 1 0.0583 0.2695 0.5408
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0094 0.0307 0.0307
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0297 0.1299 0.353
Brugia malayi Trypsin-like protease protein 5 0.0254 0.1088 0.1088
Echinococcus granulosus glutamate NMDA receptor subunit 0.0121 0.0438 0.1108
Schistosoma mansoni hypothetical protein 0.0079 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0232 0.0983 0.0983
Echinococcus multilocularis fat cadherin tumor suppressor 0.0094 0.0307 0.0769
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Onchocerca volvulus 0.1824 0.876 0.876
Toxoplasma gondii microneme protein MIC17A 0.0232 0.0983 0.1793
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0079 0.0234 0.0582
Onchocerca volvulus 0.0094 0.0307 0.0307
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0046 0.0095
Loa Loa (eye worm) Notch2 0.0094 0.0307 0.0307
Schistosoma mansoni laminin gamma-3 chain 0.0094 0.0307 0.0307
Onchocerca volvulus Neurogenic locus notch homolog 0.0094 0.0307 0.0307
Onchocerca volvulus 0.0041 0.0046 0.0046
Schistosoma mansoni cell polarity protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) glutaminase 2 0.0557 0.2569 0.2569
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0983 0.1793
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0162 0.0637 0.1619
Loa Loa (eye worm) hypothetical protein 0.0583 0.2695 0.2695
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0247 0.1053 0.1053
Brugia malayi EGF-like domain containing protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.0149 0.0149
Onchocerca volvulus Putative cubilin 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0106 0.0365 0.0365
Echinococcus granulosus slit 2 protein 0.0094 0.0307 0.0769
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0079 0.0234 0.0582
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0316
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.4671
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0121 0.0438 0.1108
Brugia malayi Fibulin-1 precursor 0.0247 0.1053 0.1053
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0247 0.1053 0.1053
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.0149 0.322
Echinococcus multilocularis nmda type glutamate receptor 0.0827 0.3889 1
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.154 0.5885
Echinococcus multilocularis NMDA receptor 0.0079 0.0234 0.0582
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0246 0.1051 0.2686
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0149 0.0316
Onchocerca volvulus 0.0254 0.1088 0.1088
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0983 0.1793
Echinococcus granulosus neurogenic locus protein delta 0.0094 0.0307 0.0769
Echinococcus granulosus tissue type plasminogen activator 0.0583 0.2695 0.6924
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0297 0.1299 0.2074
Echinococcus granulosus protein jagged 1 0.0094 0.0307 0.0769
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0365 0.0365
Schistosoma mansoni patched 1 0.0045 0.007 0.007
Schistosoma mansoni notch 0.0094 0.0307 0.0307
Loa Loa (eye worm) RGC/RGC protein kinase 0.0041 0.0046 0.0046
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Echinococcus granulosus protein jagged 1 0.0094 0.0307 0.0769
Schistosoma mansoni tyrosine kinase 0.0041 0.0046 0.0046
Schistosoma mansoni ap endonuclease 0.0062 0.0149 0.0149
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0167 0.0664 0.1582
Schistosoma mansoni hypothetical protein 0.0094 0.0307 0.0307
Echinococcus granulosus fibropellin Ia 0.0094 0.0307 0.0769
Brugia malayi CHE-14 protein 0.0045 0.007 0.007
Echinococcus granulosus Tolloid protein 1 0.0247 0.1053 0.269
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Brugia malayi thymidylate synthase 0.0728 0.3406 0.3406
Echinococcus multilocularis Mastin 0.0254 0.1088 0.2781
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.4671
Schistosoma mansoni hypothetical protein 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus granulosus Mastin 0.0254 0.1088 0.2781
Mycobacterium ulcerans glutaminase 0.0557 0.2569 0.7429
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0195 0.048
Loa Loa (eye worm) trypsin family protein 0.0254 0.1088 0.1088
Echinococcus multilocularis transmembrane protease serine 3 0.0254 0.1088 0.2781
Toxoplasma gondii kringle domain-containing protein 0.0583 0.2695 0.542
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0171 0.0171
Echinococcus granulosus notch 0.0094 0.0307 0.0769
Brugia malayi Calcium binding EGF domain containing protein 0.0094 0.0307 0.0307
Onchocerca volvulus 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus granulosus receptor type guanylyl cyclase 0.0041 0.0046 0.0095
Schistosoma mansoni notch 0.0094 0.0307 0.0307
Onchocerca volvulus Huntingtin homolog 0.0118 0.0426 0.0426
Echinococcus granulosus glutamate receptor subunit protein glur 0.0079 0.0234 0.0582
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Echinococcus multilocularis glutamate receptor 2 0.0121 0.0438 0.1108
Chlamydia trachomatis dihydrofolate reductase 0.0297 0.1299 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0094 0.0307 0.0769
Onchocerca volvulus 0.0583 0.2695 0.2695
Schistosoma mansoni hypothetical protein 0.0044 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0094 0.0307 0.0307
Onchocerca volvulus 0.0232 0.0983 0.0983
Trichomonas vaginalis glutaminase, putative 0.0557 0.2569 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.0963 0.0963
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0162 0.0637 0.1619
Brugia malayi Delta serrate ligand family protein 0.0094 0.0307 0.0307
Onchocerca volvulus 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0232 0.0983 0.0983
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0041 0.0046 0.0046
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Echinococcus multilocularis neurogenic locus protein delta 0.0094 0.0307 0.0769
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Schistosoma mansoni dihydrofolate reductase 0.0297 0.1299 0.1299
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0167 0.0664 1
Onchocerca volvulus 0.0094 0.0307 0.0307
Onchocerca volvulus 0.0232 0.0983 0.0983
Echinococcus granulosus expressed conserved protein 0.01 0.0334 0.0838
Toxoplasma gondii microneme protein, putative 0.0232 0.0983 0.1793
Echinococcus multilocularis thymidylate synthase 0.0728 0.3406 0.8757
Schistosoma mansoni hypothetical protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0254 0.1088 0.1088
Echinococcus granulosus atrial natriuretic peptide receptor 0.0041 0.0046 0.0095
Echinococcus multilocularis neurogenic locus notch protein 0.0094 0.0307 0.0769
Onchocerca volvulus 0.2078 1 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus multilocularis laminin 0.0247 0.1053 0.269
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0365 0.0919
Schistosoma mansoni tyrosine kinase 0.0041 0.0046 0.0046
Brugia malayi hypothetical protein 0.0347 0.154 0.154
Echinococcus multilocularis glutamate receptor 2 0.0082 0.025 0.0621
Brugia malayi Cadherin domain containing protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0118 0.0426 0.0426
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus granulosus neurogenic locus notch protein 0.0094 0.0307 0.0769
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.0149 0.0214
Brugia malayi hypothetical protein 0.0118 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0184 0.0747 0.0747
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0983 0.1793
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0254 0.1088 0.1088
Trypanosoma cruzi hypothetical protein, conserved 0.0583 0.2695 0.5506
Schistosoma mansoni hypothetical protein 0.0094 0.0307 0.0307
Schistosoma mansoni slit 0.0094 0.0307 0.0307
Echinococcus multilocularis tyrosine kinase 0.0041 0.0046 0.0095
Echinococcus granulosus protein jagged 2 0.0094 0.0307 0.0769
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0728 0.3406 1
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0079 0.0234 0.0582
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0041 0.0046 0.0095
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0167 0.0664 0.1582
Brugia malayi EGF-like domain containing protein 0.0094 0.0307 0.0307
Toxoplasma gondii calcium binding egf domain-containing protein 0.0247 0.1053 0.194
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0162 0.0637 0.1619
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0983 0.0983
Echinococcus granulosus delta-like protein 1 0.0094 0.0307 0.0769
Echinococcus multilocularis neurogenic locus protein delta 0.0094 0.0307 0.0769
Onchocerca volvulus 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0247 0.1053 0.1053
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0046 0.0046
Brugia malayi EGF-like domain containing protein 0.0094 0.0307 0.0307
Echinococcus granulosus geminin 0.0533 0.2452 0.6298
Echinococcus granulosus glutamate receptor NMDA 0.0581 0.2685 0.6898
Echinococcus multilocularis fibrillin 1 0.0247 0.1053 0.269
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0254 0.1088 0.2781
Toxoplasma gondii EGF family domain-containing protein 0.0094 0.0307 0.0361
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0347 0.154 0.3106
Loa Loa (eye worm) thymidylate synthase 0.0728 0.3406 0.3406
Schistosoma mansoni hypothetical protein 0.0071 0.0195 0.0195
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0167 0.0664 1
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0983 0.0983
Brugia malayi hypothetical protein 0.0041 0.0046 0.0046
Echinococcus multilocularis protein jagged 1 0.0094 0.0307 0.0769
Schistosoma mansoni hypothetical protein 0.0094 0.0307 0.0307
Echinococcus multilocularis protein dispatched 1 0.0052 0.0101 0.0238
Loa Loa (eye worm) notch protein 0.0094 0.0307 0.0307
Echinococcus multilocularis neural cadherin 0.0094 0.0307 0.0769
Echinococcus granulosus glutamate receptor 2 0.0082 0.025 0.0621
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0075 0.0075
Loa Loa (eye worm) glutamate receptor 0.0041 0.0046 0.0046
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0094 0.0307 0.0307
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0041 0.0046 0.0046
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0373 0.0373
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0184 0.0747 0.1837
Toxoplasma gondii microneme protein MIC17B 0.0232 0.0983 0.1793
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0983 0.0983
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Toxoplasma gondii microneme protein MIC4 0.0232 0.0983 0.1793
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2078 1 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0075 0.0075
Echinococcus granulosus neurogenic locus notch protein 0.0094 0.0307 0.0769
Toxoplasma gondii calcium binding egf domain-containing protein 0.0247 0.1053 0.194
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Brugia malayi EGF-like domain containing protein 0.0094 0.0307 0.0307
Brugia malayi Protein kinase domain containing protein 0.0583 0.2695 0.2695
Brugia malayi EGF-like domain containing protein 0.0094 0.0307 0.0307
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.4671
Loa Loa (eye worm) dihydrofolate reductase 0.0297 0.1299 0.1299
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0232 0.0983 0.0983
Brugia malayi metabotropic glutamate receptor type 2 0.0041 0.0046 0.0046
Leishmania major hypothetical protein, conserved 0.0583 0.2695 0.5506
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1026 0.4857 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.0983 0.0983
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0169 0.0672 0.1606
Loa Loa (eye worm) hypothetical protein 0.0247 0.1053 0.1053
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0162 0.0637 0.1619
Onchocerca volvulus 0.0232 0.0983 0.0983
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0254 0.1088 0.2781
Echinococcus multilocularis neurogenic locus notch protein 0.0094 0.0307 0.0769
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.007 0.0157
Schistosoma mansoni hypothetical protein 0.0533 0.2452 0.2452
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0232 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0254 0.1088 0.1088
Onchocerca volvulus 0.0728 0.3406 0.3406
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0232 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.0149 0.0361
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0247 0.1053 0.1053
Schistosoma mansoni d-amino acid oxidase 0.0184 0.0747 0.0747
Onchocerca volvulus 0.0041 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0533 0.2452 0.2452
Schistosoma mansoni egf-like domain protein 0.0247 0.1053 0.1053
Echinococcus multilocularis glutamate receptor NMDA 0.0581 0.2685 0.6898
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0247 0.1053 0.1053
Toxoplasma gondii PAN/Apple domain-containing protein 0.0232 0.0983 0.1793
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0583 0.2695 0.5408
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus multilocularis nmda type glutamate receptor 0.0621 0.2883 0.7409
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Schistosoma mansoni glutamate receptor NMDA 0.0121 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Schistosoma mansoni glutamate receptor kainate 0.0121 0.0438 0.0438
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0254 0.1088 0.1088
Echinococcus granulosus neural cadherin 0.0094 0.0307 0.0769
Onchocerca volvulus 0.0047 0.0075 0.0075
Brugia malayi Trypsin family protein 0.0254 0.1088 0.1088
Onchocerca volvulus Arrow homolog 0.0247 0.1053 0.1053
Mycobacterium ulcerans hypothetical protein 0.0254 0.1088 0.2883
Schistosoma mansoni glutamate receptor AMPA 0.0121 0.0438 0.0438
Schistosoma mansoni ATP-binding cassette transporter 0.0121 0.0438 0.0438
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Echinococcus multilocularis notch 0.0094 0.0307 0.0769
Onchocerca volvulus 0.0232 0.0983 0.0983
Brugia malayi glutaminase DH11.1 0.0557 0.2569 0.2569
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Echinococcus granulosus metabotropic glutamate receptor 5 0.0041 0.0046 0.0095
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0162 0.0637 0.1619
Brugia malayi Trypsin family protein 0.0254 0.1088 0.1088
Toxoplasma gondii hypothetical protein 0.0232 0.0983 0.1793
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2078 1 1
Onchocerca volvulus 0.0232 0.0983 0.0983
Onchocerca volvulus 0.0094 0.0307 0.0307
Loa Loa (eye worm) glutaminase 0.0557 0.2569 0.2569
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0365 0.0919
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Brugia malayi EGF-like domain containing protein 0.0094 0.0307 0.0307
Brugia malayi EGF-like domain containing protein 0.0094 0.0307 0.0307
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0079 0.0234 0.0582
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.007 0.007
Brugia malayi hypothetical protein 0.0096 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Schistosoma mansoni protein kinase 0.0041 0.0046 0.0046
Onchocerca volvulus 0.0232 0.0983 0.0983
Brugia malayi GCC2 and GCC3 family protein 0.0094 0.0307 0.0307
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0983 0.1793
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0162 0.0637 0.1619
Schistosoma mansoni notch 0.0094 0.0307 0.0307
Echinococcus granulosus Protein patched homolog 1 0.0045 0.007 0.0157
Loa Loa (eye worm) hypothetical protein 0.0254 0.1088 0.1088
Loa Loa (eye worm) TK/ROR protein kinase 0.0583 0.2695 0.2695
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0232 0.0983 0.1793
Loa Loa (eye worm) hypothetical protein 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0096 0.0316 0.0316
Brugia malayi Guanylyl cyclase protein 23 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0045 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0044 0.0062 0.0062
Toxoplasma gondii subtilisin SUB12 0.0232 0.0983 0.1793
Schistosoma mansoni hypothetical protein 0.0094 0.0307 0.0307
Brugia malayi Calcium binding EGF domain containing protein 0.0094 0.0307 0.0307
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0297 0.1299 0.353
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0983 0.1793
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0247 0.1053 0.1053
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0071 0.0195 0.4671
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0254 0.1088 0.2781
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0046 0.0046
Echinococcus granulosus laminin 0.0247 0.1053 0.269
Brugia malayi hypothetical protein 0.0228 0.0963 0.0963
Onchocerca volvulus 0.0232 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.0254 0.1088 0.1088
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0079 0.0234 0.0582
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0728 0.3406 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0588 0.1492
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0254 0.1088 0.2781
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0963 0.2461
Schistosoma mansoni hypothetical protein 0.0044 0.0062 0.0062
Echinococcus multilocularis fibropellin Ia 0.0094 0.0307 0.0769
Brugia malayi Glutamate receptor 2 precursor 0.0121 0.0438 0.0438
Schistosoma mansoni glutamate receptor kainate 0.0121 0.0438 0.0438
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0046 0.0095
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0041 0.0046 0.0046
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1026 0.4857 1
Brugia malayi Cadherin domain containing protein 0.0094 0.0307 0.0307
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.0149 0.0361
Brugia malayi Glutamate receptor 1 precursor 0.0121 0.0438 0.0438
Echinococcus multilocularis glutamate receptor 2 0.0162 0.0637 0.1619
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0162 0.0637 0.1619
Loa Loa (eye worm) hypothetical protein 0.0232 0.0983 0.0983
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0062 0.0149 0.5
Echinococcus granulosus nmda type glutamate receptor 0.0621 0.2883 0.7409
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0162 0.0637 0.1619
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1026 0.4857 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0041 0.0046 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.0149 0.0149
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0728 0.3406 0.3406
Onchocerca volvulus Slit protein homolog 0.0094 0.0307 0.0307
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Loa Loa (eye worm) hypothetical protein 0.2078 1 1
Echinococcus granulosus glycoprotein Antigen 5 0.0254 0.1088 0.2781
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Schistosoma mansoni cpg binding protein 0.0033 0.0009 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0195 0.0195
Echinococcus granulosus enteropeptidase 0.0254 0.1088 0.2781
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0588 0.1492
Echinococcus multilocularis Tolloid protein 1 0.0247 0.1053 0.269
Toxoplasma gondii hypothetical protein 0.0232 0.0983 0.1793
Loa Loa (eye worm) glutamate receptor 1 0.0121 0.0438 0.0438
Loa Loa (eye worm) hypothetical protein 0.0118 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0047 0.0075 0.0075
Brugia malayi PAN domain containing protein 0.0232 0.0983 0.0983
Onchocerca volvulus 0.0254 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0247 0.1053 0.1053
Loa Loa (eye worm) hypothetical protein 0.2078 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0254 0.1088 0.1088
Echinococcus granulosus glutamate receptor 2 0.0162 0.0637 0.1619
Loa Loa (eye worm) hypothetical protein 0.0247 0.1053 0.1053
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.007 0.0157
Brugia malayi Calcium binding EGF domain containing protein 0.0247 0.1053 0.1053
Echinococcus multilocularis dihydrofolate reductase 0.0297 0.1299 0.3324
Brugia malayi Calcium binding EGF domain containing protein 0.0094 0.0307 0.0307
Schistosoma mansoni cercarial elastase (S01 family) 0.0254 0.1088 0.1088
Schistosoma mansoni cpg binding protein 0.0033 0.0009 0.0009
Schistosoma mansoni glutamate receptor NMDA 0.0742 0.3474 0.3474
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1026 0.4857 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0041 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0094 0.0307 0.0307
Brugia malayi Trypsin family protein 0.0254 0.1088 0.1088
Giardia lamblia High cysteine protein 0.0094 0.0307 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0041 0.0046 0.0095
Echinococcus granulosus protein jagged 2 0.0094 0.0307 0.0769
Echinococcus granulosus dihydrofolate reductase 0.0297 0.1299 0.3324

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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