Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.4151 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1026 | 0.1026 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.4151 | 0.4151 |
Echinococcus granulosus | lamin | 0.0026 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.4151 | 0.4151 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.4151 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.4151 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.4151 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.4151 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9646 | 0.9646 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.3482 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.4151 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.4151 | 0.5 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0026 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.