Detailed information for compound 536639

Basic information

Technical information
  • TDR Targets ID: 536639
  • Name: N-methyl-4-(1-methylindazol-5-yl)azo-aniline
  • MW: 265.313 | Formula: C15H15N5
  • H donors: 1 H acceptors: 1 LogP: 3.33 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccc(cc1)N=Nc1ccc2c(c1)cnn2C
  • InChi: 1S/C15H15N5/c1-16-12-3-5-13(6-4-12)18-19-14-7-8-15-11(9-14)10-17-20(15)2/h3-10,16H,1-2H3/b19-18+
  • InChiKey: CEWVGHSHRLURPP-VHEBQXMUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-methyl-4-[(1-methyl-5-indazolyl)azo]aniline
  • N-methyl-4-(1-methylindazol-5-yl)diazenyl-aniline
  • methyl-[4-(1-methylindazol-5-yl)azophenyl]amine
  • N-methyl-4-(1-methylindazol-5-yl)diazenylaniline
  • 1-methyl-5-(4-methylaminophenylazo)indazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0834 0.0675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0128 1 1
Leishmania major cathepsin L-like protease 0.0062 0.4449 0.4262
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0535 0.037
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0326 0.0316
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0834 0.0526
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0015 0.048 0.0471
Loa Loa (eye worm) hypothetical protein 0.0026 0.1475 0.1467
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.4182 0.4081
Leishmania major hypothetical protein, conserved 0.0015 0.0535 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0621 0.1605
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.4822 0.4732
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.2336 0.2079
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0834 0.0675
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.4552 0.4457
Plasmodium vivax calpain, putative 0.0019 0.0834 0.0526
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Leishmania major cytochrome P450 reductase, putative 0.0113 0.8779 0.8738
Brugia malayi hypothetical protein 0.0016 0.0634 0.0634
Leishmania major reductase, putative 0.0015 0.048 0.016
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0015 0.048 0.048
Echinococcus granulosus lamin 0.0026 0.1475 0.1467
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0326 0.0316
Plasmodium vivax hypothetical protein, conserved 0.0049 0.3368 0.3145
Brugia malayi Cathepsin L-like precursor 0.0016 0.0621 0.0621
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0535 0.037
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.1388 0.1098
Echinococcus multilocularis calpain 5 0.0019 0.0834 0.0825
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Brugia malayi FAD binding domain containing protein 0.0128 1 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0049 0.3368 0.3252
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.2215 0.2207
Leishmania major NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Onchocerca volvulus 0.0029 0.1685 0.5395
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Echinococcus multilocularis calpain A 0.0066 0.4822 0.4817
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.1685 0.1677
Schistosoma mansoni lamin 0.0026 0.1475 0.1326
Loa Loa (eye worm) ctsf protein 0.0016 0.0621 0.0612
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0834 0.0675
Schistosoma mansoni cytochrome P450 reductase 0.0128 1 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0128 1 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0042 0.0042
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0535 0.0526
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0621 0.0458
Loa Loa (eye worm) hypothetical protein 0.0063 0.4552 0.4546
Schistosoma mansoni hypothetical protein 0.0011 0.0214 0.0044
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0834 0.2074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.1475 0.1475
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0326 0.5
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.3368 1
Brugia malayi jmjC domain containing protein 0.0057 0.4044 0.4044
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0049 0.3368 0.3145
Brugia malayi Cathepsin L-like precursor 0.0016 0.0621 0.0621
Mycobacterium tuberculosis Probable reductase 0.0084 0.6279 0.8837
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0673 0.0664
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0326 0.0157
Echinococcus granulosus methionine synthase reductase 0.0079 0.5891 0.5888
Echinococcus granulosus cpg binding protein 0.0031 0.1823 0.1815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Leishmania major nitrate reductase, putative 0.0015 0.048 0.016
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0535 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1388 0.1098
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0015 0.048 0.016
Onchocerca volvulus 0.0026 0.1475 0.4646
Plasmodium vivax vivapain-2 0.0016 0.0621 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Schistosoma mansoni cpg binding protein 0.0031 0.1823 0.1681
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0535 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Brugia malayi hypothetical protein 0.0025 0.1388 0.1388
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0621 0.1605
Trypanosoma cruzi nitrate reductase, putative 0.0015 0.048 0.016
Loa Loa (eye worm) fibroinase 0.0016 0.0621 0.0612
Schistosoma mansoni NADPH flavin oxidoreductase 0.0064 0.467 0.4578
Echinococcus multilocularis cytochrome b5 reductase 4 0.0015 0.048 0.0471
Trypanosoma cruzi oxidoreductase-protein, putative 0.0015 0.048 0.016
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0535 0.037
Brugia malayi glutathione reductase 0.0037 0.2336 0.2336
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.7062 1
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0834 0.0526
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0128 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.3999 0.3797
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0015 0.048 0.0278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0288 0.0279
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0326 0.0157
Loa Loa (eye worm) flavodoxin family protein 0.0049 0.3368 0.3361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0015 0.048 0.016
Chlamydia trachomatis sulfite reductase 0.0079 0.5891 1
Leishmania major cathepsin L-like protease 0.0062 0.4449 0.4262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Schistosoma mansoni jumonji domain containing protein 0.0057 0.4044 0.394
Trypanosoma brucei antigen, putative 0.0019 0.0834 0.0526
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.4449 0.4262
Leishmania major oxidoreductase-like protein 0.0015 0.048 0.016
Loa Loa (eye worm) hypothetical protein 0.0025 0.1388 0.138
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0015 0.048 0.016
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.2336 0.2079
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0128 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1388 0.1098
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Leishmania major hypothetical protein, conserved 0.0049 0.3368 0.3145
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0621 0.0306
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0834 0.0825
Onchocerca volvulus 0.0026 0.1475 0.4646
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0535 0.037
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0834 0.0526
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0834 0.0526
Trypanosoma cruzi p450 reductase, putative 0.0015 0.048 0.016
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0535 0.0526
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.7062 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.2378 0.237
Plasmodium vivax glutathione reductase, putative 0.0037 0.2336 0.2079
Toxoplasma gondii thioredoxin reductase 0.0037 0.2336 0.4717
Loa Loa (eye worm) hypothetical protein 0.0016 0.0621 0.0612
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0621 0.0612
Leishmania major cathepsin L-like protease 0.0062 0.4449 0.4262
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.4182 0.4176
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.4182 0.4081
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.4182 0.4176
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0621 0.0306
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.6279 0.8837
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.6279 0.8837
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.2336 0.2985
Brugia malayi calpain 7 0.0019 0.0834 0.0834
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0049 0.3368 0.3145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0326 0.5
Echinococcus multilocularis lamin 0.0026 0.1475 0.1467
Brugia malayi intermediate filament protein 0.0026 0.1475 0.1475
Onchocerca volvulus 0.0016 0.0621 0.1605
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0171 0.0171
Leishmania major cathepsin L-like protease 0.0016 0.0621 0.0306
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0214 0.0205
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.3368 1
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0049 0.3368 0.3145
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0049 0.3368 0.3145
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0535 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0128 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Entamoeba histolytica hypothetical protein 0.0035 0.2215 0.6394
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Toxoplasma gondii flavodoxin domain-containing protein 0.0063 0.4589 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Trichomonas vaginalis sulfite reductase, putative 0.0128 1 1
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0015 0.048 0.0471
Schistosoma mansoni calpain (C02 family) 0.0019 0.0834 0.0675
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0015 0.048 0.0363
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0535 0.0526
Schistosoma mansoni intermediate filament proteins 0.0026 0.1475 0.1326
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0834 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.7062 1
Loa Loa (eye worm) hypothetical protein 0.0128 1 1
Giardia lamblia Nitric oxide synthase, inducible 0.0113 0.8779 1
Echinococcus granulosus intermediate filament protein 0.0026 0.1475 0.1467
Onchocerca volvulus 0.0016 0.0621 0.1605
Brugia malayi Cathepsin L-like precursor 0.0011 0.0171 0.0171
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0015 0.048 0.0183
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0128 1 1
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0535 0.0526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0535 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0621 0.1409
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0128 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Loa Loa (eye worm) hypothetical protein 0.0044 0.2977 0.297
Echinococcus multilocularis calpain 0.0019 0.0834 0.0825
Leishmania major cytochrome-b5 reductase, putative 0.0015 0.048 0.016
Echinococcus granulosus phd:f box containing protein 0.0015 0.0535 0.0526
Entamoeba histolytica hypothetical protein 0.0035 0.2215 0.6394
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0621 0.0612
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0621 0.1605
Loa Loa (eye worm) diaphorase 0.0015 0.048 0.0471
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0049 0.3368 0.3145
Trypanosoma cruzi kinesin, putative 0.0019 0.0834 0.0526
Entamoeba histolytica hypothetical protein 0.0035 0.2215 0.6394
Brugia malayi Cathepsin L-like precursor 0.0016 0.0621 0.0621
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0621 0.0458
Brugia malayi jmjC domain containing protein 0.0015 0.0535 0.0535
Entamoeba histolytica cysteine protease, putative 0.0016 0.0621 0.1409
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Plasmodium vivax JmjC domain containing protein 0.0015 0.0535 0.0217
Loa Loa (eye worm) hypothetical protein 0.0013 0.0328 0.0319
Echinococcus granulosus cathepsin l1 0.0016 0.0621 0.0612
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0128 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.2336 0.2329
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0049 0.3368 0.3145
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.7062 1
Leishmania major trypanothione reductase 0.0037 0.2336 0.2079
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0042 0.0042
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0621 0.0612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Leishmania major NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0535 0.0217
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.4449 0.4262
Brugia malayi hypothetical protein 0.0035 0.2215 0.2215
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1388 0.1098
Mycobacterium ulcerans oxidoreductase 0.0015 0.048 0.016
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0049 0.3368 0.3252
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0621 0.0458
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.6279 0.8837
Leishmania major hypothetical protein, conserved 0.0025 0.1388 0.1098
Loa Loa (eye worm) calpain family protein 1 0.0044 0.2977 0.297
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Loa Loa (eye worm) calpain 0.0019 0.0834 0.0825
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0535 0.0526
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0113 0.8779 0.8758
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.048 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Brugia malayi Cathepsin L-like precursor 0.0016 0.0621 0.0621
Plasmodium vivax vivapain-2 0.0016 0.0621 0.0306
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0326 0.0157
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0535 0.0526
Echinococcus multilocularis methionine synthase reductase 0.0079 0.5891 0.5888
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.4449 0.4262
Loa Loa (eye worm) hypothetical protein 0.0015 0.0535 0.0526
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0128 1 1
Trypanosoma brucei kinesin, putative 0.0019 0.0834 0.0526
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0326 0.0326
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.2215 0.2207
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0128 1 1
Plasmodium falciparum glutathione reductase 0.0037 0.2336 0.2079
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0621 0.0612
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0049 0.3368 0.3252
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0015 0.048 0.016
Loa Loa (eye worm) intermediate filament protein 0.0026 0.1475 0.1467
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0621 0.0612
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0535 0.0526
Onchocerca volvulus 0.0016 0.0621 0.1605
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Echinococcus granulosus cytochrome b5 reductase 4 0.0015 0.048 0.0471
Leishmania major NADH-dependent fumarate reductase-like protein 0.0015 0.048 0.016
Onchocerca volvulus 0.0016 0.0621 0.1605
Giardia lamblia Hypothetical protein 0.0113 0.8779 1
Echinococcus granulosus cytochrome b5 reductase 4 0.0015 0.048 0.0471
Trypanosoma cruzi reductase, putative 0.0015 0.048 0.016
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0015 0.048 0.016
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0015 0.048 0.016
Leishmania major cytochrome-b5 reductase, putative 0.0015 0.048 0.016
Brugia malayi jmjC domain containing protein 0.0059 0.4182 0.4182
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0621 0.1409
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0128 1 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0446 0.0437
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.4822 0.4817
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.4449 0.4262
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0834 0.0526
Echinococcus multilocularis cpg binding protein 0.0031 0.1823 0.1815
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0834 0.0526
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.3855 0.8278
Echinococcus granulosus calpain 0.0019 0.0834 0.0825
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0673 0.0664
Loa Loa (eye worm) hypothetical protein 0.0063 0.4552 0.4546
Leishmania major p450 reductase, putative 0.0128 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0171 0.0162
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0214 0.0205
Trypanosoma brucei oxidoreductase-protein, putative 0.0015 0.048 0.016
Leishmania major NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0015 0.048 0.0508
Toxoplasma gondii flavodoxin domain-containing protein 0.0063 0.4589 1
Brugia malayi calpain family protein 1 0.0063 0.4552 0.4552
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.1388 0.1098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0171 0.0162
Brugia malayi cathepsin L-like precursor 0.0011 0.0171 0.0171
Plasmodium falciparum thioredoxin reductase 0.0037 0.2336 0.2079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.4404 0.4307
Brugia malayi Cathepsin L-like precursor 0.0016 0.0621 0.0621
Echinococcus granulosus cathepsin l1 0.0011 0.0171 0.0162
Toxoplasma gondii cathepsin CPL 0.0016 0.0621 0.0694
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.4044 0.4038
Trypanosoma brucei NADH-dependent fumarate reductase 0.0015 0.048 0.016
Loa Loa (eye worm) hypothetical protein 0.0044 0.2977 0.297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Brugia malayi Cathepsin L-like precursor 0.0011 0.0171 0.0171
Entamoeba histolytica hypothetical protein 0.0035 0.2215 0.6394
Loa Loa (eye worm) hypothetical protein 0.0015 0.0535 0.0526
Treponema pallidum flavodoxin 0.0049 0.3368 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0834 0.0526
Brugia malayi Thioredoxin reductase 0.0037 0.2336 0.2336
Loa Loa (eye worm) calpain 5 0.0019 0.0834 0.0825
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0015 0.048 0.0363
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0049 0.3368 0.3252
Schistosoma mansoni cpg binding protein 0.0031 0.1823 0.1681
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0834 0.0526
Brugia malayi Cathepsin L-like precursor 0.0016 0.0621 0.0621
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0834 0.0675
Onchocerca volvulus 0.0015 0.048 0.1102
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0328 0.0319
Leishmania major cathepsin L-like protease 0.0016 0.0621 0.0306
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0834 0.0526
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0015 0.048 0.023
Brugia malayi flavodoxin family protein 0.0049 0.3368 0.3368
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0128 1 1
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.1475 0.1467
Echinococcus multilocularis musashi 0.0026 0.1475 0.1467
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0535 0.0217
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0128 1 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.4822 0.4817
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0446 0.0446
Echinococcus multilocularis cysteine protease 0.0016 0.0621 0.0612
Echinococcus multilocularis cysteine protease 0.0016 0.0621 0.0612
Onchocerca volvulus 0.0016 0.0621 0.1605
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0621 0.0612
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0535 0.037
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.3368 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Echinococcus granulosus calpain A 0.0066 0.4822 0.4817
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Plasmodium falciparum ferredoxin--NADP reductase 0.0015 0.048 0.016
Echinococcus multilocularis lamin dm0 0.0026 0.1475 0.1467
Leishmania major cathepsin L-like protease 0.0016 0.0621 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.3368 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0015 0.048 0.023
Loa Loa (eye worm) calpain family protein 1 0.0063 0.4552 0.4546
Loa Loa (eye worm) hypothetical protein 0.0012 0.0288 0.0279
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0621 0.0621
Trypanosoma cruzi p450 reductase, putative 0.0128 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.1388 0.2492
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0621 0.0612
Brugia malayi jmjC domain containing protein 0.0015 0.0535 0.0535
Loa Loa (eye worm) FAD binding domain-containing protein 0.0079 0.5891 0.5888
Brugia malayi CXXC zinc finger family protein 0.0029 0.1685 0.1685
Loa Loa (eye worm) glutathione reductase 0.0037 0.2336 0.2329
Schistosoma mansoni diflavin oxidoreductase 0.0063 0.4589 0.4495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Mycobacterium ulcerans electron transfer protein FdxB 0.0015 0.048 0.016
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0015 0.048 0.016
Schistosoma mansoni cytochrome B5 0.0015 0.048 0.0315
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0834 0.0526
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0128 1 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0128 1 1
Plasmodium falciparum nitric oxide synthase, putative 0.0128 1 1
Echinococcus granulosus lamin dm0 0.0026 0.1475 0.1467
Brugia malayi FAD binding domain containing protein 0.0079 0.5891 0.5891
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0834 0.0825
Trypanosoma cruzi kinesin, putative 0.0019 0.0834 0.0526
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.6279 0.8837
Leishmania major kinesin, putative 0.0019 0.0834 0.0526
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Echinococcus granulosus calpain A 0.0019 0.0834 0.0825
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1388 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Loa Loa (eye worm) cysteine protease 0.0016 0.0621 0.0612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Brugia malayi jmjC domain containing protein 0.0015 0.0535 0.0535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0621 0.0458
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.4044 0.4038
Trypanosoma brucei NADH-dependent fumarate reductase 0.0015 0.048 0.016
Brugia malayi calpain 5 0.0019 0.0834 0.0834
Brugia malayi calpain family protein 1 0.0063 0.4552 0.4552
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0015 0.048 0.016
Loa Loa (eye worm) hypothetical protein 0.0026 0.1434 0.1426
Mycobacterium ulcerans oxygenase 0.0015 0.048 0.016
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.3338 0.3114
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0621 0.0306
Brugia malayi jmjC domain containing protein 0.0015 0.0535 0.0535
Trypanosoma brucei nitrate reductase, putative 0.0015 0.048 0.016
Plasmodium vivax flavodoxin domain containing protein 0.0113 0.8779 0.8738
Echinococcus granulosus calpain 5 0.0019 0.0834 0.0825
Loa Loa (eye worm) hypothetical protein 0.0011 0.0171 0.0162
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0621 0.0306
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Mycobacterium tuberculosis Possible oxygenase 0.0015 0.048 0.023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.6279 0.8837
Trypanosoma brucei trypanothione reductase 0.0037 0.2336 0.2079
Mycobacterium ulcerans monooxygenase 0.0015 0.048 0.016
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0328 0.0319
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0015 0.048 0.0315
Onchocerca volvulus 0.0044 0.2977 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.4822 0.4732
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0621 0.0458
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.2378 0.237
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0621 0.0612
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0015 0.048 0.0471
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0621 0.0458
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0535 0.0526
Schistosoma mansoni lamin 0.0026 0.1475 0.1326
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0079 0.5891 0.582
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0834 0.0526
Echinococcus multilocularis hypothetical protein 0.0019 0.0834 0.0825
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.2215 0.2079
Brugia malayi diaphorase 0.0015 0.048 0.048
Onchocerca volvulus 0.0016 0.0621 0.1605
Schistosoma mansoni hypothetical protein 0.0035 0.2215 0.2079
Entamoeba histolytica protein kinase, putative 0.0019 0.0834 0.2074
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.2977 0.297
Schistosoma mansoni cpg binding protein 0.0029 0.1685 0.154
Loa Loa (eye worm) hypothetical protein 0.0015 0.0535 0.0526
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0535 0.0491
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0621 0.0306
Leishmania major cathepsin L-like protease 0.0016 0.0621 0.0306
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0015 0.048 0.016
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0535 0.0217
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.3368 1
Onchocerca volvulus 0.0016 0.0621 0.1605
Leishmania major cathepsin L-like protease 0.0016 0.0621 0.0306
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0015 0.048 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.4449 0.4262
Mycobacterium tuberculosis Probable monooxygenase 0.0015 0.048 0.023
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.4044 0.4038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.