Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.4974 | 0.4974 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4208 | 0.8459 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4208 | 0.8459 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.4208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.4974 | 0.4974 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.4208 | 1 |
Brugia malayi | RNA binding protein | 0.0074 | 0.4208 | 0.4208 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4208 | 0.8459 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.4208 | 0.4208 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.4208 | 0.4208 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.4208 | 0.4208 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.4208 | 0.4208 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4208 | 0.8459 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.4208 | 0.8459 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.4974 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.4208 | 0.4208 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 85 % | Inhibition of ASIC3 at 20 uM assessed as inhibition of peak current by patch clamp electrophysiology relative to baseline | ChEMBL. | 19339181 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.