Detailed information for compound 53807

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 693.874 | Formula: C41H51N5O5
  • H donors: 2 H acceptors: 5 LogP: 6.36 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCOC(C1=C(C)C2=N/C/1=C\c1[nH]c(c(c1C)CC)/C=c/1\[nH]c3=C(C4=N/C(=C\2)/[C@@H](C)[C@@H]4CCC(=O)OC)C(=O)N(C(=O)c3c1C)C)C
  • InChi: 1S/C41H51N5O5/c1-10-12-13-14-17-51-25(7)35-23(5)30-18-29-22(4)27(15-16-34(47)50-9)38(44-29)37-39-36(40(48)46(8)41(37)49)24(6)31(45-39)19-32-26(11-2)21(3)28(42-32)20-33(35)43-30/h18-20,22,25,27,42,45H,10-17H2,1-9H3/b28-20-,29-18-,30-18-,31-19-,32-19-,33-20-,38-37+/t22-,25?,27-/m0/s1
  • InChiKey: BJDDJEBBIBCQGZ-TYCFMEPQSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0044 0.0128
Brugia malayi Carboxylesterase family protein 0.008 0.0511 0.1495
Brugia malayi Cytochrome P450 family protein 0.0019 0.0061 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.098 0.1327
Brugia malayi notch-like transmembrane receptor 0.0025 0.0109 0.0319
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0317
Schistosoma mansoni hypothetical protein 0.0023 0.0089 0.0175
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0974 0.7158 1
Leishmania major hypothetical protein, conserved 0.0051 0.0297 0.1302
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0162 0.0585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0304 0.089
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0101 0.0169
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0064 0.0214
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0104 0.0087
Mycobacterium ulcerans thioesterase 0.0023 0.0089 0.0072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0304 0.089
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0565 0.0786
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0114 0.0223
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0402 0.1844
Schistosoma mansoni hypothetical protein 0.0041 0.0225 0.0442
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0383 0.2761 0.2761
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0114 0.0448
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0982 0.4492
Brugia malayi MH2 domain containing protein 0.0245 0.1741 0.5091
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0101 0.0199
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0162 0.0269
Brugia malayi nuclear receptor NHR-67 0.0024 0.0101 0.0296
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0297 0.1302
Giardia lamblia High cysteine protein 0.0025 0.0109 0.0441
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0205 0.0188
Giardia lamblia Myb 1-like protein 0.0029 0.0136 0.0572
Trichomonas vaginalis spcc417.12 protein, putative 0.008 0.0511 0.2444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0304 0.089
Trichomonas vaginalis heat shock protein, putative 0.002 0.0069 0.0331
Trichomonas vaginalis heat shock protein, putative 0.0013 0.002 0.0094
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0304 0.0507
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0304 0.0598
Echinococcus multilocularis BC026374 protein (S09 family) 0.008 0.0511 0.0852
Brugia malayi tailless protein 0.0024 0.0101 0.0296
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0235 0.1014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0304 0.089
Onchocerca volvulus 0.0025 0.0109 0.0477
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0135 0.0648
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0135 0.0648
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0123 0.036
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0163 0.0679
Echinococcus multilocularis Smad4 0.0017 0.0044 0.0073
Brugia malayi Pre-SET motif family protein 0.0031 0.0148 0.0432
Brugia malayi EGF-like domain containing protein 0.0025 0.0109 0.0319
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0089 0.0072
Brugia malayi hypothetical protein 0.0024 0.0101 0.0296
Echinococcus granulosus carboxylesterase 5A 0.0471 0.342 0.6713
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0306 0.0601
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0117 0.0114
Brugia malayi GCC2 and GCC3 family protein 0.0025 0.0109 0.0319
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0044 0.0073
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0104 0.0143
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1357 1 1
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.002 0.0071
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0135 0.0559
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0683 0.1998
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0162 0.0269
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0101 0.0169
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0061 0.0044
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0023 0.0082
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1695 0.8107
Brugia malayi nuclear hormone receptor 0.0024 0.0101 0.0296
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0035
Echinococcus granulosus fibropellin Ia 0.0025 0.0109 0.0214
Schistosoma mansoni acetylcholinesterase 0.008 0.0511 0.1003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0565 0.0786
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0162 0.0671
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0135 0.0648
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.2163 1
Echinococcus granulosus delta-like protein 1 0.0025 0.0109 0.0214
Trichomonas vaginalis C-MYB, putative 0.0029 0.0135 0.0648
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0065 0.0041
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0203 0.0592
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.1741 0.5091
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0402 0.1789
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0162 0.0671
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0205 0.0238
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0089 0.0076
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0064 0.0218
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0117 0.0423
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0304 0.0598
Brugia malayi EGF-like domain containing protein 0.0025 0.0109 0.0319
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0304 0.0598
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0658 0.1292
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0044 0.0073
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0025 0.0109 0.0214
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.2163 1
Onchocerca volvulus 0.0079 0.0506 0.2212
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Plasmodium falciparum heat shock protein 90 0.0033 0.0163 0.55
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0162 0.0269
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0101 0.0199
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0044 0.0086
Brugia malayi steroid hormone receptor 0.0052 0.0304 0.089
Brugia malayi nuclear receptor RXR 0.0024 0.0101 0.0296
Echinococcus multilocularis dna polymerase eta 0.0019 0.0064 0.0107
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0304 0.089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0304 0.0507
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0506 0.1479
Schistosoma mansoni notch 0.0025 0.0109 0.0214
Echinococcus granulosus smad 0.0017 0.0044 0.0086
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0114 0.0448
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0018 0.0597
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0163 0.0592
Brugia malayi hypothetical protein 0.0051 0.0297 0.0869
Schistosoma mansoni hypothetical protein 0.0025 0.0109 0.0214
Echinococcus granulosus endoplasmin 0.0026 0.0114 0.0223
Echinococcus multilocularis para nitrobenzyl esterase 0.008 0.0511 0.0852
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0218
Plasmodium vivax SET domain protein, putative 0.0031 0.0148 0.4967
Leishmania major heat shock protein, putative 0.0013 0.002 0.0009
Brugia malayi nuclear receptor RXR 0.0027 0.0123 0.036
Plasmodium falciparum thioredoxin reductase 0.0013 0.0018 0.0597
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0101 0.0296
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0163 0.0478
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0982 0.4492
Loa Loa (eye worm) hypothetical protein 0.0043 0.0243 0.071
Echinococcus granulosus neurogenic locus protein delta 0.0025 0.0109 0.0214
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0658 0.3082
Echinococcus multilocularis carboxylesterase 5A 0.0471 0.342 0.5699
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0304 0.089
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0637 0.0844
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0297 0.1302
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0506 0.1479
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0982 0.4492
Echinococcus multilocularis heat shock protein 0.0033 0.0163 0.0272
Trypanosoma cruzi heat shock protein, putative 0.0013 0.002 0.0009
Echinococcus granulosus para nitrobenzyl esterase 0.008 0.0511 0.1003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Mycobacterium ulcerans polyketide synthase 0.0025 0.0104 0.0087
Schistosoma mansoni notch 0.0025 0.0109 0.0214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Echinococcus multilocularis protein patched 0.0043 0.0237 0.0394
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0237 0.0394
Plasmodium falciparum endoplasmin, putative 0.002 0.0069 0.233
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0297 1
Loa Loa (eye worm) endoplasmin 0.0033 0.0163 0.0478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.002 0.0071
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0066 0.0089
Brugia malayi hypothetical protein 0.0079 0.0506 0.1479
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0304 0.0598
Brugia malayi Thioredoxin reductase 0.0038 0.0203 0.0592
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0471 0.342 0.6713
Schistosoma mansoni notch 0.0025 0.0109 0.0214
Brugia malayi Carboxylesterase family protein 0.008 0.0511 0.1495
Trypanosoma brucei trypanothione reductase 0.0038 0.0203 0.0861
Onchocerca volvulus 0.008 0.0511 0.2235
Brugia malayi Carboxylesterase family protein 0.0471 0.342 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0442 0.1291
Schistosoma mansoni hypothetical protein 0.0041 0.0225 0.0442
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0101 0.0199
Echinococcus granulosus neural cadherin 0.0025 0.0109 0.0214
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0047
Loa Loa (eye worm) fatty acid synthase 0.0027 0.012 0.0352
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0203 0.0861
Schistosoma mansoni hypothetical protein 0.007 0.0442 0.0867
Brugia malayi nuclear receptor NHR-88 0.0024 0.0101 0.0296
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0052 0.0187
Echinococcus multilocularis neurogenic locus notch protein 4 0.0025 0.0109 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0044 0.0128
Echinococcus granulosus protein jagged 2 0.0025 0.0109 0.0214
Brugia malayi EGF-like domain containing protein 0.0025 0.0109 0.0319
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0089 0.0122
Echinococcus multilocularis expressed conserved protein 0.0093 0.0613 0.1022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0304 0.0598
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0123 0.036
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0117 0.0114
Schistosoma mansoni hypothetical protein 0.0025 0.0109 0.0214
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0101 0.0443
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0304 0.0507
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0104 0.0087
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0235 0.1014
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0304 0.1332
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0018 0.0052
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0109 0.0214
Brugia malayi nuclear hormone receptor 0.0052 0.0304 0.089
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0029 0.0136 0.0494
Mycobacterium tuberculosis Probable reductase 0.0087 0.0565 0.0786
Schistosoma mansoni hypothetical protein 0.0041 0.0225 0.0442
Loa Loa (eye worm) hypothetical protein 0.0051 0.0297 0.0869
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.036
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0109 0.0214
Echinococcus granulosus microtubule associated protein 2 0.0697 0.5094 1
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0163 0.0679
Brugia malayi MH2 domain containing protein 0.0017 0.0044 0.0128
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0402 0.1174
Brugia malayi Peroxidasin 0.0079 0.0506 0.1479
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0162 0.0317
Echinococcus granulosus GPCR family 2 0.0033 0.0161 0.0317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0317
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0101 0.0296
Echinococcus multilocularis geminin 0.035 0.252 0.4201
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0162 0.0671
Echinococcus granulosus geminin 0.035 0.252 0.4948
Brugia malayi MH1 domain containing protein 0.0017 0.0044 0.0128
Onchocerca volvulus 0.0253 0.18 0.7873
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0304 0.089
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0163 0.0679
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0104 0.0097
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0123 0.036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0304 0.0598
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0104 0.0143
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0565 0.0786
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.098 0.1367
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0025 0.0109 0.0477
Schistosoma mansoni zinc finger protein 0.0024 0.0101 0.0199
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0161 0.0472
Echinococcus multilocularis tumor protein p63 0.0355 0.256 0.4266
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0162 0.544
Loa Loa (eye worm) acetylcholinesterase 1 0.0471 0.342 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0018 0.0597
Toxoplasma gondii EGF family domain-containing protein 0.0025 0.0109 0.0395
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.036
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0163 0.0679
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0135 0.0648
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0304 0.0598
Brugia malayi hypothetical protein 0.008 0.0511 0.1495
Schistosoma mansoni peroxidasin 0.0079 0.0506 0.0993
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0067 0.0091
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0304 0.0598
Schistosoma mansoni nuclear receptor 0.0024 0.0101 0.0199
Schistosoma mansoni smad 0.0017 0.0044 0.0086
Echinococcus multilocularis fat cadherin tumor suppressor 0.0025 0.0109 0.0182
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0148 0.029
Trypanosoma brucei unspecified product 0.0019 0.0064 0.0218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.002 0.0033
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0061 0.0202
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0035 0.0047
Schistosoma mansoni septate junction protein 0.0025 0.0109 0.0214
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0061 0.0202
Loa Loa (eye worm) carboxylesterase 0.008 0.0511 0.1495
Schistosoma mansoni cpg binding protein 0.0031 0.0147 0.0288
Onchocerca volvulus 0.0025 0.0109 0.0477
Loa Loa (eye worm) DR-78 0.0024 0.0101 0.0296
Onchocerca volvulus 0.0026 0.011 0.048
Schistosoma mansoni nuclear receptor 0.0024 0.0101 0.0199
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Brugia malayi nuclear receptor NHR-88 0.0052 0.0304 0.089
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0104 0.0087
Schistosoma mansoni notch 0.0025 0.0109 0.0214
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0104 0.0097
Mycobacterium tuberculosis Carboxylesterase LipT 0.008 0.0511 0.0711
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0117 0.0161
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0162 0.0671
Onchocerca volvulus 0.0024 0.0101 0.0443
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Brugia malayi Cadherin domain containing protein 0.0025 0.0109 0.0319
Echinococcus multilocularis protein jagged 1 0.0025 0.0109 0.0182
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.008 0.0511 0.2444
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.008 0.0511 0.0711
Loa Loa (eye worm) hypothetical protein 0.0052 0.0306 0.0895
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0402 0.1789
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0101 0.0296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0304 0.089
Schistosoma mansoni cell polarity protein 0.0025 0.0109 0.0214
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0304 0.1332
Echinococcus multilocularis X box binding protein 1 0.0291 0.208 0.3467
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0637 0.0887
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0161 0.0317
Schistosoma mansoni slit 0.0025 0.0109 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0304 0.089
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0383 0.2761 0.2749
Echinococcus granulosus Smad4 0.0017 0.0044 0.0086
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0117 0.0161
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0203 0.6815
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0304 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.008 0.0511 0.0711
Echinococcus multilocularis cpg binding protein 0.0031 0.0147 0.0244
Plasmodium vivax heat shock protein 90, putative 0.0013 0.002 0.066
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0402 0.1174
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0304 0.0598
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0114 0.0096
Loa Loa (eye worm) pax transcription factor protein 2 0.0253 0.18 0.5265
Echinococcus multilocularis smad 0.0017 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.1495
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0101 0.0296
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0061 0.0179
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0658 0.1924
Plasmodium falciparum glutathione reductase 0.0038 0.0203 0.6815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0304 0.089
Loa Loa (eye worm) hypothetical protein 0.0103 0.0683 0.1998
Echinococcus granulosus heat shock protein 0.0033 0.0163 0.0321
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0064 0.0188
Echinococcus multilocularis protein dispatched 1 0.0049 0.0281 0.0469
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0161 0.0269
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0061 0.0179
Brugia malayi hypothetical protein 0.0124 0.0838 0.2452
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0104 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0188
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0064 0.0308
Schistosoma mansoni neuroligin 3 (S09 family) 0.008 0.0511 0.1003
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0117 0.0114
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0101 0.0296
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0304 0.0507
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0101 0.0199
Loa Loa (eye worm) heat shock protein 75 0.0013 0.002 0.0057
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0402 0.0788
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Onchocerca volvulus 0.008 0.0511 0.2235
Onchocerca volvulus Peroxidase homolog 0.0079 0.0506 0.2212
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0117 0.0099
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0123 0.0241
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.1495
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0304 0.089
Brugia malayi conserved hypotetical protein 0.0024 0.0101 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0026 0.011 0.0321
Schistosoma mansoni cpg binding protein 0.0029 0.0134 0.0264
Onchocerca volvulus 0.0025 0.0109 0.0477
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.6 1
Brugia malayi isocitrate dehydrogenase 0.0033 0.0162 0.0473
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.008 0.0511 0.0852
Echinococcus multilocularis protein jagged 1 0.0025 0.0109 0.0182
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0304 0.0598
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0442 0.1291
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0148 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0218
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0304 0.089
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1357 1 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0064 0.0127
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Brugia malayi Smad1 0.0017 0.0044 0.0128
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0044 0.0086
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0506 0.1479
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0402 0.0788
Echinococcus multilocularis heat shock protein 90 0.0026 0.0114 0.019
Schistosoma mansoni hypothetical protein 0.0025 0.0109 0.0214
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0025 0.0109 0.0319
Brugia malayi MH1 domain containing protein 0.0017 0.0044 0.0128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Loa Loa (eye worm) Notch2 0.0025 0.0109 0.0319
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0683 0.1998
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0117 0.0161
Onchocerca volvulus 0.0052 0.0306 0.1339
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0114 0.0544
Onchocerca volvulus Huntingtin homolog 0.0124 0.0838 0.3666
Loa Loa (eye worm) Smad1 0.0017 0.0044 0.0128
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.002 0.0009
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0109 0.0214
Trichomonas vaginalis endoplasmin, putative 0.002 0.0069 0.0331
Schistosoma mansoni coup transcription factor 0.0052 0.0304 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.002 0.0008
Onchocerca volvulus Putative cubilin 0.0025 0.0109 0.0477
Onchocerca volvulus Chorion peroxidase homolog 0.0079 0.0506 0.2212
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0235 0.1014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0104 0.0087
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Brugia malayi Pre-SET motif family protein 0.021 0.148 0.4329
Brugia malayi EGF-like domain containing protein 0.0025 0.0109 0.0319
Onchocerca volvulus 0.0025 0.0109 0.0477
Echinococcus granulosus acetylcholinesterase 0.0471 0.342 0.6713
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0658 0.1097
Brugia malayi Carboxylesterase family protein 0.0471 0.342 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0061 0.0179
Mycobacterium ulcerans polyketide synthase 0.0027 0.0117 0.0099
Schistosoma mansoni hypothetical protein 0.0025 0.0109 0.0214
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0205 0.0284
Schistosoma mansoni endoplasmin 0.0033 0.0163 0.0321
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.036
Onchocerca volvulus Slit protein homolog 0.0025 0.0109 0.0477
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0199 0.039
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0101 0.0199
Echinococcus granulosus peroxidasin 0.0079 0.0506 0.0993
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Mycobacterium ulcerans carboxylesterase, LipT 0.008 0.0511 0.0494
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0163 0.0694
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.5094 0.849
Schistosoma mansoni peroxidasin 0.0079 0.0506 0.0993
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0135 0.0264
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.1495
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.002 0.0086
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0304 0.0598
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.0286 0.1253
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0089 0.0148
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Echinococcus multilocularis heat shock protein 90 0.0033 0.0163 0.0272
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0506 0.1479
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0135 0.0559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0148 0.029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0064 0.0127
Onchocerca volvulus Peroxidase homolog 0.0079 0.0506 0.2212
Schistosoma mansoni smad1 5 8 and 0.0017 0.0044 0.0086
Giardia lamblia Grp94/Hsp90 0.0026 0.0114 0.0463
Schistosoma mansoni hypothetical protein 0.0291 0.208 0.4083
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0064 0.0188
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0304 0.0507
Trypanosoma brucei unspecified product 0.0013 0.002 0.0008
Echinococcus multilocularis neurogenic locus protein delta 0.0025 0.0109 0.0182
Brugia malayi EGF-like domain containing protein 0.0025 0.0109 0.0319
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.0511 0.1003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2091 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0117 0.0161
Echinococcus granulosus dna polymerase eta 0.0019 0.0064 0.0127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0304 0.089
Brugia malayi hypothetical protein 0.0024 0.0101 0.0296
Leishmania major DNA polymerase eta, putative 0.0019 0.0064 0.0218
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0117 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1357 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0206 0.0344
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0136 0.0399
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0109 0.0182
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0114 0.0096
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0565 0.0786
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.2163 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0297 1
Schistosoma mansoni hypothetical protein 0.0041 0.0225 0.0442
Giardia lamblia DINP protein human, muc B family 0.0019 0.0064 0.0225
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0064 0.0216
Brugia malayi ecdysone receptor 0.0024 0.0101 0.0296
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0135 0.0648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0304 0.089
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0304 0.0598
Leishmania major trypanothione reductase 0.0038 0.0203 0.0861
Onchocerca volvulus 0.0029 0.0134 0.0588
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0064 0.0218
Brugia malayi hypothetical protein 0.0033 0.0163 0.0478
Schistosoma mansoni BC026374 protein (S09 family) 0.008 0.0511 0.1003
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Onchocerca volvulus 0.0319 0.2287 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0304 0.0598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0135 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0304 0.089
Brugia malayi EGF-like domain containing protein 0.0025 0.0109 0.0319
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.002 0.0038
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0135 0.0648
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0101 0.0199
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2091 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0018 0.0597
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0683 0.1998
Onchocerca volvulus Neurogenic locus notch homolog 0.0025 0.0109 0.0477
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0114 0.011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.0432
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0162 0.0269
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0101 0.0296
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.0511 0.1003
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Loa Loa (eye worm) hypothetical protein 0.0043 0.0237 0.0692
Brugia malayi Hsp90 protein 0.0013 0.002 0.0057
Echinococcus granulosus protein jagged 1 0.0025 0.0109 0.0214
Schistosoma mansoni Smad4 0.0017 0.0044 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Schistosoma mansoni hypothetical protein 0.0025 0.0109 0.0214
Treponema pallidum heat shock protein 90 0.0026 0.0114 0.0096
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.1495
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0506 0.2212
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0637 0.0887
Echinococcus granulosus neurogenic locus notch protein 4 0.0025 0.0109 0.0214
Brugia malayi Pax transcription factor protein 2 0.0253 0.18 0.5265
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0637 0.0887
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0117 0.0161
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0089 0.0175
Echinococcus multilocularis peroxidasin 0.0079 0.0506 0.0843
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0162 0.0317
Echinococcus granulosus family S9 non peptidase ue S09 family 0.008 0.0511 0.1003
Brugia malayi hypothetical protein 0.0027 0.0123 0.036
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0101 0.0443
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0206 0.0405
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0044 0.0086
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0109 0.0319
Schistosoma mansoni cpg binding protein 0.0031 0.0147 0.0288
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0064 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0218
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0135 0.0648
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0135 0.0648
Schistosoma mansoni endoplasmin 0.0033 0.0163 0.0321
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0101 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Onchocerca volvulus 0.0025 0.0109 0.0477
Schistosoma mansoni DNA polymerase eta 0.0019 0.0064 0.0127
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0506 0.1479
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0205 0.0284
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0304 0.1332
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0304 0.089
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0101 0.0169
Brugia malayi Cadherin domain containing protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0101 0.0296
Loa Loa (eye worm) hypothetical protein 0.0319 0.2287 0.6687
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0061 0.0202
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0101 0.0199
Loa Loa (eye worm) glutathione reductase 0.0038 0.0203 0.0592
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0035 0.0018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0162 0.0473
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.002 0.066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0317
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0304 0.0507
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0114 0.0544
Brugia malayi EGF-like domain containing protein 0.0025 0.0109 0.0319
Echinococcus granulosus heat shock protein 90 0.0026 0.0114 0.0223
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0035 0.0018
Toxoplasma gondii hypothetical protein 0.0049 0.0282 0.102
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0162 0.0473
Trichomonas vaginalis C-MYB, putative 0.0029 0.0135 0.0648
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0304 0.0507
Echinococcus multilocularis neural cadherin 0.0025 0.0109 0.0182
Toxoplasma gondii thioredoxin reductase 0.0038 0.0203 0.0733
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0018 0.0085
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0203 0.028
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0304 0.0598
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2091 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Plasmodium vivax heat shock protein, putative 0.0013 0.002 0.066
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.098 0.0964
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0018 0.0597
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0101 0.0169
Brugia malayi Delta serrate ligand family protein 0.0025 0.0109 0.0319
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Brugia malayi Cytochrome P450 family protein 0.0029 0.0136 0.0399
Trichomonas vaginalis MYB3r3, putative 0.0029 0.0135 0.0648
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0064 0.0107
Brugia malayi Blistered cuticle protein 3 0.0079 0.0506 0.1479
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Schistosoma mansoni heat shock protein 0.0033 0.0163 0.0321
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.008 0.0511 0.1003
Echinococcus granulosus heat shock protein 90 0.0033 0.0163 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0101 0.0296
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0135 0.0559
Schistosoma mansoni smad1 5 8 and 0.0017 0.0044 0.0086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0163 0.0782
Brugia malayi CXXC zinc finger family protein 0.0029 0.0134 0.0393
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.1495
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0018 0.0022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.0107
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0304 0.089
Loa Loa (eye worm) hypothetical protein 0.0099 0.0658 0.1924
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.002 0.066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0304 0.0598
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0506 0.1479
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0061 0.0179
Onchocerca volvulus 0.0048 0.0274 0.1198
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0163 0.0592
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0163 0.0679
Schistosoma mansoni patched 1 0.0043 0.0237 0.0464
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0148 0.0535
Schistosoma mansoni gliotactin 0.008 0.0511 0.1003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0134 0.0393
Brugia malayi Muscle positioning protein 4 0.0025 0.0109 0.0319
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0383 0.2761 1
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0163 0.0694
Echinococcus granulosus tumor protein p63 0.0355 0.256 0.5025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1102 0.1537
Echinococcus granulosus cpg binding protein 0.0031 0.0147 0.0288
Loa Loa (eye worm) hypothetical protein 0.0471 0.342 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0079 0.0506 0.1479
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0136 0.0652
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0161 0.0317
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0163 0.55
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0161 0.0472
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.2091 0.2077
Schistosoma mansoni hypothetical protein 0.035 0.252 0.4948
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0136 0.0652
Onchocerca volvulus 0.0239 0.1695 0.7414
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Echinococcus multilocularis GPCR, family 2 0.0033 0.0161 0.0269
Brugia malayi Calcium binding EGF domain containing protein 0.0025 0.0109 0.0319
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0163 0.0679
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Onchocerca volvulus 0.0031 0.0148 0.0646
Mycobacterium ulcerans hypothetical protein 0.0159 0.1102 0.1086
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0163 0.0703
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Schistosoma mansoni smad1 5 8 and 0.0017 0.0044 0.0086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0308 0.09
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0974 0.7158 1
Brugia malayi ecdysteroid receptor 0.0052 0.0304 0.089
Echinococcus multilocularis notch 0.0025 0.0109 0.0182
Brugia malayi Carboxylesterase family protein 0.008 0.0511 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0304 0.089
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0162 0.0269
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.1495
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0114 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0237 0.1131
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0304 0.089
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0065 0.0047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0565 0.0743
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0402 0.1789
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.002 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0304 0.1335
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0304 0.0598
Onchocerca volvulus Huntingtin homolog 0.0124 0.0838 0.3666
Echinococcus granulosus slit 2 protein 0.0025 0.0109 0.0214
Brugia malayi heat shock protein 90 0.0033 0.0163 0.0478
Echinococcus multilocularis protein jagged 2 0.0025 0.0109 0.0182
Leishmania major DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0018 0.0018
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0304 0.0598
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0163 0.0679
Loa Loa (eye worm) notch protein 0.0025 0.0109 0.0319
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0135 0.0559
Schistosoma mansoni heat shock protein 0.0013 0.002 0.0038
Echinococcus granulosus neuroligin 0.008 0.0511 0.1003
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.5094 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.036
Schistosoma mansoni hypothetical protein 0.0025 0.0109 0.0214
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0402 0.1789
Echinococcus granulosus protein jagged 1 0.0025 0.0109 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Echinococcus multilocularis fibropellin Ia 0.0025 0.0109 0.0182
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0506 0.1479
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0237 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0506 0.1479
Schistosoma mansoni heat shock protein 0.0033 0.0163 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.002 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0304 0.089
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0161 0.0472
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0296
Brugia malayi hypothetical protein 0.0319 0.2287 0.6687
Loa Loa (eye worm) hypothetical protein 0.0052 0.0304 0.089
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0199 0.0331
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0565 0.0786
Echinococcus multilocularis neurogenic locus protein delta 0.0025 0.0109 0.0182
Leishmania major cytochrome p450-like protein 0.0019 0.0061 0.0202
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0304 0.0507
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0297 0.1302
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0975 0.1625
Loa Loa (eye worm) hypothetical protein 0.008 0.0511 0.1495
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0018 0.0085
Plasmodium falciparum thioredoxin reductase 0.0038 0.0203 0.6815
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0506 0.2212
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.011 0.0151
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0064 0.0308
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.0286 0.0838
Brugia malayi Carboxylesterase family protein 0.008 0.0511 0.1495
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0383 0.0753
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0101 0.0199
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0335 0.1212
Leishmania major heat shock protein 83-1 0.0033 0.0163 0.0679
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0162 0.0671
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0162 0.544
Trichomonas vaginalis MYB, putative 0.0029 0.0136 0.0652
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0163 0.0679
Echinococcus multilocularis endoplasmin 0.0026 0.0114 0.019
Loa Loa (eye worm) hypothetical protein 0.0124 0.0838 0.2452
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0975 0.1914
Plasmodium vivax glutathione reductase, putative 0.0038 0.0203 0.6815
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Onchocerca volvulus 0.008 0.0511 0.2235
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0101 0.0199
Trypanosoma brucei heat shock protein, putative 0.0033 0.0163 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0304 0.089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0064 0.0087
Onchocerca volvulus 0.0079 0.0506 0.2212
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0114 0.0156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0101 0.0169
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0161 0.0269
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0237 0.0464
Echinococcus granulosus expressed conserved protein 0.0093 0.0613 0.1204
Brugia malayi MH2 domain containing protein 0.0017 0.0044 0.0128
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Schistosoma mansoni notch 0.0025 0.0109 0.0214
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0669 0.1314
Loa Loa (eye worm) carboxylesterase 0.0471 0.342 1
Trypanosoma brucei unspecified product 0.0013 0.002 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0123 0.0241
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0123 0.0241
Echinococcus multilocularis acetylcholinesterase 0.0471 0.342 0.5699
Onchocerca volvulus 0.0079 0.0506 0.2212
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0235 0.1014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0148 0.029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0304 0.089
Onchocerca volvulus 0.0052 0.0304 0.1332
Onchocerca volvulus 0.008 0.0511 0.2235
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0043
Echinococcus granulosus acetylcholinesterase 0.0471 0.342 0.6713
Loa Loa (eye worm) hypothetical protein 0.0079 0.0506 0.1479
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0304 0.089
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.1741 0.5091
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.011 0.0321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0101 0.0199
Schistosoma mansoni hypothetical protein 0.0025 0.0109 0.0214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0148 0.029
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0018 0.0064
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0506 0.1479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0304 0.089
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0101 0.0199
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0065 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0304 0.0598
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0218
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0018 0.0064
Echinococcus granulosus protein jagged 2 0.0025 0.0109 0.0214
Echinococcus multilocularis slit 2 protein 0.0025 0.0109 0.0182
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.148 0.4329
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0104 0.0143
Plasmodium falciparum glutathione reductase 0.0013 0.0018 0.0597
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0304 0.0598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Onchocerca volvulus Dual oxidase homolog 0.0079 0.0506 0.2212
Brugia malayi hypothetical protein 0.0027 0.0123 0.036
Echinococcus multilocularis acetylcholinesterase 0.0471 0.342 0.5699
Onchocerca volvulus 0.0024 0.0101 0.0443
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Brugia malayi Endoplasmin precursor 0.0033 0.0163 0.0478
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0162 0.0585
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0109 0.0182
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0383 0.2761 0.3827
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0114 0.0448
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.2091 1
Brugia malayi CHE-14 protein 0.0043 0.0237 0.0692
Loa Loa (eye worm) hypothetical protein 0.0471 0.342 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0304 0.0598
Loa Loa (eye worm) carboxylesterase 0.008 0.0511 0.1495
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0064 0.0127
Echinococcus granulosus BC026374 protein S09 family 0.008 0.0511 0.1003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0148 0.0246
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0317
Schistosoma mansoni notch 0.0025 0.0109 0.0214
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0101 0.0169
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0114 0.0463
Brugia malayi glutathione reductase 0.0038 0.0203 0.0592
Onchocerca volvulus 0.008 0.0511 0.2235
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0402 0.0669
Echinococcus granulosus X box binding protein 1 0.0291 0.208 0.4083
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.2163 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0319
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0162 0.0223
Loa Loa (eye worm) hypothetical protein 0.0124 0.0838 0.2452
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0065 0.0234
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0237 0.0464
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0297 0.1076
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0064 0.0188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0304 0.0598
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0148 0.0246
Trichomonas vaginalis MYB72, putative 0.0029 0.0135 0.0648
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0018 0.003
Plasmodium vivax endoplasmin, putative 0.0033 0.0163 0.55
Echinococcus multilocularis neuroligin 0.008 0.0511 0.0852
Schistosoma mansoni hypothetical protein 0.035 0.252 0.4948
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0123 0.0205
Echinococcus granulosus notch 0.0025 0.0109 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0218

Activities

Activity type Activity value Assay description Source Reference
logP (ADMET) = 7.67 Partition coefficient (logP) ChEMBL. 11334564
Ratio (functional) = 3.61 Tumor and skin uptake ratio of the compound ChEMBL. 11334564
Skin uptake (functional) = 1.78 uM Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564
Skin uptake (functional) = 1.78 uM Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564
Tumor uptake (functional) = 6.42 uM Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564
Tumor uptake (functional) = 6.42 uM Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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