Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0281 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0281 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0281 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0281 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0281 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0281 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0281 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0281 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 98 nM | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | ChEMBL. | 12039560 |
Ki (binding) | = 340 nM | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | ChEMBL. | 12039560 |
Ki (binding) | = 1230 nM | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | ChEMBL. | 12039560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.