Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1246 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0076 | 0.0463 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 0.0463 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 0.0463 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 0.0463 | 0.0573 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0351 | 0.2706 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0059 | 0.0323 | 0.6551 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 0.0463 | 0.6341 |
Brugia malayi | glutathione reductase | 0.0076 | 0.0463 | 0.3966 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0686 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 0.0463 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.0895 | 0.7136 | 1 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0029 | 0.0076 | 0.0219 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0086 | 0.0547 | 0.5679 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0076 | 0.0461 | 0.9973 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0106 | 0.0708 | 0.6073 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.0057 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0076 | 0.0461 | 0.9973 |
Schistosoma mansoni | ryanodine receptor related | 0.0106 | 0.0708 | 0.755 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 0.0463 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 0.0463 | 0.7866 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 0.0463 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.009 | 0.0572 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 0.0463 | 0.6341 |
Leishmania major | hypothetical protein, conserved | 0.0061 | 0.0339 | 0.6944 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.0057 | 0.0489 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0132 | 0.0919 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0351 | 0.2706 | 0.2664 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.067 | 0.9738 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 0.0463 | 0.1531 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0059 | 0.0323 | 0.6551 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.0057 | 0.5 |
Brugia malayi | cation channel family protein | 0.0162 | 0.1166 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.0057 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.009 | 0.0572 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 0.0463 | 0.7866 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0351 | 0.2706 | 0.2664 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.0895 | 0.7136 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0547 | 0.7724 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1246 | 1 | 1 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0351 | 0.2706 | 0.3741 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 0.0463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0461 | 0.6324 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1246 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 0.0463 | 0.3966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 mM | In vitro inhibitory activity against Selectin E binding to human recombinant AGP (alpha-1 acid glycoprotein) | ChEMBL. | 11206447 |
IC50 (binding) | = 3 mM | In vitro inhibitory activity against Selectin E binding to human recombinant AGP (alpha-1 acid glycoprotein) | ChEMBL. | 11206447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.