Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0025 | 0.033 | 0.5463 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0502 | 0.0554 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0502 | 0.0472 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0502 | 0.0215 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.033 | 0.4065 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0027 | 0.0364 | 0.481 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.0364 | 0.481 |
Trypanosoma brucei | ISWI complex protein | 0.0016 | 0.014 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0368 | 0.0077 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0181 | 0.0064 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0241 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1343 | 0.1317 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.2337 | 0.2314 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0174 | 0.288 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.0603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0744 | 0.0716 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0267 | 0.0237 |
Echinococcus granulosus | muscleblind protein | 0.0461 | 1 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0051 | 0.091 | 0.118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.2861 | 0.2729 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0051 | 0.091 | 0.118 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0139 | 0.2861 | 0.2839 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.128 | 0.1747 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0058 | 0.1067 | 0.0901 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0196 | 0.0166 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0502 | 0.0326 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0502 | 0.0554 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0229 | 0.3792 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.0364 | 0.6033 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.2656 | 0.3855 |
Mycobacterium ulcerans | polyketide synthase | 0.0025 | 0.033 | 0.4065 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0502 | 0.0326 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0221 | 0.172 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0058 | 0.1067 | 0.0901 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.0293 | 0.0263 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0025 | 0.033 | 0.0037 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0201 | 0.4243 | 0.4136 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.2337 | 0.2106 |
Leishmania major | hypothetical protein, conserved | 0.0016 | 0.014 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0181 | 0.0064 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.2656 | 0.3855 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.0313 | 0.5182 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0221 | 0.172 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.2656 | 0.3855 |
Brugia malayi | RNA binding protein | 0.013 | 0.2656 | 0.2434 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0181 | 0.0151 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0058 | 0.1067 | 0.0797 |
Mycobacterium ulcerans | thioesterase | 0.0021 | 0.0237 | 0.2064 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.033 | 0.4065 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0086 | 0.0056 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0021 | 0.0237 | 0.2064 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0502 | 0.0326 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0051 | 0.091 | 0.0742 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0021 | 0.0237 | 0.3934 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0139 | 0.2861 | 0.2645 |
Brugia malayi | TAR-binding protein | 0.013 | 0.2656 | 0.2434 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0502 | 0.0554 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.033 | 0.4065 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0051 | 0.091 | 0.0882 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.2337 | 0.2314 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0058 | 0.1067 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1457 | 0.143 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0027 | 0.0364 | 0.481 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1343 | 0.1844 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0027 | 0.0364 | 0.481 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.2656 | 0.2633 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0706 | 0.0677 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0241 | 0.0156 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.063 | 0.0457 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0502 | 0.0326 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0461 | 1 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0051 | 0.091 | 0.0742 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1343 | 0.1082 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0293 | 0.4861 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0027 | 0.0364 | 0.6033 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0027 | 0.0364 | 0.6033 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0051 | 0.091 | 0.0742 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.0603 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0027 | 0.0364 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.014 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.0603 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.2656 | 0.3855 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.2656 | 0.2633 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0241 | 0.0061 |
Brugia malayi | mbt repeat family protein | 0.0051 | 0.091 | 0.0635 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0025 | 0.033 | 0.5463 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.2069 | 0.2044 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0312 | 0.0133 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.2861 | 0.2729 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0221 | 0.172 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.0135 | 0.2574 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0051 | 0.091 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.033 | 0.5463 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.2656 | 0.2633 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3411 | 0.329 |
Onchocerca volvulus | 0.0051 | 0.091 | 1 | |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0181 | 0.0064 |
Mycobacterium ulcerans | polyketide synthase | 0.0027 | 0.0364 | 0.481 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.079 | 0.0761 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0688 | 0.0659 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.063 | 0.0457 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0502 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.6666 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0201 | 0.4243 | 0.4136 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3411 | 0.5013 |
Mycobacterium ulcerans | thioesterase TesA | 0.0021 | 0.0237 | 0.2064 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0312 | 0.0264 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.2861 | 0.417 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0027 | 0.0364 | 0.481 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0502 | 0.0326 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.033 | 0.4065 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0045 | 0.0774 | 0.7794 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.1195 | 0.1032 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.2861 | 0.2729 |
Onchocerca volvulus | 0.0043 | 0.0739 | 0.7237 | |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0267 | 0.0194 |
Brugia malayi | Bromodomain containing protein | 0.008 | 0.1558 | 0.1303 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0181 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0502 | 0.0554 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2069 | 0.2044 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.2656 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.091 | 0.0882 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0091 | 0.1505 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0047 | 0.0825 | 0.0548 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.1195 | 0.1032 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.0603 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0051 | 0.091 | 0.118 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.2656 | 0.3855 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1067 | 0.1039 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.2861 | 0.2729 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0025 | 0.033 | 0.4065 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.0686 | 0.0405 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0502 | 0.0326 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.2656 | 0.252 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0051 | 0.091 | 0.0742 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3411 | 0.5013 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.014 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0461 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0502 | 0.0472 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.2656 | 0.2434 |
Echinococcus granulosus | geminin | 0.0164 | 0.3411 | 0.329 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.2861 | 0.417 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0312 | 0.0133 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0025 | 0.033 | 0.4065 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.0313 | 0.5182 |
Brugia malayi | mbt repeat family protein | 0.0051 | 0.091 | 0.0635 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.017 | 0.3708 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.2861 | 0.417 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0058 | 0.1067 | 0.142 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.2069 | 0.1829 |
Loa Loa (eye worm) | MBCTL1 | 0.0058 | 0.1067 | 0.1039 |
Loa Loa (eye worm) | fatty acid synthase | 0.0025 | 0.0322 | 0.0292 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0058 | 0.1067 | 0.0901 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.2069 | 0.1829 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.