Detailed information for compound 539053

Basic information

Technical information
  • TDR Targets ID: 539053
  • Name: N-[(1R)-2-(4-aminophenyl)-1-(hydroxymethyl)-2 -oxo-ethyl]-2,2-dichloro-acetamide
  • MW: 291.131 | Formula: C11H12Cl2N2O3
  • H donors: 3 H acceptors: 3 LogP: 0.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](C(=O)c1ccc(cc1)N)NC(=O)C(Cl)Cl
  • InChi: 1S/C11H12Cl2N2O3/c12-10(13)11(18)15-8(5-16)9(17)6-1-3-7(14)4-2-6/h1-4,8,10,16H,5,14H2,(H,15,18)/t8-/m1/s1
  • InChiKey: ZHFOKHSFTCVZFC-MRVPVSSYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1R)-2-(4-aminophenyl)-1-(hydroxymethyl)-2-oxoethyl]-2,2-dichloroacetamide
  • N-[(2R)-1-(4-aminophenyl)-3-hydroxy-1-oxo-propan-2-yl]-2,2-dichloro-ethanamide
  • N-[(1R)-2-(4-aminophenyl)-2-keto-1-methylol-ethyl]-2,2-dichloro-acetamide
  • N-[(2R)-1-(4-aminophenyl)-3-hydroxy-1-oxopropan-2-yl]-2,2-dichloroacetamide
  • aminodehydrochloramphenicol
  • 129085-22-9
  • (R)-N-(2-(4-Aminophenyl)-1-(hydroxymethyl)-2-oxoethyl)-2,2-dichloroacetamide
  • Acetamide, N-(2-(4-aminophenyl)-1-(hydroxymethyl)-2-oxoethyl)-2,2-dichloro-, (R)-
  • Adhcap

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0595 0.2623
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0524 0.1665
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0294 0.1005
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0294 0.0294
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0107 0.1382 0.1366
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1502 0.5131
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0019
Schistosoma mansoni lamin 0.0028 0.0195 0.0195
Echinococcus multilocularis zinc finger protein 0.006 0.068 0.0662
Loa Loa (eye worm) hypothetical protein 0.0034 0.029 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0126 0.3182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0543 0.0543
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0005 0.0015
Onchocerca volvulus 0.004 0.0388 0.2324
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0294 0.1181
Echinococcus granulosus cathepsin l1 0.0034 0.0294 0.0276
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0595 0.268
Echinococcus granulosus peptidase Clp S14 family 0.0103 0.1326 0.1309
Trypanosoma brucei ISWI complex protein 0.0046 0.0465 0.2493
Loa Loa (eye worm) hypothetical protein 0.0028 0.0195 0.0667
Loa Loa (eye worm) hypothetical protein 0.0034 0.0294 0.1005
Entamoeba histolytica cysteine protease, putative 0.0034 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0524 0.1788
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0126 0.04
Schistosoma mansoni zinc finger protein 0.006 0.068 0.068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0294 0.0276
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0294 0.1493
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0294 0.1472
Brugia malayi Cathepsin L-like precursor 0.0034 0.0294 0.0935
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0294 0.0276
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.2135 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0294 0.1493
Onchocerca volvulus 0.0034 0.0294 0.1493
Brugia malayi Bromodomain containing protein 0.0226 0.3142 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0553 0.0535
Loa Loa (eye worm) hypothetical protein 0.0122 0.1596 0.545
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0195 0.062
Loa Loa (eye worm) bromodomain containing protein 0.0053 0.0571 0.1949
Echinococcus granulosus cathepsin L 0.0018 0.0048 0.0029
Leishmania major cathepsin L-like protease 0.013 0.1724 1
Echinococcus multilocularis tumor protein p63 0.0673 0.9808 0.9808
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0126 0.3182
Schistosoma mansoni bromodomain containing protein 0.0191 0.2622 0.2622
Loa Loa (eye worm) hypothetical protein 0.0099 0.1253 0.4278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Echinococcus granulosus cathepsin l1 0.0023 0.0126 0.0107
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0057 0.0634 0.3496
Echinococcus granulosus zinc finger protein 0.006 0.068 0.0662
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0543 0.0525
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.1253 0.1253
Leishmania major cathepsin L-like protease 0.013 0.1724 1
Mycobacterium tuberculosis Hypothetical protein 0.0019 0.0072 0.0194
Echinococcus multilocularis dihydrofolate reductase 0.0017 0.0031 0.0012
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0543 0.0543
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0195 0.0667
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0069 0.0812 0.0794
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0103 0.1326 0.6153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.2928 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0687 0.0687
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0294 0.0294
Leishmania major hypothetical protein, conserved 0.0046 0.0465 0.1197
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0019 0.006
Echinococcus multilocularis cpg binding protein 0.0036 0.032 0.0301
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0057 0.0634 0.2807
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0158 0.2135 1
Echinococcus multilocularis cysteine protease 0.0034 0.0294 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Onchocerca volvulus 0.0028 0.0195 0.0613
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0158 0.2135 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0126 0.3182
Brugia malayi hypothetical protein 0.0019 0.0072 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1502 0.5131
Onchocerca volvulus 0.0034 0.0294 0.1493
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0195 0.0667
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.1724 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.004 0.0388 0.1689
Echinococcus granulosus lamin 0.0028 0.0195 0.0176
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0294 0.1181
Loa Loa (eye worm) hypothetical protein 0.0158 0.2135 0.7293
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0048 0.0151
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0158 0.2135 0.212
Brugia malayi Cathepsin L-like precursor 0.0034 0.0294 0.0935
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.2135 1
Onchocerca volvulus 0.0028 0.0195 0.0613
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0057 0.0634 0.2807
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.1888
Echinococcus granulosus dihydrofolate reductase 0.0017 0.0031 0.0012
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0294 0.0276
Echinococcus granulosus lamin dm0 0.0028 0.0195 0.0176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Onchocerca volvulus 0.0099 0.1253 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0294 0.1005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Onchocerca volvulus 0.0034 0.0294 0.1493
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0158 0.2135 0.212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0524 0.1788
Echinococcus multilocularis musashi 0.0028 0.0195 0.0176
Echinococcus multilocularis microtubule associated protein 2 0.0686 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0126 0.0431
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0107 0.1382 0.1366
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0294 0.0276
Onchocerca volvulus 0.0034 0.0294 0.1493
Loa Loa (eye worm) hypothetical protein 0.0129 0.1705 0.5823
Echinococcus multilocularis lamin 0.0028 0.0195 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0553 0.0553
Brugia malayi MH2 domain containing protein 0.0115 0.1502 0.478
Echinococcus granulosus dnaJ subfamily B 0.0407 0.584 0.5832
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.2135 1
Schistosoma mansoni microtubule-associated protein tau 0.0686 1 1
Onchocerca volvulus 0.0034 0.0294 0.1493
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0019 0.0065
Echinococcus multilocularis lamin dm0 0.0028 0.0195 0.0176
Mycobacterium ulcerans thymidylate synthase 0.004 0.0388 0.1689
Schistosoma mansoni dihydrofolate reductase 0.0017 0.0031 0.0031
Brugia malayi dihydrofolate reductase family protein 0.0017 0.0031 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.2135 0.9961
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0048 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Schistosoma mansoni cpg binding protein 0.0036 0.032 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Schistosoma mansoni hypothetical protein 0.0046 0.0465 0.0465
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0019 0.006
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.004 0.0388 0.1696
Loa Loa (eye worm) fibroinase 0.0034 0.0294 0.1005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0641
Echinococcus multilocularis cathepsin L 0.0018 0.0048 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Trypanosoma cruzi ISWI complex protein 0.0046 0.0465 0.2493
Echinococcus granulosus cpg binding protein 0.0036 0.032 0.0301
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0019 0.0072 0.0146
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0158 0.2135 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0211 0.072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0294 1
Loa Loa (eye worm) dihydrofolate reductase 0.0017 0.0031 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0702 0.2399
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0103 0.1326 0.6129
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.1309 0.7525
Echinococcus granulosus intermediate filament protein 0.0028 0.0195 0.0176
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0048 0.0151
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0019
Echinococcus granulosus thymidylate synthase 0.004 0.0388 0.037
Onchocerca volvulus 0.0034 0.0294 0.1493
Echinococcus multilocularis cysteine protease 0.0034 0.0294 0.0276
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.004 0.0388 0.0388
Onchocerca volvulus 0.0029 0.0211 0.0751
Brugia malayi thymidylate synthase 0.004 0.0388 0.1234
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0294 1
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.1724 1
Toxoplasma gondii hypothetical protein 0.0054 0.0595 0.1634
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0069 0.0812 0.0812
Brugia malayi Cathepsin L-like precursor 0.0023 0.0126 0.04
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.2135 0.9961
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Echinococcus granulosus cysteine protease 0.0018 0.0048 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0524 0.1665
Brugia malayi Bromodomain containing protein 0.0114 0.1487 0.4733
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0553 0.0553
Schistosoma mansoni zinc finger protein 0.0046 0.0465 0.0465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Schistosoma mansoni hypothetical protein 0.0034 0.029 0.029
Echinococcus granulosus tumor protein p63 0.0673 0.9808 0.9808
Echinococcus granulosus fetal alzheimer antigen falz 0.0069 0.0812 0.0794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Brugia malayi Dihydrofolate reductase 0.0017 0.0031 0.0098
Brugia malayi PHD-finger family protein 0.0076 0.0917 0.2917
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0294 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0294 0.0935
Leishmania major cathepsin L-like protease 0.013 0.1724 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Plasmodium vivax vivapain-2 0.0034 0.0294 0.1181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0158 0.2135 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0294 0.1181
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0294 0.0935
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0057 0.0634 0.3496
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0057 0.0634 0.1843
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0103 0.1326 0.6129
Echinococcus multilocularis peptidase Clp (S14 family) 0.0103 0.1326 0.1309
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0294 0.1493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0294 0.0276
Schistosoma mansoni cpg binding protein 0.0036 0.032 0.032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0294 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0158 0.2135 0.2135
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Schistosoma mansoni lamin 0.0028 0.0195 0.0195
Loa Loa (eye worm) thymidylate synthase 0.004 0.0388 0.1325
Loa Loa (eye worm) hypothetical protein 0.0023 0.0126 0.0431
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0294 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Brugia malayi intermediate filament protein 0.0028 0.0195 0.062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.018 0.2463 0.2448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.1724 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.2135 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1724 1
Schistosoma mansoni hypothetical protein 0.0407 0.584 0.584
Brugia malayi cathepsin L-like precursor 0.0023 0.0126 0.04
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0057 0.0634 0.2374
Brugia malayi Cathepsin L-like precursor 0.0034 0.0294 0.0935
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0294 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0294 0.0935
Loa Loa (eye worm) cysteine protease 0.0034 0.0294 0.1005
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.1724 1
Echinococcus multilocularis thymidylate synthase 0.004 0.0388 0.037
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0005 0.0017
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0553 0.0535
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0543 0.0525
Plasmodium vivax vivapain-2 0.0034 0.0294 0.1181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Brugia malayi Probable ClpP-like protease 0.0158 0.2135 0.6795
Onchocerca volvulus 0.0034 0.0294 0.1493
Loa Loa (eye worm) hypothetical protein 0.0115 0.1491 0.5091
Schistosoma mansoni intermediate filament proteins 0.0028 0.0195 0.0195
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.1555 0.8997
Brugia malayi Cathepsin L-like precursor 0.0023 0.0126 0.04
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0294 1
Loa Loa (eye worm) ctsf protein 0.0034 0.0294 0.1005
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0595 0.2623
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.584 0.5832
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0065
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0062 0.0702 0.0702
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0158 0.2143 1
Schistosoma mansoni cpg binding protein 0.0029 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0023 0.0126 0.0431
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.029 0.0922
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0158 0.2135 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.018 0.2463 0.2448
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0158 0.2143 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0696 0.2183
Brugia malayi CXXC zinc finger family protein 0.0029 0.0211 0.067
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0048 0.0048
Trypanosoma cruzi ISWI complex protein 0.0046 0.0465 0.2493
Brugia malayi Cathepsin L-like precursor 0.0034 0.0294 0.0935

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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