Detailed information for compound 539407

Basic information

Technical information
  • TDR Targets ID: 539407
  • Name: 2-nitro-1-nitroso-1-propyl-guanidine
  • MW: 175.146 | Formula: C4H9N5O3
  • H donors: 1 H acceptors: 3 LogP: 0.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=N[N+](=O)[O-])N)N=O
  • InChi: 1S/C4H9N5O3/c1-2-3-8(7-10)4(5)6-9(11)12/h2-3H2,1H3,(H2,5,6)
  • InChiKey: PVVCHFOAZOVDRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-nitro-1-nitroso-1-propylguanidine
  • propyl-N'-nitro-N-nitrosoguanidine
  • [[amino-(nitroso-propylamino)methylidene]amino]-hydroxy-oxoazanium
  • [[amino-(nitroso-propyl-amino)methylene]amino]-hydroxy-oxo-ammonium
  • [[amino-(nitroso-propylamino)methylene]amino]-hydroxy-oxoammonium
  • [[amino-(nitroso-propyl-amino)methylene]amino]-hydroxy-keto-ammonium
  • [[amino-(nitroso-propyl-amino)methylidene]amino]-hydroxy-oxo-azanium
  • 13010-07-6
  • Guanidine, N'-nitro-N-nitroso-N-propyl-
  • NSC33674
  • 3-Nitro-1-nitroso-1-propylguanidine
  • CCRIS 1255
  • EINECS 235-856-6
  • GUANIDINE, 3-NITRO-1-NITROSO-1-PROPYL-
  • Guanidine, N'-nitro-N-nitroso-N-propyl- (9CI)
  • N'-Nitro-N-nitroso-N-propylguanidine
  • N-Nitroso-N'-nitro-N-propylguanidine
  • N-Propyl-N'-nitro-N-nitrosoguanidine
  • NSC 33674

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3847 0.6815
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.2588 0.2588
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0765 0.0765
Brugia malayi hypothetical protein 0.0011 0.0082 0.0082
Echinococcus granulosus muscleblind protein 0.0149 1 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0765 0.0765
Brugia malayi TAR-binding protein 0.0063 0.3847 0.3847
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.2588 0.2588
Loa Loa (eye worm) hypothetical protein 0.0088 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2588 0.4585
Loa Loa (eye worm) hypothetical protein 0.0011 0.0082 0.0082
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0765 0.0765
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0765 0.0765
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0765 0.0765
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0765 0.0765
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0765 0.0765
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0765 0.0765
Loa Loa (eye worm) RNA binding protein 0.0063 0.3847 0.3847
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3847 0.6815
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0765 0.0765
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0082 0.0082
Loa Loa (eye worm) TAR-binding protein 0.0063 0.3847 0.3847
Loa Loa (eye worm) hypothetical protein 0.0011 0.0082 0.0082
Brugia malayi nuclear hormone receptor 0.002 0.0765 0.0765
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0765 0.0765
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Brugia malayi hypothetical protein 0.0088 0.5645 0.5645
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0765 0.0765
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0765 0.1356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0765 0.0765
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0765 0.1356
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2588 0.2588
Schistosoma mansoni eyes absent homolog 0.0088 0.5645 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0765 0.1356
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.3847 0.3847
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.789 0.789
Schistosoma mansoni nuclear hormone receptor 0.002 0.0765 0.1356
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3847 0.6815
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0765 1
Brugia malayi RNA binding protein 0.0063 0.3847 0.3847
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0765 0.0765
Onchocerca volvulus 0.002 0.0765 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0765 0.0765
Brugia malayi MH2 domain containing protein 0.0119 0.789 0.789
Schistosoma mansoni coup transcription factor 0.002 0.0765 0.1356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0765 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0765 0.0765
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3847 0.6815
Echinococcus multilocularis muscleblind protein 1 0.0149 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0765 0.0765
Echinococcus granulosus tar DNA binding protein 0.0063 0.3847 0.3847
Schistosoma mansoni thyroid hormone receptor 0.002 0.0765 0.1356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0765 0.0765
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0765 0.1356
Schistosoma mansoni thyroid hormone receptor 0.002 0.0765 0.1356
Brugia malayi hypothetical protein 0.0011 0.0082 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0765 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2588 0.2588
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0765 0.0765
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0765 0.1356
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.3847 0.3847
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0765 0.0765
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0765 0.0765
Schistosoma mansoni tar DNA-binding protein 0.0063 0.3847 0.6815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2588 0.2588
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765
Brugia malayi nuclear receptor RXR 0.0011 0.0082 0.0082
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0082 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0082 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0765 0.0765
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0082 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0011 0.0082 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0765 0.0765
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0082 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0765 0.0765
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0765 0.0765
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0765 0.0765
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0765 0.0765
Echinococcus multilocularis tar DNA binding protein 0.0063 0.3847 0.3847
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0765 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0765 0.0765
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0011 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2588 0.4585
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0765 0.1356
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0765 0.1356
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765
Brugia malayi ecdysteroid receptor 0.002 0.0765 0.0765
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0765 0.0765
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0765 0.1356
Echinococcus granulosus FTZ F1 alpha 0.002 0.0765 0.0765
Brugia malayi nuclear receptor NHR-88 0.002 0.0765 0.0765
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0765 0.1356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2588 0.2588
Brugia malayi steroid hormone receptor 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0088 0.5645 0.5645
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0765 0.0765
Echinococcus multilocularis muscleblind protein 0.0149 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0082 0.0082
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0082 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0765 0.0765
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2588 0.4585
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0765 0.0765
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0082 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.789 0.789
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0765 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.0765

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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