Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0372 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0372 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0372 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0372 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0372 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0372 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0372 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0372 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 12.6 nM | Inhibitory activity in displacing [125I]- RTI-55 binding to dopamine transporter in rat striatal membranes | ChEMBL. | 11334561 |
IC50 (binding) | = 12.6 nM | Inhibitory activity in displacing [125I]- RTI-55 binding to dopamine transporter in rat striatal membranes | ChEMBL. | 11334561 |
Ki (binding) | = 15.8 nM | Affinity for the displacement of [3H]-paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Ki (binding) | = 15.8 nM | Affinity for the displacement of [3H]-paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Ki (binding) | = 498 nM | Affinity for the displacement of [3H]-paroxetine binding to norepinephrine transporter (NET) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Ki (binding) | = 498 nM | Affinity for the displacement of [3H]-paroxetine binding to norepinephrine transporter (NET) in rat frontal cortex membranes | ChEMBL. | 11334561 |
Potency ratio (binding) | = 0.8 | SERT/DAT (serotonin transporter/dopamine transporter) binding potency ratio | ChEMBL. | 11334561 |
Potency ratio (binding) | = 32 | SERT/NET binding potency ratio | ChEMBL. | 11334561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.