Detailed information for compound 539857

Basic information

Technical information
  • TDR Targets ID: 539857
  • Name: (2-methyl-4-phosphonooxy-1-naphthyl) dihydrog en phosphate
  • MW: 334.156 | Formula: C11H12O8P2
  • H donors: 4 H acceptors: 6 LogP: 0.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(OP(=O)(O)O)c2c(c1OP(=O)(O)O)cccc2
  • InChi: 1S/C11H12O8P2/c1-7-6-10(18-20(12,13)14)8-4-2-3-5-9(8)11(7)19-21(15,16)17/h2-6H,1H3,(H2,12,13,14)(H2,15,16,17)
  • InChiKey: JTNHOVZOOVVGHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2-methyl-4-phosphonooxy-naphthalen-1-yl) dihydrogen phosphate
  • (2-methyl-4-phosphonooxynaphthalen-1-yl) dihydrogen phosphate
  • menadiol
  • 1,4-Naphthalenediol, 2-methyl-, bis(dihydrogen phosphate)
  • Menadiol bis(dihydrogen phosphate)
  • Menadiol diphosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni microtubule-associated protein tau 0.0709 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0497 0.0971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Brugia malayi uridine phosphorylase family protein 0.0085 0.0954 0.1713
Brugia malayi MH2 domain containing protein 0.0372 0.5112 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0497 0.0801
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0186 0.0183
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0281 0.0253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Loa Loa (eye worm) Smad1 0.0025 0.0095 0.0185
Leishmania major methylthioadenosine phosphorylase, putative 0.0085 0.0954 0.076
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0253 0.0316
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0301 0.4084 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0318 0.433 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Treponema pallidum uridine phosphorylase (udp) 0.0216 0.285 1
Schistosoma mansoni purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Echinococcus multilocularis lamin dm0 0.0059 0.0584 0.0556
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0245
Schistosoma mansoni methylthioadenosine phosphorylase 0.0085 0.0954 0.0927
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0281 0.0253
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0085 0.0954 0.0927
Schistosoma mansoni smad1 5 8 and 0.0025 0.0095 0.0065
Echinococcus multilocularis purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0301 0.4084 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0584 0.1142
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0095 0.0065
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0216 0.285 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Loa Loa (eye worm) hypothetical protein 0.0027 0.0125 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Loa Loa (eye worm) hypothetical protein 0.0059 0.0584 0.1142
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0085 0.0954 0.1464
Echinococcus multilocularis microtubule associated protein 2 0.0709 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0075 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0676 0.0762
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0584 0.0975
Brugia malayi PHD-finger family protein 0.0027 0.0112 0.0034
Schistosoma mansoni purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Brugia malayi hypothetical protein 0.0035 0.0237 0.0283
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0095 0.0065
Toxoplasma gondii phosphorylase family protein 0.0085 0.0954 0.2033
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0085 0.0954 0.1464
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0237 0.0208
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0095 0.0065
Echinococcus multilocularis musashi 0.0059 0.0584 0.0556
Echinococcus multilocularis uridine phosphorylase 1 0.0085 0.0954 0.0927
Toxoplasma gondii phosphorylase family protein 0.0085 0.0954 0.2033
Echinococcus granulosus lamin 0.0059 0.0584 0.0556
Mycobacterium ulcerans hypothetical protein 0.0167 0.2152 0.3826
Entamoeba histolytica hypothetical protein 0.0085 0.0954 0.2745
Echinococcus granulosus Smad4 0.0025 0.0095 0.0065
Loa Loa (eye worm) hypothetical protein 0.0041 0.0319 0.0624
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0216 0.285 0.6058
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0584 0.1142
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0085 0.0954 0.1464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Echinococcus granulosus methylthioadenosine phosphorylase 0.0085 0.0954 0.0927
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Schistosoma mansoni lamin 0.0059 0.0584 0.0556
Loa Loa (eye worm) transcription factor SMAD2 0.0372 0.5112 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0568 0.1112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.2152 0.3826
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0497 0.0801
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0085 0.0954 0.1464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0085 0.0954 0.1866
Toxoplasma gondii Purine nucleoside phosphorylase 0.0216 0.285 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.0085 0.0954 0.0927
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0237 0.0208
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0095 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Echinococcus multilocularis Smad4 0.0025 0.0095 0.0065
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0301 0.4084 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0141 0.0112
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.433 1
Echinococcus granulosus smad 0.0025 0.0095 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Schistosoma mansoni hypothetical protein 0.0035 0.0237 0.0208
Echinococcus multilocularis lamin 0.0059 0.0584 0.0556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0676 0.0762
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.0276
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0216 0.285 0.6058
Echinococcus granulosus lamin dm0 0.0059 0.0584 0.0556
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0676 0.0762
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0216 0.2858 0.2837
Echinococcus multilocularis purine nucleoside phosphorylase 0.0216 0.2858 0.2837
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0046 0.0089
Loa Loa (eye worm) hypothetical protein 0.0053 0.0497 0.0971
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0186 0.0365
Loa Loa (eye worm) hypothetical protein 0.0075 0.0817 0.1599
Brugia malayi MTAP 0.0085 0.0954 0.1713
Chlamydia trachomatis AMP nucleosidase 0.0085 0.0954 0.5
Brugia malayi intermediate filament protein 0.0059 0.0584 0.0975
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0516 0.0358
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0301 0.4084 0.7951
Echinococcus multilocularis smad 0.0025 0.0095 0.0065
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0075 0.0046
Echinococcus multilocularis purine nucleoside phosphorylase 0.0216 0.2858 0.2837
Schistosoma mansoni hypothetical protein 0.0036 0.0253 0.0225
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0216 0.285 1
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0676 0.0762
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.433 1
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0085 0.0954 0.1464
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0301 0.4084 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0473 0.0249
Echinococcus granulosus uridine phosphorylase 1 0.0085 0.0954 0.0927
Schistosoma mansoni lamin 0.0059 0.0584 0.0556
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0085 0.0954 0.1464
Echinococcus multilocularis purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Leishmania major mitochondrial DNA polymerase beta 0.0318 0.433 1
Schistosoma mansoni Smad4 0.0025 0.0095 0.0065
Schistosoma mansoni smad1 5 8 and 0.0025 0.0095 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0372 0.5112 1
Schistosoma mansoni smad 0.0025 0.0095 0.0065
Schistosoma mansoni uridine phosphorylase 0.0085 0.0954 0.0927
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0085 0.0954 0.2745
Echinococcus multilocularis purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Schistosoma mansoni methylthioadenosine phosphorylase 0.0085 0.0954 0.0927
Brugia malayi Bromodomain containing protein 0.0041 0.0318 0.0445
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0301 0.4084 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0216 0.285 1
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0085 0.0954 0.2745
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0095 0.0185
Schistosoma mansoni uridine phosphorylase 0.0085 0.0954 0.0927
Loa Loa (eye worm) uridine phosphorylase 0.0085 0.0954 0.1866
Schistosoma mansoni hypothetical protein 0.0022 0.0046 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0648 0.062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0253 0.0496
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Schistosoma mansoni smad1 5 8 and 0.0025 0.0095 0.0065
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0216 0.285 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0075 0.0046
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0085 0.0954 0.2745
Loa Loa (eye worm) hypothetical protein 0.0216 0.2858 0.5591
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1906 0.3871
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0676 0.0762
Brugia malayi Bromodomain containing protein 0.008 0.0883 0.1572
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0085 0.0954 0.2745
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0095 0.0065
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0301 0.4084 1
Schistosoma mansoni intermediate filament proteins 0.0059 0.0584 0.0556
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0695
Loa Loa (eye worm) hypothetical protein 0.0045 0.0385 0.0753
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1906 0.3871
Schistosoma mansoni bromodomain containing protein 0.0067 0.0703 0.0675
Plasmodium falciparum purine nucleoside phosphorylase 0.0216 0.285 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0237 0.0208
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0648 0.062
Trypanosoma brucei uridine phosphorylase 0.0085 0.0954 0.1464
Leishmania major nucleoside phosphorylase-like protein 0.0085 0.0954 0.076
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0594 0.0554
Echinococcus multilocularis purine nucleoside phosphorylase 0.0301 0.4084 0.4067
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0141 0.0112
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1906 0.3365
Echinococcus granulosus intermediate filament protein 0.0059 0.0584 0.0556
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0095 0.0065
Echinococcus granulosus purine nucleoside phosphorylase 0.0301 0.4084 0.4067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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