Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0195 | 0.0195 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | nuclear receptor NHR-88 | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | steroid hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0195 | 0.0195 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0137 | 0.0137 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0037 | 0.0137 | 0.0228 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0019 | 0.0005 | 0.0005 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0518 | 0.381 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.1329 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0195 | 0.0195 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0195 | 0.0195 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.1329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0005 | 0.0005 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0037 | 0.0137 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0005 | 0.0005 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0137 | 0.0137 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0806 | 0.601 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0005 | 0.0005 |
Schistosoma mansoni | thyroid hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0005 | 0.0005 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | nuclear receptor RXR | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0037 | 0.0137 | 0.0137 |
Onchocerca volvulus | 0.0037 | 0.0137 | 0.0228 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.1329 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0195 | 0.0195 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0195 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0137 | 0.0137 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0518 | 0.381 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | ecdysteroid receptor | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0019 | 0.0005 | 0.0005 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0.0137 | 0.0137 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0.0137 | 0.0137 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0137 | 0.0137 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0787 | 0.5862 | 0.5862 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.573 | 0.573 |
Brugia malayi | nuclear hormone receptor | 0.0787 | 0.5862 | 0.5862 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.1329 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0518 | 0.381 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0195 | 0.0195 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0.0137 | 0.0137 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0137 | 0.0137 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log ID50 (ADMET) | = 9.3 | Tested for experimental arotinoid inhibitory dose | ChEMBL. | 8057279 |
Activity (functional) | = 1 % | Activity of compound the was expressed as ratio of active hamster tracheal organ cultures(TOC) to the total cultures at 10e-10 M concentration; 1/7 | ChEMBL. | 6208361 |
Activity (binding) | = 6 % | Retinoid activity at 10 e-5 M (9Z)- RA against RXR-alpha receptor receptor for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Activity (binding) | = 6 % | Retinoid activity at 10 e-5 M (9Z)- RA against RXR-alpha receptor receptor for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Activity (functional) | = 7 % | Activity of compound the was expressed as ratio of active hamster tracheal organ cultures(TOC) to the total cultures at 10e-8 M concentration; 7/7 | ChEMBL. | 6208361 |
Activity (functional) | = 7 % | Activity of compound the was expressed as ratio of active hamster tracheal organ cultures(TOC) to the total cultures at 10e-9 M concentration; 7/7 | ChEMBL. | 6208361 |
Activity (functional) | = 12 % | Activity of compound the was expressed as ratio of active hamster tracheal organ cultures(TOC) to the total cultures at 10e-10 M concentration; 12/14 | ChEMBL. | 6208361 |
Activity (binding) | = 29 % | Retinoid activity at 10 e-5 M (E)-RA against Retinoic acid receptor beta for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Activity (binding) | = 29 % | Retinoid activity at 10 e-5 M (E)-RA against Retinoic acid receptor beta for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Activity (functional) | = 38 % | Tested for relative activity in a 20-week anti-papilloma experiment in female CD-1 mice at dose 170 nmol | ChEMBL. | 6208361 |
Activity (functional) | = 38 % | Tested for relative activity in a 20-week anti-papilloma experiment in female CD-1 mice at dose 170 nmol | ChEMBL. | 6208361 |
Activity (functional) | = 53 % | Tested for relative activity in a 20-week anti-papilloma experiment in female CD-1 mice at dose 17 nmol | ChEMBL. | 6208361 |
Activity (functional) | = 53 % | Tested for relative activity in a 20-week anti-papilloma experiment in female CD-1 mice at dose 17 nmol | ChEMBL. | 6208361 |
Activity (binding) | = 56 % | Retinoid activity at 10 e-5 M (E)-RA against RAR-alpha receptor for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Activity (binding) | = 56 % | Retinoid activity at 10 e-5 M (E)-RA against RAR-alpha receptor for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Activity (binding) | = 76 % | Retinoid activity at 10 e-5 M (E)-RA against RAR-gamma receptor for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Activity (binding) | = 76 % | Retinoid activity at 10 e-5 M (E)-RA against RAR-gamma receptor for gene transcriptional activation in transfected CV-1 cells | ChEMBL. | 8410972 |
Decrease (functional) | = 93.4 % | Percent decrease in average number of papillomas 17 at dose | ChEMBL. | 6208361 |
Decrease (functional) | = 93.4 % | Percent decrease in average number of papillomas 17 at dose | ChEMBL. | 6208361 |
Decrease (functional) | = 93.6 % | Percent decrease in average number of papillomas 170 at dose | ChEMBL. | 6208361 |
Decrease (functional) | = 93.6 % | Percent decrease in average number of papillomas 170 at dose | ChEMBL. | 6208361 |
EC50 (binding) | = 15 nM | Effective concentration against Retinoic acid receptor beta | ChEMBL. | 8410972 |
EC50 (binding) | = 15 nM | Effective concentration against Retinoic acid receptor beta | ChEMBL. | 8410972 |
EC50 (binding) | = 27 nM | Effective concentration against RAR-alpha receptor | ChEMBL. | 8410972 |
EC50 (binding) | = 27 nM | Effective concentration against RAR-alpha receptor | ChEMBL. | 8410972 |
EC50 (binding) | = 30 nM | Effective concentration against RAR-gamma receptor | ChEMBL. | 8410972 |
EC50 (binding) | = 30 nM | Effective concentration against RAR-gamma receptor | ChEMBL. | 8410972 |
ED50 (functional) | = 0.00000000005 | Molarity required to effect reversal of keratinization in 50% of cultures. | ChEMBL. | 6208361 |
Inhibition (binding) | = 68 % | TInhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC) at dose 1.7 nmol | ChEMBL. | 6208361 |
Inhibition (binding) | = 68 % | TInhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC) at dose 1.7 nmol | ChEMBL. | 6208361 |
Inhibition (binding) | = 85 % | Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC)) at dose 17 nmol | ChEMBL. | 6208361 |
Inhibition (binding) | = 85 % | Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC)) at dose 17 nmol | ChEMBL. | 6208361 |
Mortality range (functional) | = 10 day | Mortality range in days at dose 600 umol/kg day; 9-10 | ChEMBL. | 6208361 |
Mortality range (functional) | = 15 day | Mortality range in days at dose 300 umol/kg day; 14-15 | ChEMBL. | 6208361 |
Survivors at day 15 (functional) | = 0 % | Percent survivors at dose 600 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 15 (functional) | = 80 % | Percent survivors at dose 300 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 15 (functional) | = 100 % | Percent survivors at dose 100 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 15 (functional) | = 100 % | Percent survivors at dose 30 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 8 (functional) | = 100 % | Percent survivors at dose 600 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 8 (functional) | = 100 % | Percent survivors at dose 300 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 8 (functional) | = 100 % | Percent survivors at dose 200 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 8 (functional) | = 100 % | Percent survivors at dose 100 umol/kg day | ChEMBL. | 6208361 |
Survivors at day 8 (functional) | = 100 % | Percent survivors at dose 33 umol/kg day | ChEMBL. | 6208361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.