Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0042 | 0.3557 | 0.3211 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0048 | 0.4593 | 0.4593 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0048 | 0.4593 | 0.4303 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0042 | 0.3557 | 0.3211 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0048 | 0.4593 | 0.4303 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0048 | 0.4593 | 0.4303 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4593 | 0.3921 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0509 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Brugia malayi | FAD binding domain containing protein | 0.003 | 0.1106 | 0.0629 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0026 | 0.0509 | 0.0509 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0042 | 0.3557 | 0.7462 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0048 | 0.4593 | 1 |
Giardia lamblia | Hypothetical protein | 0.0042 | 0.3557 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0048 | 0.4593 | 0.4303 |
Brugia malayi | FAD binding domain containing protein | 0.0048 | 0.4593 | 0.4303 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0042 | 0.3557 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0048 | 0.4593 | 0.4303 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0026 | 0.0509 | 0.0509 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0076 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0048 | 0.4593 | 0.3921 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0048 | 0.4593 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.003 | 0.1106 | 0.0629 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0024 | 0.0069 | 0.0069 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0048 | 0.4593 | 0.4303 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0048 | 0.4593 | 0.4303 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.003 | 0.1106 | 0.1106 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.003 | 0.1106 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.0509 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.0509 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.0509 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.003 | 0.1106 | 0.0629 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Brugia malayi | flavodoxin family protein | 0.0048 | 0.4593 | 0.4303 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.0509 | 0.0509 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0048 | 0.4593 | 0.4303 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0048 | 0.4593 | 0.4303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 mM | In vitro inhibitory activity against binding of Selectin E to human recombinant AGP (alpha-1 acid glycoprotein) at a concentration of 10 mM; NA- Not active | ChEMBL. | 11206447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.