Detailed information for compound 541017

Basic information

Technical information
  • TDR Targets ID: 541017
  • Name: [(Z)-2-bromovinyl]benzene
  • MW: 183.045 | Formula: C8H7Br
  • H donors: 0 H acceptors: 0 LogP: 3.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrC=Cc1ccccc1
  • InChi: 1S/C8H7Br/c9-7-6-8-4-2-1-3-5-8/h1-7H/b7-6-
  • InChiKey: YMOONIIMQBGTDU-SREVYHEPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(Z)-2-bromoethenyl]benzene
  • beta-bromostyrene
  • 588-73-8
  • 1335-06-4
  • 41380-64-7
  • 588-72-7
  • EINECS 215-617-2
  • Benzene, (2-bromoethenyl)-, (Z)-
  • NSC147118
  • NSC147120
  • Benzene, bromoethenyl-
  • Bromostyrene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aryl hydrocarbon receptor 0.0039 0.0138 0.0138
Schistosoma mansoni inositol monophosphatase 0.0075 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Giardia lamblia PHD finger protein 15 0.0029 0.0068 0.1055
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0097 0.1801
Schistosoma mansoni lipoxygenase 0.0082 0.0454 0.0454
Mycobacterium tuberculosis Conserved protein 0.0036 0.0118 0.0592
Mycobacterium ulcerans beta-lactamase 0.0036 0.0118 0.1409
Trichomonas vaginalis chromobox protein, putative 0.007 0.0363 0.8972
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0048 0.0298
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0039 0.0039
Toxoplasma gondii ABC1 family protein 0.0036 0.0118 0.2149
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0379 0.2604 0.7489
Loa Loa (eye worm) hypothetical protein 0.0034 0.0107 0.0306
Brugia malayi Nuclear hormone receptor-like 1 0.02 0.1308 0.3763
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0118 0.2149
Brugia malayi jmjC domain containing protein 0.0154 0.0975 0.2804
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.0975 0.0975
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0379 0.2604 0.2604
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0379 0.2604 0.7489
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0138 0.3336
Schistosoma mansoni endoplasmin 0.0033 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0039 0.0138 0.0396
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0238 0.5839
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0238 0.5441
Echinococcus granulosus ecdysone induced protein 78C 0.0379 0.2604 0.2604
Schistosoma mansoni nuclear receptor 0.0179 0.1153 0.1153
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0107 0.0409
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0107 0.2425
Onchocerca volvulus 0.0379 0.2604 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0379 0.2604 0.2604
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0238 0.5441
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0379 0.2604 0.2604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.053 0.053
Plasmodium falciparum phd finger protein, putative 0.0029 0.0068 0.6407
Loa Loa (eye worm) steroid hormone receptor 0.0379 0.2604 0.7489
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0039 0.0039
Brugia malayi conserved hypotetical protein 0.0179 0.1153 0.3316
Onchocerca volvulus 0.0031 0.008 0.0306
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0068 0.0068
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0039 0.0138 0.0138
Echinococcus multilocularis tumor protein p63 0.0342 0.2337 0.2337
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0068 0.0068
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0138 0.2699
Plasmodium falciparum pyruvate kinase 0.0034 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.02 0.1308 0.3763
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0179 0.1153 0.3316
Loa Loa (eye worm) hypothetical protein 0.0029 0.0068 0.0196
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0162 0.0624
Echinococcus granulosus Nuclear hormone receptor HR96 0.0179 0.1153 0.1153
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0311 0.449
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0118 0.278
Onchocerca volvulus 0.0179 0.1153 0.4428
Loa Loa (eye worm) nuclear hormone receptor 0.0179 0.1153 0.3316
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Loa Loa (eye worm) hypothetical protein 0.0066 0.0333 0.0957
Onchocerca volvulus 0.0036 0.0118 0.0452
Echinococcus granulosus tumor protein p63 0.0342 0.2337 0.2337
Echinococcus granulosus pyruvate kinase 0.0034 0.0107 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0238 0.0238
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0107 0.0516
Brugia malayi ecdysteroid receptor 0.0379 0.2604 0.7489
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0379 0.2604 0.2604
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0379 0.2604 0.7489
Echinococcus multilocularis chromobox protein 1 0.007 0.0363 0.0363
Brugia malayi orphan nuclear receptor NR2E1 0.0179 0.1153 0.3316
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.009
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.0404 1
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0113
Echinococcus multilocularis chromobox protein 1 0.007 0.0363 0.0363
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.02 0.1308 0.1308
Echinococcus multilocularis FTZ F1 alpha 0.0379 0.2604 0.2604
Schistosoma mansoni microtubule-associated protein tau 0.14 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0311 0.7439
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0068 0.0196
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0229
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0113
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0107 0.1229
Echinococcus granulosus endoplasmin 0.0026 0.0048 0.0048
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0107 0.9043
Plasmodium falciparum heat shock protein 90 0.0033 0.0097 0.911
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0339
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0118 0.0592
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0039 0.0113
Schistosoma mansoni steroid hormone receptor ad4bp 0.0379 0.2604 0.2604
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0118 0.0118
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0379 0.2604 0.2604
Brugia malayi nuclear hormone receptor family member odr-7 0.0179 0.1153 0.3316
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0379 0.2604 0.7489
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0404 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0118 0.1409
Loa Loa (eye worm) DR-78 0.0179 0.1153 0.3316
Echinococcus granulosus FTZ F1 alpha 0.0379 0.2604 0.2604
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0039 0.0113
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0048 0.0048
Brugia malayi tailless protein 0.0179 0.1153 0.3316
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0347 0.2129
Onchocerca volvulus 0.0036 0.0118 0.0452
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0238 0.556
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0118 0.2835
Mycobacterium leprae Possible regulatory protein 0.0039 0.0138 0.3411
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0097 0.1581
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0138 0.3336
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.0975 0.0975
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0097 0.2316
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0238 0.556
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0107 0.0306
Plasmodium falciparum endoplasmin, putative 0.002 0.0004 0.0413
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Schistosoma mansoni nuclear hormone receptor 0.0379 0.2604 0.2604
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Echinococcus granulosus pyruvate kinase 0.0034 0.0107 0.0107
Schistosoma mansoni chromobox protein 0.007 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0068 0.0792
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0238 0.5441
Brugia malayi Nuclear hormone receptor E75 0.0179 0.1153 0.3316
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0048 0.0589
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.0404 0.5983
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0179 0.1153 0.3316
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0179 0.1153 0.4428
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0118 0.0118
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0238 1
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0107 0.2553
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0339
Giardia lamblia Pyruvate kinase 0.0034 0.0107 0.3073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0113
Mycobacterium tuberculosis Conserved protein 0.0036 0.0118 0.0592
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Mycobacterium ulcerans hypothetical protein 0.0036 0.0118 0.1409
Echinococcus multilocularis pyruvate kinase 0.0034 0.0107 0.0107
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.02 0.1308 0.1308
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0118 0.0592
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Leishmania major pyruvate kinase 0.0034 0.0107 0.2054
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0107 0.1841
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0085
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0238 0.5839
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Brugia malayi nuclear hormone receptor family member nhr-6 0.0179 0.1153 0.3316
Trichomonas vaginalis esterase, putative 0.0036 0.0118 0.2835
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0118 0.2835
Echinococcus granulosus heat shock protein 90 0.0033 0.0097 0.0097
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0179 0.1153 0.1153
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0097 0.1581
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0238 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0379 0.2604 0.7489
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0031 0.0043
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0039 0.3692
Trichomonas vaginalis adenylate cyclase, putative 0.0039 0.0138 0.3336
Brugia malayi beta-lactamase 0.0036 0.0118 0.0339
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0118 0.0118
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0238 0.5839
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0379 0.2604 0.2604
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.053 0.053
Schistosoma mansoni single-minded 0.0149 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0107 0.2553
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0404 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.0404 1
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.054 0.1552
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0138 0.3336
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0039 0.0138 0.3336
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0107 0.1841
Echinococcus granulosus jumonji domain containing protein 0.004 0.0151 0.0151
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0045 0.0187 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.02 0.1308 0.3763
Echinococcus granulosus heat shock protein 0.0033 0.0097 0.0097
Leishmania major pyruvate kinase 0.0034 0.0107 0.2054
Schistosoma mansoni thyroid hormone receptor 0.0379 0.2604 0.2604
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0311 0.0311
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0107 0.0306
Echinococcus multilocularis nuclear receptor nhr 48 0.0179 0.1153 0.1153
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0339
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0118 0.2835
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0238 0.0238
Onchocerca volvulus 0.0179 0.1153 0.4428
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0107 0.1841
Echinococcus multilocularis peregrin 0.0029 0.0068 0.0068
Brugia malayi Inositol-1 0.0075 0.0404 0.1163
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0379 0.2604 0.2604
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0339
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0238 0.5839
Schistosoma mansoni aryl hydrocarbon receptor 0.0149 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0107 0.0409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0379 0.2604 0.2604
Brugia malayi hypothetical protein 0.0179 0.1153 0.3316
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0039 0.0138 0.0138
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0138 0.2699
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.054 0.054
Brugia malayi photoreceptor-specific nuclear receptor 0.0379 0.2604 0.7489
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0097 0.1801
Schistosoma mansoni RAR-like nuclear receptor 0.0379 0.2604 0.2604
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0048 0.1096
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0085
Brugia malayi nuclear receptor NHR-67 0.0179 0.1153 0.3316
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0179 0.1153 0.1153
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.3414
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0379 0.2604 0.2604
Echinococcus multilocularis pyruvate kinase 0.0034 0.0107 0.0107
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0118 0.0592
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0311 0.0311
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0068 0.0792
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0404 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0379 0.2604 0.2604
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0379 0.2604 0.7489
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.071 0.071
Loa Loa (eye worm) hypoxia-induced factor 1 0.0461 0.3197 0.9194
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0379 0.2604 0.2604
Brugia malayi Heterochromatin protein 1 0.007 0.0363 0.1045
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0141 0.0541
Brugia malayi PHD-finger family protein 0.0029 0.0068 0.0196
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0405
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0118 1
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0039 0.0039
Schistosoma mansoni pyruvate kinase 0.0034 0.0107 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0118 0.2149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0379 0.2604 0.7489
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0097 0.1581
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0179 0.1153 0.1153
Brugia malayi hypothetical protein 0.0499 0.3477 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0311 0.449
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.02 0.1308 0.1308
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Onchocerca volvulus 0.0036 0.0118 0.0452
Trypanosoma brucei protein kinase, putative 0.0053 0.0238 0.5441
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0097 0.8238
Plasmodium vivax endoplasmin, putative 0.0033 0.0097 0.8238
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0138 0.3336
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0379 0.2604 0.2604
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0097 0.1581
Brugia malayi nuclear receptor RXR 0.02 0.1308 0.3763
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0138 0.3336
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.3953
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.0404 1
Echinococcus granulosus peregrin 0.0029 0.0068 0.0068
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0039 0.0039
Loa Loa (eye worm) endoplasmin 0.0033 0.0097 0.0279
Brugia malayi nuclear hormone receptor 0.0179 0.1153 0.3316
Loa Loa (eye worm) hypothetical protein 0.02 0.1308 0.3763
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0118 0.0592
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0339
Loa Loa (eye worm) hypothetical protein 0.02 0.1308 0.3763
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0031 0.009
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0311 0.0311
Schistosoma mansoni heat shock protein 0.0033 0.0097 0.0097
Schistosoma mansoni retinoic acid receptor RXR 0.0379 0.2604 0.2604
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0179 0.1153 0.1153
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0379 0.2604 0.2604
Loa Loa (eye worm) hypothetical protein 0.005 0.022 0.0634
Brugia malayi heat shock protein 90 0.0033 0.0097 0.0279
Onchocerca volvulus Bile acid receptor homolog 0.0379 0.2604 1
Brugia malayi beta-lactamase family protein 0.0036 0.0118 0.0339
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.054 0.054
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0048 0.0244
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0113
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Onchocerca volvulus 0.011 0.0656 0.2519
Echinococcus granulosus aryl hydrocarbon receptor 0.0039 0.0138 0.0138
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0039 0.0039
Onchocerca volvulus 0.0039 0.0138 0.0529
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0379 0.2604 0.2604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.053 0.053
Schistosoma mansoni hypothetical protein 0.0029 0.0068 0.0068
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0141 0.2793
Loa Loa (eye worm) hypothetical protein 0.02 0.1308 0.3763
Schistosoma mansoni endoplasmin 0.0033 0.0097 0.0097
Schistosoma mansoni chromobox protein 0.007 0.0363 0.0363
Echinococcus granulosus single minded 2 0.011 0.0656 0.0656
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0097 0.1581
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0179 0.1153 0.4428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.053 0.053
Echinococcus granulosus phd:f box containing protein 0.0025 0.0039 0.0039
Brugia malayi nuclear hormone receptor 0.0379 0.2604 0.7489
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0179 0.1153 0.1153
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0039 0.0039
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0097 0.1581
Brugia malayi Endoplasmin precursor 0.0033 0.0097 0.0279
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0238 0.0238
Brugia malayi Nuclear hormone receptor E75 0.0179 0.1153 0.3316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0379 0.2604 0.7489
Leishmania major protein kinase, putative 0.0039 0.0141 0.2981
Mycobacterium ulcerans putative regulatory protein 0.011 0.0656 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0118 0.2835
Echinococcus granulosus chromobox protein 1 0.007 0.0363 0.0363
Brugia malayi nuclear receptor NHR-88 0.0379 0.2604 0.7489
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0068 0.0068
Plasmodium vivax JmjC domain containing protein 0.0025 0.0039 0.3339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0379 0.2604 0.7489
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.3414
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0113
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0039 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0379 0.2604 0.2604
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.0404 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0379 0.2604 0.7489
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0379 0.2604 0.7489
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0097 0.1581
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0379 0.2604 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0347 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0097 0.1581
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0085
Brugia malayi PAS domain containing protein 0.0149 0.0936 0.2693
Brugia malayi hypothetical protein 0.02 0.1308 0.3763
Schistosoma mansoni cellular tumor antigen P53 0.005 0.022 0.022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0118 0.0592
Brugia malayi Nuclear hormone receptor-like 1 0.0379 0.2604 0.7489
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0039 0.0138 0.3336
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0107 0.0306
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0039 0.0113
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0363 0.1045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0311 0.1886
Schistosoma mansoni coup transcription factor 0.0379 0.2604 0.2604
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0107 0.0409
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0107 0.1841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0379 0.2604 0.7489
Leishmania major protein kinase, putative 0.0039 0.0141 0.2981
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0107 0.1841
Brugia malayi bHLH-PAS transcription factor 0.011 0.0656 0.1886
Echinococcus multilocularis heat shock protein 0.0033 0.0097 0.0097
Onchocerca volvulus Protein ultraspiracle homolog 0.0379 0.2604 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0118 0.1409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0379 0.2604 0.7489
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0097 0.1581
Brugia malayi nuclear receptor NHR-88 0.0179 0.1153 0.3316
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.1344
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0048 0.1096
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0118 0.0118
Brugia malayi jmjC domain containing protein 0.0094 0.054 0.1552
Schistosoma mansoni nuclear receptor nhr-48 0.0179 0.1153 0.1153
Echinococcus multilocularis pyruvate kinase 0.0027 0.0054 0.0054
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0151 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.053 0.1524
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0379 0.2604 0.7489
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.053 0.053
Treponema pallidum heat shock protein 90 0.0026 0.0048 0.5
Brugia malayi steroid hormone receptor 0.0379 0.2604 0.7489
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.0404 0.0404
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0138 0.3336
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0118 0.2149
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0138 0.3336
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0311 0.0311
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0379 0.2604 0.2604
Brugia malayi beta-lactamase family protein 0.0036 0.0118 0.0339
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0238 0.5441
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0162 0.3953
Echinococcus granulosus chromobox protein 1 0.007 0.0363 0.0363
Schistosoma mansoni nuclear receptor 0.0179 0.1153 0.1153
Echinococcus multilocularis microtubule associated protein 2 0.14 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0238 0.5441
Mycobacterium tuberculosis Conserved protein 0.0036 0.0118 0.0592
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Schistosoma mansoni heat shock protein 0.0033 0.0097 0.0097
Echinococcus granulosus Nuclear hormone receptor HR96 0.0179 0.1153 0.1153
Leishmania major hypothetical protein, conserved 0.0025 0.0039 0.0261
Onchocerca volvulus 0.005 0.022 0.0847
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0048 0.0125
Mycobacterium ulcerans lipase LipD 0.0036 0.0118 0.1409
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.0404 0.0404
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0118 0.0592
Echinococcus granulosus thyroid hormone receptor alpha 0.0179 0.1153 0.1153
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0118 0.0339
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0179 0.1153 0.1153
Echinococcus multilocularis heat shock protein 90 0.0026 0.0048 0.0048
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0107 0.0306
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0138 0.2889
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0311 0.449
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0238 0.5441
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0339
Echinococcus multilocularis endoplasmin 0.0026 0.0048 0.0048
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0097 0.2573
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0039 0.0039
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0404 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0379 0.2604 0.2604
Schistosoma mansoni nuclear hormone receptor 0.0179 0.1153 0.1153
Onchocerca volvulus 0.0024 0.003 0.0113
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0068 0.5794
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0179 0.1153 0.3316
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0379 0.2604 0.7489
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0138 0.3336
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.071 0.071
Brugia malayi hypothetical protein 0.0179 0.1153 0.3316
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0048 0.0499
Brugia malayi Bromodomain containing protein 0.0029 0.0068 0.0196
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0048 0.0244
Onchocerca volvulus Alhambra homolog 0.0029 0.0068 0.0262
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0141 0.2793
Brugia malayi hypothetical protein 0.02 0.1308 0.3763
Schistosoma mansoni nuclear hormone receptor 0.0179 0.1153 0.1153
Loa Loa (eye worm) nuclear receptor NHR-67 0.0179 0.1153 0.3316
Mycobacterium leprae Probable lipase LipE 0.0036 0.0118 0.278
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.0404 1
Brugia malayi nuclear receptor RXR 0.0179 0.1153 0.3316
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0293 0.0842
Loa Loa (eye worm) hypothetical protein 0.0379 0.2604 0.7489
Brugia malayi hypoxia-induced factor 1 0.0461 0.3197 0.9194
Trichomonas vaginalis chromobox protein, putative 0.007 0.0363 0.8972
Brugia malayi Steroid receptor seven-up type 2 0.0379 0.2604 0.7489
Leishmania major hypothetical protein, conserved 0.0036 0.0118 0.2355
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0379 0.2604 0.7489
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0118 0.0339
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Schistosoma mansoni inositol monophosphatase 0.0075 0.0404 0.0404
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.0404 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0379 0.2604 0.7489
Schistosoma mansoni lipoxygenase 0.0118 0.071 0.071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0379 0.2604 0.7489
Echinococcus granulosus heat shock protein 90 0.0026 0.0048 0.0048
Echinococcus multilocularis ecdysone induced protein 78C 0.0379 0.2604 0.2604
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0097 0.0279
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0085
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0238 0.0684
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0379 0.2604 0.2604
Schistosoma mansoni jumonji domain containing protein 0.0135 0.0833 0.0833
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0039 0.0039
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.054 0.054
Echinococcus multilocularis heat shock protein 90 0.0033 0.0097 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0379 0.2604 0.7489
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.053 0.053
Echinococcus granulosus nuclear receptor nhr 48 0.0179 0.1153 0.1153
Loa Loa (eye worm) hypothetical protein 0.0499 0.3477 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.054 0.054
Brugia malayi AMP-binding enzyme family protein 0.0024 0.003 0.0085
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0118 0.0592
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0097 0.1581
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0048 0.1096
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.1344
Schistosoma mansoni retinoid-x-receptor (RXR) 0.02 0.1308 0.1308
Echinococcus multilocularis transfer RNA-Lys 0.011 0.0656 0.0656
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.053 0.1524
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0039 0.0138 0.0396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.053 0.053
Leishmania major heat shock protein 83-1 0.0033 0.0097 0.1801
Loa Loa (eye worm) inositol-1 0.0075 0.0404 0.1163
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0379 0.2604 0.7489
Loa Loa (eye worm) beta-lactamase 0.0036 0.0118 0.0339
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0107 0.0306
Schistosoma mansoni zinc finger protein 0.0179 0.1153 0.1153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0179 0.1153 0.1153
Brugia malayi ecdysone receptor 0.0179 0.1153 0.3316
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0141 0.2793
Loa Loa (eye worm) hypothetical protein 0.02 0.1308 0.3763
Brugia malayi Nuclear hormone receptor-like 1 0.02 0.1308 0.3763
Brugia malayi chromobox protein homolog 3 0.0039 0.0141 0.0405
Echinococcus multilocularis thyroid hormone receptor alpha 0.0379 0.2604 0.2604
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1521 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0118 0.2835
Schistosoma mansoni pyruvate kinase 0.0034 0.0107 0.0107
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0141 0.2793
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0179 0.1153 0.1153
Schistosoma mansoni thyroid hormone receptor 0.0379 0.2604 0.2604
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0379 0.2604 0.2604
Trypanosoma brucei heat shock protein, putative 0.0033 0.0097 0.1581
Brugia malayi MAP kinase sur-1 0.0053 0.0238 0.0684
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0311 0.7505
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0179 0.1153 0.1153

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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