TDR Targets

Basic information

Technical information

TDR Targets ID: 54109
Name: 7-[(1R,2R,3R,5S)-2-[(3R)-5-(2-fluorophenyl)-3 -hydroxypentyl]-3,5-dihydroxycyclopentyl]hept anoic acid
MW: 410.519 | Formula: C23H35FO5
H donors: 4 H acceptors: 5 LogP: 3.98 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H](CCc1ccccc1F)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O
InChi: 1S/C23H35FO5/c24-20-9-6-5-7-16(20)11-12-17(25)13-14-19-18(21(26)15-22(19)27)8-3-1-2-4-10-23(28)29/h5-7,9,17-19,21-22,25-27H,1-4,8,10-15H2,(H,28,29)/t17-,18+,19+,21-,22+/m0/s1
InChiKey: ZGXUCMQIVLIZTA-DMPNSMEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-[(1R,2R,3R,5S)-2-[(3R)-5-(2-fluorophenyl)-3-hydroxy-pentyl]-3,5-dihydroxy-cyclopentyl]heptanoic acid
7-[(1R,2R,3R,5S)-2-[(3R)-5-(2-fluorophenyl)-3-hydroxy-pentyl]-3,5-dihydroxy-cyclopentyl]enanthic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin E receptor 3 (subtype EP3)	Starlite/ChEMBL	References
Homo sapiens	prostaglandin F receptor (FP)	Starlite/ChEMBL	References
Homo sapiens	thromboxane A2 receptor	Starlite/ChEMBL	References
Homo sapiens	prostaglandin E receptor 1 (subtype EP1), 42kDa	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0186	0.5272	0.6909
Echinococcus granulosus	intermediate filament protein	0.0031	0.0297	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0108	0.2763	0.3653
Brugia malayi	hypothetical protein	0.0098	0.2453	0.311
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0857	0.152
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Brugia malayi	Bromodomain containing protein	0.0041	0.0603	0.0616
Onchocerca volvulus		0.0088	0.2115	0.3654
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0186	0.5272	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0857	0.1625
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0088	0.2115	0.3654
Entamoeba histolytica	hypothetical protein	0.0038	0.0523	0.5
Toxoplasma gondii	hypothetical protein	0.0054	0.1023	0.5
Onchocerca volvulus		0.0088	0.2115	0.3654
Brugia malayi	orphan nuclear receptor NR2E1	0.0088	0.2115	0.2654
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Loa Loa (eye worm)	nuclear hormone receptor	0.0088	0.2115	0.2796
Brugia malayi	nuclear hormone receptor family member odr-7	0.0088	0.2115	0.2654
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0393	0.063
Brugia malayi	photoreceptor-specific nuclear receptor	0.0186	0.5272	0.6909
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0186	0.5272	0.6909
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0186	0.5272	0.6909
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0065	0.0124
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0088	0.2115	0.3937
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0088	0.2115	0.3937
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0857	0.1625
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0186	0.5272	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0523	0.088
Schistosoma mansoni	nuclear hormone receptor	0.0186	0.5272	1
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0297	0.0564
Loa Loa (eye worm)	steroid hormone receptor	0.0186	0.5272	0.6968
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0088	0.2115	0.3654
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0605	0.08
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0088	0.2115	0.2654
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0088	0.2115	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0333	1	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.0746
Brugia malayi	Steroid receptor seven-up type 2	0.0186	0.5272	0.6909
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0186	0.5272	1
Echinococcus multilocularis	lamin	0.0031	0.0297	0.0446
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0186	0.5272	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0186	0.5272	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0523	0.0993
Brugia malayi	ecdysone receptor	0.0088	0.2115	0.2654
Brugia malayi	Nuclear hormone receptor E75	0.0088	0.2115	0.2654
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0522	0.0877
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0186	0.5272	0.6909
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0186	0.5272	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0186	0.5272	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0186	0.5272	1
Brugia malayi	hypothetical protein	0.0088	0.2115	0.2654
Entamoeba histolytica	hypothetical protein	0.0038	0.0523	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.2763	0.3528
Schistosoma mansoni	coup transcription factor	0.0186	0.5272	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0186	0.5272	0.6909
Echinococcus multilocularis	lamin dm0	0.0031	0.0297	0.0446
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0522	0.0877
Brugia malayi	nuclear hormone receptor	0.0088	0.2115	0.2654
Echinococcus granulosus	lamin	0.0031	0.0297	0.0446
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0186	0.5272	0.6968
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0393	0.0333
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0098	0.2453	0.4586
Brugia malayi	nuclear receptor RXR	0.0098	0.2453	0.311
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0088	0.2115	0.4012
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.1333	0.2434
Brugia malayi	Bromodomain containing protein	0.008	0.1855	0.2303
Schistosoma mansoni	nuclear receptor	0.0088	0.2115	0.4012
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0523	0.088
Entamoeba histolytica	hypothetical protein	0.0038	0.0523	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0186	0.5272	0.6968
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0186	0.5272	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0186	0.5272	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0257	0.7566	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0186	0.5272	1
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0393	0.063
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Onchocerca volvulus	Protein ultraspiracle homolog	0.0186	0.5272	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0088	0.2115	0.3937
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0186	0.5272	1
Echinococcus multilocularis	musashi	0.0031	0.0297	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0393	0.063
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0158	0.4362	0.3871
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0297	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0186	0.5272	0.6909
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0186	0.5272	0.6909
Loa Loa (eye worm)	hypothetical protein	0.013	0.3475	0.4593
Onchocerca volvulus	Huntingtin homolog	0.013	0.3475	0.6388
Schistosoma mansoni	retinoic acid receptor RXR	0.0186	0.5272	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0088	0.2115	0.3937
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0088	0.2115	0.4012
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Echinococcus multilocularis	nuclear receptor nhr 48	0.0088	0.2115	0.3937
Brugia malayi	hypothetical protein	0.0038	0.0523	0.0509
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0186	0.5272	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0857	0.152
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.1666	0.2049
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0186	0.5272	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0857	0.1625
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.1333	0.2434
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0098	0.2453	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2453	0.3242
Onchocerca volvulus	Bile acid receptor homolog	0.0186	0.5272	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0857	0.1132
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0186	0.5272	0.6909
Brugia malayi	conserved hypotetical protein	0.0088	0.2115	0.2654
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0057	0.113	0.0358
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0186	0.5272	0.6909
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0088	0.2115	0.3937
Brugia malayi	Cytochrome P450 family protein	0.005	0.0914	0.1035
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0333	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0098	0.2453	0.311
Echinococcus multilocularis	ecdysone induced protein 78C	0.0186	0.5272	1
Onchocerca volvulus	Huntingtin homolog	0.013	0.3475	0.6388
Brugia malayi	steroid hormone receptor	0.0186	0.5272	0.6909
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0297	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2453	0.3242
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0186	0.5272	1
Brugia malayi	nuclear hormone receptor	0.0186	0.5272	0.6909
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0279	0.0369
Echinococcus granulosus	FTZ F1 alpha	0.0186	0.5272	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Brugia malayi	follicle stimulating hormone receptor	0.0257	0.7566	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.2763	0.3528
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2453	0.3242
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0186	0.5272	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0088	0.2115	0.3937
Loa Loa (eye worm)	DR-78	0.0088	0.2115	0.2796
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0088	0.2115	0.3937
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0186	0.5272	0.6968
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0393	0.052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0186	0.5272	0.6968
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0751	0.0993
Schistosoma mansoni	nuclear hormone receptor	0.0088	0.2115	0.4012
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0523	0.0993
Brugia malayi	nuclear receptor NHR-88	0.0088	0.2115	0.2654
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0857	0.152
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0297	0.0204
Brugia malayi	Nuclear hormone receptor-like 1	0.0098	0.2453	0.311
Brugia malayi	nuclear receptor RXR	0.0088	0.2115	0.2654
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0088	0.2115	0.2654
Mycobacterium ulcerans	hypothetical protein	0.0175	0.4934	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0098	0.2453	0.4653
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0297	0.0393
Schistosoma mansoni	hypothetical protein	0.0074	0.1666	0.3161
Brugia malayi	nuclear receptor NHR-67	0.0088	0.2115	0.2654
Brugia malayi	Nuclear hormone receptor-like 1	0.0186	0.5272	0.6909
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.2763	0.3653
Loa Loa (eye worm)	cytochrome P450 family protein	0.005	0.0914	0.1208
Brugia malayi	Nuclear hormone receptor E75	0.0088	0.2115	0.2654
Onchocerca volvulus		0.0186	0.5272	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0088	0.2115	0.3937
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0175	0.4934	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2453	0.3242
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0186	0.5272	1
Schistosoma mansoni	lamin	0.0031	0.0297	0.0564
Schistosoma mansoni	nuclear receptor nhr-48	0.0088	0.2115	0.4012
Loa Loa (eye worm)	hypothetical protein	0.013	0.3475	0.4593
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0098	0.2453	0.4586
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0186	0.5272	0.6909
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0857	0.0958
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0186	0.5272	0.6968
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0186	0.5272	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0186	0.5272	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0186	0.5272	0.6909
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0333	1	1
Brugia malayi	intermediate filament protein	0.0031	0.0297	0.0204
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0393	0.0333
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0186	0.5272	0.6968
Brugia malayi	hypothetical protein	0.0098	0.2453	0.311
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0393	0.063
Brugia malayi	hypothetical protein	0.0088	0.2115	0.2654
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1709	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Schistosoma mansoni	nuclear receptor	0.0088	0.2115	0.4012
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0186	0.5272	0.6909
Entamoeba histolytica	hypothetical protein	0.0038	0.0523	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0393	0.063
Schistosoma mansoni	zinc finger protein	0.0088	0.2115	0.4012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0186	0.5272	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0098	0.2453	0.4653
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0857	0.152
Schistosoma mansoni	nuclear hormone receptor	0.0088	0.2115	0.4012
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0393	0.052
Schistosoma mansoni	bromodomain containing protein	0.0067	0.1455	0.2759
Schistosoma mansoni	thyroid hormone receptor	0.0186	0.5272	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2453	0.3242
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0158	0.4362	0.3871
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1666	0.2203
Schistosoma mansoni	thyroid hormone receptor	0.0186	0.5272	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0186	0.5272	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0088	0.2115	0.3937
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0186	0.5272	0.6968
Schistosoma mansoni	lamin	0.0031	0.0297	0.0564
Echinococcus granulosus	lamin dm0	0.0031	0.0297	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5272	0.6968
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2115	0.2796
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.0746
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0186	0.5272	1
Brugia malayi	hypothetical protein	0.013	0.3475	0.4487
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0088	0.2115	0.2796
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0088	0.2115	0.3937
Schistosoma mansoni	hypothetical protein	0.0034	0.0393	0.0746
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0186	0.5272	1
Brugia malayi	tailless protein	0.0088	0.2115	0.2654
Echinococcus granulosus	thyroid hormone receptor alpha	0.0088	0.2115	0.3937
Echinococcus multilocularis	FTZ F1 alpha	0.0186	0.5272	1
Brugia malayi	nuclear receptor NHR-88	0.0186	0.5272	0.6909
Brugia malayi	ecdysteroid receptor	0.0186	0.5272	0.6909
Echinococcus granulosus	GPCR family 2	0.0034	0.0393	0.063
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0686	0.0906
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0186	0.5272	0.6909
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0186	0.5272	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 76 nM	Displacement of [3H]-PGF-2 from human FP-receptor expressed in CHO-KI cells	ChEMBL.	10915040
IC50 (binding)	= 76 nM	Displacement of [3H]-PGF-2 from human FP-receptor expressed in CHO-KI cells	ChEMBL.	10915040
IC50 (binding)	= 3100 nM	Displacement of [3H]-PGE-2 from Prostaglandin E receptor EP1 expressed in CHO-KI cells	ChEMBL.	10915040
IC50 (binding)	= 3100 nM	Displacement of [3H]-PGE-2 from Prostaglandin E receptor EP1 expressed in CHO-KI cells	ChEMBL.	10915040
IC50 (binding)	> 10000 nM	Displacement of [3H]-U-46,619 from human TP-receptor expressed in CHO-KI cells	ChEMBL.	10915040
IC50 (binding)	> 10000 nM	Displacement of [3H]-PGE-2 from human Prostaglandin E receptor EP3 expressed in CHO-KI cells	ChEMBL.	10915040
IC50 (binding)	> 10000 nM	Displacement of [3H]-U-46,619 from human TP-receptor expressed in CHO-KI cells	ChEMBL.	10915040
IC50 (binding)	> 10000 nM	Displacement of [3H]-PGE-2 from human Prostaglandin E receptor EP3 expressed in CHO-KI cells	ChEMBL.	10915040

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL289373
PubChem: 9909510

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 54109