Detailed information for compound 541533

Basic information

Technical information
  • TDR Targets ID: 541533
  • Name: [N'-(pyridine-4-carbonyl)hydrazino]methanesul fonic acid
  • MW: 231.229 | Formula: C7H9N3O4S
  • H donors: 3 H acceptors: 5 LogP: -3.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccncc1)NNCS(=O)(=O)O
  • InChi: 1S/C7H9N3O4S/c11-7(6-1-3-8-4-2-6)10-9-5-15(12,13)14/h1-4,9H,5H2,(H,10,11)(H,12,13,14)
  • InChiKey: GQZQCROBCYNTMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [N'-[oxo(4-pyridyl)methyl]hydrazino]methanesulfonic acid
  • (2-pyridin-4-ylcarbonylhydrazinyl)methanesulfonic acid
  • (N'-isonicotinoylhydrazino)methanesulfonic acid
  • [2-(pyridine-4-carbonyl)hydrazinyl]methanesulfonic acid
  • methaniazide
  • (2-(pyridine-4-carbonyl)hydrazinyl)methanesulfonic acid
  • (N'-(pyridine-4-carbonyl)hydrazino)methanesulfonic acid
  • [N'-[oxo-(4-pyridyl)methyl]hydrazino]methanesulfonic acid
  • EINECS 236-605-3
  • Isonicotinic acid 2-(sulfomethyl)hydrazine
  • Metaniazida [INN-Spanish]
  • Metaniazide [DCIT]
  • Methaniazide [INN]
  • Methaniazidum [INN-Latin]

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0166 0.0653
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0136 0.0542
Brugia malayi Flap endonuclease-1 0.0026 0.0033 0.0532
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0237
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0019 0.0017
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0118 0.187
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0022 0.0378
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0073 0.0118 0.1994
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0002 0.0009
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0068 0.5435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0022 0.0081
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0045 0.3667
Brugia malayi hypothetical protein 0.0011 0.0004 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0022 0.0349
Echinococcus granulosus bloom syndrome protein 0.0046 0.0068 0.0263
Schistosoma mansoni patched 1 0.0043 0.0063 0.0249
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0024 0.0088
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0068 0.5435
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0045 0.3604
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0029 0.2258
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0022 0.0349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0000000012988
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.2549
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0019 0.0301
Leishmania major GTP-binding protein, putative 0.0021 0.0024 0.1776
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0000000012988
Schistosoma mansoni cpg binding protein 0.0062 0.0096 0.0382
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0012
Echinococcus multilocularis dnaJ subfamily B 0.083 0.1485 0.59
Brugia malayi Importin beta-1 subunit 0.0029 0.0038 0.062
Schistosoma mansoni importin beta-1 0.0029 0.0038 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0048
Giardia lamblia DNA repair protein RAD52 0.0352 0.0621 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0184 0.0182
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0022 0.0087
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0022 0.0081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0022 0.0349
Brugia malayi ecdysteroid receptor 0.002 0.0022 0.0349
Brugia malayi nuclear receptor RXR 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0053 0.008 0.1349
Trypanosoma brucei glucosidase, putative 0.0073 0.0118 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0136 0.0536
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0208 0.0828
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0022 0.0349
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0012
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0019 0.0069
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0017 0.0265
Loa Loa (eye worm) hypothetical protein 0.0139 0.0237 0.4054
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0118 0.187
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0004 0.0018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.033 0.0583 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0024 0.0356
Echinococcus granulosus expressed protein 0.0034 0.0046 0.0176
Onchocerca volvulus 0.0306 0.0538 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0063 0.0242
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0019 0.0301
Loa Loa (eye worm) RecQ helicase 0.0046 0.0068 0.114
Trichomonas vaginalis ran, putative 0.0021 0.0024 0.1376
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0011 0.0037
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0038 0.0035
Schistosoma mansoni coup transcription factor 0.002 0.0022 0.0087
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0022 0.0081
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0022 0.0081
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0003 0.0001
Schistosoma mansoni zinc finger protein 0.001 0.0002 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0022 0.0349
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Echinococcus granulosus muscleblind protein 0.0303 0.0533 0.2112
Entamoeba histolytica recQ family DNA helicase 0.001 0.0002 0.0011
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0002 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0011 0.0044
Onchocerca volvulus 0.001 0.0002 0.0013
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0073 0.0118 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0022 0.0349
Echinococcus multilocularis snurportin 1 0.0311 0.0548 0.2173
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.01 0.0166 0.2827
Brugia malayi nuclear receptor NHR-67 0.001 0.0002 0.0012
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0136 0.0536
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0029 0.2258
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0045 0.3667
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0024 0.1856
Echinococcus granulosus cpg binding protein 0.0062 0.0096 0.0376
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0024 0.1186
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0136 0.0536
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.5537 1 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0002 0.0012
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0002 0.0012
Schistosoma mansoni par domain protein 0.0009 0.0002 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0022 0.0349
Onchocerca volvulus 0.001 0.0002 0.0013
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0009
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0244 0.0962
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0063 0.1048
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0011 0.0037
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0002 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0069 0.0273
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.01 0.0166 0.2651
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Brugia malayi CHE-14 protein 0.0043 0.0063 0.1048
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0048
Schistosoma mansoni thyroid hormone receptor 0.002 0.0022 0.0087
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0022 0.0349
Brugia malayi hypothetical protein 0.0011 0.0004 0.0048
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0034 0.0561
Onchocerca volvulus Huntingtin homolog 0.0125 0.021 0.3887
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.2622
Schistosoma mansoni ran 0.0021 0.0024 0.0094
Schistosoma mansoni hypothetical protein 0.0084 0.0136 0.0542
Echinococcus multilocularis expressed protein 0.0034 0.0046 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0022 0.0349
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0046 0.0763
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.174
Echinococcus multilocularis protein patched 0.0043 0.0063 0.0242
Echinococcus granulosus importin subunit beta 1 0.0029 0.0038 0.0143
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0048
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0022 0.0349
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0017 0.0063
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0002 0.0003
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0069 0.1152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0022 0.0349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0301
Brugia malayi hypothetical protein 0.001 0.0002 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0009 0.0000000012988
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0118 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0118 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0034 0.2702
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0022 0.0349
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0019 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0118 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0069 0.0266
Loa Loa (eye worm) hypothetical protein 0.0084 0.0136 0.232
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0022 0.0349
Echinococcus multilocularis lysosomal alpha glucosidase 0.033 0.0583 0.231
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0022 0.0081
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0034 0.2347
Schistosoma mansoni thyrotroph embryonic factor related 0.0009 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0125 0.021 0.3588
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.004 0.0038
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0058 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0022 0.0087
Schistosoma mansoni hypothetical protein 0.0084 0.0136 0.0542
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0011 0.0037
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Schistosoma mansoni hypothetical protein 0.0311 0.0548 0.2179
Echinococcus granulosus microtubule associated protein 2 0.14 0.2517 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.033 0.0583 0.231
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0024 0.0021
Brugia malayi hypothetical protein 0.0125 0.021 0.3588
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0034 0.2347
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0024 0.1776
Schistosoma mansoni hypothetical protein 0.0293 0.0515 0.2045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.174
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0002 0.0003
Schistosoma mansoni flap endonuclease-1 0.0024 0.0028 0.0111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0561
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0022 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0022 0.0378
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0022 0.0081
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0002 0.0012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0002 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0118 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0022 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0022 0.0349
Echinococcus granulosus expressed conserved protein 0.0094 0.0155 0.0609
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.062
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0069 0.0266
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0048
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0303 0.0533 0.9145
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0028 0.174
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0024 0.0356
Onchocerca volvulus 0.002 0.0022 0.0378
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0038 0.2998
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0004 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0069 0.0266
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0118 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0019 0.0069
Onchocerca volvulus 0.0058 0.009 0.1652
Onchocerca volvulus 0.0191 0.0331 0.6133
Brugia malayi nuclear receptor NHR-88 0.002 0.0022 0.0349
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0022 0.0081
Loa Loa (eye worm) hypothetical protein 0.0125 0.021 0.3588
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0045 0.0693
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0002 0.0012
Brugia malayi nuclear receptor RXR 0.0011 0.0004 0.0048
Schistosoma mansoni hypothetical protein 0.0084 0.0136 0.0542
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0034 0.2773
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0034 0.2347
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0022 0.0349
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0003 0.0098
Schistosoma mansoni nuclear hormone receptor 0.002 0.0022 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0041 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0073 0.0118 0.0461
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0033 0.2549
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0022 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0048
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0166 0.2827
Loa Loa (eye worm) DR-78 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0048
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0237
Brugia malayi conserved hypotetical protein 0.001 0.0002 0.0012
Echinococcus multilocularis X box binding protein 1 0.0293 0.0515 0.2039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0022 0.0349
Schistosoma mansoni microtubule-associated protein tau 0.14 0.2517 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0022 0.0349
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0000000012988
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0118 1
Brugia malayi CXXC zinc finger family protein 0.0058 0.009 0.1525
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0022 0.0087
Brugia malayi ecdysone receptor 0.001 0.0002 0.0012
Onchocerca volvulus Huntingtin homolog 0.0125 0.021 0.3887
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0136 0.232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0022 0.0081
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0118 1
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0033 0.0499
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0118 1
Echinococcus granulosus dnaJ subfamily B 0.083 0.1485 0.59
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0136 0.0536
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Schistosoma mansoni ran 0.0021 0.0024 0.0094
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0007
Plasmodium vivax importin-beta 2, putative 0.0029 0.0038 0.915
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0118 1
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0002 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0022 0.0349
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0022 0.0081
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0169 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0063 0.4947
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0024 0.1856
Entamoeba histolytica hypothetical protein 0.01 0.0166 0.2651
Brugia malayi steroid hormone receptor 0.002 0.0022 0.0349
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0022 0.0378
Echinococcus multilocularis muscleblind protein 0.0303 0.0533 0.2112
Schistosoma mansoni nuclear receptor 0.001 0.0002 0.0009
Brugia malayi tailless protein 0.001 0.0002 0.0012
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0034 0.2347
Echinococcus multilocularis cpg binding protein 0.0062 0.0096 0.0376
Echinococcus granulosus FTZ F1 alpha 0.002 0.0022 0.0081
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0002 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0034 0.2347
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0024 0.038
Echinococcus multilocularis protein dispatched 1 0.0049 0.0074 0.0286
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0033 0.003
Brugia malayi Glycosyl hydrolases family 31 protein 0.033 0.0583 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0045 0.3604
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0038 0.2998
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0166 0.0653
Plasmodium falciparum importin beta, putative 0.0029 0.0038 0.479
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0034 0.2702
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0019 0.0301
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0002 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0024 0.038
Loa Loa (eye worm) hypothetical protein 0.0306 0.0538 0.9232
Schistosoma mansoni hypothetical protein 0.083 0.1485 0.5903
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0003 0.0098
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0022 0.0087
Echinococcus multilocularis expressed conserved protein 0.0094 0.0155 0.0609
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.0548 0.9409
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0349
Toxoplasma gondii pantoate-beta-alanine ligase 0.5537 1 1
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0063 0.0242
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0024 0.0088
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0022 0.0081
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0012
Trichomonas vaginalis rotamase, putative 0.0033 0.0045 0.3293
Schistosoma mansoni DNA helicase recq1 0.0019 0.0019 0.0076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0022 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0069 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0000000012988
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0029 0.2333
Schistosoma mansoni rotamase 0.0034 0.0046 0.0183
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0019 0.0282
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0022 0.0349
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0002 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0022 0.0349
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0022 0.0081
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0002 0.0003
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0019 0.0069
Echinococcus granulosus snurportin 1 0.0311 0.0548 0.2173
Leishmania major importin beta-1 subunit, putative 0.0024 0.0028 0.2122
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.1048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0069 0.0273
Echinococcus granulosus X box binding protein 1 0.0293 0.0515 0.2039
Trichomonas vaginalis rotamase, putative 0.0034 0.0046 0.3426
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0019 0.0069
Brugia malayi hypothetical protein 0.001 0.0002 0.0012
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0136 0.0542
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0002 0.0012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0118 0.1994
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0046 0.3426
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0034 0.2347
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0017 0.0272
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0068 0.0263
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0022 0.0087
Schistosoma mansoni alpha-glucosidase 0.0284 0.0499 0.1984
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0033 0.0499
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0069 0.0266
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0033 0.785
Plasmodium falciparum flap endonuclease 1 0.0026 0.0033 0.3468
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0022 0.0081
Echinococcus multilocularis muscleblind protein 1 0.0303 0.0533 0.2112
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0000000012988
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0022 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0022 0.0087
Brugia malayi RNA, U transporter 1 0.0083 0.0135 0.2294
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0033 0.0532
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0034 0.0608
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0004 0.0048
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0046 0.0763
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0033 0.0123
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.5537 1 0.5
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0009 0.0002 0.0007
Schistosoma mansoni cpg binding protein 0.0058 0.009 0.0359
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0034 0.2347
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0033 0.2187
Schistosoma mansoni DNA helicase recq5 0.0019 0.0019 0.0076
Echinococcus granulosus flap endonuclease 1 0.0026 0.0033 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0012
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0029 0.1882
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0303 0.0533 0.9145
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0017 0.0063
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.005 0.02
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0063 0.0242
Brugia malayi nuclear hormone receptor 0.002 0.0022 0.0349
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0237
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0022 0.0087
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0136 0.232
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0118 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0073 0.0118 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0003
Leishmania major alpha glucosidase II subunit, putative 0.0073 0.0118 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0022 0.0349
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0002 0.0003
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0244 0.0962
Schistosoma mansoni alpha-glucosidase 0.0284 0.0499 0.1984
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0237
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0068 0.114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0022 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0022 0.0349
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0034 0.2347
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0038 0.0143
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0022 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0022 0.0081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.009 0.1525
Schistosoma mansoni cpg binding protein 0.0062 0.0096 0.0382
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0069 0.1152
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0004 0.0011
Schistosoma mansoni alpha glucosidase 0.0073 0.0118 0.0467
Echinococcus multilocularis microtubule associated protein 2 0.14 0.2517 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0022 0.0349
Entamoeba histolytica hypothetical protein 0.0024 0.0028 0.042
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0045 0.0042
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0166 0.2651
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0024 0.5607
Echinococcus granulosus lysosomal alpha glucosidase 0.033 0.0583 0.231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0000000012988
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0029 0.0445
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0003 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0009 0.0000000012988
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0034 0.0527
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0028 0.2199
Echinococcus granulosus neutral alpha glucosidase AB 0.0073 0.0118 0.0461
Brugia malayi Muscleblind-like protein 0.0303 0.0533 0.9145
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0352 0.0621 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0034 0.2773
Brugia malayi hypothetical protein 0.0306 0.0538 0.9232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0022 0.0081
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0007

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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