Detailed information for compound 541600
Basic information
Technical information
- TDR Targets ID: 541600
- Name: zinc 1-oxidopyridin-1-ium-2-thiolate
- MW: 317.693 | Formula: C10H8N2O2S2Zn
-
H donors: 0
H acceptors: 2
LogP: 0.68
Rotable bonds: 0
Rule of 5 violations (Lipinski): 1 - SMILES: [S-]c1cccc[n+]1[O-].[S-]c1cccc[n+]1[O-].[Zn+2]
- InChi: 1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
- InChiKey: OTPSWLRZXRHDNX-UHFFFAOYSA-L
Network
Hover on a compound node to display the structore
Synonyms
- zinc 1-oxido-2-pyridin-1-iumthiolate
- zinc 1-oxidanidylpyridin-1-ium-2-thiolate
- zinc pyrithione
- pyrithione
- selenium disulfide
- 109702-19-4
- 118480-78-7
- 1192-70-7
- 1320-68-9
- 13463-41-7
- 14376-32-0
- 15686-64-3
- 162400-43-3
- 16782-00-6
- 17652-47-0
- 192458-89-2
- 208398-70-3
- 226883-65-4
- 244778-79-8
- 31089-48-2
- 3138-01-0
- 35430-20-7
- 3590-23-6
- 39412-61-8
- 51148-10-8
- 51406-57-6
- 55172-61-7
- 74261-71-5
- Omadine Zinc
- Piritionato cincico [INN-Spanish]
- Pyrithione zinc [USAN:BAN:INN]
- Pyrithione zinc derivative
- Pyrithione zincique [INN-French]
- Pyrithionum zincicum [INN-Latin]
- Sebulon Shampoo
- Tomicide Z 50
- Tomicide ZPT 50
- Top Brass
- Vancide P
- Vancide ZP
- Wella Crisan
- ZNP Bar
- ZPT
- Zinc - pyrion
- Zinc 1-hydroxy-2-pyridinethione
- Zinc 2-mercaptopyridine N-oxide
- Zinc 2-pyridinethiol-1-oxide
- Zinc Omadine
- Zinc PT
- Zinc bis(2-pyridylthio)-N-oxide
- Zinc pyrethion
- Zinc pyridine-2-thiol 1-oxide
- Zinc pyridine-2-thiol-1-oxide
- Zinc pyridinethione
- Zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-
- Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-
- Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- (8CI)
- Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4)-
- Zinc, bis(2-pyridinylthio)-, N,N'-dioxide
- Zinc, bis(2-pyridylthio)-, 1,1'-dioxide
- Zinc, bis(2-pyridylthio)-, N,N'-dioxide
- Zinci pyrithionum
- Zincon Dandruff Shampoo
- Zincpolyanemine
- Zn - pyrion
- ZnPT
- NCGC00091933-01
- Zinc, bis[1-(hydroxy-.kappa.O)-2(1H)-pyridinethionato-.kappa.S2]-, (T-4)-
- zinc bis(2-thioxopyridin-1(2H)-olate)
- (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc
- 2(1H)-Pyridinethione, 1-hydroxy-, zinc complex
- 2-Mercaptopyridine 1-oxide zinc salt
- 2-Pyridinethiol-1-oxide, zinc salt
- AI3-62421
- BC-J
- Biocut ZP
- Bis(1-hydroxy-2(1H)-pyridinethionato)zinc
- Bis(2-pyridinethiol-1-oxide)zinc
- Bis(2-pyridylthio)zinc 1,1'-dioxide
- Breck One Dandruff Shampoo
- CCRIS 4894
- Caswell No. 923
- EINECS 236-671-3
- EPA Pesticide Chemical Code 088002
- Evafine P 50
- FSB 8332
- Finecide ZPT
- HSDB 4498
- Head and Shoulders
- Hokucide ZPT
- NSC 290409
- Niccanon SKT
- OM-1563
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Homo sapiens | core-binding factor, beta subunit | No references | |
| Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
| Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | No references |
| Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | No references |
| Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
| Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
| Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | No references |
| Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
| Photinus pyralis | Luciferin 4-monooxygenase | Starlite/ChEMBL | No references |
| Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
| Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
| Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | No references |
| Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
| Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
| Rattus norvegicus | Peripheral myelin protein 22 | Starlite/ChEMBL | No references |
| Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
| Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | No references |
| Trypanosoma brucei gambiense | ATP-dependent phosphofructokinase,6-phospho-1-fructokinase | No references | |
| Homo sapiens | RAR-related orphan receptor C | Starlite/ChEMBL | No references |
| Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
| Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | Starlite/ChEMBL | No references |
| Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | No references |
| Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
| Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
| Homo sapiens | nuclear receptor subfamily 1, group H, member 4 | Starlite/ChEMBL | No references |
| Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | No references |
| Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 10 | Starlite/ChEMBL | No references |
| Homo sapiens | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Starlite/ChEMBL | No references |
| Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
| Homo sapiens | arachidonate 12-lipoxygenase | Starlite/ChEMBL | No references |
| Homo sapiens | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Starlite/ChEMBL | No references |
| Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
| Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | No references |
| Trypanosoma cruzi | cysteine peptidase, putative | Starlite/ChEMBL | No references |
| Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
| Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | No references |
| Homo sapiens | runt-related transcription factor 1 | Starlite/ChEMBL | No references |
| Homo sapiens | heat shock 27kDa protein 1 | Starlite/ChEMBL | No references |
| Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
| Homo sapiens | arachidonate 15-lipoxygenase, type B | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Onchocerca volvulus | 0.006 | 0.0645 | 0.0819 | |
| Onchocerca volvulus | 0.002 | 0.0066 | 0.0055 | |
| Schistosoma mansoni | coup transcription factor | 0.0117 | 0.1488 | 0.3191 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0074 | 0.0854 | 0.4838 |
| Onchocerca volvulus | 0.0055 | 0.058 | 0.0732 | |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0066 | 0.0042 |
| Leishmania major | cysteine peptidase A (CPA) | 0.002 | 0.0066 | 0.0381 |
| Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0117 | 0.1488 | 0.2586 |
| Schistosoma mansoni | lamin | 0.0033 | 0.0247 | 0.0486 |
| Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 0.1695 | 1 |
| Brugia malayi | ecdysone receptor | 0.0055 | 0.058 | 0.0557 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.1695 | 0.3583 |
| Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.029 | 0.2976 |
| Brugia malayi | hypothetical protein | 0.0062 | 0.0677 | 0.0655 |
| Schistosoma mansoni | nuclear hormone receptor | 0.0055 | 0.058 | 0.1212 |
| Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0055 | 0.058 | 0.1008 |
| Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0025 | 0.0025 |
| Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.0024 | 0.000000080466 |
| Schistosoma mansoni | thyroid hormone receptor | 0.0269 | 0.3718 | 0.8052 |
| Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0247 | 0.0224 |
| Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0845 | 0.1468 |
| Schistosoma mansoni | single-minded | 0.0059 | 0.0631 | 0.1323 |
| Echinococcus multilocularis | cysteine protease | 0.002 | 0.0066 | 0.0115 |
| Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0845 | 0.1682 |
| Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0117 | 0.1488 | 0.1467 |
| Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0032 | 0.0008 |
| Echinococcus granulosus | geminin | 0.0205 | 0.2771 | 0.4815 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0074 | 0.0854 | 0.1809 |
| Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0066 | 0.0091 |
| Brugia malayi | tailless protein | 0.0055 | 0.058 | 0.0557 |
| Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0117 | 0.1488 | 0.2586 |
| Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0055 | 0.058 | 0.0557 |
| Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0117 | 0.1488 | 0.2586 |
| Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0845 | 0.4782 |
| Brugia malayi | conserved hypotetical protein | 0.0055 | 0.058 | 0.0557 |
| Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0066 | 0.0115 |
| Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0677 | 0.0677 |
| Onchocerca volvulus | Bile acid receptor homolog | 0.0117 | 0.1488 | 0.1928 |
| Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.029 | 0.2976 |
| Brugia malayi | AMP-binding enzyme family protein | 0.0029 | 0.0189 | 0.0166 |
| Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.0672 | 0.0672 |
| Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0423 | 0.0423 |
| Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0071 | 0.0817 | 0.142 |
| Loa Loa (eye worm) | hypothetical protein | 0.0698 | 1 | 1 |
| Brugia malayi | ecdysteroid receptor | 0.0117 | 0.1488 | 0.1467 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0672 | 0.1333 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.0672 | 0.1412 |
| Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0483 | 0.1 |
| Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.3965 | 0.8578 |
| Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0117 | 0.1488 | 0.1467 |
| Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0236 | 0.3234 | 0.562 |
| Onchocerca volvulus | 0.0018 | 0.003 | 0.0007 | |
| Onchocerca volvulus | Cathepsin F homolog | 0.002 | 0.0066 | 0.0055 |
| Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0117 | 0.1488 | 0.1467 |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Echinococcus granulosus | Polycystic kidney disease protein | 0.0071 | 0.0817 | 0.142 |
| Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.3872 | 0.3872 |
| Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0066 | 0.0115 |
| Echinococcus granulosus | Ankyrin | 0.0018 | 0.0026 | 0.0046 |
| Entamoeba histolytica | acyl-coA synthetase, putative | 0.0029 | 0.0189 | 0.0757 |
| Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.0189 | 0.0234 |
| Brugia malayi | nuclear receptor NHR-67 | 0.0055 | 0.058 | 0.0557 |
| Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.0672 | 0.396 |
| Loa Loa (eye worm) | runx1 | 0.0067 | 0.0754 | 0.0754 |
| Schistosoma mansoni | nuclear receptor | 0.0055 | 0.058 | 0.1212 |
| Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0407 | 0.0707 |
| Echinococcus granulosus | single minded 2 | 0.0048 | 0.0467 | 0.0812 |
| Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0117 | 0.1488 | 0.3191 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0117 | 0.1488 | 0.1488 |
| Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0117 | 0.1488 | 0.3191 |
| Onchocerca volvulus | 0.002 | 0.0066 | 0.0055 | |
| Schistosoma mansoni | zinc finger protein | 0.0055 | 0.058 | 0.1212 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0066 | 0.0042 |
| Echinococcus granulosus | cathepsin L cysteine proteinase | 0.002 | 0.0066 | 0.0115 |
| Loa Loa (eye worm) | fibroinase | 0.002 | 0.0066 | 0.0066 |
| Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.0939 | 0.1631 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0624 | 0.1307 |
| Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0029 | 0.0189 | 0.0757 |
| Brugia malayi | Death domain containing protein | 0.0017 | 0.0024 | 0.000000037 |
| Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.0672 | 1 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0276 | 0.3814 | 0.6628 |
| Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0083 | 0.0229 |
| Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.3456 | 0.344 |
| Mycobacterium ulcerans | glutaminase | 0.033 | 0.4611 | 1 |
| Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0066 | 0.0115 |
| Leishmania major | cathepsin L-like protease | 0.0077 | 0.0899 | 0.5303 |
| Echinococcus granulosus | ecdysone induced protein 78C | 0.0117 | 0.1488 | 0.2586 |
| Onchocerca volvulus | 0.0071 | 0.0817 | 0.1045 | |
| Echinococcus granulosus | lipoxygenase domain containing protein | 0.0071 | 0.0817 | 0.142 |
| Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0189 | 0.0189 |
| Brugia malayi | Nuclear hormone receptor E75 | 0.0055 | 0.058 | 0.0557 |
| Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0055 | 0.058 | 0.1008 |
| Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.3958 | 0.3958 |
| Echinococcus multilocularis | 6 phosphofructokinase | 0.0131 | 0.1695 | 0.2945 |
| Plasmodium falciparum | LCCL domain-containing protein | 0.0071 | 0.0817 | 1 |
| Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.5754 | 1 |
| Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.0672 | 0.7779 |
| Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 0.1695 | 1 |
| Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.1074 | 0.1866 |
| Echinococcus granulosus | lipoxygenase domain containing protein | 0.0071 | 0.0817 | 0.142 |
| Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0845 | 1 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0074 | 0.0854 | 0.1484 |
| Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0189 | 0.0189 |
| Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0845 | 0.1468 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0066 | 0.0381 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0117 | 0.1488 | 0.1488 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0066 | 0.0042 |
| Onchocerca volvulus | 0.0029 | 0.0189 | 0.0218 | |
| Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0407 | 0.0707 |
| Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0117 | 0.1488 | 0.1467 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0074 | 0.0854 | 0.1484 |
| Brugia malayi | hypothetical protein | 0.0535 | 0.7615 | 0.7609 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0074 | 0.0854 | 0.0832 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.1695 | 0.3583 |
| Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.0024 | 0.000000037 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0035 | 0.029 | 0.0492 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0677 | 0.0677 |
| Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.0189 | 0.0234 |
| Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.0672 | 0.396 |
| Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.266 | 0.266 |
| Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2771 | 0.5988 |
| Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0117 | 0.1488 | 0.1467 |
| Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0055 | 0.058 | 0.058 |
| Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0298 | 0.0518 |
| Onchocerca volvulus | 0.0043 | 0.0407 | 0.0505 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0117 | 0.1488 | 0.2586 |
| Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0055 | 0.058 | 0.058 |
| Entamoeba histolytica | phosphofructokinase, putative | 0.0131 | 0.1695 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0117 | 0.1488 | 0.1467 |
| Schistosoma mansoni | nuclear receptor nhr-48 | 0.0055 | 0.058 | 0.1212 |
| Onchocerca volvulus | Protein ultraspiracle homolog | 0.0117 | 0.1488 | 0.1928 |
| Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0117 | 0.1488 | 0.1467 |
| Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.038 | 0.069 |
| Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0055 | 0.058 | 0.0732 |
| Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.3456 | 0.3456 |
| Brugia malayi | photoreceptor-specific nuclear receptor | 0.0117 | 0.1488 | 0.1467 |
| Schistosoma mansoni | lamin | 0.0033 | 0.0247 | 0.0486 |
| Schistosoma mansoni | retinoic acid receptor RXR | 0.0236 | 0.3234 | 0.6998 |
| Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0423 | 0.0735 |
| Toxoplasma gondii | phosphofructokinase PFKII | 0.0035 | 0.029 | 0.287 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0066 | 0.0042 |
| Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0483 | 0.1 |
| Brugia malayi | 6-phosphofructokinase | 0.0131 | 0.1695 | 0.1675 |
| Brugia malayi | AMP-binding enzyme family protein | 0.0029 | 0.0189 | 0.0166 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Onchocerca volvulus | 0.002 | 0.0066 | 0.0055 | |
| Brugia malayi | PAS domain containing protein | 0.0059 | 0.0631 | 0.0608 |
| Onchocerca volvulus | 0.0058 | 0.0624 | 0.079 | |
| Brugia malayi | Steroid receptor seven-up type 2 | 0.0117 | 0.1488 | 0.1467 |
| Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0035 | 0.029 | 0.1373 |
| Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.1999 | 0.3474 |
| Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0131 | 0.1695 | 1 |
| Schistosoma mansoni | RAR-like nuclear receptor | 0.0117 | 0.1488 | 0.3191 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0029 | 0.0189 | 0.0234 |
| Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0083 | 0.0083 |
| Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.0672 | 0.396 |
| Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0055 | 0.058 | 0.1008 |
| Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0117 | 0.1488 | 0.3191 |
| Onchocerca volvulus | 0.0033 | 0.0247 | 0.0294 | |
| Schistosoma mansoni | lozenge | 0.0067 | 0.0754 | 0.159 |
| Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.7615 | 0.7615 |
| Plasmodium vivax | 6-phosphofructokinase, putative | 0.0035 | 0.029 | 0.2976 |
| Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0174 | 0.2326 | 0.4043 |
| Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0062 | 0.0677 | 0.1424 |
| Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.1074 | 0.1866 |
| Echinococcus multilocularis | geminin | 0.0205 | 0.2771 | 0.4815 |
| Brugia malayi | nuclear receptor RXR | 0.0062 | 0.0677 | 0.0655 |
| Brugia malayi | AMP-binding enzyme family protein | 0.0029 | 0.0189 | 0.0166 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0117 | 0.1488 | 0.1488 |
| Brugia malayi | nuclear receptor NHR-88 | 0.0055 | 0.058 | 0.0557 |
| Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0407 | 0.2092 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0117 | 0.1488 | 0.1488 |
| Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0117 | 0.1488 | 0.1467 |
| Leishmania major | protein kinase, putative | 0.0022 | 0.0088 | 0.051 |
| Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.0939 | 0.2608 |
| Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.0024 | 0.0042 |
| Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0066 | 0.0091 |
| Schistosoma mansoni | polycystin 1-related | 0.0071 | 0.0817 | 0.1729 |
| Trypanosoma cruzi | major cysteine proteinase, putative | 0.0061 | 0.0658 | 0.3874 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0074 | 0.0854 | 0.5034 |
| Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0117 | 0.1488 | 0.1488 |
| Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.0939 | 0.5535 |
| Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0247 | 0.0429 |
| Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0645 | 0.0645 |
| Loa Loa (eye worm) | nuclear hormone receptor | 0.0055 | 0.058 | 0.058 |
| Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.0024 | 0.0042 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Echinococcus multilocularis | musashi | 0.0033 | 0.0247 | 0.0429 |
| Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0066 | 0.0066 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0026 | 0.0026 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0074 | 0.0854 | 0.1702 |
| Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.0446 | 0.0776 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.1695 | 0.3583 |
| Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.0672 | 0.396 |
| Toxoplasma gondii | 6-phosphofructokinase | 0.0035 | 0.029 | 0.287 |
| Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0024 | 0.0024 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0035 | 0.029 | 0.0492 |
| Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.0939 | 0.5535 |
| Brugia malayi | steroid hormone receptor | 0.0117 | 0.1488 | 0.1467 |
| Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0845 | 0.1682 |
| Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0117 | 0.1488 | 0.3191 |
| Brugia malayi | hypothetical protein | 0.0286 | 0.3958 | 0.3943 |
| Echinococcus granulosus | cathepsin l cysteine peptidase | 0.002 | 0.0066 | 0.0115 |
| Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0238 | 0.0238 |
| Brugia malayi | hypothetical protein | 0.0071 | 0.0817 | 0.0795 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0117 | 0.1488 | 0.1488 |
| Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0029 | 0.0189 | 0.0234 |
| Onchocerca volvulus | 0.002 | 0.0066 | 0.0055 | |
| Schistosoma mansoni | nuclear hormone receptor | 0.0055 | 0.058 | 0.1212 |
| Schistosoma mansoni | 6-phosphofructokinase | 0.0131 | 0.1695 | 0.3642 |
| Echinococcus multilocularis | Ankyrin | 0.0018 | 0.0026 | 0.0046 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0247 | 0.0247 |
| Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.3872 | 0.3857 |
| Onchocerca volvulus | 0.002 | 0.0066 | 0.0055 | |
| Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.5754 | 1 |
| Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.0024 | 0.0024 |
| Loa Loa (eye worm) | doublecortin family protein | 0.0071 | 0.0817 | 0.0817 |
| Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0407 | 0.2092 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Schistosoma mansoni | lipoxygenase | 0.0147 | 0.1928 | 0.4151 |
| Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.0939 | 0.1631 |
| Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0407 | 0.0834 |
| Brugia malayi | hypothetical protein | 0.0062 | 0.0677 | 0.0655 |
| Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0117 | 0.1488 | 0.1467 |
| Leishmania major | cathepsin L-like protease | 0.0077 | 0.0899 | 0.5303 |
| Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0029 | 0.0189 | 0.0757 |
| Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0083 | 0.0083 |
| Brugia malayi | hypothetical protein | 0.0071 | 0.0817 | 0.0795 |
| Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0247 | 0.0486 |
| Leishmania major | ATP-dependent phosphofructokinase | 0.0131 | 0.1695 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Schistosoma mansoni | glutaminase | 0.033 | 0.4611 | 1 |
| Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0845 | 0.4981 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0407 | 0.2092 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0269 | 0.3718 | 0.6461 |
| Onchocerca volvulus | 0.0036 | 0.0298 | 0.0361 | |
| Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0035 | 0.029 | 1 |
| Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0062 | 0.0677 | 0.1424 |
| Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0131 | 0.1695 | 1 |
| Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0071 | 0.0817 | 0.142 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0066 | 0.0042 |
| Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0624 | 0.1307 |
| Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0337 | 0.0337 |
| Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1939 | 0.2523 |
| Brugia malayi | Nuclear hormone receptor-like 1 | 0.0117 | 0.1488 | 0.1467 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0035 | 0.029 | 0.0492 |
| Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0247 | 0.0429 |
| Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.0672 | 0.396 |
| Brugia malayi | nuclear hormone receptor | 0.0055 | 0.058 | 0.0557 |
| Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0117 | 0.1488 | 0.2586 |
| Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.0939 | 0.5358 |
| Onchocerca volvulus | 0.0071 | 0.0817 | 0.1045 | |
| Brugia malayi | Papain family cysteine protease containing protein | 0.002 | 0.0066 | 0.0042 |
| Echinococcus multilocularis | FTZ F1 alpha | 0.0117 | 0.1488 | 0.2586 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0066 | 0.0381 |
| Echinococcus multilocularis | ecdysone induced protein 78C | 0.0117 | 0.1488 | 0.2586 |
| Brugia malayi | intermediate filament protein | 0.0033 | 0.0247 | 0.0224 |
| Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.0672 | 0.1168 |
| Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0131 | 0.1695 | 1 |
| Echinococcus multilocularis | Polycystic kidney disease protein | 0.0071 | 0.0817 | 0.142 |
| Echinococcus granulosus | nuclear receptor nhr 48 | 0.0055 | 0.058 | 0.1008 |
| Schistosoma mansoni | 6-phosphofructokinase | 0.0131 | 0.1695 | 0.3642 |
| Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0117 | 0.1488 | 0.2586 |
| Mycobacterium ulcerans | putative regulatory protein | 0.0043 | 0.0407 | 0.0715 |
| Loa Loa (eye worm) | DR-78 | 0.0055 | 0.058 | 0.058 |
| Schistosoma mansoni | nuclear hormone receptor | 0.0117 | 0.1488 | 0.3191 |
| Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0062 | 0.0677 | 0.0677 |
| Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0407 | 0.0834 |
| Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0298 | 0.0518 |
| Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0066 | 0.0115 |
| Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0055 | 0.058 | 0.1008 |
| Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0117 | 0.1488 | 0.1467 |
| Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1939 | 0.1939 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0672 | 0.1333 |
| Echinococcus granulosus | lamin | 0.0033 | 0.0247 | 0.0429 |
| Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0117 | 0.1488 | 0.1928 |
| Mycobacterium ulcerans | acyl-CoA synthetase | 0.0029 | 0.0189 | 0.0234 |
| Brugia malayi | bHLH-PAS transcription factor | 0.0043 | 0.0407 | 0.0384 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Brugia malayi | nuclear hormone receptor | 0.0117 | 0.1488 | 0.1467 |
| Brugia malayi | hypothetical protein | 0.0197 | 0.266 | 0.2642 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0672 | 0.1333 |
| Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0298 | 0.3091 |
| Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0279 | 0.0484 |
| Trypanosoma cruzi | cruzipain precursor, putative | 0.0077 | 0.0899 | 0.5303 |
| Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0845 | 0.1682 |
| Brugia malayi | hypoxia-induced factor 1 | 0.0182 | 0.2436 | 0.2418 |
| Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0677 | 0.0677 |
| Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0055 | 0.058 | 0.1008 |
| Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0055 | 0.058 | 0.1008 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0025 | 0.0001 |
| Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0645 | 0.1355 |
| Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.038 | 0.069 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0624 | 0.0601 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Loa Loa (eye worm) | ctsf protein | 0.002 | 0.0066 | 0.0066 |
| Schistosoma mansoni | rab6-interacting | 0.0071 | 0.0817 | 0.1729 |
| Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0298 | 0.0598 |
| Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0817 | 0.1729 |
| Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2771 | 0.5988 |
| Schistosoma mansoni | loxhd1 | 0.0071 | 0.0817 | 0.1729 |
| Schistosoma mansoni | thyroid hormone receptor | 0.0269 | 0.3718 | 0.8052 |
| Onchocerca volvulus | 0.002 | 0.0066 | 0.0055 | |
| Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0298 | 0.0598 |
| Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0117 | 0.1488 | 0.2586 |
| Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.0672 | 0.1168 |
| Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0423 | 0.0735 |
| Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0055 | 0.058 | 0.0557 |
| Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.0939 | 0.5535 |
| Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0298 | 0.0275 |
| Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.0717 | 0.0717 |
| Mycobacterium ulcerans | 6-phosphofructokinase | 0.0131 | 0.1695 | 0.3559 |
| Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.0189 | 0.1109 |
| Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0117 | 0.1488 | 0.1467 |
| Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0062 | 0.0677 | 0.1177 |
| Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0298 | 0.0598 |
| Schistosoma mansoni | hypothetical protein | 0.0152 | 0.1999 | 0.4306 |
| Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0189 | 0.0189 |
| Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.3958 | 0.6878 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0055 | 0.058 | 0.1212 |
| Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0055 | 0.058 | 0.1212 |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0035 | 0.029 | 0.287 |
| Loa Loa (eye worm) | phosphofructokinase | 0.0131 | 0.1695 | 0.1695 |
| Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0083 | 0.0105 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0131 | 0.1695 | 0.3583 |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.0899 | 0.5303 |
| Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0055 | 0.058 | 0.0557 |
| Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0677 | 0.0677 |
| Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0817 | 0.0817 |
| Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.7615 | 0.7615 |
| Onchocerca volvulus | 0.0286 | 0.3967 | 0.5195 | |
| Leishmania major | cathepsin L-like protease | 0.0077 | 0.0899 | 0.5303 |
| Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.1999 | 0.3474 |
| Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0817 | 0.0817 |
| Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.4611 | 0.4611 |
| Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0247 | 0.0247 |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.002 | 0.0066 | 0.0381 |
| Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.0672 | 0.1168 |
| Onchocerca volvulus | 0.0055 | 0.058 | 0.0732 | |
| Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0298 | 0.2981 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Loa Loa (eye worm) | 6-phosphofructokinase | 0.0131 | 0.1695 | 0.1695 |
| Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.0939 | 0.0917 |
| Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0117 | 0.1488 | 0.1467 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0066 | 0.0381 |
| Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0077 | 0.0899 | 0.2224 |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.0899 | 0.5303 |
| Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0407 | 0.2092 |
| Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0117 | 0.1488 | 0.3191 |
| Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0298 | 0.0298 |
| Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.4611 | 1 |
| Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0055 | 0.058 | 0.1008 |
| Echinococcus multilocularis | cysteine protease | 0.002 | 0.0066 | 0.0115 |
| Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.0026 | 0.0005 |
| Echinococcus multilocularis | RUN | 0.0071 | 0.0817 | 0.142 |
| Brugia malayi | hypothetical protein | 0.0055 | 0.058 | 0.0557 |
| Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0845 | 0.1789 |
| Brugia malayi | orphan nuclear receptor NR2E1 | 0.0055 | 0.058 | 0.0557 |
| Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0083 | 0.0083 |
| Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0066 | 0.0055 |
| Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.0939 | 0.1994 |
| Schistosoma mansoni | nuclear receptor | 0.0055 | 0.058 | 0.1212 |
| Echinococcus granulosus | RUN | 0.0071 | 0.0817 | 0.142 |
| Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.0672 | 0.1168 |
| Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1939 | 0.2523 |
| Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0131 | 0.1695 | 1 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0035 | 0.029 | 0.0492 |
| Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0035 | 0.029 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0117 | 0.1488 | 0.2586 |
| Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.0672 | 0.396 |
| Echinococcus multilocularis | lamin | 0.0033 | 0.0247 | 0.0429 |
| Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0686 | 0.1442 |
| Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0055 | 0.058 | 0.1008 |
| Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0029 | 0.0189 | 0.0234 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Brugia malayi | glutaminase DH11.1 | 0.033 | 0.4611 | 0.4598 |
| Brugia malayi | hypothetical protein | 0.0148 | 0.1939 | 0.192 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0117 | 0.1488 | 0.1488 |
| Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0066 | 0.0055 |
| Onchocerca volvulus | 0.0117 | 0.1488 | 0.1928 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0083 | 0.0083 |
| Echinococcus granulosus | death domain containing protein | 0.0017 | 0.0024 | 0.0042 |
| Loa Loa (eye worm) | 6-phosphofructokinase | 0.0131 | 0.1695 | 0.1695 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0074 | 0.0854 | 0.1702 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0066 | 0.0381 |
| Brugia malayi | 6-phosphofructokinase | 0.0131 | 0.1695 | 0.1675 |
| Echinococcus multilocularis | Protein lozenge | 0.0067 | 0.0754 | 0.131 |
| Onchocerca volvulus | 0.0033 | 0.0247 | 0.0294 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1488 | 0.1488 |
| Brugia malayi | nuclear receptor NHR-88 | 0.0117 | 0.1488 | 0.1467 |
| Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.0446 | 0.0776 |
| Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.0677 | 0.0655 |
| Echinococcus granulosus | FTZ F1 alpha | 0.0117 | 0.1488 | 0.2586 |
| Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0117 | 0.1488 | 0.2586 |
| Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.0672 | 0.0649 |
| Onchocerca volvulus | 0.002 | 0.0066 | 0.0055 | |
| Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0117 | 0.1488 | 0.1467 |
| Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0117 | 0.1488 | 0.3191 |
| Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0035 | 0.029 | 0.0492 |
| Leishmania major | cathepsin L-like protease | 0.002 | 0.0066 | 0.0381 |
| Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.058 | 0.058 |
| Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0845 | 0.1789 |
| Brugia malayi | Doublecortin family protein | 0.0071 | 0.0817 | 0.0795 |
| Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.0939 | 0.0939 |
| Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1939 | 0.1939 |
| Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0029 | 0.0189 | 0.0234 |
| Echinococcus granulosus | 6 phosphofructokinase | 0.0131 | 0.1695 | 0.2945 |
| Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0247 | 0.0247 |
| Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.3958 | 0.6878 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0035 | 0.029 | 0.0492 |
| Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0677 | 0.0677 |
| Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0298 | 0.0518 |
| Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0117 | 0.1488 | 0.3191 |
| Brugia malayi | nuclear receptor RXR | 0.0055 | 0.058 | 0.0557 |
| Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0035 | 0.029 | 0.2976 |
| Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.0189 | 0.1109 |
| Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0066 | 0.0042 |
| Trichomonas vaginalis | phosphofructokinase, putative | 0.0035 | 0.029 | 0.0492 |
| Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.002 | 0.0066 | 0.0066 |
| Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0083 | 0.0229 |
| Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.002 | 0.0066 | 0.0066 |
| Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.0677 | 0.0655 |
| Onchocerca volvulus | 0.0535 | 0.7615 | 1 | |
| Brugia malayi | phosphofructokinase | 0.0131 | 0.1695 | 0.1675 |
| Schistosoma mansoni | rab6-interacting | 0.0071 | 0.0817 | 0.1729 |
| Loa Loa (eye worm) | steroid hormone receptor | 0.0117 | 0.1488 | 0.1488 |
| Echinococcus multilocularis | netrin receptor unc 5 | 0.0017 | 0.0024 | 0.0042 |
| Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0117 | 0.1488 | 0.2586 |
| Echinococcus granulosus | netrin receptor unc 5 | 0.0017 | 0.0024 | 0.0042 |
| Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0066 | 0.0115 |
| Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0276 | 0.3814 | 0.6628 |
| Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0117 | 0.1488 | 0.2586 |
| Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0055 | 0.058 | 0.1008 |
| Loa Loa (eye worm) | glutaminase | 0.033 | 0.4611 | 0.4611 |
| Plasmodium vivax | multidomain scavenger receptor, putative | 0.0071 | 0.0817 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0083 | 0.0083 |
| Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0117 | 0.1488 | 0.2586 |
| Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0131 | 0.1695 | 1 |
| Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0423 | 0.04 |
| Loa Loa (eye worm) | cysteine protease | 0.002 | 0.0066 | 0.0066 |
| Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0182 | 0.2436 | 0.2436 |
| Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0055 | 0.058 | 0.0732 |
| Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0.0189 | 0.0234 |
| Brugia malayi | Nuclear hormone receptor E75 | 0.0055 | 0.058 | 0.0557 |
| Echinococcus multilocularis | transfer RNA-Lys | 0.0043 | 0.0407 | 0.0708 |
| Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0247 | 0.0429 |
| Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0029 | 0.0189 | 0.0757 |
| Schistosoma mansoni | lipoxygenase | 0.0276 | 0.3814 | 0.8262 |
| Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0298 | 0.0598 |
| Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0062 | 0.0677 | 0.1177 |
| Leishmania major | 4-coumarate:coa ligase-like protein | 0.0029 | 0.0189 | 0.1109 |
| Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0029 | 0.0189 | 0.0757 |
| Trypanosoma cruzi | cysteine peptidase, putative | 0.0077 | 0.0899 | 0.5303 |
| Brugia malayi | hypothetical protein | 0.0055 | 0.058 | 0.0557 |
| Schistosoma mansoni | aryl hydrocarbon receptor | 0.0059 | 0.0631 | 0.1323 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0672 | 0.1333 |
| Brugia malayi | hypothetical protein | 0.0043 | 0.0407 | 0.0384 |
| Echinococcus granulosus | thyroid hormone receptor alpha | 0.0055 | 0.058 | 0.1008 |
| Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.007 | 0.0801 | 0.4724 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| GI50 (functional) | -6.635 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -5.919 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -5.729 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -5.705 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -5.615 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -5.494 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| GI50 (functional) | -5.49 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Inhibition (ADMET) | = 92.52137816 % | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
| Inhibition (ADMET) | = 94.53822627 % | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | ChEMBL. | 23571415 |
| Potency (functional) | 0.006 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0085 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0088 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0139 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0188 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0197 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0213 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0219 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0441 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0477 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.0531 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.0631 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.0794 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.1059 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.1199 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.1345 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.1883 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-022. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-005. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-012. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-001. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-007. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-014. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-011. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-009. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-015. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-017. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-010. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-018. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-004. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-013. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-019. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-024. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.2512 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-003. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.3013 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-016. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-008. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-021. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-025. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-006. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.3613 uM | PUBCHEM_BIOASSAY: Biochemical firefly luciferase enzyme assay for NPC. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-020. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-002. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-023. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.4053 uM | PUBCHEM_BIOASSAY: Biochemical firefly luciferase enzyme assay for NPC. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.4256 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
| Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP1-002 - Assay at 24 hr. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.7496 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.7943 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP2-026. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.7943 um | PUBCHEM_BIOASSAY: MultiTox-Fluor Cytotoxicity Assay - LYMP1-001 - Live Cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.7943 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP1-002 - Assay at 40 hr. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 0.8485 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 0.8913 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
| Potency (functional) | 0.9074 uM | PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
| Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP1-003 - Assay at 40 hr. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP1-002 - Assay at 16 hr. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 1.1986 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
| Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 1.2589 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485367, AID485368, AID488768] | ChEMBL. | No reference |
| Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: MultiTox-Fluor Cytotoxicity Assay - LYMP1-001 - Dead Cells. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: MultiTox-Fluor Cytotoxicity Assay - LYMP1-003 - Live Cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: Cell Viability - LYMP1-003 - Assay at 24 hr. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 1.3336 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 1.3825 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of glucocorticoid receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 1.5849 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] | ChEMBL. | No reference |
| Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of androgen receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 1.8834 uM | PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 2.5119 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of estrogen receptor alpha signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Live Cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor delta signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Inducers of Hypoxia Response. (Class of assay: confirmatory) [Related pubchem assays: 914 (Primary screen.), 915 (Primary screen.)] | ChEMBL. | No reference |
| Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of retinoid X receptor alpha signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of retinoid X receptor alpha signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 4.2163 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of peroxisome proliferator-activated receptor delta signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor gamma signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (binding) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 6.007 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
| Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
| Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of androgen receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of vitamin D receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 11.079 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of farnesoid X receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of farnesoid X receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of estrogen receptor alpha signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 15.8369 uM | PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element beta-lactamase assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] | ChEMBL. | No reference |
| Potency (binding) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] | ChEMBL. | No reference |
| Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 23.9145 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS assay for small molecule activators of the p53 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of glucocorticoid receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of vitamin D receptor signaling. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
| Potency (functional) | 66.8242 uM | PubChem BioAssay. qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion. (Class of assay: confirmatory) | ChEMBL. | No reference |
| Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Plasmodium falciparum | ChEMBL23 | ||
| Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- Search by CAS
- ChEMBL: CHEMBL1200471
- PubChem: 26041
- PubChem: 415267
Bibliographic References
2 literature references were collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.