Detailed information for compound 541986

Basic information

Technical information
  • TDR Targets ID: 541986
  • Name: rifamycin S
  • MW: 695.753 | Formula: C37H45NO12
  • H donors: 4 H acceptors: 8 LogP: 4.1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1C=COC2(C)Oc3c(C2=O)c2C(=O)C=C(C(=O)c2c(c3C)O)NC(=O)C(=CC=CC(C(C(C(C(C(C1C)OC(=O)C)C)O)C)O)C)C
  • InChi: 1S/C37H45NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,41-43H,1-9H3,(H,38,46)/b11-10-,14-13-,17-12-
  • InChiKey: BTVYFIMKUHNOBZ-QXMMDKDBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • Rafamycin S
  • WLN: T C6 B65-24- A D E 2BC G& AV DV GV LO NO F&VM OU B&U D&U MHT&&TJ IQ J1 M1 QO1 R1 SOV1 T1 UQ V1
  • 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, -5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate
  • 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone, 5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate
  • NSC144130

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0086 0.0803 0.0803
Schistosoma mansoni gamma-secretase subunit aph-1 0.0124 0.1281 0.1271
Echinococcus granulosus Mastin 0.0086 0.0803 0.1526
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0045 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Echinococcus multilocularis neurogenic locus notch protein 0.0055 0.0417 0.0687
Trypanosoma brucei nucleoside transporter 1, putative 0.0071 0.0611 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0071 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0408 0.4828 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0071 0.0611 1
Schistosoma mansoni 3-dehydroquinate synthase 0.0061 0.0489 0.0477
Onchocerca volvulus 0.0151 0.1608 0.153
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0071 0.0611 0.0962
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0496 0.5932 1
Loa Loa (eye worm) hypothetical protein 0.0408 0.4828 0.4828
Onchocerca volvulus Arrow homolog 0.0045 0.0283 0.0193
Onchocerca volvulus 0.0426 0.5053 0.5007
Loa Loa (eye worm) hypothetical protein 0.0045 0.0283 0.0283
Leishmania major nucleobase transporter 0.0071 0.0611 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0061 0.0489 0.0566
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Onchocerca volvulus 0.0735 0.8922 0.8912
Onchocerca volvulus Chorion peroxidase homolog 0.0151 0.1608 0.153
Echinococcus multilocularis tissue type plasminogen activator 0.0059 0.0461 0.078
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Trypanosoma brucei adenosine transporter 2 0.0071 0.0611 1
Trypanosoma cruzi nucleoside transporter 1, putative 0.0071 0.0611 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0071 0.0611 1
Schistosoma mansoni notch 0.0055 0.0417 0.0405
Trypanosoma cruzi nucleobase transporter, putative 0.0071 0.0611 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0096 0.0924 0.1319
Trypanosoma brucei purine nucleoside transporter 0.0071 0.0611 1
Onchocerca volvulus Peroxidasin homolog 0.0151 0.1608 0.153
Leishmania major nucleoside transporter 1, putative 0.0071 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0821 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0071 0.0611 1
Echinococcus multilocularis laminin 0.0045 0.0283 0.0404
Loa Loa (eye worm) hypothetical protein 0.0086 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0252 0.2879 0.2879
Onchocerca volvulus 0.0233 0.2635 0.2567
Echinococcus multilocularis notch 0.0055 0.0417 0.0687
Schistosoma mansoni notch 0.0055 0.0417 0.0405
Loa Loa (eye worm) hypothetical protein 0.0086 0.0803 0.0803
Brugia malayi Blistered cuticle protein 3 0.0151 0.1608 0.1608
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0163 0.015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0803 0.0791
Onchocerca volvulus Putative cubilin 0.0055 0.0417 0.0328
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Brugia malayi Animal haem peroxidase family protein 0.0151 0.1608 0.1608
Loa Loa (eye worm) animal heme peroxidase 0.0151 0.1608 0.1608
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Brugia malayi Nucleoside transporter family protein 0.0408 0.4828 0.4828
Loa Loa (eye worm) hypothetical protein 0.0035 0.0163 0.0163
Echinococcus multilocularis transmembrane protease serine 3 0.0086 0.0803 0.1501
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0803 0.0791
Loa Loa (eye worm) hypothetical protein 0.0086 0.0803 0.0803
Echinococcus multilocularis neural cadherin 0.0055 0.0417 0.0687
Brugia malayi EGF-like domain containing protein 0.0055 0.0417 0.0417
Trypanosoma cruzi nucleoside transporter 1, putative 0.0071 0.0611 1
Brugia malayi Trypsin family protein 0.0086 0.0803 0.0803
Onchocerca volvulus 0.0151 0.1608 0.153
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Onchocerca volvulus 0.0151 0.1608 0.153
Toxoplasma gondii calcium binding egf domain-containing protein 0.0045 0.0283 0.12
Toxoplasma gondii EGF family domain-containing protein 0.0055 0.0417 0.2039
Onchocerca volvulus 0.0055 0.0417 0.0328
Trypanosoma cruzi nucleoside transporter 1, putative 0.0071 0.0611 1
Entamoeba histolytica nucleoside transporter, putative 0.0408 0.4828 1
Trypanosoma brucei adenosine transporter 2, putative 0.0071 0.0611 1
Echinococcus multilocularis neurogenic locus notch protein 0.0055 0.0417 0.0687
Mycobacterium ulcerans hypothetical protein 0.0086 0.0803 0.111
Leishmania major nucleoside transporter 1, putative 0.0071 0.0611 1
Onchocerca volvulus 0.0252 0.2879 0.2812
Trypanosoma brucei adenosine transporter 2 0.0071 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0283 0.0283
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0086 0.0803 0.1526
Onchocerca volvulus 0.0055 0.0417 0.0328
Brugia malayi Trypsin family protein 0.0086 0.0803 0.0803
Schistosoma mansoni hypothetical protein 0.0086 0.0803 0.0791
Onchocerca volvulus Neurogenic locus notch homolog 0.0055 0.0417 0.0328
Schistosoma mansoni hypothetical protein 0.0055 0.0417 0.0405
Onchocerca volvulus 0.0821 1 1
Echinococcus granulosus slit 2 protein 0.0055 0.0417 0.0714
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0086 0.0803 0.1501
Brugia malayi Kringle domain containing protein 0.0059 0.0461 0.0461
Onchocerca volvulus 0.0055 0.0417 0.0328
Loa Loa (eye worm) hypothetical protein 0.0045 0.0283 0.0283
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0408 0.4828 1
Brugia malayi notch-like transmembrane receptor 0.0055 0.0417 0.0417
Echinococcus multilocularis fibrillin 1 0.0045 0.0283 0.0404
Echinococcus granulosus glycoprotein Antigen 5 0.0086 0.0803 0.1526
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0803 0.1501
Loa Loa (eye worm) hypothetical protein 0.0408 0.4828 0.4828
Onchocerca volvulus 0.0086 0.0803 0.0718
Schistosoma mansoni cell polarity protein 0.0055 0.0417 0.0405
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0408 0.4828 1
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0061 0.0489 0.0566
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Schistosoma mansoni hypothetical protein 0.0055 0.0417 0.0405
Loa Loa (eye worm) hypothetical protein 0.0035 0.0163 0.0163
Echinococcus granulosus protein jagged 2 0.0055 0.0417 0.0714
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0071 0.0611 1
Schistosoma mansoni hypothetical protein 0.0055 0.0417 0.0405
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0086 0.0803 0.0791
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0408 0.4828 0.478
Trypanosoma cruzi nucleobase transporter, putative 0.0071 0.0611 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Echinococcus granulosus notch 0.0055 0.0417 0.0714
Toxoplasma gondii nucleoside transporter protein 0.0071 0.0611 0.3255
Schistosoma mansoni hypothetical protein 0.0055 0.0417 0.0405
Echinococcus granulosus gamma secretase subunit aph 1 0.0124 0.1281 0.2533
Schistosoma mansoni notch 0.0055 0.0417 0.0405
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0496 0.5932 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0408 0.4828 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0163 0.2508
Plasmodium falciparum cysteine repeat modular protein 1 0.0059 0.0461 0.0446
Brugia malayi hypothetical protein 0.0071 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Brugia malayi EGF-like domain containing protein 0.0055 0.0417 0.0417
Toxoplasma gondii nucleoside transporter protein 0.0071 0.0611 0.3255
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Onchocerca volvulus 0.0055 0.0417 0.0328
Onchocerca volvulus 0.0035 0.0163 0.0071
Trypanosoma brucei unspecified product 0.0071 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Echinococcus multilocularis protein jagged 1 0.0055 0.0417 0.0687
Trypanosoma brucei adenosine transporter 2, putative 0.0071 0.0611 1
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0496 0.5932 1
Onchocerca volvulus Peroxidase homolog 0.0151 0.1608 0.153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0163 0.0163
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0071 0.0611 0.0962
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0163 0.015
Onchocerca volvulus 0.0055 0.0417 0.0328
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0408 0.4828 0.478
Loa Loa (eye worm) animal heme peroxidase 0.0151 0.1608 0.1608
Echinococcus granulosus neurogenic locus notch protein 0.0055 0.0417 0.0714
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0092 0.0028
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0157 0.1688 1
Echinococcus multilocularis Mastin 0.0086 0.0803 0.1501
Loa Loa (eye worm) hypothetical protein 0.0035 0.0163 0.0163
Echinococcus multilocularis neurogenic locus notch protein 4 0.0055 0.0417 0.0687
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0059 0.0461 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0045 0.0283 0.0283
Echinococcus granulosus equilibrative nucleoside transporter 0.0408 0.4828 1
Echinococcus granulosus enteropeptidase 0.0086 0.0803 0.1526
Brugia malayi EGF-like domain containing protein 0.0055 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Brugia malayi Fibulin-1 precursor 0.0045 0.0283 0.0283
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0055 0.0417 0.0405
Brugia malayi Animal haem peroxidase family protein 0.0151 0.1608 0.1608
Echinococcus multilocularis neurogenic locus protein delta 0.0055 0.0417 0.0687
Schistosoma mansoni septate junction protein 0.0055 0.0417 0.0405
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.1917 0.376
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0821 1 1
Echinococcus granulosus neurogenic locus protein delta 0.0055 0.0417 0.0714
Toxoplasma gondii calcium binding egf domain-containing protein 0.0045 0.0283 0.12
Echinococcus multilocularis gamma secretase subunit aph 1 0.0124 0.1281 0.2512
Echinococcus multilocularis protein jagged 2 0.0055 0.0417 0.0687
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2282 0.2282
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Schistosoma mansoni notch 0.0055 0.0417 0.0405
Echinococcus granulosus transmembrane protease serine 3 0.0086 0.0803 0.1526
Echinococcus granulosus protein jagged 2 0.0055 0.0417 0.0714
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Brugia malayi hypothetical protein 0.0252 0.2879 0.2879
Trypanosoma cruzi nucleobase transporter, putative 0.0071 0.0611 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0803 0.0791
Brugia malayi hypothetical protein 0.0151 0.1608 0.1608
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0038 0.0206 0.3097
Echinococcus multilocularis protein jagged 1 0.0055 0.0417 0.0687
Leishmania major hypothetical protein, conserved 0.0059 0.0461 0.666
Trypanosoma brucei adenosine transporter, putative 0.0071 0.0611 1
Trypanosoma brucei adenosine transporter 2, putative 0.0071 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0071 0.0611 0.0962
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Schistosoma mansoni notch 0.0055 0.0417 0.0405
Loa Loa (eye worm) animal heme peroxidase 0.0151 0.1608 0.1608
Schistosoma mansoni egf-like domain protein 0.0045 0.0283 0.0271
Trypanosoma cruzi nucleoside transporter-like, putative 0.0071 0.0611 1
Echinococcus multilocularis fibropellin Ia 0.0055 0.0417 0.0687
Loa Loa (eye worm) beta-lactamase 0.0035 0.0163 0.0163
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0071 0.0611 0.0962
Echinococcus granulosus protein jagged 1 0.0055 0.0417 0.0714
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.0417 0.0417
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0061 0.0489 0.0566
Brugia malayi Pre-SET motif family protein 0.0029 0.0092 0.0092
Toxoplasma gondii nucleoside transporter protein 0.0071 0.0611 0.3255
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0337 0.3942 0.8129
Brugia malayi Protein kinase domain containing protein 0.0059 0.0461 0.0461
Giardia lamblia Hypothetical protein 0.0408 0.4828 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0283 0.0283
Onchocerca volvulus 0.0086 0.0803 0.0718
Echinococcus multilocularis neurogenic locus protein delta 0.0055 0.0417 0.0687
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0163 0.0177
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0071 0.0611 1
Brugia malayi beta-lactamase family protein 0.0035 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.0079
Brugia malayi Animal haem peroxidase family protein 0.0151 0.1608 0.1608
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0055 0.0417 0.0328
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Echinococcus granulosus delta-like protein 1 0.0055 0.0417 0.0714
Loa Loa (eye worm) hypothetical protein 0.018 0.1978 0.1978
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0055 0.0417 0.0417
Brugia malayi EGF-like domain containing protein 0.0055 0.0417 0.0417
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0071 0.0611 0.0962
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0408 0.4828 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Loa Loa (eye worm) notch protein 0.0055 0.0417 0.0417
Schistosoma mansoni hypothetical protein 0.0055 0.0417 0.0405
Loa Loa (eye worm) hypothetical protein 0.0071 0.0611 0.0611
Onchocerca volvulus Peroxidasin homolog 0.0151 0.1608 0.153
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0071 0.0611 1
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0496 0.5932 1
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0461 0.666
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.018 0.1978 0.1978
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0408 0.4828 1
Loa Loa (eye worm) hypothetical protein 0.0821 1 1
Toxoplasma gondii kringle domain-containing protein 0.0059 0.0461 0.2316
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Echinococcus multilocularis slit 2 protein 0.0055 0.0417 0.0687
Echinococcus granulosus neurogenic locus notch protein 4 0.0055 0.0417 0.0714
Schistosoma mansoni peroxidasin 0.0151 0.1608 0.1598
Trypanosoma brucei adenosine transporter 2, putative 0.0071 0.0611 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0045 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.0079
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0061 0.0489 0.0566
Trypanosoma brucei adenosine transporter, putative 0.0071 0.0611 1
Onchocerca volvulus 0.0086 0.0803 0.0718
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0086 0.0803 0.0803
Schistosoma mansoni hypothetical protein 0.0055 0.0417 0.0405
Brugia malayi Trypsin family protein 0.0086 0.0803 0.0803
Schistosoma mansoni hypothetical protein 0.0059 0.0461 0.045
Loa Loa (eye worm) animal heme peroxidase 0.0151 0.1608 0.1608
Onchocerca volvulus 0.0035 0.0163 0.0071
Brugia malayi gamma-secretase subunit aph-1 0.0124 0.1281 0.1281
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0283 0.0283
Onchocerca volvulus Dual oxidase homolog 0.0151 0.1608 0.153
Onchocerca volvulus Slit protein homolog 0.0055 0.0417 0.0328
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Loa Loa (eye worm) Notch2 0.0055 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0035 0.0163 0.0163
Onchocerca volvulus 0.0035 0.0163 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Loa Loa (eye worm) blistered cuticle protein 3 0.0151 0.1608 0.1608
Echinococcus multilocularis enteropeptidase 0.0086 0.0803 0.1501
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0163 0.0149
Loa Loa (eye worm) trypsin family protein 0.0086 0.0803 0.0803
Onchocerca volvulus 0.0086 0.0803 0.0718
Trypanosoma brucei Aph-1 protein, putative 0.0048 0.0332 0.5329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0092 0.0079
Brugia malayi beta-lactamase family protein 0.0035 0.0163 0.0163
Brugia malayi EGF-like domain containing protein 0.0055 0.0417 0.0417
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2635 0.53
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Brugia malayi Pre-SET motif family protein 0.0204 0.2282 0.2282
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0071 0.0611 1
Trypanosoma brucei unspecified product 0.0071 0.0611 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0283 0.0271
Brugia malayi EGF-like domain containing protein 0.0055 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0157 0.1688 0.2643
Loa Loa (eye worm) hypothetical protein 0.0059 0.0461 0.0461
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Trypanosoma brucei adenosine transporter 2, putative 0.0071 0.0611 1
Schistosoma mansoni notch 0.0055 0.0417 0.0405
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0408 0.4828 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Brugia malayi Animal haem peroxidase family protein 0.0151 0.1608 0.1608
Brugia malayi beta-lactamase 0.0035 0.0163 0.0163
Echinococcus granulosus peroxidasin 0.0151 0.1608 0.3221
Schistosoma mansoni laminin gamma-3 chain 0.0055 0.0417 0.0405
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0821 1 1
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0124 0.1281 0.1281
Echinococcus granulosus tissue type plasminogen activator 0.0059 0.0461 0.0807
Echinococcus multilocularis glycoprotein Antigen 5 0.0086 0.0803 0.1501
Echinococcus granulosus fibropellin Ia 0.0055 0.0417 0.0714
Brugia malayi hypothetical protein 0.0408 0.4828 0.4828
Onchocerca volvulus 0.0086 0.0803 0.0718
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Onchocerca volvulus 0.0059 0.0461 0.0373
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0496 0.5932 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.252 0.4086
Echinococcus granulosus Tolloid protein 1 0.0045 0.0283 0.0431
Echinococcus multilocularis peroxidasin 0.0151 0.1608 0.3202
Brugia malayi Delta serrate ligand family protein 0.0055 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Toxoplasma gondii ABC1 family protein 0.0035 0.0163 0.0443
Echinococcus granulosus protein jagged 1 0.0055 0.0417 0.0714
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0408 0.4828 0.4828
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0036 0.0175 0.0518
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.0417 0.0417
Schistosoma mansoni equilibrative nucleoside transporter 0.0071 0.0611 0.06
Echinococcus multilocularis fat cadherin tumor suppressor 0.0055 0.0417 0.0687
Brugia malayi Cadherin domain containing protein 0.0055 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Trypanosoma cruzi Aph-1 protein, putative 0.0048 0.0332 0.3766
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0496 0.5932 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0163 0.1915
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0096 0.0924 0.0799
Loa Loa (eye worm) hypothetical protein 0.0045 0.0283 0.0283
Trypanosoma brucei nucleoside transporter 1, putative 0.0071 0.0611 1
Schistosoma mansoni protein kinase 0.0071 0.0612 0.0601
Loa Loa (eye worm) TK/ROR protein kinase 0.0059 0.0461 0.0461
Echinococcus granulosus laminin 0.0045 0.0283 0.0431
Trypanosoma cruzi Aph-1 protein, putative 0.0048 0.0332 0.3766
Trypanosoma cruzi nucleoside transporter-like, putative 0.0071 0.0611 1
Echinococcus granulosus neural cadherin 0.0055 0.0417 0.0714
Leishmania major nucleobase transporter 0.0071 0.0611 1
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.0417 0.0417
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0803 0.0791
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0086 0.0803 0.1526
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0157 0.1688 0.2643
Onchocerca volvulus Peroxidase homolog 0.0151 0.1608 0.153
Schistosoma mansoni hypothetical protein 0.0055 0.0417 0.0405
Brugia malayi GCC2 and GCC3 family protein 0.0055 0.0417 0.0417
Brugia malayi EGF-like domain containing protein 0.0055 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0157 0.1688 0.2202
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0496 0.5932 1
Brugia malayi hypothetical protein 0.0086 0.0803 0.0803
Brugia malayi Peroxidasin 0.0151 0.1608 0.1608
Brugia malayi Cadherin domain containing protein 0.0055 0.0417 0.0417
Schistosoma mansoni peroxidasin 0.0151 0.1608 0.1598
Trypanosoma brucei purine nucleoside transporter 0.0071 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.1608 0.1608
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0086 0.0803 0.0791
Schistosoma mansoni cercarial elastase (S01 family) 0.0086 0.0803 0.0791
Brugia malayi Muscle positioning protein 4 0.0055 0.0417 0.0417
Brugia malayi Trypsin-like protease protein 5 0.0086 0.0803 0.0803
Schistosoma mansoni hypothetical protein 0.0086 0.0803 0.0791
Echinococcus granulosus neurogenic locus notch protein 0.0055 0.0417 0.0714
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0283 0.0404
Loa Loa (eye worm) hypothetical protein 0.0086 0.0803 0.0803
Schistosoma mansoni slit 0.0055 0.0417 0.0405
Loa Loa (eye worm) hypothetical protein 0.0055 0.0417 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0092 0.0079
Brugia malayi Animal haem peroxidase family protein 0.0151 0.1608 0.1608

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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