Detailed information for compound 542084

Basic information

Technical information
  • TDR Targets ID: 542084
  • Name: 3-(4-chlorophenyl)-1-phenyl-2,3-dihydro-1H-be nzo[f][1,3]benzoxazine
  • MW: 371.859 | Formula: C24H18ClNO
  • H donors: 1 H acceptors: 0 LogP: 6.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1Oc2ccc3c(c2C(N1)c1ccccc1)cccc3
  • InChi: 1S/C24H18ClNO/c25-19-13-10-18(11-14-19)24-26-23(17-7-2-1-3-8-17)22-20-9-5-4-6-16(20)12-15-21(22)27-24/h1-15,23-24,26H
  • InChiKey: PTSGIYDZVYWRDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 24609-76-5
  • NSC135846

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0061 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.024 0.0266
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0068 0.008
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.088 0.0973
Plasmodium falciparum heat shock protein 90 0.0033 0.0356 0.1766
Brugia malayi RNA recognition motif domain containing protein 0.0186 0.5109 0.8998
Echinococcus multilocularis heat shock protein 90 0.0026 0.0147 0.0147
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0061 0.0062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1247 0.6182
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0356 0.0394
Schistosoma mansoni intermediate filament proteins 0.0054 0.1008 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1505 0.1759
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.088 0.088
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0149 0.0262
Brugia malayi hypothetical protein 0.0125 0.3199 0.5633
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.0149 0.0149
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0356 0.0416
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1353 0.6704
Schistosoma mansoni heat shock protein 0.0033 0.0356 0.0361
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.088 0.088
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0068 0.0338
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Leishmania major basic transcription factor 3a, putative 0.007 0.1505 0.7461
Loa Loa (eye worm) intermediate filament protein 0.0054 0.1008 0.1114
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0356 0.0416
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.2018 1
Brugia malayi MH2 domain containing protein 0.0118 0.2988 0.5263
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.022 0.6145 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0229 0.0253
Brugia malayi Importin beta-1 subunit 0.0029 0.024 0.0423
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.088 0.155
Loa Loa (eye worm) doublecortin family protein 0.0058 0.1142 0.1262
Onchocerca volvulus 0.0029 0.024 0.0276
Schistosoma mansoni endoplasmin 0.0033 0.0356 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0729 0.0739
Brugia malayi RNA binding protein 0.0186 0.5109 0.8998
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.0149 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.088 0.0892
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.3838 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0165
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.088 0.088
Echinococcus multilocularis transcription factor btf3 0.007 0.1505 0.1505
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.5678 0.6274
Echinococcus multilocularis FTZ F1 alpha 0.005 0.088 0.088
Brugia malayi Thioredoxin reductase 0.0087 0.2018 0.3553
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.012
Trichomonas vaginalis set domain proteins, putative 0.0233 0.6555 0.7659
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0261 0.0305
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0061 0.0061
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0356 0.1766
Brugia malayi nuclear receptor NHR-88 0.005 0.088 0.155
Plasmodium vivax glutathione reductase, putative 0.0087 0.2018 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0261 0.0261
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.905 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.024 0.0244
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0261 0.1295
Onchocerca volvulus Bile acid receptor homolog 0.005 0.088 0.1261
Brugia malayi hypothetical protein 0.0024 0.0061 0.0108
Loa Loa (eye worm) hypothetical protein 0.0054 0.1008 0.1114
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0061 0.0108
Plasmodium falciparum glutathione reductase 0.0087 0.2018 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.1353 0.137
Schistosoma mansoni lipoxygenase 0.012 0.3065 0.3104
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0061 0.0068
Echinococcus granulosus transcription factor btf3 0.007 0.1505 0.1505
Schistosoma mansoni hypothetical protein 0.0313 0.905 0.9166
Entamoeba histolytica hypothetical protein 0.0024 0.0068 0.008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.085 0.1498
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0261 0.1295
Mycobacterium tuberculosis Probable oxidoreductase 0.022 0.6145 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.0149 0.0149
Brugia malayi steroid hormone receptor 0.005 0.088 0.155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0198 0.5461 0.8859
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0061 0.0108
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.024 0.1192
Leishmania major trypanothione reductase 0.0087 0.2018 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.088 0.0892
Schistosoma mansoni heat shock protein 0.0033 0.0356 0.0361
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0356 0.1766
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0729 0.0729
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.088 0.088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Loa Loa (eye worm) hypothetical protein 0.018 0.4931 0.5448
Loa Loa (eye worm) hypothetical protein 0.0049 0.085 0.094
Brugia malayi nuclear hormone receptor 0.005 0.088 0.155
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0356 0.1766
Schistosoma mansoni loxhd1 0.0058 0.1142 0.1157
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0198 0.5461 0.8859
Onchocerca volvulus 0.0058 0.1142 0.1665
Toxoplasma gondii NAC domain-containing protein 0.007 0.1505 0.7461
Brugia malayi Endoplasmin precursor 0.0033 0.0356 0.0627
Schistosoma mansoni tar DNA-binding protein 0.0186 0.5109 0.5175
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0147 0.0172
Plasmodium falciparum glutathione reductase 0.003 0.0261 0.1295
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.1008 0.1114
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Echinococcus multilocularis heat shock protein 0.0033 0.0356 0.0356
Entamoeba histolytica hypothetical protein 0.0035 0.0431 0.0503
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0068 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0729 0.0739
Entamoeba histolytica hypothetical protein 0.0035 0.0431 0.0503
Brugia malayi hypothetical protein 0.0058 0.1142 0.2012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.088 0.155
Entamoeba histolytica hypothetical protein 0.0035 0.0431 0.0503
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0261 0.0305
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0061 0.0108
Echinococcus multilocularis snurportin 1 0.0313 0.905 0.905
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.088 0.155
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0165
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.024 0.024
Schistosoma mansoni zinc finger protein 0.0024 0.0061 0.0062
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0356 0.1766
Echinococcus granulosus FTZ F1 alpha 0.005 0.088 0.088
Brugia malayi nuclear receptor RXR 0.0026 0.0149 0.0262
Loa Loa (eye worm) hypothetical protein 0.0125 0.3199 0.3534
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0198 0.5461 0.8859
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0356 0.1766
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.088 0.0892
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.2018 0.3118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.024 0.0244
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.1142 0.5662
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0356 0.1766
Schistosoma mansoni importin beta-1 0.0029 0.024 0.0243
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1247 0.1263
Brugia malayi ecdysteroid receptor 0.005 0.088 0.155
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1247 0.298
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0261 0.1295
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0261 0.1295
Schistosoma mansoni tar DNA-binding protein 0.0186 0.5109 0.5175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0431 0.0431
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.024 0.0244
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0261 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0729 0.0729
Brugia malayi conserved hypotetical protein 0.0024 0.0061 0.0108
Plasmodium vivax endoplasmin, putative 0.0033 0.0356 0.1766
Brugia malayi heat shock protein 90 0.0033 0.0356 0.0627
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0014 0.0025
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0501 0.0501
Echinococcus granulosus heat shock protein 0.0033 0.0356 0.0356
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0261 0.1295
Schistosoma mansoni tar DNA-binding protein 0.0186 0.5109 0.5175
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0061 0.0062
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2988 0.3302
Loa Loa (eye worm) hypothetical protein 0.0029 0.024 0.0266
Mycobacterium tuberculosis Probable reductase 0.0198 0.5461 0.8859
Brugia malayi glutathione reductase 0.0087 0.2018 0.3553
Treponema pallidum NADH oxidase 0.003 0.0261 0.0136
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.1505 0.7461
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0149 0.0262
Brugia malayi nuclear receptor NHR-88 0.0024 0.0061 0.0108
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.2034 0.2034
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.2018 1
Echinococcus multilocularis heat shock protein 90 0.0033 0.0356 0.0356
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0261 0.1295
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0356 0.1766
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.088 0.1261
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.088 0.088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Plasmodium falciparum thioredoxin reductase 0.0087 0.2018 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0061 0.0061
Onchocerca volvulus 0.0058 0.1142 0.1665
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0261 0.1295
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.024 0.024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.088 0.088
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.085 0.1498
Brugia malayi hypothetical protein 0.0024 0.0061 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.088 0.088
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.1353 0.1353
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0061 0.0062
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0261 0.1295
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.8559 1
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Echinococcus granulosus intermediate filament protein 0.0054 0.1008 0.1008
Brugia malayi beta-NAC-like protein 0.007 0.1505 0.2651
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0729 0.0739
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.088 0.0892
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0068 0.008
Onchocerca volvulus Huntingtin homolog 0.0125 0.3199 0.4831
Echinococcus granulosus endoplasmin 0.0026 0.0147 0.0147
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0147 0.073
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0356 0.1766
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.022 0.6145 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Echinococcus granulosus heat shock protein 90 0.0033 0.0356 0.0356
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.1353 0.158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.088 0.155
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.088 0.088
Loa Loa (eye worm) TAR-binding protein 0.0186 0.5109 0.5645
Schistosoma mansoni lamin 0.0054 0.1008 0.1021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0261 0.1295
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0061 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.088 0.0973
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.088 0.088
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.3838 0.6154
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0261 0.0265
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.088 0.0892
Plasmodium falciparum thioredoxin reductase 0.003 0.0261 0.1295
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.8559 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Loa Loa (eye worm) hypothetical protein 0.0058 0.1142 0.1262
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0729 0.1285
Brugia malayi nuclear hormone receptor 0.0024 0.0061 0.0108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.088 0.0973
Echinococcus granulosus RUN 0.0058 0.1142 0.1142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.088 0.155
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.1505 0.7461
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.088 0.0892
Schistosoma mansoni thyroid hormone receptor 0.005 0.088 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.088 0.155
Plasmodium vivax SET domain protein, putative 0.0029 0.024 0.1192
Schistosoma mansoni endoplasmin 0.0033 0.0356 0.0361
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0014 0.0025
Mycobacterium tuberculosis Probable dehydrogenase 0.0198 0.5461 0.8859
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.4778 0.5582
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0061 0.0061
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.1142 0.1142
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0261 0.1295
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0061 0.0061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.088 0.0892
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0061 0.0108
Echinococcus multilocularis tumor protein p63 0.0344 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0369 0.065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.088 0.155
Loa Loa (eye worm) DR-78 0.0024 0.0061 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1247 0.298
Schistosoma mansoni hypothetical protein 0.0035 0.0431 0.0436
Brugia malayi nuclear receptor RXR 0.0024 0.0061 0.0108
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0261 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0729 0.0806
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0149 0.0151
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0356 0.0416
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.024 0.1192
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0147 0.0172
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0165
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.1142 0.1142
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Plasmodium falciparum importin beta, putative 0.0029 0.024 0.1192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.024 0.0244
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0356 0.1766
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.018 0.4931 0.8684
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0261 0.1295
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0225 0.6327 0.6327
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.014 0.014
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.1353 0.1353
Schistosoma mansoni hypothetical protein 0.0058 0.1142 0.1157
Brugia malayi RNA, U transporter 1 0.0083 0.1919 0.338
Schistosoma mansoni rab6-interacting 0.0058 0.1142 0.1157
Echinococcus granulosus tar DNA binding protein 0.0186 0.5109 0.5109
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0186 0.5109 0.5645
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0261 0.1295
Onchocerca volvulus 0.005 0.0892 0.1279
Loa Loa (eye worm) glutathione reductase 0.0087 0.2018 0.2229
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.088 0.155
Brugia malayi TAR-binding protein 0.0186 0.5109 0.8998
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0207 0.0207
Giardia lamblia Grp94/Hsp90 0.0026 0.0147 0.0172
Echinococcus multilocularis musashi 0.0054 0.1008 0.1008
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0261 0.046
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2988 0.3302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.1142 0.5662
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.088 0.1261
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.8559 1
Schistosoma mansoni lamin 0.0054 0.1008 0.1021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0198 0.5461 0.8859
Schistosoma mansoni nuclear receptor 0.0024 0.0061 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.1142 0.1142
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0356 0.1766
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0198 0.5461 0.8859
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Brugia malayi hypothetical protein 0.0026 0.0149 0.0262
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0061 0.0061
Onchocerca volvulus 0.005 0.088 0.1261
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.088 0.0892
Onchocerca volvulus 0.0054 0.1008 0.1458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.088 0.0973
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Echinococcus multilocularis importin subunit beta 1 0.0029 0.024 0.024
Schistosoma mansoni hypothetical protein 0.034 0.9873 1
Brugia malayi intermediate filament protein 0.0054 0.1008 0.1775
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.2034 0.2034
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0431 0.0436
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0225 0.6327 0.6327
Entamoeba histolytica hypothetical protein 0.0035 0.0431 0.0503
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.1142 0.1142
Loa Loa (eye worm) RNA binding protein 0.0186 0.5109 0.5645
Schistosoma mansoni tar DNA-binding protein 0.0186 0.5109 0.5175
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.022 0.6145 1
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.2018 0.2229
Echinococcus multilocularis RUN 0.0058 0.1142 0.1142
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.088 0.088
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1247 0.1263
Plasmodium vivax importin-beta 2, putative 0.0029 0.024 0.1192
Onchocerca volvulus 0.0054 0.1008 0.1458
Brugia malayi hypothetical protein 0.0035 0.0431 0.0759
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.088 0.088
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0147 0.0172
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.088 0.088
Brugia malayi Doublecortin family protein 0.0058 0.1142 0.2012
Trypanosoma brucei trypanothione reductase 0.0087 0.2018 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.8559 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1353 0.6704
Loa Loa (eye worm) ICD-1 protein 0.007 0.1505 0.1663
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.088 0.155
Brugia malayi Steroid receptor seven-up type 2 0.005 0.088 0.155
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0061 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.088 0.088
Schistosoma mansoni tar DNA-binding protein 0.0186 0.5109 0.5175
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0892 0.0903
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0729 0.0729
Loa Loa (eye worm) hypothetical protein 0.0058 0.1142 0.1262
Echinococcus granulosus importin subunit beta 1 0.0029 0.024 0.024
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.1353 0.2382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Brugia malayi tailless protein 0.0024 0.0061 0.0108
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1247 0.6182
Trypanosoma brucei transcription factor BTF3, putative 0.007 0.1505 0.7461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.088 0.0973
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0261 0.0309
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0147 0.0147
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.024 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.088 0.155
Schistosoma mansoni nuclear receptor 0.0024 0.0061 0.0062
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0501 0.0501
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.0149 0.0165
Echinococcus granulosus lamin dm0 0.0054 0.1008 0.1008
Brugia malayi Pre-SET motif family protein 0.0205 0.5678 1
Schistosoma mansoni transcription factor btf3 0.007 0.1505 0.1525
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0147 0.073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0729 0.0729
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0261 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Echinococcus granulosus lamin 0.0054 0.1008 0.1008
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0356 0.0416
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.088 0.088
Loa Loa (eye worm) hypothetical protein 0.0026 0.014 0.0154
Echinococcus multilocularis tar DNA binding protein 0.0186 0.5109 0.5109
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0061 0.0068
Brugia malayi nuclear receptor NHR-67 0.0024 0.0061 0.0108
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0261 0.1295
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.088 0.155
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0261 0.0261
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Plasmodium falciparum basic transcription factor 3b, putative 0.007 0.1505 0.7461
Schistosoma mansoni nuclear hormone receptor 0.005 0.088 0.0892
Schistosoma mansoni thyroid hormone receptor 0.005 0.088 0.0892
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1247 0.1247
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.088 0.155
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.088 0.088
Echinococcus granulosus geminin 0.034 0.9873 0.9873
Brugia malayi hypothetical protein 0.0026 0.0149 0.0262
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.088 0.088
Toxoplasma gondii thioredoxin reductase 0.0087 0.2018 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0261 0.1295
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.024 0.1192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0356 0.1766
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.088 0.155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0431 0.0431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.088 0.0973
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.1008 0.1775
Schistosoma mansoni rab6-interacting 0.0058 0.1142 0.1157
Schistosoma mansoni coup transcription factor 0.005 0.088 0.0892
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0061 0.0108
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1247 0.1247
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0147 0.0172
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0261 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1247 0.298
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0061 0.0061
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.1353 0.6704
Echinococcus multilocularis endoplasmin 0.0026 0.0147 0.0147
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0261 0.019
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.014 0.014
Echinococcus granulosus heat shock protein 90 0.0026 0.0147 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.085 0.094
Loa Loa (eye worm) hypothetical protein 0.0053 0.0977 0.108
Loa Loa (eye worm) hypothetical protein 0.0125 0.3199 0.3534
Schistosoma mansoni hypothetical protein 0.0033 0.0369 0.0374
Echinococcus multilocularis lamin dm0 0.0054 0.1008 0.1008
Trypanosoma brucei heat shock protein, putative 0.0033 0.0356 0.1766
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1505 0.1759
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.088 0.155
Brugia malayi hypothetical protein 0.0058 0.1142 0.2012
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.1142 0.1142
Loa Loa (eye worm) steroid hormone receptor 0.005 0.088 0.0973
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Onchocerca volvulus 0.0233 0.6555 1
Loa Loa (eye worm) endoplasmin 0.0033 0.0356 0.0394
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0061 0.0068
Leishmania major importin beta-1 subunit, putative 0.0024 0.0068 0.0338
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0261 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0061 0.0061
Plasmodium vivax basic transcription factor 3b, putative 0.007 0.1505 0.7461
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.1353 0.1495
Schistosoma mansoni hypothetical protein 0.034 0.9873 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Schistosoma mansoni lipoxygenase 0.0225 0.6327 0.6409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Brugia malayi Pre-SET motif family protein 0.0029 0.024 0.0423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.088 0.0973
Loa Loa (eye worm) hypothetical protein 0.005 0.0892 0.0985
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.088 0.155
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.024 0.024
Echinococcus multilocularis lamin 0.0054 0.1008 0.1008
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0261 0.1295
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.1353 0.6704
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0061 0.0062
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.3838 0.6154
Leishmania major heat shock protein 83-1 0.0033 0.0356 0.1766
Onchocerca volvulus Huntingtin homolog 0.0125 0.3199 0.4831
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0261 0.0309
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.1142 0.1142
Brugia malayi ecdysone receptor 0.0024 0.0061 0.0108
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0261 0.1295
Loa Loa (eye worm) hypothetical protein 0.0033 0.0369 0.0408
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.8559 1
Echinococcus granulosus snurportin 1 0.0313 0.905 0.905
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.007 0.1505 0.1759
Entamoeba histolytica transcription factor BTF3, putative 0.007 0.1505 0.1759
Loa Loa (eye worm) hypothetical protein 0.005 0.088 0.0973
Echinococcus multilocularis geminin 0.034 0.9873 0.9873
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1247 0.1834
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0147 0.073
Schistosoma mansoni polycystin 1-related 0.0058 0.1142 0.1157
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.088 0.0892
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0229 0.0403
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1505 0.1759

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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