Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0195 | 0.5562 | 0.5485 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5562 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.1915 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0346 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0346 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0028 | 0.0647 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0269 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0171 | 0.086 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.1915 | 0.1775 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0171 | 0.086 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0171 | 0.0296 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.1915 | 0.5 |
Echinococcus granulosus | geminin | 0.0195 | 0.5562 | 0.5485 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0269 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.1915 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1915 | 0.5 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0171 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.3919 | 0.3916 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0022 | 0.0476 | 0.0846 |
Echinococcus multilocularis | muscleblind protein | 0.0346 | 1 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0.0006 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1915 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0019 | 0.0384 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0028 | 0.0647 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0171 | 0.0296 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.1915 | 0.1775 |
Entamoeba histolytica | recQ family DNA helicase | 0.0006 | 0.0006 | 0.0241 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0028 | 0.0647 | 0.0485 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.1915 | 0.3436 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.1915 | 0.3436 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0011 | 0.0171 | 0.0164 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0171 | 0.0164 |
Loa Loa (eye worm) | RecQ helicase | 0.0028 | 0.0647 | 0.0641 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0024 | 0.0549 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0018 | 0.0378 | 0.1945 |
Echinococcus multilocularis | bloom syndrome protein | 0.0028 | 0.0647 | 0.0485 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1915 | 0.5 |
Echinococcus granulosus | bloom syndrome protein | 0.0028 | 0.0647 | 0.0485 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0269 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.