Detailed information for compound 542239

Basic information

Technical information
  • TDR Targets ID: 542239
  • Name: N-(3,4-dichlorophenyl)-3-phenyl-6-(trifluorom ethyl)quinoxalin-2-amine
  • MW: 434.241 | Formula: C21H12Cl2F3N3
  • H donors: 1 H acceptors: 2 LogP: 6.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1Cl)Nc1nc2ccc(cc2nc1c1ccccc1)C(F)(F)F
  • InChi: 1S/C21H12Cl2F3N3/c22-15-8-7-14(11-16(15)23)27-20-19(12-4-2-1-3-5-12)28-18-10-13(21(24,25)26)6-9-17(18)29-20/h1-11H,(H,27,29)
  • InChiKey: XKGROWNDYQUOML-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,4-dichlorophenyl)-3-phenyl-6-(trifluoromethyl)-2-quinoxalinamine
  • (3,4-dichlorophenyl)-[3-phenyl-6-(trifluoromethyl)quinoxalin-2-yl]amine
  • 2-Quinoxalineamine, N-(3,4-dichlorophenyl)-3-phenyl-6- trifluoromethyl-
  • NCI60_012374
  • AIDS-136253
  • AIDS136253
  • N-(3,4-Dichlorophenyl)-N-(3-phenyl-6-(trifluoromethyl)-2-quinoxalinyl)amine
  • NSC637410

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0013 0.0171 0.0162
Echinococcus granulosus transcription factor Dp 1 0.0049 0.0751 0.0822
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0668 0.0728
Plasmodium vivax casein kinase II beta chain, putative 0.0035 0.0536 0.0534
Echinococcus granulosus casein kinase ii subunit beta 0.0035 0.0536 0.0577
Loa Loa (eye worm) hypothetical protein 0.0007 0.0079 0.021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0285 0.5112
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0285 0.1479
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Schistosoma mansoni amine oxidase 0.0044 0.0668 0.1579
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0008 0.0084 0.0063
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0208 0.0205
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0285 0.0647
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0249 0.3989 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0084 0.0239
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0035 0.0536 0.0534
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0044 0.0668 0.0939
Echinococcus multilocularis geminin 0.018 0.2879 0.7197
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0285 0.5112
Leishmania major hypothetical protein, unknown function 0.0015 0.0204 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0208 0.1002
Echinococcus granulosus cpg binding protein 0.0018 0.0247 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0668 0.0684
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0204 0.0159
Schistosoma mansoni cell adhesion molecule 0.0015 0.0209 0.0494
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0285 0.1752
Plasmodium falciparum casein kinase II beta chain 0.0035 0.0536 0.0418
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.062 1 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.0536 0.3741
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 0.1473
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0171 0.0779
Loa Loa (eye worm) hypothetical protein 0.0048 0.0741 0.4277
Echinococcus granulosus nibrin 0.002 0.0285 0.0292
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 0.1473
Plasmodium vivax casein kinase II beta chain, putative 0.0035 0.0536 0.0534
Schistosoma mansoni hypothetical protein 0.018 0.2879 0.6803
Trichomonas vaginalis DNA helicase recq1, putative 0.0013 0.0171 0.289
Schistosoma mansoni hypothetical protein 0.0238 0.3812 0.9009
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0015 0.0204 0.0159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0022 0.0000000016839
Entamoeba histolytica recQ family DNA helicase 0.0007 0.0068 0.0032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0749 0.4322
Echinococcus granulosus twitchin 0.0015 0.0209 0.0206
Brugia malayi topoisomerase 0.002 0.0285 0.1479
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.0232 0.1147
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0208 0.0454
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0171 0.0847
Brugia malayi RE40412p 0.0015 0.0204 0.0983
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0285 0.1725
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0749 0.1819
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0204 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0285 0.1725
Loa Loa (eye worm) hypothetical protein 0.0044 0.0668 0.3827
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Giardia lamblia Casein kinase II beta chain 0.0035 0.0536 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0068 0.0005
Echinococcus granulosus intermediate filament protein 0.0016 0.0215 0.0213
Brugia malayi cytoplasmic intermediate filament protein 0.0008 0.0097 0.0328
Schistosoma mansoni topbp1 0.002 0.0285 0.0673
Schistosoma mansoni hypothetical protein 0.0015 0.0208 0.0492
Schistosoma mansoni hypothetical protein 0.0015 0.0208 0.0492
Echinococcus granulosus Immunoglobulin 0.0015 0.0209 0.0206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Loa Loa (eye worm) hypothetical protein 0.0044 0.0668 0.3827
Trichomonas vaginalis protein kinase ck2-beta, putative 0.001 0.0129 0.2076
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0044 0.0668 0.0684
Schistosoma mansoni hypothetical protein 0.0015 0.0204 0.0482
Brugia malayi Bloom's syndrome protein homolog 0.0013 0.0171 0.0779
Echinococcus multilocularis 0.0044 0.0668 0.1616
Mycobacterium ulcerans monoamine oxidase 0.0044 0.0668 0.0395
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0044 0.0668 0.1579
Loa Loa (eye worm) hypothetical protein 0.0044 0.0668 0.3827
Schistosoma mansoni hypothetical protein 0.0264 0.4231 1
Echinococcus granulosus GPCR family 2 0.0015 0.0208 0.0205
Schistosoma mansoni amine oxidase 0.0044 0.0668 0.1579
Echinococcus granulosus geminin 0.018 0.2879 0.3245
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0084 0.1325 0.7859
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.001 0.0129 0.0516
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0535 0.1264
Toxoplasma gondii histone lysine-specific demethylase 0.0044 0.0668 0.0684
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0045 0.0019
Plasmodium vivax chorismate synthase 0.0552 0.8898 1
Schistosoma mansoni DNA helicase recq1 0.0013 0.0171 0.0404
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0285 0.5112
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0015 0.0204 0.0038
Brugia malayi intermediate filament protein 0.0016 0.0215 0.1051
Brugia malayi Intermediate filament tail domain containing protein 0.0016 0.0215 0.1051
Toxoplasma gondii ck2 beta subunit 0.0035 0.0536 0.0534
Toxoplasma gondii zinc finger cdgsh type protein 0.0015 0.0204 0.0159
Schistosoma mansoni hypothetical protein 0.0033 0.0495 0.1169
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0015 0.0204 0.0038
Plasmodium falciparum casein kinase II beta chain 0.0035 0.0536 0.0418
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0668 0.0728
Schistosoma mansoni vesicular amine transporter 0.0015 0.0209 0.0494
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0044 0.0668 0.1579
Echinococcus multilocularis dnaJ subfamily B 0.0238 0.3812 0.9554
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0008 0.0084 0.014
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0264 0.4231 1
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0285 0.0673
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 0.1473
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0171 0.289
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Loa Loa (eye worm) casein kinase II 0.001 0.0129 0.0517
Echinococcus granulosus neuroglian 0.0015 0.0209 0.0206
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0249 0.3989 0.4508
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0285 0.5112
Schistosoma mansoni casein kinase II beta subunit 0.0035 0.0536 0.1266
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0016 0.0215 0.1045
Echinococcus multilocularis conserved hypothetical protein 0.0015 0.0204 0.0443
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Echinococcus multilocularis bloom syndrome protein 0.0013 0.0171 0.036
Loa Loa (eye worm) intermediate filament protein 0.0016 0.0215 0.1045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0171 0.0121
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.0536 0.3741
Echinococcus granulosus lamin dm0 0.0016 0.0215 0.0213
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0668 0.4775
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0013 0.0171 0.0773
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0171 0.0779
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0285 0.1725
Schistosoma mansoni cpg binding protein 0.0017 0.0232 0.0547
Loa Loa (eye worm) hypothetical protein 0.0044 0.0668 0.3827
Leishmania major UDP-galactopyranose mutase 0.0044 0.0668 0.431
Echinococcus multilocularis neuroglian 0.0015 0.0209 0.0457
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0208 0.0454
Chlamydia trachomatis chorismate synthase 0.0552 0.8898 1
Echinococcus multilocularis cpg binding protein 0.0018 0.0247 0.0552
Loa Loa (eye worm) hypothetical protein 0.0015 0.0204 0.0977
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0084 0.1325 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Brugia malayi CXXC zinc finger family protein 0.0017 0.0232 0.1152
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0022 0.0000000016839
Brugia malayi hypothetical protein 0.0044 0.0668 0.3831
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0015 0.0209 0.0494
Echinococcus granulosus dnaJ subfamily B 0.0238 0.3812 0.4307
Brugia malayi amine oxidase, flavin-containing family protein 0.0044 0.0668 0.3831
Onchocerca volvulus 0.0017 0.0232 0.0188
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0013 0.0171 0.036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0032 0.0473 0.0464
Loa Loa (eye worm) hypothetical protein 0.0033 0.0495 0.2761
Schistosoma mansoni DNA ligase IV 0.002 0.0285 0.0673
Mycobacterium ulcerans dehydrogenase 0.0044 0.0668 0.0395
Echinococcus granulosus bloom syndrome protein 0.0013 0.0171 0.0162
Loa Loa (eye worm) Csnk2b protein 0.0035 0.0536 0.3013
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0749 0.1819
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0084 0.1325 0.3131
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Echinococcus granulosus conserved hypothetical protein 0.0015 0.0204 0.02
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0022 0.0000000016839
Echinococcus multilocularis roundabout 2 0.0015 0.0209 0.0457
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0204 0.0159
Schistosoma mansoni DNA helicase recq5 0.0013 0.0171 0.0404
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 0.1473
Loa Loa (eye worm) hypothetical protein 0.0015 0.0204 0.0977
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0044 0.0668 0.1616
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0209 0.0457
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0044 0.0668 0.057
Echinococcus granulosus lamin 0.0016 0.0215 0.0213
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Echinococcus granulosus roundabout 2 0.0015 0.0209 0.0206
Echinococcus multilocularis nibrin 0.002 0.0285 0.0647
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0084 0.1325 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 0.1473
Loa Loa (eye worm) hypothetical protein 0.0007 0.0079 0.021
Echinococcus multilocularis transcription factor Dp 1 0.0049 0.0751 0.1823
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0171 0.289
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0749 0.4326
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0285 0.025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0668 0.3827
Schistosoma mansoni lamin 0.0016 0.0215 0.0508
Schistosoma mansoni intermediate filament proteins 0.0016 0.0215 0.0508
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0084 0.1325 0.1476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0022 0.0000000016839
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0028 0.0067
Schistosoma mansoni cpg binding protein 0.0018 0.0247 0.0584
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0035 0.0536 0.3161
Echinococcus multilocularis lamin 0.0016 0.0215 0.0471
Mycobacterium ulcerans chorismate synthase 0.0552 0.8898 0.8866
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0741 0.4281
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0285 0.1479
Echinococcus multilocularis lamin dm0 0.0016 0.0215 0.0471
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0285 0.025
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0232 0.1153
Onchocerca volvulus 0.0016 0.0215 0.0076
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0035 0.0536 0.2257
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0285 0.0988
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Brugia malayi hypothetical protein 0.002 0.0285 0.1479
Giardia lamblia Replication factor C, subunit 1 0.002 0.0285 0.3832
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0015 0.0204 0.0159
Loa Loa (eye worm) hypothetical protein 0.002 0.0285 0.1473
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0749 0.177
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0668 0.4775
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0035 0.0536 0.3721
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.0272 0.4368 0.429
Chlamydia trachomatis protoporphyrinogen oxidase 0.0044 0.0668 0.0445
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0285 0.5112
Echinococcus multilocularis GPCR, family 2 0.0015 0.0208 0.0454
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0106 0.1674 1
Brugia malayi casein kinase II, putaitve 0.001 0.0129 0.0523
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0576 0.9293 1
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0285 0.025
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0015 0.0204 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Echinococcus multilocularis musashi 0.0016 0.0215 0.0471
Treponema pallidum DNA ligase (lig) 0.002 0.0285 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0208 0.1008
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0209 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0749 0.177
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0285 0.5112
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0285 0.5
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0064 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0215 0.1045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Brugia malayi hypothetical protein 0.002 0.0285 0.1479
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.001 0.0129 0.0516
Loa Loa (eye worm) hypothetical protein 0.0007 0.0068 0.0142
Entamoeba histolytica hypothetical protein 0.002 0.0285 0.1752
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.0022 0.0000000016839
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0013 0.0171 0.0162
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0773
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0035 0.0536 0.3721
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0008 0.0097 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0749 0.082
Loa Loa (eye worm) RecQ helicase 0.0013 0.0171 0.0773
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Schistosoma mansoni hypothetical protein 0.0015 0.0208 0.0492
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0285 0.5112
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0208 0.1008
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0084 0.1325 0.3274
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0209 0.1015
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0007 0.0068 0.0005
Brugia malayi DKFZp564C0469 protein 0.002 0.0285 0.1479
Onchocerca volvulus 0.0044 0.0668 0.3159
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0209 0.1015
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0546 0.8813 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0741 0.4277
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0495 0.2766
Loa Loa (eye worm) hypothetical protein 0.0007 0.0068 0.0142
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0232 0.1148
Mycobacterium ulcerans oxidoreductase 0.0044 0.0668 0.0395
Echinococcus multilocularis Immunoglobulin 0.0015 0.0209 0.0457
Echinococcus multilocularis casein kinase ii subunit beta 0.0035 0.0536 0.1281
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0013 0.0171 0.036
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0022 0.0000000016839
Echinococcus granulosus defective proboscis extension response 0.0015 0.0209 0.0206
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0013 0.0171 0.0121
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0084 0.1325 0.786
Echinococcus granulosus replication factor c subunit 1 0.002 0.0285 0.0292
Onchocerca volvulus 0.0016 0.0215 0.0076
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.0272 0.4368 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.0022 0.0000000016839
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0022 0.0000000016839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0749 0.177
Plasmodium falciparum protoporphyrinogen oxidase 0.0044 0.0668 0.057
Schistosoma mansoni cpg binding protein 0.0018 0.0247 0.0584
Trichomonas vaginalis casein kinase II beta chain, putative 0.001 0.0129 0.2076
Onchocerca volvulus 0.0106 0.1674 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0044 0.0668 0.0395
Giardia lamblia Sgs1 DNA helicase, putative 0.0013 0.0171 0.1027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0045 0.0042
Echinococcus multilocularis Immunoglobulin 0.0015 0.0209 0.0457
Brugia malayi Csnk2b protein 0.0035 0.0536 0.3018
Schistosoma mansoni lamin 0.0016 0.0215 0.0508
Loa Loa (eye worm) hypothetical protein 0.0015 0.0209 0.1009
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0285 0.1725
Plasmodium falciparum chorismate synthase 0.0552 0.8898 1
Schistosoma mansoni hypothetical protein 0.018 0.2879 0.6803
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0044 0.0668 0.057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0171 0.0817
Onchocerca volvulus 0.002 0.0285 0.055
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0668 0.0684
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0084 0.1325 1
Schistosoma mansoni hypothetical protein 0.0015 0.0208 0.0492
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0068 0.0161
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.0536 0.3741
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0285 0.5112
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0285 0.5112
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.0685 0.0703
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0044 0.0668 0.0684
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0208 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0285 0.5112
Brugia malayi SWIRM domain containing protein 0.0044 0.0668 0.3831
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0208 0.1002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0035 0.0536 0.2257
Brugia malayi RE40412p 0.0015 0.0204 0.0983
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0668 0.3827
Schistosoma mansoni topbp1 0.002 0.0285 0.0673
Echinococcus multilocularis protoporphyrinogen oxidase 0.0044 0.0668 0.1616
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0749 0.082
Trichomonas vaginalis protein kinase ck2-beta, putative 0.001 0.0129 0.2076
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0015 0.0209 0.0494
Schistosoma mansoni nephrin 0.0015 0.0209 0.0494
Loa Loa (eye worm) hypothetical protein 0.0015 0.021 0.1017
Loa Loa (eye worm) hypothetical protein 0.0106 0.1674 1
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0285 0.0131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0741 0.4281
Toxoplasma gondii chorismate synthase, putative 0.0552 0.8898 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0084 0.1325 1
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0035 0.0536 0.3161
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0084 0.1325 1
Brugia malayi hypothetical protein 0.0015 0.0209 0.1015

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.067 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.712 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.395 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.331 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.124 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.