Detailed information for compound 542477

Basic information

Technical information
  • TDR Targets ID: 542477
  • Name: calcium oxido(oxo)borane
  • MW: 127.713 | Formula: B2CaH2O4
  • H donors: 0 H acceptors: 4 LogP: -2.22 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]B=O.[O-]B=O.[CaH2+2]
  • InChi: 1S/2BO2.Ca/c2*2-1-3;/q2*-1;+2
  • InChiKey: ILOKQJWLMPPMQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • calcium oxidanidyl(oxo)borane
  • calcium keto(oxido)borane
  • calcium oxido-oxoborane
  • calcium oxido-oxo-borane
  • calcium keto-oxido-borane

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.021 0.021
Trichomonas vaginalis ran, putative 0.0046 0.0226 0.4335
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.0068 0.1271
Brugia malayi Nuclear hormone receptor E75 0.002 0.0068 0.0126
Loa Loa (eye worm) oxidoreductase 0.002 0.0068 0.0127
Onchocerca volvulus 0.002 0.0068 0.0201
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0245 0.0491
Schistosoma mansoni hypothetical protein 0.0661 0.4091 0.4091
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0014 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0044 0.0038
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Loa Loa (eye worm) patched family protein 0.0013 0.002 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0069 0.0375 0.0437
Echinococcus multilocularis snurportin 1 0.0661 0.4091 0.4087
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0014 0.0098
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0077 0.2006
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0068 0.0061
Brugia malayi ecdysone receptor 0.002 0.0068 0.0126
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0084 0.0467 0.9247
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0068 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0375 0.0414
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.002 0.0068 0.0062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0255 0.4929
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0036 0.003
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0178 0.0225
Toxoplasma gondii histone lysine methyltransferase SET1 0.013 0.0755 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0184 0.3477
Onchocerca volvulus Protein patched homolog 0.0013 0.002 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0035 0.0435
Leishmania major acetyl-CoA synthetase, putative 0.002 0.0068 0.1198
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0179 0.5243
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0274 0.0268
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.021 0.0204
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0068 0.0061
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0178 0.0695
Brugia malayi Glycosyl hydrolases family 31 protein 0.0378 0.2315 0.4755
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.013 0.2636
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0375 0.0414
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Mycobacterium ulcerans hypothetical protein 0.0069 0.0375 0.0414
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.021 0.0421
Schistosoma mansoni hypothetical protein 0.0096 0.0545 0.0545
Giardia lamblia Flap structure-specific endonuclease 0.003 0.013 0.0501
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0117 0.211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.021 0.0421
Schistosoma mansoni hypothetical protein 0.0333 0.2035 0.2035
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0375 0.0414
Echinococcus multilocularis geminin 0.0331 0.2022 0.2017
Echinococcus granulosus FTZ F1 alpha 0.0043 0.021 0.0204
Trypanosoma brucei glucosidase, putative 0.0084 0.0467 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.009
Echinococcus multilocularis protein dispatched 1 0.0102 0.0584 0.0578
Loa Loa (eye worm) hypothetical protein 0.0052 0.0265 0.0533
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0069 0.0375 0.0414
Schistosoma mansoni nuclear receptor 0.002 0.0068 0.0068
Onchocerca volvulus 0.002 0.0068 0.0201
Echinococcus multilocularis bloom syndrome protein 0.0053 0.0271 0.0265
Loa Loa (eye worm) hypothetical protein 0.0052 0.0265 0.0533
Entamoeba histolytica hypothetical protein 0.005 0.0255 0.1006
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0375 0.7981
Schistosoma mansoni thyroid hormone receptor 0.0043 0.021 0.021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.6744
Loa Loa (eye worm) hypothetical protein 0.0033 0.0148 0.0292
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Schistosoma mansoni hypothetical protein 0.0033 0.0148 0.0148
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.0068 0.0127
Loa Loa (eye worm) hypothetical protein 0.0048 0.0245 0.0491
Echinococcus multilocularis transportin 1 0.0012 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Echinococcus multilocularis lysosomal alpha glucosidase 0.0378 0.2315 0.231
Plasmodium falciparum acetyl-CoA synthetase, putative 0.002 0.0068 0.1723
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.021 0.0204
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0068 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.021 0.0204
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0329 0.0323
Schistosoma mansoni nuclear receptor 0.002 0.0068 0.0068
Toxoplasma gondii patched family protein 0.0013 0.002 0.0013
Brugia malayi AMP-binding enzyme family protein 0.002 0.0068 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.021 0.0421
Schistosoma mansoni hypothetical protein 0.0087 0.0484 0.0484
Trichomonas vaginalis alpha-glucosidase, putative 0.0084 0.0467 0.9247
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0031 0.0136 0.2503
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Schistosoma mansoni nuclear hormone receptor 0.002 0.0068 0.0068
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0068 0.0068
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0069 0.0063
Brugia malayi Bloom's syndrome protein homolog 0.0053 0.0271 0.0546
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.021 0.0204
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.0359 0.0726
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0036 0.0062
Loa Loa (eye worm) hypothetical protein 0.0052 0.0265 0.0533
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.021 0.0421
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0068 0.0061
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0068 0.0061
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.002 0.0068 0.1198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0035 0.0435
Trichomonas vaginalis sucrase-isomaltase, putative 0.0084 0.0467 0.9247
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0136 0.2503
Echinococcus granulosus geminin 0.0331 0.2022 0.2017
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.021 0.0666
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0069 0.0375 0.0414
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.1818 0.1813
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0077 0.007
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1203 0.75 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.009
Onchocerca volvulus 0.0013 0.002 0.0043
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0013 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Toxoplasma gondii patched family protein 0.0013 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0036
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0014 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.021 0.0421
Echinococcus granulosus expressed conserved protein 0.0196 0.1174 0.1169
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0378 0.2315 0.4755
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.013 0.238
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.016 0.0947 0.1938
Brugia malayi Patched related family protein 4 0.0013 0.002 0.0027
Brugia malayi hypothetical protein 0.0023 0.0083 0.0158
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0083 0.0083
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.021 0.021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0274 0.0552
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0036 0.0062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0035 0.0435
Echinococcus granulosus dnaJ subfamily B 0.0949 0.5903 0.59
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0828 0.0828
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.002 0.0068 0.0024
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.0068 0.0127
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0044 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.021 0.0204
Echinococcus multilocularis flap endonuclease 1 0.003 0.013 0.0124
Brugia malayi hypothetical protein 0.002 0.0068 0.0126
Loa Loa (eye worm) hypothetical protein 0.0498 0.3072 0.6314
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Onchocerca volvulus 0.0013 0.002 0.0043
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.0068 0.1108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0062
Onchocerca volvulus Huntingtin homolog 0.0142 0.0831 0.269
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0068 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0035 0.0435
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Trichomonas vaginalis DNA helicase recq1, putative 0.0053 0.0271 0.5256
Brugia malayi nuclear hormone receptor 0.002 0.0068 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0265 0.0533
Echinococcus granulosus translational activator gcn1 0.0012 0.0013 0.0007
Schistosoma mansoni cpg binding protein 0.0067 0.0359 0.0359
Schistosoma mansoni DNA helicase recq5 0.0022 0.0077 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.021 0.0421
Toxoplasma gondii patched family protein 0.0013 0.002 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.021 0.0421
Brugia malayi protein C24B5.3 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0136 0.2503
Plasmodium vivax importin-beta 2, putative 0.0062 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.021 0.021
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0375 0.076
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.002 0.0068 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0084 0.0467 0.9247
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0209 0.1254 0.5044
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Entamoeba histolytica Flap nuclease, putative 0.003 0.013 0.0501
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.021 0.0204
Trichomonas vaginalis alpha-glucosidase, putative 0.0084 0.0467 0.9247
Entamoeba histolytica recQ family DNA helicase 0.0011 0.001 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.02 0.0194
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0036 0.0164 0.4878
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.002 0.0068 0.1198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0375 0.0437
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0069 0.0375 0.0414
Schistosoma mansoni importin-beta 2 0.0012 0.0013 0.0013
Brugia malayi Glycosyl hydrolases family 31 protein 0.0031 0.0136 0.0268
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0077 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0083 0.0158
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0044 0.0038
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0069 0.0375 0.076
Loa Loa (eye worm) acetyltransferase 0.0141 0.0826 0.1688
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.021 0.0204
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0179 0.0697
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.021 0.0204
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0068 0.0126
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0226 0.022
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0013 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0274 0.0268
Onchocerca volvulus 0.0219 0.1314 0.4265
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1203 0.75 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0036 0.003
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0184 0.0366
Loa Loa (eye worm) hypothetical protein 0.0142 0.0831 0.1698
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0158
Onchocerca volvulus 0.0013 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.021 0.0204
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Brugia malayi hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0158
Loa Loa (eye worm) hypothetical protein 0.0142 0.0831 0.1698
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.021 0.021
Onchocerca volvulus 0.0013 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0329 0.6952
Brugia malayi Glycosyl hydrolases family 31 protein 0.0084 0.0467 0.0949
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0083 0.0083
Trypanosoma brucei acetyl-CoA synthetase, putative 0.002 0.0068 0.1198
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0404 0.248 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0245 0.0491
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Echinococcus multilocularis X box binding protein 1 0.0333 0.2035 0.203
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0013 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0248 0.0265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0248 0.0265
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.002 0.0068 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0274 0.0268
Brugia malayi ecdysteroid receptor 0.0043 0.021 0.0421
Brugia malayi Flap endonuclease-1 0.003 0.013 0.0255
Brugia malayi protein C24B5.3 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0158
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0068 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.021 0.0421
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0375 0.076
Schistosoma mansoni par domain protein 0.0011 0.0006 0.0006
Leishmania major alpha glucosidase II subunit, putative 0.0084 0.0467 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0031 0.0136 0.0525
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.0145
Brugia malayi hypothetical protein 0.0013 0.002 0.0027
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0068 0.0024
Onchocerca volvulus Huntingtin homolog 0.0142 0.0831 0.269
Onchocerca volvulus Protein patched homolog 0.0013 0.002 0.0043
Brugia malayi AMP-binding enzyme family protein 0.002 0.0068 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Onchocerca volvulus 0.002 0.0068 0.02
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.1254 0.1249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.021 0.0421
Brugia malayi nuclear receptor NHR-88 0.0043 0.021 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0096 0.0545 0.0539
Trichomonas vaginalis alpha-glucosidase, putative 0.0084 0.0467 0.9247
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0158
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.021 0.021
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.1254 0.1249
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0375 0.7981
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.002 0.0068 0.0024
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0052 0.0265 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0178 0.3686
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.002 0.0068 0.0078
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0148 0.0292
Plasmodium falciparum lipid/sterol:H+ symporter 0.0013 0.002 0.0195
Echinococcus multilocularis dnaJ subfamily B 0.0949 0.5903 0.59
Loa Loa (eye worm) flap endonuclease-1 0.003 0.013 0.0255
Schistosoma mansoni hypothetical protein 0.0087 0.0484 0.0484
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0136 0.2503
Echinococcus granulosus importin subunit beta 1 0.0062 0.0329 0.0323
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0329 0.0426
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0226 0.681
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.021 0.0421
Schistosoma mansoni nuclear hormone receptor 0.0043 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0062 0.0329 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.021 0.0421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0035 0.0435
Giardia lamblia DNA repair protein RAD52 0.0404 0.248 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0069 0.0063
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.013 0.0161
Schistosoma mansoni rotamase 0.0039 0.0184 0.0184
Toxoplasma gondii hypothetical protein 0.0013 0.002 0.0013
Schistosoma mansoni alpha-glucosidase 0.0325 0.1984 0.1984
Brugia malayi hypothetical protein 0.002 0.0068 0.0126
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0031 0.0136 0.2768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0068 0.0024
Onchocerca volvulus 0.0069 0.0375 0.1204
Echinococcus multilocularis muscleblind protein 0.0783 0.4861 0.4858
Loa Loa (eye worm) patched family protein 0.0013 0.002 0.0027
Brugia malayi Patched protein homolog 1 0.0013 0.002 0.0027
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.02 0.3813
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0068 0.0061
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0068 0.0068
Trichomonas vaginalis maltase-glucoamylase, putative 0.0084 0.0467 0.9247
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0826 0.0826
Onchocerca volvulus 0.0043 0.021 0.0666
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0127
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0077 0.0145
Trichomonas vaginalis rotamase, putative 0.0038 0.0178 0.336
Brugia malayi steroid hormone receptor 0.0043 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Schistosoma mansoni zinc finger protein 0.002 0.0068 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0375 0.0414
Schistosoma mansoni ran 0.0046 0.0226 0.0226
Brugia malayi Patched related family protein 10 0.0013 0.002 0.0027
Trichomonas vaginalis importin beta-1, putative 0.005 0.0255 0.4929
Plasmodium falciparum flap endonuclease 1 0.003 0.013 0.3703
Schistosoma mansoni thyrotroph embryonic factor related 0.0011 0.0006 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.021 0.0204
Trichomonas vaginalis rotamase, putative 0.0039 0.0184 0.3477
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0084 0.0467 0.1862
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.0069 0.0375 0.076
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.0068 0.1108
Brugia malayi Nuclear hormone receptor E75 0.002 0.0068 0.0126
Echinococcus granulosus X box binding protein 1 0.0333 0.2035 0.203
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Leishmania major glycosyl hydrolase-like protein 0.0031 0.0136 0.2707
Schistosoma mansoni cpg binding protein 0.007 0.0382 0.0382
Echinococcus multilocularis microtubule associated protein 2 0.1601 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0046 0.0231 0.69
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0031 0.0136 0.0424
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Loa Loa (eye worm) hypothetical protein 0.0069 0.0375 0.076
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.021 0.0666
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.02 0.0255
Leishmania major importin beta-1 subunit, putative 0.005 0.0255 0.5331
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0161 0.0202
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.02 0.3813
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0265 0.0266
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.002 0.0068 0.0078
Schistosoma mansoni hypothetical protein 0.0331 0.2022 0.2022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0084 0.0467 0.0611
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0265 0.0533
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0068 0.0127
Brugia malayi nuclear hormone receptor 0.0043 0.021 0.0421
Echinococcus granulosus lysosomal alpha glucosidase 0.0378 0.2315 0.231
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0068 0.0126
Schistosoma mansoni acetyl-CoA synthetase 0.002 0.0068 0.0068
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.021 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.021 0.0421
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0077 0.007
Schistosoma mansoni hypothetical protein 0.0096 0.0545 0.0545
Brugia malayi nuclear receptor RXR 0.002 0.0068 0.0126
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0375 0.0414
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.002 0.0068 0.0062
Schistosoma mansoni alpha glucosidase 0.0084 0.0467 0.0467
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0375 0.076
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0504 0.0498
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0826 0.1688
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.021 0.0421
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0504 0.0498
Loa Loa (eye worm) patched family protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.002 0.0068 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.021 0.0204
Toxoplasma gondii propionate-CoA ligase 0.002 0.0068 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0274 0.0268
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0068 0.0061
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1203 0.75 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0274 0.0274
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0044 0.0044
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0031 0.0136 0.2768
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0467 1
Onchocerca volvulus 0.0013 0.002 0.0043
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.02 0.6013
Plasmodium falciparum acyl-CoA synthetase 0.0052 0.0265 0.7988
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0248 0.0265
Toxoplasma gondii pantoate-beta-alanine ligase 0.1203 0.75 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0096 0.0545 0.0539
Brugia malayi RNA, U transporter 1 0.0176 0.1046 0.2141
Echinococcus multilocularis muscleblind protein 1 0.0783 0.4861 0.4858
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0255 0.537
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0096 0.0545 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0274 0.0274
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.0068 0.1271
Echinococcus granulosus muscleblind protein 0.0783 0.4861 0.4858
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0044 0.0038
Brugia malayi hypothetical protein 0.0498 0.3072 0.6314
Echinococcus granulosus bloom syndrome protein 0.0053 0.0271 0.0265
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0068 0.0061
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.0068 0.1271
Loa Loa (eye worm) RecQ helicase 0.0053 0.0271 0.0546
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0011 0.0006 0.0006
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0068 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0084 0.0467 0.9247
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0801 0.0795
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0031 0.0136 0.2503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0035 0.0435
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.021 0.0204
Brugia malayi hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0077 0.0145
Loa Loa (eye worm) apoptosis regulator protein 0.0096 0.0545 0.111
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0226 0.0289
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0329 0.6952
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0504 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0084 0.0467 0.0949
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0184 0.0366
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0068 0.02
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.021 0.0421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0035 0.0435
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0014 0.0098
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0178 0.3633
Brugia malayi CHE-14 protein 0.009 0.0504 0.1025
Echinococcus granulosus importin 5 0.0012 0.0013 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.021 0.0204
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0068 0.02
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.002 0.0068 0.0024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.021 0.021
Echinococcus granulosus neutral alpha glucosidase AB 0.0084 0.0467 0.0461
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0115 0.0663 0.2653
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0212 0.1275 0.1275
Schistosoma mansoni DNA helicase recq1 0.0022 0.0077 0.0077
Schistosoma mansoni patched 1 0.009 0.0504 0.0504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.021 0.0421
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0036 0.003
Brugia malayi Patched related family protein 12 0.0013 0.002 0.0027
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.021 0.0421
Brugia malayi nuclear receptor NHR-67 0.002 0.0068 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0136 0.2503
Trypanosoma brucei glycosyl hydrolase-like protein 0.0031 0.0136 0.2707
Brugia malayi nuclear receptor RXR 0.0023 0.0083 0.0158
Plasmodium vivax transportin, putative 0.0012 0.0013 0.0201
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0375 0.1492
Loa Loa (eye worm) hypothetical protein 0.0209 0.1254 0.257
Echinococcus granulosus cpg binding protein 0.007 0.0382 0.0376
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.021 0.0204
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Entamoeba histolytica Ran family GTPase 0.0046 0.0226 0.0888
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Schistosoma mansoni coup transcription factor 0.0043 0.021 0.021
Echinococcus multilocularis lysosomal alpha glucosidase 0.0378 0.2315 0.231
Plasmodium vivax flap endonuclease 1, putative 0.003 0.013 0.383
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0255 0.4929
Brugia malayi Myosin head containing protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0545 0.111
Brugia malayi conserved hypotetical protein 0.002 0.0068 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0226 0.4733
Brugia malayi Importin beta-1 subunit 0.0062 0.0329 0.0664
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Echinococcus granulosus Protein patched homolog 1 0.009 0.0504 0.0498
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0013 0.0029
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.013 0.2574
Schistosoma mansoni importin beta-1 0.0062 0.0329 0.0329
Echinococcus multilocularis expressed conserved protein 0.0196 0.1174 0.1169
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.021 0.0421
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0274 0.0552
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0226 0.4688
Schistosoma mansoni hypothetical protein 0.0949 0.5903 0.5903
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0068 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.021 0.021
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0013 0.0005
Echinococcus multilocularis translational activator gcn1 0.0012 0.0013 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0068 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.021 0.0204
Onchocerca volvulus 0.002 0.0068 0.02
Schistosoma mansoni hypothetical protein 0.0087 0.0484 0.0484
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0226 0.4733
Loa Loa (eye worm) hypothetical protein 0.0783 0.4861 1
Brugia malayi tailless protein 0.002 0.0068 0.0126
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0084 0.0467 0.1862
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0069 0.0375 0.0414
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.001 0.5
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0014 0.5
Brugia malayi AMP-binding enzyme family protein 0.002 0.0068 0.0127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Plasmodium vivax acetyl-CoA synthetase, putative 0.002 0.0068 0.189
Echinococcus granulosus transportin 1 0.0012 0.0013 0.0007
Trichomonas vaginalis maltase-glucoamylase, putative 0.0031 0.0136 0.2503
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.021 0.021
Schistosoma mansoni alpha-glucosidase 0.0325 0.1984 0.1984
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0052 0.0265 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Brugia malayi hypothetical protein 0.0023 0.0083 0.0158
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0117 0.2281
Schistosoma mansoni hypothetical protein 0.0331 0.2022 0.2022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0178 0.3633
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.013 0.2574
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0068 0.0126
Toxoplasma gondii patched family protein 0.0013 0.002 0.0013
Echinococcus multilocularis cpg binding protein 0.007 0.0382 0.0376
Echinococcus multilocularis expressed protein 0.0039 0.0184 0.0178
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0083 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Echinococcus granulosus flap endonuclease 1 0.003 0.013 0.0124
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0504 0.1025
Schistosoma mansoni apoptosis regulator bax 0.0096 0.0545 0.0545
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0036 0.003
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.0888
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Plasmodium vivax patched family protein, putative 0.0013 0.002 0.0393
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0826 0.082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.021 0.0421
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0077 0.007
Schistosoma mansoni nuclear hormone receptor 0.002 0.0068 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0245 0.0491
Brugia malayi CXXC zinc finger family protein 0.0067 0.0359 0.0726
Schistosoma mansoni cpg binding protein 0.007 0.0382 0.0382
Echinococcus granulosus GPCR family 2 0.0015 0.0036 0.003
Leishmania major acetyl-CoA synthetase, putative 0.002 0.0068 0.1198
Onchocerca volvulus 0.0067 0.0359 0.1149
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0007 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0117 0.2346
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0068 0.0126
Loa Loa (eye worm) hypothetical protein 0.0783 0.4861 1
Echinococcus granulosus snurportin 1 0.0661 0.4091 0.4087
Onchocerca volvulus 0.0013 0.002 0.0043
Leishmania major GTP-binding protein, putative 0.0046 0.0226 0.4688
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.021 0.0421
Brugia malayi kap beta 3 protein 0.0012 0.0013 0.0015
Plasmodium falciparum importin beta, putative 0.0062 0.0329 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0096 0.0545 0.111
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Brugia malayi Patched family protein 0.0013 0.002 0.0027
Onchocerca volvulus 0.002 0.0068 0.0201
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0084 0.0467 0.9247
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Trichomonas vaginalis DNA helicase recq, putative 0.0053 0.0271 0.5256
Brugia malayi Muscleblind-like protein 0.0783 0.4861 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0068 0.0127
Loa Loa (eye worm) patched family protein 0.0013 0.002 0.0027
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.1818 0.1813
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.021 0.0421
Brugia malayi AMP-binding enzyme family protein 0.002 0.0068 0.0127
Echinococcus multilocularis protein patched 0.009 0.0504 0.0498
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0117 0.2281
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0179 0.0697
Trichomonas vaginalis alpha-glucosidase, putative 0.0031 0.0136 0.2503
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.021 0.0204
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0158
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.021 0.021
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.021 0.0666
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.021 0.0421
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.002 0.0068 0.0024
Loa Loa (eye worm) hypothetical protein 0.009 0.0504 0.1025
Echinococcus multilocularis neutral alpha glucosidase AB 0.0084 0.0467 0.0461
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0421
Echinococcus multilocularis importin 5 0.0012 0.0013 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0375 0.1492
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0467 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.0453
Brugia malayi hypothetical protein 0.0142 0.0831 0.1698
Plasmodium vivax acyl-CoA synthetase, putative 0.0052 0.0265 0.8028
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0375 0.7981
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0036 0.0062
Loa Loa (eye worm) DR-78 0.002 0.0068 0.0126
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0096 0.0545 0.0539
Schistosoma mansoni blooms syndrome DNA helicase 0.0042 0.0202 0.0202
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0035 0.0435
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.4868 0.4865
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0069 0.013
Brugia malayi hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0083 0.0158
Loa Loa (eye worm) hypothetical protein 0.011 0.0631 0.1286
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0248 0.0265
Schistosoma mansoni thyroid hormone receptor 0.0043 0.021 0.021
Brugia malayi nuclear receptor NHR-88 0.002 0.0068 0.0126
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.02 0.0255
Schistosoma mansoni ran 0.0046 0.0226 0.0226
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.0068 0.1271
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0178 0.3686
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.021 0.0421
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0126
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0068 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0035 0.0435
Schistosoma mansoni flap endonuclease-1 0.0027 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0036
Loa Loa (eye worm) patched family protein 0.0013 0.002 0.0027
Brugia malayi acetyl-Coenzyme A synthetase 2 0.002 0.0068 0.0127
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Echinococcus granulosus expressed protein 0.0039 0.0184 0.0178
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.002 0.0068 0.0024
Schistosoma mansoni hypothetical protein 0.0096 0.0545 0.0545
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0226 0.0453
Entamoeba histolytica acyl-coA synthetase, putative 0.0069 0.0375 0.1492
Onchocerca volvulus 0.0498 0.3072 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0036 0.003
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0068 0.0061
Schistosoma mansoni hypothetical protein 0.0087 0.0484 0.0484
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0226 0.022
Schistosoma mansoni microtubule-associated protein tau 0.1601 1 1
Onchocerca volvulus 0.002 0.0068 0.0201
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0068 0.0024
Trichomonas vaginalis helicase, putative 0.0015 0.0035 0.0435
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0068 0.0126
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0083 0.0077
Onchocerca volvulus 0.0013 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0127
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0096 0.0545 0.0539
Entamoeba histolytica recQ family helicase, putative 0.0028 0.0117 0.0447
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0661 0.4091 0.8413
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0083 0.0158
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0027
Entamoeba histolytica hypothetical protein 0.0115 0.0663 0.2653
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0077 0.007
Brugia malayi Niemann-Pick C1 protein precursor 0.0209 0.1254 0.257

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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