Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor gamma | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Schistosoma japonicum | ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | Get druggable targets OG5_130073 | All targets in OG5_130073 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.274 | Plasma lipid-lowering activity at a dosage of 0.001% in the diet in KKAy mice | ChEMBL. | 11906293 |
Activity (functional) | = 53 | Plasma glucose-lowering activity at a dosage of 0.001% in the diet in KKAy mice | ChEMBL. | 11906293 |
Activity (functional) | = 54 | Plasma glucose-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. | ChEMBL. | 11906293 |
Activity (functional) | = 69 | Plasma lipid-lowering activity at a dosage of 0.005% in the diet in KKA(y) mice. | ChEMBL. | 11906293 |
Activity (functional) | = 82 | Plasma lipid-lowering activity at a dosage of 0.01% in the diet in KKAy mice | ChEMBL. | 11906293 |
EC50 (functional) | = 16.5 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
EC50 (functional) | = 16.5 nM | Transcriptional activation in COS cells expressing PPAR gamma and RXR alpha | ChEMBL. | 11906293 |
ED25 (functional) | = 0.048 mg kg-1 day-1 | Effective dose for 25% reduction in plasma glucose-lowering activity in Wistar fatty rats | ChEMBL. | 11906293 |
ND (functional) | 0 | Effective dose for 25% reduction in plasma glucose-lowering activity of KKAy mice;ND denotes no-data | ChEMBL. | 11906293 |
ND (functional) | 0 | Plasma glucose-lowering activity at a dosage of 0.01% in the diet in KKA(y) mice. | ChEMBL. | 11906293 |
ND (functional) | 0 | Effective dose for 25% reduction in plasma lipid-lowering activity of KKA(y) mice. | ChEMBL. | 11906293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.