Detailed information for compound 542829

Basic information

Technical information
  • TDR Targets ID: 542829
  • Name: (4R)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)tetrahydropyran -2-yl]oxy-cyclohexene-1-carbaldehyde
  • MW: 330.373 | Formula: C16H26O7
  • H donors: 4 H acceptors: 5 LogP: -0.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@@H](O[C@H]2CC(=C(C(C2)(C)C)C=O)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C16H26O7/c1-8-4-9(5-16(2,3)10(8)6-17)22-15-14(21)13(20)12(19)11(7-18)23-15/h6,9,11-15,18-21H,4-5,7H2,1-3H3/t9-,11-,12-,13+,14-,15-/m1/s1
  • InChiKey: WMHJCSAICLADIN-WYWSWGBSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R)-2,6,6-trimethyl-4-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-1-cyclohexenecarboxaldehyde
  • (4R)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-cyclohexene-1-carbaldehyde
  • (4R)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-cyclohexene-1-carbaldehyde
  • (4R)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycyclohexene-1-carbaldehyde
  • picrocrocin
  • 138-55-6
  • (R)-4-(beta-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde
  • 1-Cyclohexene-1-carboxaldehyde, 4-(beta-D-glucopyranosyloxy)-2,6,6-trimethyl-, (R)-
  • 4-(beta-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0552
Schistosoma mansoni hypothetical protein 0.033 0.8152 0.8144
Brugia malayi Pre-SET motif family protein 0.0208 0.5064 0.835
Loa Loa (eye worm) hypothetical protein 0.0122 0.2906 0.3529
Onchocerca volvulus 0.0236 0.5784 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0601 0.0688
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0826
Schistosoma mansoni apoferritin-2 0.0008 0.0044 0.0001
Brugia malayi intermediate filament protein 0.0027 0.0519 0.0791
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0044 0.0076
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.001 0.0093 0.005
Echinococcus granulosus low density lipoprotein receptor ldl 0.001 0.0093 0.005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0326 0.4208
Brugia malayi RNA, U transporter 1 0.0088 0.2053 0.3342
Loa Loa (eye worm) beta-lactamase 0.0035 0.0714 0.0826
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.0989 0.095
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.3711 0.6099
Chlamydia trachomatis metal transport ATPase 0.0008 0.0044 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.543 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0714 0.1114
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0326 0.4208
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0326 0.0284
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.1023 0.0985
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0044 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.2486 0.4061
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.156 0.1523
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0826
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0412 0.5491
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0137
Schistosoma mansoni tar DNA-binding protein 0.019 0.4618 0.4594
Onchocerca volvulus 0.003 0.0601 0.0971
Echinococcus multilocularis expressed protein 0.0008 0.0044 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.1023 0.0985
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0412 0.3133
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.001 0.0093 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0714 0.0673
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.001 0.0093 0.006
Echinococcus multilocularis lamin dm0 0.0027 0.0519 0.0478
Entamoeba histolytica hypothetical protein 0.011 0.2605 1
Schistosoma mansoni hypothetical protein 0.005 0.1107 0.1068
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0044 0.0076
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.001 0.0093 0.0081
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0412 0.5491
Schistosoma mansoni hypothetical protein 0.001 0.0093 0.005
Brugia malayi calpain 5 0.0019 0.0326 0.0469
Echinococcus granulosus calpain A 0.0019 0.0326 0.0284
Echinococcus granulosus calpain 0.0019 0.0326 0.0284
Mycobacterium tuberculosis Conserved protein 0.0035 0.0714 0.1243
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0601 0.0561
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0601 0.0561
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.4508 0.4484
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0714 0.0673
Brugia malayi Importin beta-1 subunit 0.0031 0.0617 0.0954
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.3711 0.4523
Loa Loa (eye worm) hypothetical protein 0.0027 0.0519 0.0587
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Echinococcus multilocularis low density lipoprotein receptor protein 0.001 0.0093 0.005
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0326 0.4208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1009 0.097
Brugia malayi hypothetical protein 0.011 0.2605 0.4259
Trichomonas vaginalis importin beta-1, putative 0.0025 0.047 0.0812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1009 0.097
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0044 0.0001
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0044 0.0009
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.001 0.0093 0.006
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.0081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1009 0.097
Echinococcus multilocularis geminin 0.0164 0.3957 0.3931
Leishmania major importin beta-1 subunit, putative 0.0025 0.047 0.6361
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0087 0.0044
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Loa Loa (eye worm) calpain family protein 1 0.0065 0.1476 0.1766
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1107 0.1768
Echinococcus granulosus low density lipoprotein receptor protein 0.001 0.0093 0.005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0326 0.4208
Echinococcus multilocularis GPCR, family 2 0.0049 0.1064 0.1025
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0412 0.0454
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0093 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0167 0.0124
Brugia malayi enteropeptidase precursor 0.001 0.0093 0.0081
Schistosoma mansoni copper ABC transporter ATPase 0.0008 0.0044 0.0001
Entamoeba histolytica hypothetical protein 0.0025 0.047 0.1664
Echinococcus multilocularis basement membrane specific heparan sulfate 0.001 0.0093 0.005
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.1023 0.1208
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0826
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0601 0.0561
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0714 1
Onchocerca volvulus 0.0035 0.0714 0.1167
Echinococcus granulosus ferritin 0.0008 0.0044 0.0001
Echinococcus multilocularis copper transporting ATPase 1 0.0008 0.0044 0.0001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0412 0.5491
Loa Loa (eye worm) hypothetical protein 0.0085 0.198 0.2388
Schistosoma mansoni cpg binding protein 0.0028 0.0552 0.0511
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.001 0.0093 0.005
Echinococcus granulosus phospholipid transporting ATPase VA 0.0008 0.0044 0.0001
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0008 0.0044 0.0001
Loa Loa (eye worm) TAR-binding protein 0.019 0.4618 0.5641
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.047 0.6361
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0044 0.0076
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0326 0.0284
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0044 0.0076
Echinococcus multilocularis calpain 0.0019 0.0326 0.0284
Mycobacterium tuberculosis Conserved protein 0.0035 0.0714 0.1243
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.047 0.0812
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.006
Onchocerca volvulus 0.001 0.0093 0.0085
Schistosoma mansoni lamin 0.0027 0.0519 0.0478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1009 0.097
Echinococcus granulosus tar DNA binding protein 0.019 0.4618 0.4594
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.1023 0.0985
Trichomonas vaginalis set domain proteins, putative 0.0236 0.5784 1
Brugia malayi Pre-SET motif family protein 0.003 0.0601 0.0927
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0044 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0714 0.0826
Brugia malayi calpain family protein 1 0.0065 0.1476 0.2382
Onchocerca volvulus Basement membrane proteoglycan homolog 0.001 0.0093 0.0085
Loa Loa (eye worm) hypothetical protein 0.0154 0.3711 0.4523
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0137
Echinococcus multilocularis ferritin 0.0008 0.0044 0.0001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0167 0.0124
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0008 0.0044 0.0001
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.001 0.0093 0.0081
Schistosoma mansoni ferritin 0.0008 0.0044 0.0001
Schistosoma mansoni ferritin light chain 0.0008 0.0044 0.0001
Echinococcus multilocularis musashi 0.0027 0.0519 0.0478
Schistosoma mansoni hypothetical protein 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.2486 0.3011
Schistosoma mansoni hypothetical protein 0.0049 0.1064 0.1025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0558 0.0517
Loa Loa (eye worm) hypothetical protein 0.0031 0.0617 0.0707
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0714 0.1234
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0601 0.0561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.2605 0.2573
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0044 0.0001
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0068 0.156 0.1523
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0044 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.5064 0.6192
Leishmania major GTP-binding protein, putative 0.0023 0.0412 0.5491
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.1187 0.1149
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.001 0.0093 0.005
Echinococcus multilocularis lamin 0.0027 0.0519 0.0478
Schistosoma mansoni hypothetical protein 0.0049 0.1064 0.1025
Echinococcus granulosus cation transporting atpase worm 0.0008 0.0044 0.0001
Brugia malayi mbt repeat family protein 0.0047 0.1023 0.1629
Onchocerca volvulus 0.001 0.0093 0.0085
Loa Loa (eye worm) hypothetical protein 0.0049 0.1064 0.1258
Loa Loa (eye worm) hypothetical protein 0.0027 0.0507 0.0571
Onchocerca volvulus 0.0035 0.0714 0.1167
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.04 0.0358
Schistosoma mansoni atpase class VI type 11c 0.0008 0.0044 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.1023 0.1208
Schistosoma mansoni survival motor neuron protein 0.005 0.1107 0.1068
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0326 0.1101
Schistosoma mansoni ferritin 0.0008 0.0044 0.0001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0326 0.4208
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.1187 0.1149
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0044 0.0001
Loa Loa (eye worm) calpain family protein 1 0.0046 0.0989 0.1165
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0044 0.0001
Schistosoma mansoni hypothetical protein 0.0105 0.2486 0.2453
Leishmania major hypothetical protein, conserved 0.0035 0.0714 1
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0044 1
Schistosoma mansoni transcription factor LCR-F1 0.011 0.2605 0.2573
Onchocerca volvulus Huntingtin homolog 0.0122 0.2906 0.4985
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0068 0.156 0.1523
Onchocerca volvulus 0.0027 0.0519 0.0829
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.0081
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.0081
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.1064 0.1025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1379 0.1342
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.047 0.0812
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0044 0.0001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0412 0.5491
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0044 0.0076
Echinococcus multilocularis hypothetical protein 0.0019 0.0326 0.0284
Loa Loa (eye worm) hypothetical protein 0.0247 0.6056 0.7415
Onchocerca volvulus Huntingtin homolog 0.0122 0.2906 0.4985
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0714 0.1243
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0714 0.1243
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Brugia malayi Latrophilin receptor protein 2 0.0049 0.1064 0.1696
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.001 0.0093 0.005
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.6056 0.6039
Onchocerca volvulus 0.001 0.0093 0.0085
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0552
Plasmodium vivax calpain, putative 0.0019 0.0326 0.4208
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.0081
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0617 0.0577
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0008 0.0044 0.0076
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0008 0.0044 0.0076
Trichomonas vaginalis esterase, putative 0.0035 0.0714 0.1234
Plasmodium vivax SET domain protein, putative 0.003 0.0601 0.8324
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0326 0.4208
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1009 0.119
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0519 0.0587
Echinococcus multilocularis cation transporting ATPase 13A3 0.0008 0.0044 0.0001
Schistosoma mansoni ran 0.0023 0.0412 0.037
Echinococcus granulosus geminin 0.0164 0.3957 0.3931
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.4508 0.4484
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.1023 0.0985
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Echinococcus granulosus basement membrane specific heparan sulfate 0.001 0.0093 0.005
Loa Loa (eye worm) histone methyltransferase 0.001 0.0087 0.0053
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.1187 0.1149
Loa Loa (eye worm) hypothetical protein 0.0085 0.198 0.2388
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.1187 0.1902
Leishmania major kinesin, putative 0.0019 0.0326 0.4208
Loa Loa (eye worm) MBCTL1 0.0054 0.1187 0.141
Trypanosoma brucei kinesin, putative 0.0019 0.0326 0.4208
Onchocerca volvulus 0.0046 0.0989 0.1646
Loa Loa (eye worm) hypothetical protein 0.0046 0.0989 0.1165
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.1023 0.0985
Echinococcus granulosus low density lipoprotein receptor ldl 0.001 0.0093 0.005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.4618 0.5641
Loa Loa (eye worm) hypothetical protein 0.0013 0.0167 0.0152
Plasmodium vivax importin-beta 2, putative 0.0031 0.0617 0.8561
Echinococcus granulosus cation transporting ATPase 13A1 0.0008 0.0044 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0714 0.1243
Brugia malayi calpain 7 0.0019 0.0326 0.0469
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0714 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0714 0.1243
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.1064 0.1696
Schistosoma mansoni ferritin 0.0008 0.0044 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0989 0.1165
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0714 1
Echinococcus multilocularis snurportin 1 0.033 0.8152 0.8144
Mycobacterium leprae Probable lipase LipE 0.0035 0.0714 1
Echinococcus multilocularis calpain A 0.0068 0.156 0.1523
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.006
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0714 1
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0008 0.0044 0.0001
Onchocerca volvulus 0.0027 0.0519 0.0829
Schistosoma mansoni tar DNA-binding protein 0.019 0.4618 0.4594
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0826
Schistosoma mansoni cation-transporting atpase worm 0.0008 0.0044 0.0001
Brugia malayi TAR-binding protein 0.019 0.4618 0.7607
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.6056 0.6039
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0714 0.1243
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0065 0.1476 0.1439
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0552
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0617 0.4885
Schistosoma mansoni cation-transporting ATPase 0.0008 0.0044 0.0001
Onchocerca volvulus Terribly reduced optic lobes homolog 0.001 0.0093 0.0085
Onchocerca volvulus 0.001 0.0093 0.0085
Brugia malayi follicle stimulating hormone receptor 0.0233 0.57 0.9408
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.2605 0.2573
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0552
Loa Loa (eye worm) hypothetical protein 0.0065 0.1476 0.1766
Echinococcus granulosus snurportin 1 0.033 0.8152 0.8144
Echinococcus granulosus lamin 0.0027 0.0519 0.0478
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0714 0.1234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0601 0.0561
Onchocerca volvulus 0.001 0.0093 0.0085
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.1064 0.1258
Echinococcus granulosus GPCR family 2 0.0049 0.1064 0.1025
Brugia malayi mbt repeat family protein 0.0047 0.1023 0.1629
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0008 0.0044 0.0076
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0008 0.0044 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0714 0.1234
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0714 0.1243
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Schistosoma mansoni tar DNA-binding protein 0.019 0.4618 0.4594
Mycobacterium ulcerans beta-lactamase 0.0035 0.0714 1
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0008 0.0044 0.0076
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.1023 0.0985
Onchocerca volvulus 0.0047 0.1023 0.1706
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0601 0.475
Brugia malayi RNA recognition motif domain containing protein 0.019 0.4618 0.7607
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0008 0.0044 0.0001
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0044 0.0076
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0203 0.0197
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0412 0.037
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0519 0.0791
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Schistosoma mansoni hypothetical protein 0.001 0.0093 0.005
Trypanosoma cruzi kinesin, putative 0.0019 0.0326 0.4208
Brugia malayi beta-lactamase 0.0035 0.0714 0.1114
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.1023 0.0985
Onchocerca volvulus 0.001 0.0093 0.0085
Schistosoma mansoni importin beta-1 0.0031 0.0617 0.0577
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0326 0.4208
Entamoeba histolytica Ran family GTPase 0.0023 0.0412 0.1436
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0714 0.1234
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0008 0.0044 0.0001
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0008 0.0044 0.0076
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.001 0.0093 0.005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0412 0.0612
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.04 0.0358
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0601 0.0561
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1009 0.097
Echinococcus multilocularis dnaJ subfamily B 0.0404 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0087 0.0044
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0412 0.037
Schistosoma mansoni tar DNA-binding protein 0.019 0.4618 0.4594
Schistosoma mansoni lamin 0.0027 0.0519 0.0478
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0326 0.4208
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Echinococcus multilocularis tar DNA binding protein 0.019 0.4618 0.4594
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0044 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0617 0.8561
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0326 0.4208
Echinococcus granulosus importin subunit beta 1 0.0031 0.0617 0.0577
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.1023 0.1706
Schistosoma mansoni hypothetical protein 0.0164 0.3957 0.3931
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0714 1
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0326 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1009 0.097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0714 0.0673
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.001 0.0093 0.005
Onchocerca volvulus 0.0035 0.0714 0.1167
Schistosoma mansoni ferritin light chain 0.0008 0.0044 0.0001
Brugia malayi calpain family protein 1 0.0065 0.1476 0.2382
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0008 0.0044 0.0001
Echinococcus granulosus calpain A 0.0068 0.156 0.1523
Brugia malayi beta-lactamase family protein 0.0035 0.0714 0.1114
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.001 0.0093 0.005
Loa Loa (eye worm) RNA binding protein 0.019 0.4618 0.5641
Echinococcus granulosus calpain 5 0.0019 0.0326 0.0284
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0084 0.0066
Brugia malayi CUB domain containing protein 0.001 0.0093 0.0081
Entamoeba histolytica hypothetical protein 0.011 0.2605 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0519 0.0587
Brugia malayi CXXC zinc finger family protein 0.0028 0.0552 0.0845
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0326 0.4208
Echinococcus granulosus basement membrane specific heparan sulfate 0.001 0.0093 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1009 0.1605
Loa Loa (eye worm) hypothetical protein 0.0122 0.2906 0.3529
Brugia malayi basement membrane proteoglycan precursor 0.001 0.0093 0.0081
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0412 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1187 0.141
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0714 0.1243
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0044 0.0001
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0008 0.0044 0.0001
Echinococcus granulosus intermediate filament protein 0.0027 0.0519 0.0478
Brugia malayi hypothetical protein 0.0085 0.198 0.3221
Schistosoma mansoni phosphoserine phosphatase 0.0008 0.0044 0.0001
Loa Loa (eye worm) hypothetical protein 0.0065 0.1476 0.1766
Brugia malayi hypothetical protein 0.0247 0.6056 1
Plasmodium falciparum importin beta, putative 0.0031 0.0617 1
Schistosoma mansoni hypothetical protein 0.011 0.2605 0.2573
Loa Loa (eye worm) calpain 5 0.0019 0.0326 0.0348
Schistosoma mansoni ferritin 0.0008 0.0044 0.0001
Schistosoma mansoni tar DNA-binding protein 0.019 0.4618 0.4594
Echinococcus multilocularis cation transporting atpase worm 0.0008 0.0044 0.0001
Schistosoma mansoni hypothetical protein 0.0286 0.7042 0.7029
Onchocerca volvulus 0.0028 0.0552 0.0885
Brugia malayi Calcium binding EGF domain containing protein 0.001 0.0093 0.0081
Toxoplasma gondii ABC1 family protein 0.0035 0.0714 0.5706
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0326 0.0284
Entamoeba histolytica hypothetical protein 0.011 0.2605 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0714 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0044 0.5
Trichomonas vaginalis ran, putative 0.0023 0.0412 0.0711
Echinococcus granulosus expressed protein 0.0008 0.0044 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0826
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0714 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.57 0.6976
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.1064 0.1025
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0617 0.8561
Schistosoma mansoni type V p-type atpase isoform 0.0008 0.0044 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0714 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0552 0.0627
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0008 0.0044 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.1064 0.1025
Loa Loa (eye worm) calpain 0.0019 0.0326 0.0348
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0714 0.0673
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1218 1
Echinococcus granulosus cation transporting ATPase 13A3 0.0008 0.0044 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0826
Echinococcus multilocularis calpain 5 0.0019 0.0326 0.0284
Mycobacterium tuberculosis Conserved protein 0.0035 0.0714 0.1243
Schistosoma mansoni ATPase 0.0008 0.0044 0.0001
Entamoeba histolytica protein kinase, putative 0.0019 0.0326 0.1101
Brugia malayi beta-lactamase family protein 0.0035 0.0714 0.1114
Echinococcus multilocularis basement membrane specific heparan sulfate 0.001 0.0093 0.005
Schistosoma mansoni eyes absent homolog 0.0085 0.198 0.1946
Schistosoma mansoni apoferritin-2 0.0008 0.0044 0.0001
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0412 0.6414
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0714 0.1234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.3711 0.6099
Schistosoma mansoni hypothetical protein 0.0164 0.3957 0.3931
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0044 0.0009
Echinococcus granulosus lamin dm0 0.0027 0.0519 0.0478
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.1064 0.1025
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0203 0.0265
Loa Loa (eye worm) hypothetical protein 0.001 0.0093 0.006
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.1187 0.1149
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.1064 0.1025
Echinococcus multilocularis cation transporting ATPase 13A1 0.0008 0.0044 0.0001
Mycobacterium ulcerans lipase LipD 0.0035 0.0714 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0601 0.0561
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0044 0.0001
Trypanosoma brucei antigen, putative 0.0019 0.0326 0.4208
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0326 0.4208
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.1187 0.1149
Brugia malayi hypothetical protein 0.0122 0.2906 0.476
Echinococcus granulosus copper transporting ATPase 1 0.0008 0.0044 0.0001
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0068 0.156 0.1523
Schistosoma mansoni hypothetical protein 0.0049 0.1064 0.1025
Trypanosoma cruzi kinesin, putative 0.0019 0.0326 0.4208
Echinococcus multilocularis phosphoserine phosphatase 0.0008 0.0044 0.0001
Trichomonas vaginalis cation-transporting ATPase, putative 0.0008 0.0044 0.0076
Schistosoma mansoni ran 0.0023 0.0412 0.037
Onchocerca volvulus 0.005 0.1107 0.1851
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.001 0.0093 0.005
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0044 0.0001
Schistosoma mansoni intermediate filament proteins 0.0027 0.0519 0.0478
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.8152 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1009 0.097
Schistosoma mansoni ATPase 0.0008 0.0044 0.0001
Brugia malayi RNA binding protein 0.019 0.4618 0.7607
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.001 0.0093 0.0081
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.001 0.0093 0.005
Entamoeba histolytica hypothetical protein 0.011 0.2605 1
Onchocerca volvulus Arrow homolog 0.001 0.0093 0.0085
Schistosoma mansoni calpain (C02 family) 0.0019 0.0326 0.0284
Trichomonas vaginalis ferritin, putative 0.0008 0.0044 0.0077
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0008 0.0044 0.0001
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0326 0.4208

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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