Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thioredoxin reductase | 0.0097 | 0.2735 | 0.5915 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0519 | 0.0459 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0604 | 0.123 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0161 | 0.0099 |
Treponema pallidum | NADH oxidase | 0.0034 | 0.0566 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1514 | 0.146 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0604 | 0.123 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0034 | 0.0566 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.1514 | 0.3395 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.2902 | 0.6509 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0826 | 0.1852 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0097 | 0.2735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0669 |
Plasmodium falciparum | glutathione reductase | 0.0097 | 0.2735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0763 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0684 | 0.1535 |
Leishmania major | trypanothione reductase | 0.0097 | 0.2735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1754 | 0.3934 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0519 | 0.1037 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0025 | 0.0261 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4458 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0646 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.4458 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0097 | 0.2735 | 0.6079 |
Plasmodium falciparum | thioredoxin reductase | 0.0097 | 0.2735 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1514 | 0.146 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0519 | 0.1164 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.1514 | 0.3395 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0034 | 0.0566 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.1514 | 0.302 |
Toxoplasma gondii | thioredoxin reductase | 0.0097 | 0.2735 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.1514 | 0.33 |
Onchocerca volvulus | 0.0026 | 0.0315 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0061 | 0.1514 | 0.302 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0161 | 0.0223 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0034 | 0.0566 | 0.1144 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0222 | 0.6986 | 0.8837 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0646 | 0.0965 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0315 | 0.0572 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1514 | 0.146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1514 | 0.146 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0246 | 0.7831 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0519 | 0.1037 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1389 | 0.3018 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.1799 | 0.1747 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0025 | 0.0261 | 0.0051 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0034 | 0.0566 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0098 | 0.022 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0097 | 0.2735 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.4458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4458 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.4458 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0646 | 0.0587 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0034 | 0.0566 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0682 | 0.1049 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.1508 | 0.1454 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0315 | 0.0572 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0097 | 0.2735 | 0.6079 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0034 | 0.0566 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.1514 | 0.33 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0519 | 0.1037 |
Trypanosoma brucei | trypanothione reductase | 0.0097 | 0.2735 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0246 | 0.7831 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0315 | 0.0572 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0222 | 0.6986 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0315 | 0.0706 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.2902 | 0.6311 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0646 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0646 | 0.1327 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.2902 | 0.6311 |
Plasmodium vivax | glutathione reductase, putative | 0.0097 | 0.2735 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0646 | 0.1327 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.1895 | 0.3925 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0098 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1799 | 0.4035 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1514 | 0.146 |
Loa Loa (eye worm) | glutathione reductase | 0.0097 | 0.2735 | 0.6134 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0161 | 0.0223 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0246 | 0.7831 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0034 | 0.0566 | 0.5 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0034 | 0.0566 | 0.0506 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0097 | 0.2735 | 0.6134 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0097 | 0.2735 | 0.2985 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0646 | 0.0587 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0315 | 0.0572 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0519 | 0.1037 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0315 | 0.0706 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0519 | 0.1037 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0519 | 0.1037 |
Onchocerca volvulus | 0.0026 | 0.0315 | 0.5 | |
Schistosoma mansoni | lamin | 0.0026 | 0.0315 | 0.0253 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0034 | 0.0566 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0315 | 0.0572 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0519 | 0.0459 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.2902 | 0.6509 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0315 | 0.0178 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.1799 | 0.3696 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0034 | 0.0566 | 0.0774 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0315 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0519 | 0.0459 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1389 | 0.3018 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0222 | 0.6986 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0222 | 0.6986 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0222 | 0.6986 | 0.8837 |
Schistosoma mansoni | lamin | 0.0026 | 0.0315 | 0.0253 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0222 | 0.6986 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0246 | 0.7831 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0034 | 0.0566 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0519 | 0.0662 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0315 | 0.0706 |
Brugia malayi | glutathione reductase | 0.0097 | 0.2735 | 0.5915 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0519 | 0.0459 |
Echinococcus granulosus | lamin | 0.0026 | 0.0315 | 0.0572 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0646 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.1514 | 0.3395 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.4458 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.1514 | 0.302 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0034 | 0.0566 | 0.1144 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0034 | 0.0566 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0519 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0519 | 0.1164 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0315 | 0.0253 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.