Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0096 | 0.0707 | 0.0697 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0205 | 0.2338 | 0.2331 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0096 | 0.0707 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0205 | 0.2338 | 0.2331 |
Leishmania major | histone deacetylase, putative | 0.0719 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0049 | 0.001 | 0.001 |
Entamoeba histolytica | histone deacetylase, putative | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0289 | 0.3598 | 0.3592 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0719 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0719 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0289 | 0.3598 | 0.3592 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0205 | 0.2338 | 0.2331 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0719 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0359 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.3598 | 0.3592 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0359 | 0.035 |
Brugia malayi | Histone deacetylase 1 | 0.0719 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0205 | 0.2338 | 0.2331 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0205 | 0.2338 | 0.2338 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0719 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0334 | 0.0325 |
Schistosoma mansoni | acetylcholinesterase | 0.0049 | 0.001 | 0.001 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0205 | 0.2338 | 0.1756 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0719 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0719 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0719 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0049 | 0.001 | 0.001 |
Echinococcus granulosus | histone deacetylase 1 | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0071 | 0.0334 | 0.0325 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0359 | 0.035 |
Echinococcus multilocularis | histone deacetylase | 0.0205 | 0.2338 | 0.2331 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0205 | 0.2338 | 0.1756 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0359 | 0.035 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0719 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0334 | 0.0325 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0289 | 0.3598 | 0.3592 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0359 | 0.035 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.3598 | 0.3592 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0334 | 0.0325 |
Leishmania major | histone deacetylase, putative | 0.0719 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0205 | 0.2338 | 0.2338 |
Echinococcus multilocularis | acetylcholinesterase | 0.0289 | 0.3598 | 0.3592 |
Echinococcus multilocularis | acetylcholinesterase | 0.0289 | 0.3598 | 0.3592 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0071 | 0.0334 | 0.0325 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0719 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0205 | 0.2338 | 0.2338 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0096 | 0.0707 | 0.0697 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0289 | 0.3598 | 0.3592 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0205 | 0.2338 | 0.2331 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0707 | 0.0697 |
Echinococcus granulosus | histone deacetylase 3 | 0.0719 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0205 | 0.2338 | 0.2331 |
Loa Loa (eye worm) | histone deacetylase | 0.0205 | 0.2338 | 0.2331 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.001 | 0.001 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0205 | 0.2338 | 0.1756 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0719 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0359 | 0.035 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0205 | 0.2338 | 0.2331 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.3598 | 0.3592 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0205 | 0.2338 | 0.2338 |
Brugia malayi | Peptidase family M13 containing protein | 0.0096 | 0.0707 | 0.0697 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0205 | 0.2338 | 0.2331 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0049 | 0.001 | 0.001 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0719 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0719 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0205 | 0.2338 | 0.2331 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0096 | 0.0707 | 0.0697 |
Trypanosoma brucei | histone deacetylase 1 | 0.0719 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0719 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0096 | 0.0707 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0096 | 0.0707 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0707 | 0.0697 |
Echinococcus granulosus | carboxylesterase 5A | 0.0289 | 0.3598 | 0.3592 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0707 | 0.0697 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0096 | 0.0707 | 0.0707 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0289 | 0.3598 | 0.3598 |
Echinococcus granulosus | histone deacetylase 8 | 0.0205 | 0.2338 | 0.2331 |
Echinococcus granulosus | histone deacetylase 6 | 0.0205 | 0.2338 | 0.2331 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0205 | 0.2338 | 0.2331 |
Brugia malayi | histone deacetylase 11 | 0.0205 | 0.2338 | 0.2331 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0205 | 0.2338 | 0.2338 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0049 | 0.001 | 0.001 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.3598 | 0.3592 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0334 | 0.0325 |
Echinococcus granulosus | acetylcholinesterase | 0.0289 | 0.3598 | 0.3592 |
Echinococcus granulosus | histone deacetylase 6 | 0.0205 | 0.2338 | 0.2331 |
Giardia lamblia | Histone deacetylase | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 7 | 0.0205 | 0.2338 | 0.2331 |
Echinococcus granulosus | histone deacetylase | 0.0205 | 0.2338 | 0.2331 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0205 | 0.2338 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0719 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0719 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.2338 | 0.2331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.