Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.4215 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.4215 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.4215 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.4215 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.4215 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.4215 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.4215 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4215 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.4215 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.4215 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.4215 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.4215 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EDMES(2.5) (functional) | > 200 mg kg-1 | Anticonvulsant activity measured as effective dose required toproduce a response score of 2.5 in MES assay on mice | ChEMBL. | 14998338 |
EDMES(2.5) (functional) | > 200 mg kg-1 | Anticonvulsant activity measured as effective dose required toproduce a response score of 2.5 in MES assay on mice | ChEMBL. | 14998338 |
Log 1/EDMES(2.5) (functional) | = -2.3 | Anticonvulsant activity expressed as log(1/EDMES(2.5)) in MES assay on mice that responded a score of 2.5 | ChEMBL. | 14998338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.