Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.049 | 0.2463 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0211 | 0.0169 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0552 | 0.0512 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0039 | 0.0843 | 0.0843 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.049 | 0.8591 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0416 | 0.1717 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0.0843 | 0.4505 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.157 | 0.8702 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.021 | 0.0168 |
Echinococcus multilocularis | muscleblind protein | 0.0328 | 1 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0536 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.021 | 0.0168 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0211 | 0.085 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0211 | 0.022 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0416 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0843 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3759 | 0.3924 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0211 | 0.0211 |
Onchocerca volvulus | 0.003 | 0.0552 | 0.176 | |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1794 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0536 | 0.0536 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.1794 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0535 | 0.0494 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0536 | 0.2728 |
Onchocerca volvulus | 0.0026 | 0.0416 | 0.1268 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3759 | 0.3924 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1794 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.157 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0843 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0416 | 0.2034 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0843 | 0.4505 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.006 | 0.006 |
Echinococcus multilocularis | lamin | 0.003 | 0.0552 | 0.0552 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0416 | 0.2034 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0416 | 0.1514 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0289 | 0.2432 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0416 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.4419 | 0.4613 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0111 | 0.0047 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0359 | 0.3789 |
Brugia malayi | RNA, U transporter 1 | 0.0084 | 0.2259 | 0.2209 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0111 | 0.0068 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.3567 | 0.3539 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0416 | 0.0354 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.157 | 0.157 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0211 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.3759 | 0.3759 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0359 | 0.1707 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0416 | 0.1514 |
Schistosoma mansoni | ran | 0.0022 | 0.0289 | 0.0302 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0211 | 0.1886 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0211 | 0.022 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0289 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.006 | 0.0017 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.021 | 0.0168 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0871 | 0.0871 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0211 | 0.0246 |
Echinococcus multilocularis | snurportin 1 | 0.0315 | 0.9579 | 0.9579 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.049 | 0.8591 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0416 | 0.0375 |
Schistosoma mansoni | lamin | 0.003 | 0.0552 | 0.0576 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.049 | 0.2463 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0416 | 0.1514 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.3567 | 0.3539 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.05 | 0.0459 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.021 | 0.0239 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0416 | 0.0354 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0359 | 0.3789 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.157 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.157 | 1 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0552 | 0.0491 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0536 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0211 | 0.085 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.3759 | 0.3719 |
Trichomonas vaginalis | ran, putative | 0.0022 | 0.0289 | 0.2891 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0843 | 0.4655 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.3759 | 0.3732 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0843 | 0.4505 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0359 | 0.1707 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1794 | 0.1794 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.157 | 0.1639 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0416 | 0.2034 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.021 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0416 | 0.0375 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0039 | 0.0843 | 1 |
Echinococcus granulosus | lamin | 0.003 | 0.0552 | 0.0552 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0359 | 0.1707 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0289 | 0.0247 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0536 | 0.0475 |
Schistosoma mansoni | lamin | 0.003 | 0.0552 | 0.0576 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.049 | 0.2463 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0552 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0536 | 0.0495 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.049 | 0.2054 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0536 | 0.056 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0536 | 0.2728 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0211 | 0.1886 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1794 | 0.1873 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.157 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0416 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.157 | 1 |
Schistosoma mansoni | ran | 0.0022 | 0.0289 | 0.0302 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0871 | 0.0871 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1794 | 0.1794 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0416 | 0.1717 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0416 | 0.1514 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0177 | 0.5199 | 0.5199 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.5199 | 0.5199 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.4419 | 0.4613 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0359 | 0.3789 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0.0843 | 0.4505 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0416 | 0.1514 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0843 | 0.088 |
Onchocerca volvulus | 0.0102 | 0.2839 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0552 | 0.0512 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0552 | 0.0552 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3759 | 0.3924 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0289 | 0.1302 |
Echinococcus granulosus | muscleblind protein | 0.0328 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.5199 | 0.5199 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0039 | 0.0843 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.021 | 0.0168 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0552 | 0.0512 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.157 | 0.1639 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0843 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0211 | 0.5 |
Echinococcus multilocularis | musashi | 0.003 | 0.0552 | 0.0552 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0843 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.3759 | 0.3732 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.049 | 0.8591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3759 | 0.3924 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.1794 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3759 | 0.3924 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0211 | 0.0032 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0289 | 0.0227 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0843 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.006 | 0.006 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0177 | 0.5199 | 0.5178 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0289 | 0.0289 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0211 | 0.0032 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0552 | 0.0576 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0289 | 0.1302 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.1794 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0289 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0416 | 0.2034 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0039 | 0.0843 | 0.0843 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.157 | 0.157 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0211 | 0.085 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0175 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.049 | 0.0449 |
Brugia malayi | RNA binding protein | 0.0131 | 0.3759 | 0.3719 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0416 | 0.0375 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0211 | 0.0211 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0416 | 0.2034 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0843 | 0.4505 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.049 | 0.2463 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0064 | 0.0021 |
Echinococcus granulosus | snurportin 1 | 0.0315 | 0.9579 | 0.9579 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0315 | 0.9579 | 0.9578 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.9579 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0328 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0211 | 0.085 |
Onchocerca volvulus | 0.003 | 0.0552 | 0.176 | |
Entamoeba histolytica | Ran family GTPase | 0.0022 | 0.0289 | 0.1302 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0552 | 0.0491 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0289 | 0.2432 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0843 | 0.0804 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0211 | 0.0008 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0177 | 0.5199 | 0.5168 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0843 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0843 | 0.4505 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0536 | 0.2393 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.05 | 0.0439 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0843 | 0.0784 |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0289 | 0.1302 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0416 | 0.1514 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.3759 | 0.3719 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.3759 | 0.3732 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0416 | 0.1514 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1794 | 0.1759 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0416 | 0.1514 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.3759 | 0.3759 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0416 | 0.2034 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0289 | 0.0576 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.3567 | 0.3526 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0843 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0211 | 0.085 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0289 | 0.1302 |
Brugia malayi | hypothetical protein | 0.0028 | 0.049 | 0.0429 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0552 | 0.0552 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0211 | 0.0148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.