Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.1719 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.1719 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1719 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.3717 | 0.7403 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1719 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1719 | 0.1719 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0283 | 0.0283 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0389 | 0.0774 |
Onchocerca volvulus | 0.0029 | 0.2201 | 1 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.5021 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.3717 | 0.3717 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1205 | 0.1205 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1719 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0389 | 0.0774 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2837 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1122 | 0.6071 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0283 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0283 | 0.0283 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0283 | 0.0546 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.2837 | 0.565 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.3717 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.1205 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.1719 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.2201 | 0.2201 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1205 | 0.1205 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0283 | 0.0546 |
Echinococcus multilocularis | smad | 0.0008 | 0.0389 | 0.1046 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2837 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.2201 | 0.4384 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0454 | 0.0454 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0389 | 0.0389 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1719 | 0.1719 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0464 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1719 | 0.1719 |
Echinococcus granulosus | smad | 0.0008 | 0.0389 | 0.1046 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.1719 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0389 | 0.0389 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.3717 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.3717 | 0.3717 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.3717 | 0.7403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.3717 | 0.7403 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.4451 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0464 | 0.1249 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0283 | 0.0546 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0389 | 0.0774 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0283 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2837 | 0.565 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0283 | 0.0283 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0283 | 0.5 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0464 | 0.0464 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0389 | 0.0389 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0283 | 0.0546 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.1205 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.3717 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0389 | 0.1046 |
Brugia malayi | Smad1 | 0.0008 | 0.0389 | 0.0389 |
Brugia malayi | hypothetical protein | 0.0036 | 0.2837 | 0.2837 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0311 | 0.0619 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1719 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0283 | 0.0283 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.2837 | 0.7632 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0311 | 0.0836 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.1205 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0004 | 0.0075 | 0.0075 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0389 | 0.1046 |
Onchocerca volvulus | 0.0007 | 0.0283 | 0.1285 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1122 | 0.6071 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0283 | 0.0283 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.2345 | 0.6308 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.2201 | 0.2201 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0283 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0283 | 0.0283 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.1205 | 0.6421 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.1719 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 1 | 1 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0007 | 0.0283 | 0.0761 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0389 | 0.1046 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1122 | 0.6071 |
Onchocerca volvulus | 0.0007 | 0.0283 | 0.1285 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0311 | 0.0836 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1719 | 1 |
Onchocerca volvulus | 0.0007 | 0.0283 | 0.1285 | |
Onchocerca volvulus | 0.0023 | 0.1719 | 0.7809 | |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0389 | 0.0389 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0283 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0389 | 0.0389 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.2345 | 0.4669 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.2837 | 0.7632 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0311 | 0.0836 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1205 | 0.1205 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0389 | 0.1046 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0.0283 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.0283 | 0.5 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0283 | 0.0563 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1719 | 0.1719 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.1719 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1205 | 0.1205 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0283 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0283 | 0.0283 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.2345 | 0.6308 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0283 | 0.0283 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.2345 | 0.4669 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.1719 | 0.5622 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1719 | 0.5622 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0075 | 0.0075 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1719 | 0.5622 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0283 | 0.0546 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.3717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1205 | 0.1205 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1719 | 1 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0007 | 0.0283 | 0.0761 |
Schistosoma mansoni | smad | 0.0008 | 0.0389 | 0.0774 |
Brugia malayi | MH1 domain containing protein | 0.0004 | 0.0075 | 0.0075 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1719 | 0.1719 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1719 | 0.1719 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0389 | 0.0389 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0283 | 0.0546 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0047 | 0.0093 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1719 | 1 |
Onchocerca volvulus | 0.0007 | 0.0283 | 0.1285 | |
Loa Loa (eye worm) | nuclear factor I | 0.0004 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 1 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0283 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0389 | 0.0389 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0389 | 0.1046 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1719 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1719 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.0283 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2837 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.1205 | 0.6617 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2837 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.1122 | 0.6071 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0311 | 0.0836 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0283 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0283 | 0.0283 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0389 | 0.1046 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0389 | 0.0774 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0389 | 0.0774 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0283 | 0.0546 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0283 | 0.0546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.